Altered protamine expression and diminished spermatogenesis: what is the link?

abstract：:Single-dose and multiple-rising dose studies of recombinant follicle stimulating hormone (rFSH) in hypogonadotrophic male and female volunteers demonstrated that the rate of FSH absorption after i.m. injection is higher in men than in women. In the absence of endogenous FSH, a correlation between serum FSH and body we...

journal_title：Human reproduction update

authors： Mannaerts BM,Rombout F,Out HJ,Coelingh Bennink H

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:IUI for unexplained infertility can be performed in a natural cycle or in combination with ovarian stimulation. A disadvantage of ovarian stimulation is an increased risk of multiple pregnancies with its inherent maternal and neonatal complication risks. Stimulation agents for ovarian stimulation are clomiph...

journal_title：Human reproduction update

authors： Danhof NA,Wang R,van Wely M,van der Veen F,Mol BWJ,Mochtar MH

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many ye...

journal_title：Human reproduction update

authors： Zimmerman Y,Eijkemans MJ,Coelingh Bennink HJ,Blankenstein MA,Fauser BC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of f...

journal_title：Human reproduction update

authors： Tatone C,Di Emidio G,Barbonetti A,Carta G,Luciano AM,Falone S,Amicarelli F

更新日期：2018-05-01 00:00:00

abstract：:Conservative management of at least part of both the ovary and uterus can be proposed in patients with borderline ovarian tumour, in order to preserve fertility potential. This conservative management could be carried out even in patients with borderline ovarian tumour associated with non-invasive peritoneal implants ...

journal_title：Human reproduction update

authors： Morice P,Camatte S,Wicart-Poque F,Atallah D,Rouzier R,Pautier P,Pomel C,Lhommé C,Duvillard P,Castaigne D

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Genetic testing of preimplantation embryos has been used for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). Microarray technology is being introduced in both these contexts, and whole genome sequencing of blastomeres is also expeted to become possible soon. The amount of...

journal_title：Human reproduction update

authors： Hens K,Dondorp W,Handyside AH,Harper J,Newson AJ,Pennings G,Rehmann-Sutter C,de Wert G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Preimplantation embryos are particularly susceptible to in vitro developmental blocks. These could be alleviated by lowering culture medium osmolarity. Because mammalian cells regulate their volumes by adjusting intracellular osmotic pressure, cell volume regulation could be critical to early embryos. METHO...

journal_title：Human reproduction update

authors： Baltz JM,Tartia AP

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an arthropod-borne virus of the family Flaviviridae, genus Flavivirus. ZIKV is currently the focus of an ongoing pandemic and worldwide public health emergency. Although originally isolated in 1947, its pathogenesis was poorly known and very few documented infections were published until...

journal_title：Human reproduction update

authors： Epelboin S,Dulioust E,Epelboin L,Benachi A,Merlet F,Patrat C

更新日期：2017-11-01 00:00:00

abstract：:Malnutrition is a major problem in developing countries, and obesity and eating disorders are increasingly common in developing as well as developed countries. The reproductive axis is closely linked to nutritional status, especially undernutrition in the female, and inhibitory pathways involving detectors in the hind...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2006-05-01 00:00:00

abstract：:BACKGROUND Angiogenesis, i.e. the development of new blood vessels from pre-existing ones, represents an integral part in the pathogenesis of endometriosis. During the last decade, an increasing number of studies have therefore focused on the anti-angiogenic treatment of the disease. The present review provides a syst...

journal_title：Human reproduction update

authors： Laschke MW,Menger MD

更新日期：2012-11-01 00:00:00

abstract：:In those clinical situations in which an immediate and profound suppression of gonadotrophins is desired, LHRH agonists have the disadvantage of producing an initial stimulatory effect on hormone secretion. Therefore, the use of GnRH antagonists which cause an immediate and dose-related inhibition of LH and FSH by com...

