Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.


BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics propofol and sevoflurane. METHODS:Fifty-four adults undergoing thoracic surgery with OLV were randomly assigned to receive either anesthesia with intravenously applied propofol or the volatile anesthetic sevoflurane. A bronchoalveolar lavage was performed before and after OLV on the lung side undergoing surgery. Inflammatory mediators (tumor necrosis factor alpha, interleukin 1beta, interleukin 6, interleukin 8, monocyte chemoattractant protein 1) and cells were analyzed in lavage fluid as the primary endpoint. The clinical outcome determined by postoperative adverse events was assessed as the secondary endpoint. RESULTS:The increase of inflammatory mediators on OLV was significantly less pronounced in the sevoflurane group. No difference in neutrophil recruitment was found between the groups. A positive correlation between neutrophils and mediators was demonstrated in the propofol group, whereas this correlation was missing in the sevoflurane group. The number of composite adverse events was significantly lower in the sevoflurane group. CONCLUSIONS:This prospective, randomized clinical study suggests an immunomodulatory role for the volatile anesthetic sevoflurane in patients undergoing OLV for thoracic surgery with significant reduction of inflammatory mediators and a significantly better clinical outcome (defined by postoperative adverse events) during sevoflurane anesthesia.






De Conno E,Steurer MP,Wittlinger M,Zalunardo MP,Weder W,Schneiter D,Schimmer RC,Klaghofer R,Neff TA,Schmid ER,Spahn DR,Z'graggen BR,Urner M,Beck-Schimmer B




Has Abstract


2009-06-01 00:00:00












  • Hemodynamic predictors of myocardial ischemia during halothane anesthesia for coronary-artery revascularization.

    abstract::The authors undertook a prospective study of 30 patients undergoing halothane anesthesia for coronary-artery revascularization to ascertain which clinically monitored hemodynamic variables--or combination of variables--associated with myocardial oxygen supply and demand best predict myocardial ischemia. Simultaneous r...


    pub_type: 杂志文章


    authors: Lieberman RW,Orkin FK,Jobes DR,Schwartz AJ

    更新日期:1983-07-01 00:00:00

  • Vecuronium neuromuscular blockade reflects liver function during hepatic autotransplantation in pigs.

    abstract:BACKGROUND:Rapid assessment of hepatic function early after reperfusion of the liver graft is of great importance, because it may allow for prompt detection of incipient hepatic graft failure. The current study was undertaken to determine whether the continuous recording of neuromuscular transmission could be used as a...


    pub_type: 杂志文章


    authors: Pittet JF,Morel DR,Mentha G,Schopfer C,Belenger J,Benakis A,Tassonyi E

    更新日期:1994-07-01 00:00:00

  • Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy.

    abstract:BACKGROUND:Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the ef...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rusy LM,Hoffman GM,Weisman SJ

    更新日期:2002-02-01 00:00:00

  • A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.

    abstract:BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...


    pub_type: 杂志文章


    authors: Todd MM,Weeks JB,Warner DS

    更新日期:1993-07-01 00:00:00

  • Retrograde light-guided laryngoscopy for tracheal intubation: clinical practice and comparison with conventional direct laryngoscopy.

    abstract:BACKGROUND:Tracheal intubation with conventional laryngoscopy requires many trials until beginners are sufficiently skilled in intubating patients safely. To facilitate intubation, the authors used retrograde light-guided laryngoscopy (RLGL) and compared its feasibility with conventional direct laryngoscopy (DL). METH...


    pub_type: 杂志文章,随机对照试验


    authors: Yang T,Hou J,Li J,Zhang X,Zhu X,Ni W,Mao Y,Deng X

    更新日期:2013-05-01 00:00:00

  • Acute pain management. Programs in U.S. hospitals and experiences and attitudes among U.S. adults.

    abstract:BACKGROUND:The objective of the survey was to assess the status of acute pain management in U.S. hospitals and attitudes of adults in the U.S. toward postoperative pain management, information that has not been previously available. METHODS:Two telephone questionnaire surveys were conducted U.S. hospital participants,...


    pub_type: 杂志文章


    authors: Warfield CA,Kahn CH

    更新日期:1995-11-01 00:00:00

  • Contact-free infrared thermography for assessing effects during acupuncture: a randomized, single-blinded, placebo-controlled crossover clinical trial.

    abstract:BACKGROUND:Although evidence of its effects is tentative, acupuncture has long been used in the treatment of multiple maladies. So far, it has not been possible to discriminate the effects of the venue from specific results of needling itself, thus physicians merely depend on patients' statements. The authors investiga...


