Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice.

abstract：:Contraception is one of the keystones of reproductive health. The availability of effective contraception has helped to change dramatically the structure of the world's population during the last 50 years, through a demographic transition involving lower fertility rates and longer survival. As the transition evolves m...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:There have been conflicting results in randomized trials of the effects of laparoscopic uterosacral nerve ablation (LUNA) in chronic pelvic pain. Our objective was to perform a meta-analysis using individual patient data (IPD) to provide the most comprehensive and reliable assessment of the effectiveness of ...

journal_title：Human reproduction update

authors： Daniels JP,Middleton L,Xiong T,Champaneria R,Johnson NP,Lichten EM,Sutton C,Vercellini P,Gray R,Hills RK,Jones KD,Aimi G,Khan KS,International LUNA IPD Meta-analysis Collaborative Group.

更新日期：2010-11-01 00:00:00

abstract：:As soon as leptin was discovered four years ago, its potential as a player in the polycystic ovary syndrome (PCOS) was explored in a primitive way, though little light was shed on the enigma that is PCOS. As a second wave of leptin research is now available, we review how the expanded role of the cytokine in reproduct...

journal_title：Human reproduction update

authors： Jacobs HS,Conway GS

更新日期：1999-03-01 00:00:00

abstract：:This paper investigates the relationship of features of in-vitro fertilization (IVF) embryos and the associated oocyte and follicle to the outcome of transfer. It differs from previous studies in including a range of features (n = 53) and in using class probability tree analysis. This is a non-parametric multivariate ...

journal_title：Human reproduction update

authors： Saith RR,Srinivasan A,Michie D,Sargent IL

更新日期：1998-03-01 00:00:00

abstract：:The number of cell divisions during embryonic and fetal life makes the embryo/fetus particularly vulnerable to effects resulting from exposure to an adverse intrauterine environment. Exposure to drugs and irradiation at this stage of development are able to cause congenital malformations and various cancers in later l...

journal_title：Human reproduction update

authors： Petry CJ,Hales CN

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Induced abortion is a common procedure. However, there is marked variation in accessibility of services across England. Accessing abortion services may be difficult, particularly for women who live in remote areas, are in the second trimester of pregnancy, have complex pre-existing conditions or have difficu...

journal_title：Human reproduction update

authors： O'Shea LE,Hawkins JE,Lord J,Schmidt-Hansen M,Hasler E,Cameron S,Cameron IT

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The aim of this meta-analysis was to investigate whether any difference exists in success rate of clinical outcomes of assisted reproductive technologies (ART) between women who actively smoke cigarettes at the time of treatment and those who do not. METHODS:An intensive computerized search was conducted on...

journal_title：Human reproduction update

authors： Waylen AL,Metwally M,Jones GL,Wilkinson AJ,Ledger WL

更新日期：2009-01-01 00:00:00

abstract：:It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppre...

journal_title：Human reproduction update

authors： Filippini A,Riccioli A,Padula F,Lauretti P,D'Alessio A,De Cesaris P,Gandini L,Lenzi A,Ziparo E

更新日期：2001-09-01 00:00:00

abstract：:Homocysteine, a product of the methionine cycle, is known to play an important role in cardiovascular diseases, neurological disorders and embryology, and in very important, fast growing fields concerning obstetrics and gynaecology. Therefore, we attempted an actual overview on possible obstetrical and gynaecological ...

journal_title：Human reproduction update

authors： Obwegeser R,Hohlagschwandtner M,Sinzinger H

更新日期：1999-01-01 00:00:00

abstract：:The placenta plays a key role in pregnancy, mediating exchanges between mother and fetus and maternal tolerance of fetopaternal antigens. In some species, it also produces hormones that ensure the maintenance of gestation and fetal well-being. This unique organ also has considerable potential for use as a model for va...

