Laparoscopic procedures for treatment of infertility related to polycystic ovarian syndrome.

abstract：BACKGROUND:With the recent development of CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing technology, the possibility to genetically manipulate the human germline (gametes and embryos) has become a distinct technical possibility. Although many technical challenges still need to be...

journal_title：Human reproduction update

authors： Vassena R,Heindryckx B,Peco R,Pennings G,Raya A,Sermon K,Veiga A

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Worldwide, placenta-related complications contribute to adverse pregnancy outcomes, such as pre-eclampsia, fetal growth restriction and preterm birth, with implications for the future health of mothers and offspring. The placenta develops in the periconception period and forms the interface between mother an...

journal_title：Human reproduction update

authors： Reijnders IF,Mulders AGMGJ,van der Windt M,Steegers EAP,Steegers-Theunissen RPM

更新日期：2019-01-01 00:00:00

abstract：:At present, the management of non-organ confined prostate cancer, whether it is a recurrence or metastasis, continues to evolve based on prostate cancer detection using prostate-specific antigen and the development of medications as alternatives for the classical orchiectomy, which induced irreversible implications fo...

journal_title：Human reproduction update

authors： d'Ancona FC,Debruyne FM

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Although fertility preservation (FP) treatment options have increased, the existing evidence suggests that many women with cancer do not feel well supported in making these decisions, but find them stressful and complex and fail to take up fertility care at this crucial time. Whilst existing reviews have all...

journal_title：Human reproduction update

authors： Jones G,Hughes J,Mahmoodi N,Smith E,Skull J,Ledger W

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging tasks in reproductive medicine. OBJECTIVE AND RATIONALE:The aim of this systemic review is to evaluate the role of different adjuvant treatment strategies on the probabi...

journal_title：Human reproduction update

authors： Zhang Y,Zhang C,Shu J,Guo J,Chang HM,Leung PCK,Sheng JZ,Huang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Estrogens are known to orchestrate reproductive events and to regulate the immune system during infections and following tissue damage. Recent findings suggest that, in the absence of any danger signal, estrogens trigger the physiological expansion and functional specialization of macrophages, which are immu...

journal_title：Human reproduction update

authors： Pepe G,Locati M,Della Torre S,Mornata F,Cignarella A,Maggi A,Vegeto E

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. OBJECTIVE AND RATIONALE:Over the past several years, a number of paradigm-shifting breakthroughs have occurred in...

journal_title：Human reproduction update

authors： Yilmaz BD,Bulun SE

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Recurrent pregnancy loss (RPL) occurs in 1-3% of all couples trying to conceive. No consensus exists regarding when to perform testing for risk factors in couples with RPL. Some guidelines recommend testing if a patient has had two pregnancy losses whereas others advise to test after three losses. OBJECTIVE...

journal_title：Human reproduction update

authors： van Dijk MM,Kolte AM,Limpens J,Kirk E,Quenby S,van Wely M,Goddijn M

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Mast cells (MCs) are the classical mediators of allergy, however, their importance in the development of innate and adaptive immune responses is increasingly being recognized. Herein, the present MC literature is summarized, with particular focus on studies of MCs in the endometrium and myometrium, and their...

journal_title：Human reproduction update

authors： Menzies FM,Shepherd MC,Nibbs RJ,Nelson SM

更新日期：2011-05-01 00:00:00

abstract：:Endometriosis is considered primarily a disease of the endometrial-subendometrial unit or archimetra. The clinical picture of endometriosis characterises this disease as a hyperactivation of genuine archimetrial functions such as proliferation, inflammatory defence and peristalsis. While the aetiology of the disease r...

journal_title：Human reproduction update

authors： Leyendecker G,Kunz G,Noe M,Herbertz M,Mall G

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely uncle...

journal_title：Human reproduction update

authors： Guo SW,Groothuis PG

更新日期：2018-09-01 00:00:00

abstract：:During the last decade oocyte donation has been highly successful for treating women previously thought to be hopelessly infertile. The pregnancy rate after oocyte donation is among the highest reported for any fertility-enhancing procedure. Most investigators have noted an increased rate of obstetric complications in...

journal_title：Human reproduction update

authors： Söderström-Anttila V

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) typically occurs when ovaries are primed with FSH/LH and subsequently exposed to hCG. The ultimate pathophysiological step underlying this clinical picture is increased vascular permeability (VP). METHODS:A search of the literature was carried out using PubMed and th...

journal_title：Human reproduction update

authors： Soares SR,Gómez R,Simón C,García-Velasco JA,Pellicer A

更新日期：2008-07-01 00:00:00

abstract：:Mammalian oocytes begin meiosis in the fetal ovary, but only complete it when fertilized in the adult reproductive tract. This review examines the cell biology of this protracted process: from entry of primordial germ cells into meiosis to conception. The defining feature of meiosis is two consecutive cell divisions (...

journal_title：Human reproduction update

authors： Jones KT

更新日期：2008-03-01 00:00:00

abstract：:BACKGROUND Endometriosis associated with pain symptoms in adolescents has been extensively reported, but the exact prevalence is unclear because pain symptoms may be atypical and endometriosis can only be diagnosed by laparoscopy. The aim of this paper is to provide a systematic review of the prevalence of endometrios...