    pub_type: 杂志文章,随机对照试验


    authors: Agarwal-Kozlowski K,Lange AC,Beck H

    更新日期:2009-09-01 00:00:00

  • Differential effects of inhalation anesthetics on myocardial potentiated-state contractions in vitro.

    abstract::The effects of enflurane, halothane, and isoflurane on myocardial potentiated-state contractions were examined in a study in which each of the anesthetics was presented, in random order, to each of eight isolated rabbit papillary muscles. Post-rest potentiated-state contractions were elicited by imposing a stimulus at...


    pub_type: 杂志文章


    authors: DeTraglia MC,Komai H,Rusy BF

    更新日期:1988-04-01 00:00:00

  • Thiopental requirements for induction of anesthesia in neonates and in infants one to six months of age.

    abstract::The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the ...


    pub_type: 杂志文章


    authors: Westrin P,Jonmarker C,Werner O

    更新日期:1989-09-01 00:00:00

  • Local versus central effect of halothane on carotid sinus baroreceptor function.

    abstract::Depressive effect of halothane on carotid sinus baroreceptor function may be due to direct local action, in the CNS, or both. Paris of dogs were anesthetized with pentobarbital and ventilated with oxygen. The carotid sinus of the recipient dog was isolated and perfused with blood from the common carotid artery of the ...


    pub_type: 杂志文章


    authors: Behnia R,Koushanpour E

    更新日期:1984-08-01 00:00:00

  • The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium.

    abstract:BACKGROUND:The direct action of sevoflurane on systemic resistance arteries is not fully understood. METHODS:Isometric force was recorded in isolated rat small mesenteric arteries. RESULTS:Sevoflurane (2-5%) enhanced contractile response to norepinephrine only in the presence of endothelium, but inhibited it in its a...


    pub_type: 杂志文章


    authors: Izumi K,Akata T,Takahashi S

    更新日期:2000-05-01 00:00:00

  • Interaction of halothane with alpha- and beta-adrenoceptor stimulations in rat myocardium.

    abstract:BACKGROUND:Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor...


    pub_type: 杂志文章


    authors: Hanouz JL,Riou B,Massias L,Lecarpentier Y,Coriat P

    更新日期:1997-01-01 00:00:00

  • The detrimental effects of prolonged hypothermia and rewarming in the dog.

    abstract::The authors had previously observed a deleterious cerebrovascular effect of prolonged hypothermia in primates and cats. In this study they examined the systemic as well as cerebral hemodynamic and metabolic effects of 24 hours of hypothermia in the dog. With decreases in temperature to 29 C, cardiac output (Q) and who...


    pub_type: 杂志文章


    authors: Steen PA,Milde JH,Michenfelder JD

    更新日期:1980-03-01 00:00:00

  • Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells.

    abstract:BACKGROUND:It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinically, on nA...


    pub_type: 杂志文章


    authors: Yamashita M,Mori T,Nagata K,Yeh JZ,Narahashi T

    更新日期:2005-01-01 00:00:00

  • Can we trust the direct radial artery pressure immediately following cardiopulmonary bypass?

    abstract::Reversal of the usual relationship between aortic and radial artery pressure can occur in patients following cardiopulmonary bypass. Radial systolic (and often radial mean) pressures were lower, relative to aortic pressure, after cardiopulmonary bypass than before bypass in all 18 patients studied. The systolic pressu...


    pub_type: 杂志文章


    authors: Stern DH,Gerson JI,Allen FB,Parker FB

    更新日期:1985-05-01 00:00:00

  • Laparoscopy explosion hazards with nitrous oxide.

    abstract:BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...


    pub_type: 杂志文章


    authors: Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

    更新日期:1993-05-01 00:00:00

  • Halothane and isoflurane differentially affect the regulation of dopamine and gamma-aminobutyric acid release mediated by presynaptic acetylcholine receptors in the rat striatum.

    abstract:BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...


    pub_type: 杂志文章


    authors: Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

    更新日期:1997-03-01 00:00:00

  • Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice.

    abstract:BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...


    pub_type: 杂志文章


    authors: Fairbanks CA,Nguyen HO,Grocholski BM,Wilcox GL

    更新日期:2000-09-01 00:00:00

  • Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy.

    abstract:BACKGROUND:Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS:Forty patients scheduled ...


    pub_type: 杂志文章,随机对照试验


    authors: Kaba A,Laurent SR,Detroz BJ,Sessler DI,Durieux ME,Lamy ML,Joris JL

    更新日期:2007-01-01 00:00:00

  • Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane.

