Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery.

abstract：BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...

journal_title：Anesthesiology

authors： Stowe DF,Sprung J,Turner LA,Kampine JP,Bosnjak ZJ

更新日期：1994-06-01 00:00:00

abstract：:Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa (κ), and delta (δ) opioid receptors represent the originally classified receptor subtypes, with opioid receptor like-1 (ORL1) being the leas...

journal_title：Anesthesiology

authors： Al-Hasani R,Bruchas MR

更新日期：2011-12-01 00:00:00

abstract：:I653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of I653 on the EEG (in both the "time" and "frequency" domain). The...

journal_title：Anesthesiology

authors： Rampil IJ,Weiskopf RB,Brown JG,Eger EI 2nd,Johnson BH,Holmes MA,Donegan JH

更新日期：1988-09-01 00:00:00

abstract：:Dexmedetomidine (DMED) is a novel alpha 2 adrenergic agonist that has been shown to have potent analgesic and anesthetic sparing effects. This study was designed to investigate the effects of DMED, both alone and combined with isoflurane, on resting ventilation, the hypercapnic response, and the hypoxic response in do...

journal_title：Anesthesiology

authors： Nguyen D,Abdul-Rasool I,Ward D,Hsieh J,Kobayashi D,Hadlock S,Singer F,Bloor B

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:It has been suggested that blood transfusion has an adverse effect on long-term health, mainly through immune modulation and tumor promotion. To further assess this concern, the authors have performed a prospective observational study with the hypothesis that after taking perioperative risk factors relevant ...

journal_title：Anesthesiology

authors： Weightman WM,Gibbs NM,Sheminant MR,Newman MA,Grey DE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Positive end expiratory pressure (PEEP) is an important component of therapy in patients with acute lung injury or acute respiratory distress syndrome. The independent effect of PEEP on mortality is currently unknown. METHODS:A systematic review and meta-analysis of randomized controlled clinical trials com...

journal_title：Anesthesiology

authors： Phoenix SI,Paravastu S,Columb M,Vincent JL,Nirmalan M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic cardiomyocyte contractility, intracellular free Ca2+ concentration ([Ca2+]i), and myofilament Ca2+ sensitivity. METHODS:Freshly isolated ventricular myocyt...

journal_title：Anesthesiology

authors： Wickley PJ,Shiga T,Murray PA,Damron DS

更新日期：2006-05-01 00:00:00

abstract：:To investigate the hemodynamic correlates of perioperative regional wall motion abnormalities (RWMA), we measured wall motion continuously via transesophageal echocardiography (TEE), and related RWMA to continuously measured hemodynamic indices of myocardial oxygen supply and demand (heart rate [HR] and systemic and p...

journal_title：Anesthesiology

authors： Leung JM,O'Kelly BF,Mangano DT

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The study was designed to compare the effects of equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, anisotropy, duration and homogeneity of refractoriness, and wavelengths, and to provide a potency ratio for effects on conduction velocity. METHODS:Is...

journal_title：Anesthesiology

authors： Aya AG,de la Coussaye JE,Robert E,Ripart J,Cuvillon P,Mazoit JX,Jeannes P,Fabbro-Péray P,Eledjam JJ

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...

journal_title：Anesthesiology

authors： Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Alveolar macrophages are a critical part of the defense against pulmonary infection. Thus the authors determined time-dependent changes in alveolar macrophage functions in patients having surgery who were anesthetized with isoflurane or propofol. METHODS:Patients anesthetized with propofol (n = 30) or isofl...

journal_title：Anesthesiology

authors： Kotani N,Hashimoto H,Sessler DI,Kikuchi A,Suzuki A,Takahashi S,Muraoka M,Matsuki A

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The diagnosis of an acute malignant hyperthermia reaction by clinical criteria can be difficult because of the nonspecific nature and variable incidence of many of the clinical signs and laboratory findings. Development of a standardized means for estimating the qualitative likelihood of malignant hypertherm...

journal_title：Anesthesiology

authors： Larach MG,Localio AR,Allen GC,Denborough MA,Ellis FR,Gronert GA,Kaplan RF,Muldoon SM,Nelson TE,Ording H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether combination of 1-5 microg intrathecal neostigmine would enhance analgesia from a fixed intrathecal dose of morphine. METHODS:A total of 60 patients undergoing gynecologic surgery were randomized to one of five groups. Patients received 15 mg bupivacaine plu...

journal_title：Anesthesiology

authors： Almeida RA,Lauretti GR,Mattos AL

更新日期：2003-02-01 00:00:00

abstract：:The authors studied the influence of locally administered isoflurane anesthesia on the pulmonary vascular response to regional alveolar hypoxia (hypoxic pulmonary vasoconstriction [HPV]) over a range of cardiac outputs (COs) in seven mechanically ventilated, closed-chest dogs. The right lung was ventilated with 100% O...

journal_title：Anesthesiology

authors： Domino KB,Borowec L,Alexander CM,Williams JJ,Chen L,Marshall C,Marshall BE

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Despite decreasing cardiac events, perioperative beta-blockade also increases perioperative stroke and mortality. Major bleeding and/or hypotension are independently associated with these outcomes. To investigate the hypothesis that beta-blockade limits the cardiac reserve to compensate for acute surgical an...

journal_title：Anesthesiology

authors： Beattie WS,Wijeysundera DN,Karkouti K,McCluskey S,Tait G,Mitsakakis N,Hare GM

