The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa.

abstract：:Ca(2+) is a ubiquitous intracellular messenger which encodes information by temporal and spatial patterns of concentration. In spermatozoa, several key functions, including acrosome reaction and motility, are regulated by cytoplasmic Ca(2+) concentration. Despite the very small size and apparent structural simplicity ...

journal_title：Human reproduction update

authors： Jimenez-Gonzalez C,Michelangeli F,Harper CV,Barratt CL,Publicover SJ

更新日期：2006-05-01 00:00:00

abstract：:Contraception is one of the keystones of reproductive health. The availability of effective contraception has helped to change dramatically the structure of the world's population during the last 50 years, through a demographic transition involving lower fertility rates and longer survival. As the transition evolves m...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The aim of this meta-analysis was to investigate whether any difference exists in success rate of clinical outcomes of assisted reproductive technologies (ART) between women who actively smoke cigarettes at the time of treatment and those who do not. METHODS:An intensive computerized search was conducted on...

journal_title：Human reproduction update

authors： Waylen AL,Metwally M,Jones GL,Wilkinson AJ,Ledger WL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of f...

journal_title：Human reproduction update

authors： Tatone C,Di Emidio G,Barbonetti A,Carta G,Luciano AM,Falone S,Amicarelli F

更新日期：2018-05-01 00:00:00

abstract：:Conservative management of at least part of both the ovary and uterus can be proposed in patients with borderline ovarian tumour, in order to preserve fertility potential. This conservative management could be carried out even in patients with borderline ovarian tumour associated with non-invasive peritoneal implants ...

journal_title：Human reproduction update

authors： Morice P,Camatte S,Wicart-Poque F,Atallah D,Rouzier R,Pautier P,Pomel C,Lhommé C,Duvillard P,Castaigne D

更新日期：2003-03-01 00:00:00

abstract：:Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of protamine 2 (P2) proteins (P2, P3 and P4), all also encoded by a single gene that is transcribed and translated into a precursor protein. The protam...

journal_title：Human reproduction update

authors： Oliva R

更新日期：2006-07-01 00:00:00

abstract：:Leiomyomata represent the most common gynaecological tumour in women of reproductive age, and are the primary indication for hysterectomy in the USA. Cytogenetic and genetic studies have, in recent years, advanced our understanding of the aetiology of these tumours. Cytogenetic aberrations involving chromosomes 6, 7, ...

journal_title：Human reproduction update

authors： Ligon AH,Morton CC

更新日期：2001-01-01 00:00:00

abstract：:Nitric oxide (NO) is an important mediator of paracrine interactions, especially within the vascular system. It is a powerful inhibitor of platelet aggregation and a potent vasodilator. NO is also a neurotransmitter and it plays a role in cell-mediated cytotoxicity. NO-generating enzymes (nitric oxide synthases, NOS) ...

journal_title：Human reproduction update

authors： Cameron IT,Campbell S

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial. OBJECTIVE AND RATIONALE:We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk amo...

journal_title：Human reproduction update

authors： Oliver-Williams C,Glisic M,Shahzad S,Brown E,Pellegrino Baena C,Chadni M,Chowdhury R,Franco OH,Muka T

更新日期：2019-03-01 00:00:00

abstract：:This paper investigates the relationship of features of in-vitro fertilization (IVF) embryos and the associated oocyte and follicle to the outcome of transfer. It differs from previous studies in including a range of features (n = 53) and in using class probability tree analysis. This is a non-parametric multivariate ...

journal_title：Human reproduction update

authors： Saith RR,Srinivasan A,Michie D,Sargent IL

更新日期：1998-03-01 00:00:00

abstract：:The examination of fetal cells, specifically erythroblasts, and cell-free fetal DNA from the blood of pregnant women is currently the subject of intense research with the aim of developing new risk-free methods for prenatal diagnosis. An unexpected finding made during these studies was that the traffic of fetal erythr...

journal_title：Human reproduction update

authors： Hahn S,Holzgreve W

更新日期：2002-11-01 00:00:00

abstract：:BACKGROUND To review the accuracy of multivariate models for the prediction of ovarian reserve and pregnancy in women undergoing IVF compared with the antral follicle count (AFC) as single test. METHODS We performed a computerized MEDLINE and EMBASE search to identify articles published on multivariate models for ovar...

journal_title：Human reproduction update

authors： Verhagen TE,Hendriks DJ,Bancsi LF,Mol BW,Broekmans FJ

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with male infertility. However, the underlying mechanisms remain elusive. METHODS:Literature databases were searched for papers on the topi...

journal_title：Human reproduction update

authors： Chen H,Ruan YC,Xu WM,Chen J,Chan HC

更新日期：2012-11-01 00:00:00

abstract：:As soon as leptin was discovered four years ago, its potential as a player in the polycystic ovary syndrome (PCOS) was explored in a primitive way, though little light was shed on the enigma that is PCOS. As a second wave of leptin research is now available, we review how the expanded role of the cytokine in reproduct...

journal_title：Human reproduction update

authors： Jacobs HS,Conway GS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The main objective of individualization of treatment in IVF is to offer every single woman the best treatment tailored to her own unique characteristics, thus maximizing the chances of pregnancy and eliminating the iatrogenic and avoidable risks resulting from ovarian stimulation. Personalization of treatmen...