journal_title：Human reproduction update

authors： Janssen EB,Rijkers AC,Hoppenbrouwers K,Meuleman C,D'Hooghe TM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Preimplantation embryos are particularly susceptible to in vitro developmental blocks. These could be alleviated by lowering culture medium osmolarity. Because mammalian cells regulate their volumes by adjusting intracellular osmotic pressure, cell volume regulation could be critical to early embryos. METHO...

journal_title：Human reproduction update

authors： Baltz JM,Tartia AP

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Hirsutism is the presence of excess body or facial terminal (coarse) hair growth in females in a male-like pattern, affects 5-15% of women, and is an important sign of underlying androgen excess. Different methods are available for the assessment of hair growth in women. METHODS:We conducted a literature se...

journal_title：Human reproduction update

authors： Yildiz BO,Bolour S,Woods K,Moore A,Azziz R

更新日期：2010-01-01 00:00:00

abstract：:Polychlorinated dioxins, furans and polychlorinated benzene constitute a family of toxic persistent environmental pollutants. In Europe, environmental concentrations increased slowly throughout this century until the late 1980s. Dioxins have been shown to be carcinogenic in animals and humans. In humans, excess risks ...

journal_title：Human reproduction update

authors： Kogevinas M

更新日期：2001-05-01 00:00:00

abstract：:Homocysteine, a product of the methionine cycle, is known to play an important role in cardiovascular diseases, neurological disorders and embryology, and in very important, fast growing fields concerning obstetrics and gynaecology. Therefore, we attempted an actual overview on possible obstetrical and gynaecological ...

journal_title：Human reproduction update

authors： Obwegeser R,Hohlagschwandtner M,Sinzinger H

更新日期：1999-01-01 00:00:00

abstract：:Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After transfection into various cell types it has proven to be a very fusogenic pr...

journal_title：Human reproduction update

authors： Pötgens AJ,Drewlo S,Kokozidou M,Kaufmann P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:A dynamic balance between pro- and anti-inflammatory factors contributes to regulating human female reproduction. Chronic low-grade inflammation has been detected in several female reproductive conditions, from anovulation to embryo implantation failure. C-reactive protein (CRP) is a reliable marker of infla...

journal_title：Human reproduction update

authors： Brouillet S,Boursier G,Anav M,Du Boulet De La Boissière B,Gala A,Ferrieres-Hoa A,Touitou I,Hamamah S

更新日期：2020-09-01 00:00:00

abstract：:It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppre...

journal_title：Human reproduction update

authors： Filippini A,Riccioli A,Padula F,Lauretti P,D'Alessio A,De Cesaris P,Gandini L,Lenzi A,Ziparo E

更新日期：2001-09-01 00:00:00

abstract：:The improved long-term survival of adolescents and young women treated for cancer has resulted in an increased focus on the effects of chemotherapy on ovarian function and its preservation. These women may seek advice and treatment regarding their reproductive status, including ways of preserving their fertility and p...

journal_title：Human reproduction update

authors： Lutchman Singh K,Davies M,Chatterjee R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Spermatogenesis culminates in production of one of the most highly differentiated cells in biology, the spermatozoon. The gametes that emerge from the testes are, however, functionally immature and only acquire full functionality once they have completed a process of post-testicular maturation in the epididy...

journal_title：Human reproduction update

authors： Dun MD,Aitken RJ,Nixon B

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Fear from increased cancer risk is one of the most significant reasons for low acceptance of reliable contraceptive methods and low compliance. METHODS:In this review, we included all cohort and case-control studies published in English up to December 2008. They were identified through a search of the liter...

journal_title：Human reproduction update

authors： Cibula D,Gompel A,Mueck AO,La Vecchia C,Hannaford PC,Skouby SO,Zikan M,Dusek L

更新日期：2010-11-01 00:00:00

abstract：:In 1987, Nigel Harris cautioned against over-diagnosing the antiphospholipid syndrome (APS). In what was a rather prophetic editorial titled 'The Syndrome of the Black Swan', he suggested that while patients with APS do indeed exist, they are probably much more unusual than many medical professionals might like to bel...

journal_title：Human reproduction update

authors： Clark CA,Laskin CA,Spitzer KA

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of f...

journal_title：Human reproduction update

authors： Tatone C,Di Emidio G,Barbonetti A,Carta G,Luciano AM,Falone S,Amicarelli F

更新日期：2018-05-01 00:00:00

abstract：:This review addresses research on gamete donors, recipients, and offspring and demonstrates that the foci on all three within the triad are largely directed at disclosure or anonymity; and each in turn centers on the perceived importance of the genetic link. The importance attached to genetics has led some countries t...

journal_title：Human reproduction update

authors： van den Akker O

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Clinical trials yield discrepant information about the impact of hormone therapy on verbal memory and executive function. This issue is clinically relevant because declines in verbal memory are the earliest predictor of Alzheimer's disease and declines in executive function are central to some theories of no...

journal_title：Human reproduction update

authors： Maki PM,Sundermann E

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Transfer of more than a single embryo in an IVF cycle comes with the finite possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both mother and babies. The move to single-embryo transfer for all patients will be greatly facilitated by the ability to quantify embryo viabilit...

journal_title：Human reproduction update

authors： Gardner DK,Meseguer M,Rubio C,Treff NR

更新日期：2015-11-01 00:00:00