journal_title：Human reproduction update

authors： Malassiné A,Frendo JL,Evain-Brion D

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The prevalence of congenital uterine anomalies in high-risk women is unclear, as several different diagnostic approaches have been applied to different groups of patients. This review aims to evaluate the prevalence of such anomalies in unselected populations and in women with infertility, including those un...

journal_title：Human reproduction update

authors： Chan YY,Jayaprakasan K,Zamora J,Thornton JG,Raine-Fenning N,Coomarasamy A

更新日期：2011-11-01 00:00:00

abstract：:Recent studies suggest a possible link between human assisted reproductive technology and genomic imprinting disorders. Assisted reproductive technology includes the isolation, handling and culture of gametes and early embryos at times when imprinted genes are likely to be particularly vulnerable to external influence...

journal_title：Human reproduction update

authors： Lucifero D,Chaillet JR,Trasler JM

更新日期：2004-01-01 00:00:00

abstract：:Follicle stimulating hormone (FSH) is one of the two pituitary gonadotrophins involved in the regulation of gonadal function. Structurally, this gonadotrophin is a heterodimer composed of two non-covalently associated subunits containing several heterogenous oligosaccharide residues which play an important role in bot...

journal_title：Human reproduction update

authors： Ulloa-Aguirre A,Timossi C

更新日期：1998-05-01 00:00:00

abstract：:In those clinical situations in which an immediate and profound suppression of gonadotrophins is desired, LHRH agonists have the disadvantage of producing an initial stimulatory effect on hormone secretion. Therefore, the use of GnRH antagonists which cause an immediate and dose-related inhibition of LH and FSH by com...

journal_title：Human reproduction update

authors： Reissmann T,Schally AV,Bouchard P,Riethmiiller H,Engel J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Genetic testing of preimplantation embryos has been used for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). Microarray technology is being introduced in both these contexts, and whole genome sequencing of blastomeres is also expeted to become possible soon. The amount of...

journal_title：Human reproduction update

authors： Hens K,Dondorp W,Handyside AH,Harper J,Newson AJ,Pennings G,Rehmann-Sutter C,de Wert G

更新日期：2013-07-01 00:00:00

abstract：:Insulin plays a central role in human pregnancy. Maternal insulin sensitivity decreases with advancing gestation in order to provide glucose and possibly other nutrients for feto-placental growth and energy needs. Moreover, alterations of insulin metabolism are clearly involved in the development of gestational diabet...

journal_title：Human reproduction update

authors： Ciampelli M,Lanzone A,Caruso A

更新日期：1998-11-01 00:00:00

abstract：:Relatively recent discoveries of the hormone disrupting properties of some pesticides have raised interest in how contemporary pesticide exposures, which primarily take the form of low level environmental or occupational exposures, impact spermatogenesis. The objective of the present review was to summarize results to...

journal_title：Human reproduction update

authors： Perry MJ

更新日期：2008-05-01 00:00:00

abstract：:In the male genital tract, reactive oxygen species (ROS) are generated by spermatozoa and leukocytes including neutrophils and macrophages. ROS are involved in the regulation of sperm functions such as capacitation and the acrosome reaction. Infections lead to an excessive ROS production, resulting in an 'oxidative bu...

journal_title：Human reproduction update

authors： Ochsendorf FR

更新日期：1999-09-01 00:00:00

abstract：:The clinical significance of micro-organisms in semen samples of asymptomatic subfertile patients is a matter of constant debate. Usually little attention is paid to anaerobic bacteria as they are sensitive to transportation and culturing, and differentiation is difficult, costly and time-consuming. In the present stu...

journal_title：Human reproduction update

authors： Eggert-Kruse W,Rohr G,Ströck W,Pohl S,Schwalbach B,Runnebaum B

更新日期：1995-09-01 00:00:00

abstract：:Ca(2+) is a ubiquitous intracellular messenger which encodes information by temporal and spatial patterns of concentration. In spermatozoa, several key functions, including acrosome reaction and motility, are regulated by cytoplasmic Ca(2+) concentration. Despite the very small size and apparent structural simplicity ...