更新日期：2010-01-01 00:00:00

abstract：:In the absence of data on the anatomic localization of the cuff of the laryngeal mask airway (LMA) in children, radiologic images were obtained from 50 infants and children (aged 1 month to 15 yr) undergoing diagnostic radiologic procedures during halothane and N2O:O2 anesthesia. In 46 patients, the cuff of the LMA wa...

journal_title：Anesthesiology

authors： Goudsouzian NG,Denman W,Cleveland R,Shorten G

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing ...

journal_title：Anesthesiology

authors： Mann R,Blobner M,Jelen-Esselborn S,Busley R,Werner C

更新日期：2000-08-01 00:00:00

abstract：:Postoperative adrenocortical function was compared in 23 out-patients receiving either thiopental, 4 mg/kg, for induction and a thiopental infusion, 0.26 mg . kg-1 . min-1, in combination with nitrous oxide 70% for maintenance of anesthesia (control); etomidate, 0.4 mg/kg, for induction followed by an etomidate infusi...

journal_title：Anesthesiology

authors： Wagner RL,White PF

更新日期：1984-12-01 00:00:00

abstract：:In experiments with rats, the authors compared potency ratios and slopes of dose-effect curves of isoflurane, halothane, and diethyl ether for three end points of anesthesia: loss of righting reflex (RR), abolition of purposeful movement (PM) response to painful stimuli, and abolition of heart rate (HR) response to pa...

journal_title：Anesthesiology

authors： Kissin I,Morgan PL,Smith LR

更新日期：1983-01-01 00:00:00

abstract：:The effect of halothane, at clinically relevant concentrations on the ability of human polymorphonuclear leukocytes (PMNL) to kill the most frequently isolated gram-negative organisms responsible for human bacteremias, Escherichia coli and Klebsiella pneumoniae, was studied. Exposure of PMNL to 0.75 per cent halothane...

journal_title：Anesthesiology

authors： Welch WD

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:General anesthetics reduce neuronal death caused by focal cerebral ischemia in rodents and by in vitro ischemia in cultured neurons and brain slices. However, in intact animals, the protective effect may enhance neuronal survival for only several days after an ischemic injury, possibly because anesthetics pr...

journal_title：Anesthesiology

authors： Sullivan BL,Leu D,Taylor DM,Fahlman CS,Bickler PE

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:One-lung ventilation (OLV) results in alveolar proinflammatory effects, whereas their extent may depend on administration of anesthetic drugs. The current study evaluates the effects of different volatile anesthetics compared with an intravenous anesthetic and the relationship between pulmonary and systemic ...

journal_title：Anesthesiology

authors： Schilling T,Kozian A,Senturk M,Huth C,Reinhold A,Hedenstierna G,Hachenberg T

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...

journal_title：Anesthesiology

authors： Bernards CM,Kopacz DJ,Michel MZ

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...

journal_title：Anesthesiology

authors： Peters CM,Hayashida K,Suto T,Houle TT,Aschenbrenner CA,Martin TJ,Eisenach JC

更新日期：2015-04-01 00:00:00

abstract：:To determine the effects of cardiopulmonary bypass (CPB) and hypothermia on the neuromuscular blockade produced by pancuronium, this relaxant was infused intravenously into 10 anesthetized patients to produce and maintain 90% depression of the twitch tension of the adductor pollicis muscle following supramaximal ulnar...

journal_title：Anesthesiology

authors： d'Hollander AA,Duvaldestin P,Henzel D,Nevelsteen M,Bomblet JP

更新日期：1983-06-01 00:00:00

abstract：:Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the bioavailability and absorption of fentanyl from OTFC, 12 volunteers were given intravenous fentanyl citrate or OTFC 15 microg...

journal_title：Anesthesiology

authors： Streisand JB,Varvel JR,Stanski DR,Le Maire L,Ashburn MA,Hague BI,Tarver SD,Stanley TH

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:The minimum time interval between administration of oral midazolam and separation of children from their parents that ensures good anterograde amnesia has not been previously determined. This is of particular importance in a busy operating room setting where schedule delays secondary to midazolam administrat...

journal_title：Anesthesiology

authors： Kain ZN,Hofstadter MB,Mayes LC,Krivutza DM,Alexander G,Wang SM,Reznick JS

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:To interpret correctly the results from studies performed during surgery and anesthesia it is necessary to dissect the separate effect of the anesthetic technique itself. The purpose of this study was to investigate the metabolic effects of epidural blockade (T7-S1) with bupivacaine 0.25% after 12 h fasting ...

journal_title：Anesthesiology

authors： Schricker T,Klubien K,Wykes L,Carli F

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Acid aspiration into one lung causes contralateral lung injury and systemic organ injury; this injury is thought to be mediated by the sequestration of activated neutrophils. Recombinant human soluble complement receptor 1 (sCR1) inhibits both the classical and alternative complement pathways; this study inv...

journal_title：Anesthesiology

authors： Nishizawa H,Yamada H,Miyazaki H,Ohara M,Kaneko K,Yamakawa T,Wiener-Kronish J,Kudoh I

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Airway pressure-release ventilation provides ventilation comparable to controlled mechanical ventilation (CMV), but with lower peak airway pressures and less dead-space ventilation. To obtain these advantages for patients administered general anesthesia, the authors (1) designed a mode similar to airway pres...

journal_title：Anesthesiology

authors： Bratzke E,Downs JB,Smith RA

更新日期：1998-08-01 00:00:00