Microinjection of an adenosine A1 agonist into the medial pontine reticular formation increases tail flick latency to thermal stimulation.

abstract：:The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six...

journal_title：Anesthesiology

authors： Segredo V,Shin YS,Sharma ML,Gruenke LD,Caldwell JE,Khuenl-Brady KS,Agoston S,Miller RD

更新日期：1991-06-01 00:00:00

abstract：:The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis and in ten control patients undergoing elective surgery. All patients received 2.5 mg.kg-1 propofol as an intravenous bolus injection for the induction of anesthesia. Whole blood propofol concentrations were measured at in...

journal_title：Anesthesiology

authors： Servin F,Desmonts JM,Haberer JP,Cockshott ID,Plummer GF,Farinotti R

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not bee...

journal_title：Anesthesiology

authors： Ngan Kee WD

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse. METHODS:Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spin...

journal_title：Anesthesiology

authors： Amar D,Grant FM,Zhang H,Boland PJ,Leung DH,Healey JA

更新日期：2003-02-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：:The need for accurate clinical diagnosis and appropriate intervention requires that a modern blood-gas laboratory have the means to correct for significant discrepancies between patient temperature and the temperature at which in vitro blood samples are analyzed. Recent advances in mini- and microcomputer technology p...

journal_title：Anesthesiology

authors： Andritsch RF,Muravchick S,Gold MI

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:The authors compare three techniques for insertion of the ProSeal laryngeal mask airway. METHODS:Two hundred forty healthy patients aged 18-80 yr were randomly allocated for ProSeal laryngeal mask airway insertion using the digital, introducer tool (IT), or gum elastic bougie (GEB)-guided techniques. The di...

journal_title：Anesthesiology

authors： Brimacombe J,Keller C,Judd DV

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:In this study, the authors determined the success and failure rates for interns learning bag-and-mask ventilation and orotracheal intubation. Their goal was to determine the amount of experience needed to perform these procedures correctly. METHODS:The authors recorded 695 bag-and-mask ventilations and 679 ...

journal_title：Anesthesiology

authors： Komatsu R,Kasuya Y,Yogo H,Sessler DI,Mascha E,Yang D,Ozaki M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:There is an unmet clinical need to develop a pharmacological therapy to counter opioid-induced respiratory depression without interfering with analgesia or behavior. Several studies have demonstrated that 5-HT1A receptor agonists alleviate opioid-induced respiratory depression in rodent models. However, ther...

journal_title：Anesthesiology

authors： Ren J,Ding X,Greer JJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS:Pigs (n = 27, 9 per group) were anesthetized and me...

journal_title：Anesthesiology

authors： Kimberger O,Arnberger M,Brandt S,Plock J,Sigurdsson GH,Kurz A,Hiltebrand L

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Despite improvements in neonatal heart surgery, neurologic complications continue to occur from low-flow cardiopulmonary bypass (LF-CPB) and deep hypothermic circulatory arrest (DHCA). Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of ...

journal_title：Anesthesiology

authors： Loepke AW,Priestley MA,Schultz SE,McCann J,Golden J,Kurth CD

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. ...

journal_title：Anesthesiology

authors： Kakinohana M,Harada H,Mishima Y,Kano T,Sugahara K

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...

journal_title：Anesthesiology

authors： Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isofor...

journal_title：Anesthesiology

authors： OuYang W,Hemmings HC Jr

更新日期：2007-07-01 00:00:00

abstract：:Binding of thiopental to proteins in plasma from healthy, cirrhotic, and uremic subjects was studied using equilibrium dialysis. In plasma from healthy volunteers 28.0 plus or minus 0.9 per cent of thiopental was unbound. In plasma from patients with hepatic disease 53.0 plus or minus 2.1 per cent was unbound, while i...

journal_title：Anesthesiology

authors： Ghoneim MM,Pandya H

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:Reduction of nocturnal obstructive events during lateral position in patients with obstructive sleep apnea was previously reported. However, little information is available regarding mechanisms of the improvement and the precise pharyngeal site influenced by the lateral position. The authors tested the hypot...

journal_title：Anesthesiology

authors： Isono S,Tanaka A,Nishino T

更新日期：2002-10-01 00:00:00

abstract：:Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil. Following placement of subcutaneous electrodes in each animal's left gastrocnemius muscle, rigidity was ...