journal_title：Human reproduction update

authors： La Marca A,Sunkara SK

更新日期：2014-01-01 00:00:00

abstract：:In 1987, Nigel Harris cautioned against over-diagnosing the antiphospholipid syndrome (APS). In what was a rather prophetic editorial titled 'The Syndrome of the Black Swan', he suggested that while patients with APS do indeed exist, they are probably much more unusual than many medical professionals might like to bel...

journal_title：Human reproduction update

authors： Clark CA,Laskin CA,Spitzer KA

更新日期：2012-09-01 00:00:00

abstract：:From a public health viewpoint, the intrauterine device (IUD) is the most widely used contraceptive method in the world. Prevalence rates range among countries from 2 to 80% of contraceptive users. During 5 years of IUD use, pregnancy occurs in less than 2 per 100 insertions. Bleeding and pain are the most common reas...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2008-05-01 00:00:00

abstract：:Cancer treatment modalities are increasingly more effective in achieving complete remission and cure. Aggressive chemotherapy and radiotherapy, as well as bone marrow transplantation, results in >90% cure in many cancers of children and young women. As a result of this success however, a new problem has arisen. Many y...

journal_title：Human reproduction update

authors： Oktay K

更新日期：2001-11-01 00:00:00

abstract：:The clinical significance of micro-organisms in semen samples of asymptomatic subfertile patients is a matter of constant debate. Usually little attention is paid to anaerobic bacteria as they are sensitive to transportation and culturing, and differentiation is difficult, costly and time-consuming. In the present stu...

journal_title：Human reproduction update

authors： Eggert-Kruse W,Rohr G,Ströck W,Pohl S,Schwalbach B,Runnebaum B

更新日期：1995-09-01 00:00:00

abstract：:Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is approximately 4.3%, in infertile patients approximately 3.5% and in patients with recurrent pregnancy losses approximate...

journal_title：Human reproduction update

authors： Grimbizis GF,Camus M,Tarlatzis BC,Bontis JN,Devroey P

更新日期：2001-03-01 00:00:00

abstract：:After colonization of the gonad, mouse female germ cells enter into the prophase of the first meiotic division as a mid-gestational hallmark of gender. Perinatally, oocytes interact with granulosa cells to form primordial follicles which, with cyclic periodicity, enter into a 3-week growth phase that culminates in mei...

journal_title：Human reproduction update

authors： Amleh A,Dean J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Clinical trials yield discrepant information about the impact of hormone therapy on verbal memory and executive function. This issue is clinically relevant because declines in verbal memory are the earliest predictor of Alzheimer's disease and declines in executive function are central to some theories of no...

journal_title：Human reproduction update

authors： Maki PM,Sundermann E

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The reproductive impact of adenomyosis and endometriosis is widely researched but the extent of these impacts remains elusive. It has been demonstrated that endometriosis, in particular, is known to result in subfertility but endometriosis and adenomyosis are increasingly linked to late pregnancy complicatio...

journal_title：Human reproduction update

authors： Horton J,Sterrenburg M,Lane S,Maheshwari A,Li TC,Cheong Y

更新日期：2019-09-11 00:00:00

abstract：:The improved long-term survival of adolescents and young women treated for cancer has resulted in an increased focus on the effects of chemotherapy on ovarian function and its preservation. These women may seek advice and treatment regarding their reproductive status, including ways of preserving their fertility and p...

journal_title：Human reproduction update

authors： Lutchman Singh K,Davies M,Chatterjee R

更新日期：2005-01-01 00:00:00

abstract：:BACKGROUND Angiogenesis, i.e. the development of new blood vessels from pre-existing ones, represents an integral part in the pathogenesis of endometriosis. During the last decade, an increasing number of studies have therefore focused on the anti-angiogenic treatment of the disease. The present review provides a syst...

journal_title：Human reproduction update

authors： Laschke MW,Menger MD

更新日期：2012-11-01 00:00:00

abstract：:The use of physical techniques such as scanning electron microscopy and microprobe analysis permits the analysis of valuable details of the structure of dried samples of mid-cycle cervical mucus during the period of maximum ferning. From a crystallographic point of view, particular attention was paid to the location, ...

journal_title：Human reproduction update

authors： Berthou J,Chrétien FC

更新日期：1997-07-01 00:00:00

abstract：:Varicocele is often cited as the most common cause of male factor infertility. Arguments in support of this statement include reports of increased prevalence of varicocele in populations of infertile men compared with fertile or otherwise unselected men, association of varicocele with abnormal semen parameters, and im...

journal_title：Human reproduction update

authors： Redmon JB,Carey P,Pryor JL

更新日期：2002-01-01 00:00:00

abstract：:Malnutrition is a major problem in developing countries, and obesity and eating disorders are increasingly common in developing as well as developed countries. The reproductive axis is closely linked to nutritional status, especially undernutrition in the female, and inhibitory pathways involving detectors in the hind...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2006-05-01 00:00:00

abstract：:Great progress had been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory women with PCOS, since in properly selected patients the cumulative pregnancy rate approaches that ...

journal_title：Human reproduction update

authors： Messinis IE,Milingos SD

更新日期：1997-05-01 00:00:00

abstract：:The number of cell divisions during embryonic and fetal life makes the embryo/fetus particularly vulnerable to effects resulting from exposure to an adverse intrauterine environment. Exposure to drugs and irradiation at this stage of development are able to cause congenital malformations and various cancers in later l...

journal_title：Human reproduction update

authors： Petry CJ,Hales CN

更新日期：2000-11-01 00:00:00