journal_title：Human reproduction update

authors： Reissmann T,Schally AV,Bouchard P,Riethmiiller H,Engel J

更新日期：2000-07-01 00:00:00

abstract：:Sperm transport from the cervix into the tube is an important uterine function within the process of reproduction. This function is exerted by uterine peristalsis and is controlled by the dominant ovarian structure via a cascade of endocrine events. The uterine peristaltic activity involves only the stratum subvascula...

journal_title：Human reproduction update

authors： Kunz G,Herbertz M,Noe M,Leyendecker G

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:A dynamic balance between pro- and anti-inflammatory factors contributes to regulating human female reproduction. Chronic low-grade inflammation has been detected in several female reproductive conditions, from anovulation to embryo implantation failure. C-reactive protein (CRP) is a reliable marker of infla...

journal_title：Human reproduction update

authors： Brouillet S,Boursier G,Anav M,Du Boulet De La Boissière B,Gala A,Ferrieres-Hoa A,Touitou I,Hamamah S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Approximately half recurrent miscarriage (RM) cases remain unexplained after standard investigations. Secondary RM (SRM) is, in contrast to primary RM, preceded by a birth, which increases the transfer of fetal cells into the maternal circulation. Mothers of boys are often immunized against male-specific min...

journal_title：Human reproduction update

authors： Nielsen HS

更新日期：2011-07-01 00:00:00

abstract：:Androgen levels are measured in today's clinical practice almost exclusively by immunoassays. The androgen that is most frequently determined is testosterone (T), but sometimes also the levels of other testicular, ovarian and adrenal androgens such as 5alpha-dihydrotestosterone, androstenedione, dehydroepiandrosterone...

journal_title：Human reproduction update

authors： Roy P,Alevizaki M,Huhtaniemi I

更新日期：2008-01-01 00:00:00

abstract：:After colonization of the gonad, mouse female germ cells enter into the prophase of the first meiotic division as a mid-gestational hallmark of gender. Perinatally, oocytes interact with granulosa cells to form primordial follicles which, with cyclic periodicity, enter into a 3-week growth phase that culminates in mei...

journal_title：Human reproduction update

authors： Amleh A,Dean J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Important roles for G-protein-coupled receptors (GPCRs) have been identified in the maternal physiological adaptations to pregnancy and in the pathogenesis of preeclampsia. On this basis, GPCRs are potential therapeutic targets for preeclampsia. OBJECTIVES AND RATIONALE:In this review, vasopressin and apeli...

journal_title：Human reproduction update

authors： Conrad KP

更新日期：2016-09-01 00:00:00

abstract：:Mammalian oocytes begin meiosis in the fetal ovary, but only complete it when fertilized in the adult reproductive tract. This review examines the cell biology of this protracted process: from entry of primordial germ cells into meiosis to conception. The defining feature of meiosis is two consecutive cell divisions (...

journal_title：Human reproduction update

authors： Jones KT

更新日期：2008-03-01 00:00:00

abstract：:Cryopreservation of testicular tissue might benefit prepubertal boys who must undergo chemotherapy or radiotherapy. Cryopreservation of testicular tissue and testicular cells for intracytoplasmic sperm injection (ICSI) is feasible and widely applied. Testicular tissue from prepubertal boys can also be frozen, by apply...

journal_title：Human reproduction update

authors： Hovatta O

更新日期：2001-07-01 00:00:00

abstract：:The clinical significance of micro-organisms in semen samples of asymptomatic subfertile patients is a matter of constant debate. Usually little attention is paid to anaerobic bacteria as they are sensitive to transportation and culturing, and differentiation is difficult, costly and time-consuming. In the present stu...

journal_title：Human reproduction update

authors： Eggert-Kruse W,Rohr G,Ströck W,Pohl S,Schwalbach B,Runnebaum B

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Recurrent pregnancy loss (RPL) occurs in 1-3% of all couples trying to conceive. No consensus exists regarding when to perform testing for risk factors in couples with RPL. Some guidelines recommend testing if a patient has had two pregnancy losses whereas others advise to test after three losses. OBJECTIVE...

