Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores.

abstract：BACKGROUND:Infertility is estimated to affect as many as 186 million people worldwide. Although male infertility contributes to more than half of all cases of global childlessness, infertility remains a woman's social burden. Unfortunately, areas of the world with the highest rates of infertility are often those with p...

journal_title：Human reproduction update

authors： Inhorn MC,Patrizio P

更新日期：2015-07-01 00:00:00

abstract：:The clinical significance of micro-organisms in semen samples of asymptomatic subfertile patients is a matter of constant debate. Usually little attention is paid to anaerobic bacteria as they are sensitive to transportation and culturing, and differentiation is difficult, costly and time-consuming. In the present stu...

journal_title：Human reproduction update

authors： Eggert-Kruse W,Rohr G,Ströck W,Pohl S,Schwalbach B,Runnebaum B

更新日期：1995-09-01 00:00:00

abstract：:Operative hysteroscopy is a relatively new technique that has significantly improved the diagnosis and therapy of abnormal uterine bleeding. At first, the success of operative hysteroscopy in controlling this bleeding seemed extremely high but, with long-term follow-up, a significant failure rate became evident requir...

journal_title：Human reproduction update

authors： McCausland V,McCausland A

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:IUI for unexplained infertility can be performed in a natural cycle or in combination with ovarian stimulation. A disadvantage of ovarian stimulation is an increased risk of multiple pregnancies with its inherent maternal and neonatal complication risks. Stimulation agents for ovarian stimulation are clomiph...

journal_title：Human reproduction update

authors： Danhof NA,Wang R,van Wely M,van der Veen F,Mol BWJ,Mochtar MH

更新日期：2020-01-01 00:00:00

abstract：:This paper investigates the relationship of features of in-vitro fertilization (IVF) embryos and the associated oocyte and follicle to the outcome of transfer. It differs from previous studies in including a range of features (n = 53) and in using class probability tree analysis. This is a non-parametric multivariate ...

journal_title：Human reproduction update

authors： Saith RR,Srinivasan A,Michie D,Sargent IL

更新日期：1998-03-01 00:00:00

abstract：:The results of the Transnational Study on Oral Contraceptives and the Health of Young Women studies are reviewed, potential biases shown, and new analyses are presented. The initial finding was a slight increase in the risk of venous thromboboembolism (VTE) when users of third generation OC (containing the progestins ...

journal_title：Human reproduction update

authors： Lewis MA

更新日期：1999-11-01 00:00:00

abstract：:Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After transfection into various cell types it has proven to be a very fusogenic pr...

journal_title：Human reproduction update

authors： Pötgens AJ,Drewlo S,Kokozidou M,Kaufmann P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) typically occurs when ovaries are primed with FSH/LH and subsequently exposed to hCG. The ultimate pathophysiological step underlying this clinical picture is increased vascular permeability (VP). METHODS:A search of the literature was carried out using PubMed and th...

journal_title：Human reproduction update

authors： Soares SR,Gómez R,Simón C,García-Velasco JA,Pellicer A

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Preimplantation embryos are particularly susceptible to in vitro developmental blocks. These could be alleviated by lowering culture medium osmolarity. Because mammalian cells regulate their volumes by adjusting intracellular osmotic pressure, cell volume regulation could be critical to early embryos. METHO...

journal_title：Human reproduction update

authors： Baltz JM,Tartia AP

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:More than 15 million women, many of reproductive age, were infected with human immunodeficiency virus (HIV) at the end of 2007. As the HIV epidemic evolves, heterosexual intercourse is increasingly risky: the risk of infection in exposed young women is 4- to 7-fold higher than in young men and nearly half a ...

journal_title：Human reproduction update

authors： Heikinheimo O,Lähteenmäki P

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The main objective of individualization of treatment in IVF is to offer every single woman the best treatment tailored to her own unique characteristics, thus maximizing the chances of pregnancy and eliminating the iatrogenic and avoidable risks resulting from ovarian stimulation. Personalization of treatmen...

journal_title：Human reproduction update

authors： La Marca A,Sunkara SK

更新日期：2014-01-01 00:00:00

abstract：:During the elongating spermatid stage of spermiogenesis, human sperm chromatin undergoes a complex transition in which histones are extensively replaced by protamines in a carefully regulated transition including histone modifications and intermediate and temporary replacement of the histones by sperm-specific transit...

journal_title：Human reproduction update

authors： Carrell DT,Emery BR,Hammoud S

更新日期：2007-05-01 00:00:00

abstract：:BACKGROUND Angiogenesis, i.e. the development of new blood vessels from pre-existing ones, represents an integral part in the pathogenesis of endometriosis. During the last decade, an increasing number of studies have therefore focused on the anti-angiogenic treatment of the disease. The present review provides a syst...

journal_title：Human reproduction update

authors： Laschke MW,Menger MD

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Clinical trials yield discrepant information about the impact of hormone therapy on verbal memory and executive function. This issue is clinically relevant because declines in verbal memory are the earliest predictor of Alzheimer's disease and declines in executive function are central to some theories of no...

journal_title：Human reproduction update

authors： Maki PM,Sundermann E

更新日期：2009-11-01 00:00:00

abstract：:The number of cell divisions during embryonic and fetal life makes the embryo/fetus particularly vulnerable to effects resulting from exposure to an adverse intrauterine environment. Exposure to drugs and irradiation at this stage of development are able to cause congenital malformations and various cancers in later l...

journal_title：Human reproduction update

authors： Petry CJ,Hales CN

更新日期：2000-11-01 00:00:00

abstract：:BACKGROUND To review the accuracy of multivariate models for the prediction of ovarian reserve and pregnancy in women undergoing IVF compared with the antral follicle count (AFC) as single test. METHODS We performed a computerized MEDLINE and EMBASE search to identify articles published on multivariate models for ovar...