journal_title：Human reproduction update

authors： Jimenez-Gonzalez C,Michelangeli F,Harper CV,Barratt CL,Publicover SJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with male infertility. However, the underlying mechanisms remain elusive. METHODS:Literature databases were searched for papers on the topi...

journal_title：Human reproduction update

authors： Chen H,Ruan YC,Xu WM,Chen J,Chan HC

更新日期：2012-11-01 00:00:00

abstract：:Following its benchmark discovery, nitric oxide (NO) is now known to play important functional roles in a variety of physiological systems. Within the vasculature, NO induces vasodilation, inhibits platelet aggregation, prevents neutrophil/platelet adhesion to endothelial cells, inhibits smooth muscle cell proliferati...

journal_title：Human reproduction update

authors： Rosselli M,Keller PJ,Dubey RK

更新日期：1998-01-01 00:00:00

abstract：:Pregnancy induces physiological alterations in thyroid function which may make difficult the interpretation of results of thyroid hormone measurement. A state of hyperstimulation of the thyroid gland is common in early pregnancy. In a few cases, thyroid hormone values will deviate from the normal range, which correspo...

journal_title：Human reproduction update

authors： Rodien P,Jordan N,Lefèvre A,Royer J,Vasseur C,Savagner F,Bourdelot A,Rohmer V

更新日期：2004-03-01 00:00:00

abstract：:Endometriosis is considered primarily a disease of the endometrial-subendometrial unit or archimetra. The clinical picture of endometriosis characterises this disease as a hyperactivation of genuine archimetrial functions such as proliferation, inflammatory defence and peristalsis. While the aetiology of the disease r...

journal_title：Human reproduction update

authors： Leyendecker G,Kunz G,Noe M,Herbertz M,Mall G

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Hirsutism is the presence of excess body or facial terminal (coarse) hair growth in females in a male-like pattern, affects 5-15% of women, and is an important sign of underlying androgen excess. Different methods are available for the assessment of hair growth in women. METHODS:We conducted a literature se...

journal_title：Human reproduction update

authors： Yildiz BO,Bolour S,Woods K,Moore A,Azziz R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Threatened miscarriage affects one in five women and is associated with significant emotional distress. The uncertainty around the prognosis of threatened miscarriage makes it equally challenging to the healthcare professionals. Various biochemical markers have been investigated in the past to predict the ou...

journal_title：Human reproduction update

authors： Pillai RN,Konje JC,Tincello DG,Potdar N

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Mast cells (MCs) are the classical mediators of allergy, however, their importance in the development of innate and adaptive immune responses is increasingly being recognized. Herein, the present MC literature is summarized, with particular focus on studies of MCs in the endometrium and myometrium, and their...

journal_title：Human reproduction update

authors： Menzies FM,Shepherd MC,Nibbs RJ,Nelson SM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Activins are members of the pleiotrophic family of the transforming growth factor-beta (TGF-β) superfamily of cytokines, initially isolated for their capacity to induce the release of FSH from pituitary extracts. Subsequent research has demonstrated that activins are involved in multiple biological functions...

journal_title：Human reproduction update

authors： Wijayarathna R,de Kretser DM

更新日期：2016-04-01 00:00:00

abstract：:Leiomyomata represent the most common gynaecological tumour in women of reproductive age, and are the primary indication for hysterectomy in the USA. Cytogenetic and genetic studies have, in recent years, advanced our understanding of the aetiology of these tumours. Cytogenetic aberrations involving chromosomes 6, 7, ...

journal_title：Human reproduction update

authors： Ligon AH,Morton CC

更新日期：2001-01-01 00:00:00

abstract：:Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is approximately 4.3%, in infertile patients approximately 3.5% and in patients with recurrent pregnancy losses approximate...

journal_title：Human reproduction update

authors： Grimbizis GF,Camus M,Tarlatzis BC,Bontis JN,Devroey P

更新日期：2001-03-01 00:00:00