    abstract:BACKGROUND:(human ether-a-gogo related gene) encodes the cardiac rapidly activating delayed rectifier potassium currents (I(kr)), which play an important role in cardiac action potential repolarization. General anesthetics, like halothane, can prolong Q-T interval, suggesting that they act on myocellular repolarization...


    pub_type: 杂志文章


    authors: Li J,Correa AM

    更新日期:2002-10-01 00:00:00

  • Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity.

    abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...


    pub_type: 杂志文章


    authors: Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

    更新日期:2018-02-01 00:00:00

  • Neuroprotective effect of epidural electrical stimulation against ischemic spinal cord injury in rats: electrical preconditioning.

    abstract:BACKGROUND:Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. ...


    pub_type: 杂志文章


    authors: Kakinohana M,Harada H,Mishima Y,Kano T,Sugahara K

    更新日期:2005-07-01 00:00:00

  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

    abstract:BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...


    pub_type: 杂志文章


    authors: Kharasch ED,Thummel KE

    更新日期:1993-10-01 00:00:00

  • Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat.

    abstract::The effect of liposome encapsulation on the analgesia produced by intrathecally administered alfentanil was examined in the rat. In rats prepared with chronic intrathecal catheters, alfentanil in doses of 1-50 micrograms was administered intrathecally in either saline or in multilamellar liposomes (dipalmitoylphosphat...


    pub_type: 杂志文章


    authors: Bernards CM,Luger TJ,Malmberg AB,Hill HF,Yaksh TL

    更新日期:1992-09-01 00:00:00

  • Does the brain influence somatic responses to noxious stimuli during isoflurane anesthesia?

    abstract:BACKGROUND:Recent evidence suggests that anesthetic action within the spinal cord is important in suppressing somatic responses to painful stimuli. Whether the brain influences this response is not clear. This study was designed to test the hypothesis that the brain affects anesthetic requirements. METHODS:Six goats w...


    pub_type: 杂志文章


    authors: Borges M,Antognini JF

    更新日期:1994-12-01 00:00:00

  • Beneficial effects from beta-adrenergic blockade in elderly patients undergoing noncardiac surgery.

    abstract:BACKGROUND:Perioperative beta-blockade has been shown to improve long-term cardiac outcome in noncardiac surgical patients. A possible mechanism for the reduced risk of perioperative myocardial infarction is the attenuation of the excitotoxic effects of catecholamine surges by beta-blockade. It was hypothesized that be...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zaugg M,Tagliente T,Lucchinetti E,Jacobs E,Krol M,Bodian C,Reich DL,Silverstein JH

    更新日期:1999-12-01 00:00:00

  • Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol.

    abstract:BACKGROUND:The Atenolol study of 1996 provided evidence that perioperative β-blockade reduced postsurgical mortality. In 1998, the indications for perioperative β-blockade were codified as the Perioperative Cardiac Risk Reduction protocol and implemented at the San Francisco Veterans Affairs Medical Center. The current...


    pub_type: 杂志文章


    authors: Wallace AW,Au S,Cason BA

    更新日期:2011-04-01 00:00:00

  • The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers.

    abstract:BACKGROUND:Because patients may be taking clonidine chronically or may be receiving it as a premedication before surgery, the authors investigated its effect on cerebral hemodynamics. METHODS:In nine volunteers, middle cerebral artery mean blood flow velocity (Vm) was measured using transcranial Doppler ultrasonograph...


    pub_type: 杂志文章


    authors: Lee HW,Caldwell JE,Dodson B,Talke P,Howley J

    更新日期:1997-09-01 00:00:00

  • Efficacy of oral clonidine premedication in children.

    abstract:BACKGROUND:Clonidine, an alpha 2-adrenoceptor agonist, has been shown to be effective as a preanesthetic medication in adults. The current study was designed to investigate the efficacy of two doses of oral clonidine as a premedicant preceding oral atropine in children. METHODS:In a prospective, randomized, double-bli...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mikawa K,Maekawa N,Nishina K,Takao Y,Yaku H,Obara H

    更新日期:1993-11-01 00:00:00

  • Epidural catheter reconnection. Safe and unsafe practice.

    abstract:BACKGROUND:An in vitro model of epidural catheter contamination was used to determine if disconnected catheters can be safely reconnected. METHODS:Epidural catheters were filled with brain-heart infusion (BHI) broth or preservative-free saline containing 5 micrograms/ml fentanyl. Escherichia coli, Pseudomonas aerugino...


    pub_type: 杂志文章


    authors: Langevin PB,Gravenstein N,Langevin SO,Gulig PA

    更新日期:1996-10-01 00:00:00