journal_title：Human reproduction update

authors： Verhagen TE,Hendriks DJ,Bancsi LF,Mol BW,Broekmans FJ

更新日期：2008-03-01 00:00:00

abstract：:Mammals are generally held to be exceptions to the rule that organization of the egg plays a role in specifying the differentiation of cells, axes, or other aspects of patterning in the early embryo. However, there are several grounds for questioning this conclusion. Not only do certain experimental findings remain un...

journal_title：Human reproduction update

authors： Gardner RL

更新日期：1996-01-01 00:00:00

abstract：:Conservative management of at least part of both the ovary and uterus can be proposed in patients with borderline ovarian tumour, in order to preserve fertility potential. This conservative management could be carried out even in patients with borderline ovarian tumour associated with non-invasive peritoneal implants ...

journal_title：Human reproduction update

authors： Morice P,Camatte S,Wicart-Poque F,Atallah D,Rouzier R,Pautier P,Pomel C,Lhommé C,Duvillard P,Castaigne D

更新日期：2003-03-01 00:00:00

abstract：:It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppre...

journal_title：Human reproduction update

authors： Filippini A,Riccioli A,Padula F,Lauretti P,D'Alessio A,De Cesaris P,Gandini L,Lenzi A,Ziparo E

更新日期：2001-09-01 00:00:00

abstract：:Significant association between endometriosis, including minor endometriosis, and infertility (or strictly subfertility) is shown by prevalence studies, but a causal relationship has not been established. This review focuses on evidence for pituitary-ovarian dysfunction as a cause for the subfertility. A methodologica...

journal_title：Human reproduction update

authors： Cahill DJ,Hull MG

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Genetic testing of preimplantation embryos has been used for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). Microarray technology is being introduced in both these contexts, and whole genome sequencing of blastomeres is also expeted to become possible soon. The amount of...

journal_title：Human reproduction update

authors： Hens K,Dondorp W,Handyside AH,Harper J,Newson AJ,Pennings G,Rehmann-Sutter C,de Wert G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging tasks in reproductive medicine. OBJECTIVE AND RATIONALE:The aim of this systemic review is to evaluate the role of different adjuvant treatment strategies on the probabi...

journal_title：Human reproduction update

authors： Zhang Y,Zhang C,Shu J,Guo J,Chang HM,Leung PCK,Sheng JZ,Huang H

更新日期：2020-02-28 00:00:00

abstract：:Anti-Müllerian hormone (AMH) produced by fetal Sertoli cells is responsible for regression of Müllerian ducts, the anlage for uterus and Fallopian tubes, during male sex differentiation. A member of the transforming growth factor-beta superfamily, AMH signals through two transmembrane receptors, type II which is speci...

journal_title：Human reproduction update

authors： Josso N,Belville C,di Clemente N,Picard JY

更新日期：2005-07-01 00:00:00

abstract：:Recent studies suggest a possible link between human assisted reproductive technology and genomic imprinting disorders. Assisted reproductive technology includes the isolation, handling and culture of gametes and early embryos at times when imprinted genes are likely to be particularly vulnerable to external influence...

journal_title：Human reproduction update

authors： Lucifero D,Chaillet JR,Trasler JM

更新日期：2004-01-01 00:00:00

abstract：:We have examined aspects of the fine structure of the basal laminae associated with the luminal and glandular epithelium and small blood vessels in the human endometrium. Four short studies are presented and reviewed. Study 1 examined biopsies from 20 fertile women taken on days after the luteinizing hormone surge (LH...

journal_title：Human reproduction update

authors： Dockery P,Khalid J,Sarani SA,Bulut HE,Warren MA,Li TC,Cooke ID

更新日期：1998-09-01 00:00:00

abstract：:Follicle stimulating hormone (FSH) is one of the two pituitary gonadotrophins involved in the regulation of gonadal function. Structurally, this gonadotrophin is a heterodimer composed of two non-covalently associated subunits containing several heterogenous oligosaccharide residues which play an important role in bot...

journal_title：Human reproduction update

authors： Ulloa-Aguirre A,Timossi C

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorrhage (abruption) can occur throughout pregnancy from poorly transformed spiral ar...

journal_title：Human reproduction update

authors： Schatz F,Guzeloglu-Kayisli O,Arlier S,Kayisli UA,Lockwood CJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are essential in human ovarian folliculogenesis. However, the interactions between these four players is not fully understood. OBJECTIVES AND RATIONALE:The purpose of this review is to highlight the chronological sequence of the appearance and ...

journal_title：Human reproduction update

authors： Dewailly D,Robin G,Peigne M,Decanter C,Pigny P,Catteau-Jonard S

更新日期：2016-11-01 00:00:00

abstract：:At present, the management of non-organ confined prostate cancer, whether it is a recurrence or metastasis, continues to evolve based on prostate cancer detection using prostate-specific antigen and the development of medications as alternatives for the classical orchiectomy, which induced irreversible implications fo...

journal_title：Human reproduction update

authors： d'Ancona FC,Debruyne FM

更新日期：2005-05-01 00:00:00

abstract：:Apoptosis is a selective process for deletion of cells in various biological systems. This event, similar to proliferation, is tightly regulated, with both processes playing essential roles in the homeostasis of renewable tissues. In human endometrium, proliferation and apoptosis occur at opposing poles of the menstru...

journal_title：Human reproduction update

authors： Tabibzadeh S

更新日期：1995-07-01 00:00:00