journal_title：Human reproduction update

authors： van Dijk MM,Kolte AM,Limpens J,Kirk E,Quenby S,van Wely M,Goddijn M

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Thyroid hormone disorders and thyroid peroxidase autoantibodies (TPO-Ab) in women are associated with subfertility and early pregnancy loss. Here, we aim to provide a comprehensive overview of the literature on the pathophysiology of these associations. METHODS:A review of the literature in the English lang...

journal_title：Human reproduction update

authors： Vissenberg R,Manders VD,Mastenbroek S,Fliers E,Afink GB,Ris-Stalpers C,Goddijn M,Bisschop PH

更新日期：2015-05-01 00:00:00

abstract：:Apoptosis is a selective process for deletion of cells in various biological systems. This event, similar to proliferation, is tightly regulated, with both processes playing essential roles in the homeostasis of renewable tissues. In human endometrium, proliferation and apoptosis occur at opposing poles of the menstru...

journal_title：Human reproduction update

authors： Tabibzadeh S

更新日期：1995-07-01 00:00:00

abstract：:Mammals are generally held to be exceptions to the rule that organization of the egg plays a role in specifying the differentiation of cells, axes, or other aspects of patterning in the early embryo. However, there are several grounds for questioning this conclusion. Not only do certain experimental findings remain un...

journal_title：Human reproduction update

authors： Gardner RL

更新日期：1996-01-01 00:00:00

abstract：:Pregnancy induces physiological alterations in thyroid function which may make difficult the interpretation of results of thyroid hormone measurement. A state of hyperstimulation of the thyroid gland is common in early pregnancy. In a few cases, thyroid hormone values will deviate from the normal range, which correspo...

journal_title：Human reproduction update

authors： Rodien P,Jordan N,Lefèvre A,Royer J,Vasseur C,Savagner F,Bourdelot A,Rohmer V

更新日期：2004-03-01 00:00:00

abstract：:The use of laparoscopic techniques for the treatment of polycystic ovarian syndrome (PCOS) has included many different approaches in the 1980s and 90s. Broadly similiar results have been obtained using biopsy, cauterization, multi-electrocoagulation and laser surgery; i.e. > 50% ovulation and a mean pregnancy rate of ...

journal_title：Human reproduction update

authors： Cohen J

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial. OBJECTIVE AND RATIONALE:We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk amo...

journal_title：Human reproduction update

authors： Oliver-Williams C,Glisic M,Shahzad S,Brown E,Pellegrino Baena C,Chadni M,Chowdhury R,Franco OH,Muka T

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Activins are members of the pleiotrophic family of the transforming growth factor-beta (TGF-β) superfamily of cytokines, initially isolated for their capacity to induce the release of FSH from pituitary extracts. Subsequent research has demonstrated that activins are involved in multiple biological functions...

journal_title：Human reproduction update

authors： Wijayarathna R,de Kretser DM

更新日期：2016-04-01 00:00:00

abstract：:From a public health viewpoint, the intrauterine device (IUD) is the most widely used contraceptive method in the world. Prevalence rates range among countries from 2 to 80% of contraceptive users. During 5 years of IUD use, pregnancy occurs in less than 2 per 100 insertions. Bleeding and pain are the most common reas...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2008-05-01 00:00:00

abstract：:In 1987, Nigel Harris cautioned against over-diagnosing the antiphospholipid syndrome (APS). In what was a rather prophetic editorial titled 'The Syndrome of the Black Swan', he suggested that while patients with APS do indeed exist, they are probably much more unusual than many medical professionals might like to bel...

journal_title：Human reproduction update

authors： Clark CA,Laskin CA,Spitzer KA

更新日期：2012-09-01 00:00:00