journal_title：Anesthesiology

authors： Weinger MB,Cline EJ,Smith NT,Koob GF

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Isoflurane and sevoflurane have been shown to elicit myocardial postconditioning, but the effect of desflurane remain unknown. The authors studied the mechanisms involved in desflurane-induced myocardial postconditioning. METHODS:Contracting isolated human right atrial trabeculae (34 degrees C, stimulation ...

journal_title：Anesthesiology

authors： Lemoine S,Beauchef G,Zhu L,Renard E,Lepage O,Massetti M,Khayat A,Galera P,Gérard JL,Hanouz JL

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Increasing age appears to be associated with a slower onset of neuromuscular blockade, but such an effect has not been studied with the same doses of the same drugs across pediatric and adult age groups. METHODS:The authors measured the evoked compound action potential of the adductor pollicis muscle in res...

journal_title：Anesthesiology

authors： Koscielniak-Nielsen ZJ,Bevan JC,Popovic V,Baxter MR,Donati F,Bevan DR

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:In 2001, the Centers for Medicare and Medicaid Services issued a rule allowing U.S. states to "opt out" of the regulations requiring physician supervision of nurse anesthetists in an effort to increase access to anesthesia care. Whether "opt out" has successfully achieved this goal remains unknown. METHODS:...

journal_title：Anesthesiology

authors： Sun EC,Dexter F,Miller TR,Baker LC

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Thermoregulatory vasoconstriction minimizes further core hypothermia during anesthesia. Elderly patients become more hypothermic during surgery than do younger patients, and take longer to rewarm postoperatively. These data indicate that perianesthetic thermoregulatory responses may be especially impaired in...

journal_title：Anesthesiology

authors： Kurz A,Plattner O,Sessler DI,Huemer G,Redl G,Lackner F

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...

journal_title：Anesthesiology

authors： Bernards CM,Kopacz DJ,Michel MZ

更新日期：1994-04-01 00:00:00

abstract：:Eighty-three ASA Physical Status 1-2 patients were orally premedicated with triazolam (0.125, 0.25, or 0.5 mg), diazepam (5, 10, or 15 mg), or placebo to evaluate the effectiveness of these drugs and doses in reducing preoperative anxiety, providing sedation, and producing amnesia. The drug treatments were administere...

journal_title：Anesthesiology

authors： Baughman VL,Becker GL,Ryan CM,Glaser M,Abenstein JP

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...

journal_title：Anesthesiology

authors： Rehm M,Zahler S,Lötsch M,Welsch U,Conzen P,Jacob M,Becker BF

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on...

journal_title：Anesthesiology

authors： Kagawa K,Mammoto T,Hayashi Y,Kamibayashi T,Mashimo T,Yoshiya I

更新日期：1997-10-01 00:00:00

abstract：:Intravenous lidocaine has been shown to relieve acute postoperative pain and chronic neuropathic pain. It is not known whether analgesia produced by 2-10 micrograms/ml plasma concentrations of lidocaine is due to an effect on peripheral-pain-transducing nerves or to central nervous system effects. The current study ex...

journal_title：Anesthesiology

authors： Tanelian DL,MacIver MB

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) and the Patient State Index (PSI) quantify depth of anesthesia by analyzing the electroencephalogram. The authors examined the response of BIS and PSI to sevoflurane anesthesia. METHODS:In 22 patients, sevoflurane anesthesia was induced by inhalation with a tight-fitting facemask ...

journal_title：Anesthesiology

authors： Soehle M,Ellerkmann RK,Grube M,Kuech M,Wirz S,Hoeft A,Bruhn J

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Acid aspiration into one lung causes contralateral lung injury and systemic organ injury; this injury is thought to be mediated by the sequestration of activated neutrophils. Recombinant human soluble complement receptor 1 (sCR1) inhibits both the classical and alternative complement pathways; this study inv...

journal_title：Anesthesiology

authors： Nishizawa H,Yamada H,Miyazaki H,Ohara M,Kaneko K,Yamakawa T,Wiener-Kronish J,Kudoh I

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...

journal_title：Anesthesiology

authors： Sabir H,Bishop S,Cohen N,Maes E,Liu X,Dingley J,Thoresen M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The concept of the axillary "sheath" has been a central tenet of brachial plexus regional anesthesia for many years. Recent investigations have cast doubt on its nature and existence. This study further examines the issue. METHODS:Computerized axial tomographic dye studies were performed using continuous ca...

journal_title：Anesthesiology

authors： Cornish PB,Leaper C

更新日期：2006-09-01 00:00:00