Abstract:
BACKGROUND:When performing experiments at room temperature with volatile general anesthetics and in vitro mammalian preparations (such as isolated neurons), the question arises as to which concentrations of anesthetics are "clinically relevant." Different choices can lead to different interpretations of the anesthetic sensitivities of putative target sites. METHODS:Published data on the temperature dependence of minimum alveolar concentration were analyzed. RESULTS:Although gas-phase potencies of volatile anesthetics increase markedly with decreasing temperature, the corresponding aqueous-phase potencies are relatively constant. Changes in minimum alveolar concentration with temperature can be accounted for, on physical grounds, in terms of the temperature dependencies of anesthetics binding to their central nervous system target sites. CONCLUSION:When performing room-temperature in vitro experiments on simple mammalian preparations with a volatile anesthetic, the aqueous-phase (but not the gas- phase) minimum alveolar concentration calculated at normal body temperature is, to a first approximation, the appropriate choice for a clinically relevant anesthetic concentration. Recommended aqueous-phase minimum alveolar concentration values (in MM) for desflurane, enflurane, halothane, isoflurane, and sevoflurane have have been calculated.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Franks NP,Lieb WRdoi
10.1097/00000542-199603000-00027subject
Has Abstractpub_date
1996-03-01 00:00:00pages
716-20issue
3eissn
0003-3022issn
1528-1175journal_volume
84pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Although inhalation anesthetic agents are thought to impair cerebral autoregulation more than intravenous agents, there are few controlled studies in humans. METHODS:In the first group (n = 24), dynamic autoregulation was assessed from the response of middle cerebral artery blood flow velocity (Vmca) to a t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199507000-00008
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emerge...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000161
更新日期:2014-05-01 00:00:00
abstract::Nonsteroidal antiinflammatory drugs (NSAIDs) are commonly combined with intravenous morphine patient-controlled analgesia to relieve postoperative pain. NSAIDs have a documented 30-50% sparing effect on morphine consumption. However, most of the studies have not demonstrated a decrease in morphine adverse effects. A m...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/00000542-200506000-00027
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS:The authors determined isoflurane-induced cy...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000299435.59242.0e
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-methyl-D-aspartate receptor activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism responsible for this opioid-...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002648
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Tight perioperative control of blood glucose improves the outcome of diabetic patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass can induce profound hyperglycemia, intraoperative glycemic control may become difficult. The authors undertook a prospective cohort study to de...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200510000-00006
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Only limited data exist comparing differences in sensory function and responses to neural blockade in infant and adult rats. Therefore, the authors sought (1) to compare baseline thermal, proprioceptive, and postural responses in infant, adolescent, and adult rats; and (2) to compare the effects of sciatic n...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199704000-00026
更新日期:1997-04-01 00:00:00
abstract::To study the effect of halothane on the coronary circulation, the circumflex diastolic coronary vascular resistance was measured in the working heart and total mean coronary resistance (TCR) in the isolated nonworking heart of the dog during administration of 100 per cent oxygen and during administration of 2--3 per c...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197704000-00002
更新日期:1977-04-01 00:00:00
abstract::Methylnaltrexone Reverses Chronic Opioid-induced Constipation: A Randomized, Controlled Trial. By Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. JAMA 2000; 130:142-8. Reprinted with permission. CONTEXT:Constipation is the most common chronic adverse effect of opioid pain medications in patien...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002428
更新日期:2019-01-01 00:00:00
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002417
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Anesthetics inhibit airway smooth muscle contraction in part by a direct effect on the smooth muscle cell. This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200407000-00019
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to predict changes in sedation and memory produced by various drugs was t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200110000-00018
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Optimal management of anesthesia-induced respiratory depression requires identification of the neural pathways that are most effective in maintaining breathing during anesthesia. Lesion studies point to the brainstem retrotrapezoid nucleus. We therefore examined the respiratory effects of common anesthetic/a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002675
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:In cardiac patients, pulmonary capillary wedge pressure (PCWP) is estimated using color M-mode Doppler study of left ventricular filling and Doppler tissue imaging. The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients. METHODS:Sixty ventilated pa...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200305000-00011
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (NO), an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. The authors investigated whether inhaled NO decreases pulmonary vascular resistance (PVR) while preserving hypoxic pulmonary vasoconstriction and whether it maintains or improves oxygenation in patients d...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:A primary source of calcium (Ca2+) necessary for excitation contraction in vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force generation in VSM is coupled closely to resting transmembrane potential, which itself is primarily a function of potassium conductance. Previously...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199903000-00021
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200608000-00009
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:To compare continuous cardiac output obtained by simulation of an aortic input impedance model to bolus injection thermodilution (TDCO) in critically ill patients with septic shock. METHODS:In an open study, mechanically ventilated patients with septic shock were monitored for 1 (32 patients), 2 (15 patient...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199905000-00016
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Indirect evidence supports a role of spinal cholinergic neurons in tonically reducing response to noxious mechanical stimulation and in effecting analgesia from alpha2-adrenergic agonists. This study directly assessed the role of cholinergic neurons in regulating the level of mechanical allodynia and in part...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200106000-00023
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:The Bispectral Index (BIS) and the Patient State Index (PSI) quantify depth of anesthesia by analyzing the electroencephalogram. The authors examined the response of BIS and PSI to sevoflurane anesthesia. METHODS:In 22 patients, sevoflurane anesthesia was induced by inhalation with a tight-fitting facemask ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181895fd0
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Although evidence of its effects is tentative, acupuncture has long been used in the treatment of multiple maladies. So far, it has not been possible to discriminate the effects of the venue from specific results of needling itself, thus physicians merely depend on patients' statements. The authors investiga...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e3181b31e24
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The authors recently established that the analgesic actions of the inhalation anesthetic nitrous oxide were mediated by noradrenergic bulbospinal neurons and spinal alpha2B adrenoceptors. They now determined whether noradrenergic brainstem nuclei and descending spinal pathways are responsible for the antinoc...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200202000-00023
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Percutaneous cannulation of the internal jugular vein in infants is technically more difficult and carries a higher risk of carotid artery puncture than in older children and adults. In this prospective study, the authors tested their hypothesis that using an ultrasound scanner would increase the success of ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199907000-00013
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Anesthesia personnel are at risk for occupational infection with bloodborne pathogens from contaminated percutaneous injuries (CPIs). Additional information is needed to formulate methods to reduce risk. METHODS:The authors analyzed CPIs collected during a 2-yr period at 11 hospitals, assessed CPI underrepo...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00000542-199812000-00013
更新日期:1998-12-01 00:00:00
abstract::Operating room fires are rare but devastating events. Guidelines are available for the prevention and management of surgical fires; however, these recommendations are based on expert opinion and case series. The three components of an operating room fire are present in virtually all surgical procedures: an oxidizer (o...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0000000000002598
更新日期:2019-03-01 00:00:00
abstract::To assess the effect of a glucose infusion on brain extracellular fluid (ECF) during systemic hypoxia, changes in glucose and lactate concentrations in cerebral ECF during and after moderate hypoxic hypoxia were measured in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. T...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199210000-00017
更新日期:1992-10-01 00:00:00
abstract::Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is cl...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0b013e318210483d
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess p...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e3181a10731
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We performed a systematic review with meta-analysis of randomized trials to assess whether extracorporeal blood purification reduces mortality in this setting. METHODS:Electronic databases were searched for p...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/ALN.0000000000002820
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199412000-00016
更新日期:1994-12-01 00:00:00