Abstract:
:BACKGROUND To review the accuracy of multivariate models for the prediction of ovarian reserve and pregnancy in women undergoing IVF compared with the antral follicle count (AFC) as single test. METHODS We performed a computerized MEDLINE and EMBASE search to identify articles published on multivariate models for ovarian reserve testing in patients undergoing IVF. In order to be selected, articles had to contain data on the outcome of IVF in terms of either pregnancy and/or poor response and on the prediction of these events based on a multivariate model. For the selected studies, sensitivity and specificity of the test in the prediction of poor ovarian response and non-pregnancy were calculated. Overall performance was assessed by estimating a summary receiver operating characteristic (ROC) curve, which was compared with the ROC curve for the AFC as the current best single test. RESULTS We identified 11 studies reporting on the predictive capacity of multivariate models in ovarian reserve testing. All studies reported on the prediction of poor ovarian response, whereas none reported on the occurrence of pregnancy. The sensitivity for prediction of poor ovarian response varied between 39% and 97% and the specificity between 50% and 96%. Logistic regression analysis indicated that cohort studies provided a significantly better discriminative performance than case-control studies. As cohort studies are superior to case-control studies, further analysis was limited to the cohort studies. For the cohort studies, a summary ROC curve could be estimated, which had a shape similar to that previously made for the AFC. CONCLUSIONS The accuracy of multivariate models for the prediction of ovarian response in women undergoing IVF is similar to the accuracy of AFC. No data are available on the capacity of these models to predict pregnancy, let alone live birth. On the basis of these findings, the use of more than one single test for the assessment of ovarian reserve cannot currently be supported.
journal_name
Hum Reprod Updatejournal_title
Human reproduction updateauthors
Verhagen TE,Hendriks DJ,Bancsi LF,Mol BW,Broekmans FJdoi
10.1093/humupd/dmn001subject
Has Abstractpub_date
2008-03-01 00:00:00pages
95-100issue
2eissn
1355-4786issn
1460-2369pii
14/2/95journal_volume
14pub_type
杂志文章,meta分析abstract::Relatively recent discoveries of the hormone disrupting properties of some pesticides have raised interest in how contemporary pesticide exposures, which primarily take the form of low level environmental or occupational exposures, impact spermatogenesis. The objective of the present review was to summarize results to...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmm039
更新日期:2008-05-01 00:00:00
abstract::This review presents detailed risk estimates from relevant epidemiological and other studies on the comparative safety of second and third generation oral contraceptives (OC). Written with the intention of presenting a repository of the available information, it also discourses briefly into the symptomatology and diag...
journal_title:Human reproduction update
pub_type: 历史文章,杂志文章,评审
doi:10.1093/humupd/5.6.565
更新日期:1999-11-01 00:00:00
abstract::Nitric oxide (NO) is an important mediator of paracrine interactions, especially within the vascular system. It is a powerful inhibitor of platelet aggregation and a potent vasodilator. NO is also a neurotransmitter and it plays a role in cell-mediated cytotoxicity. NO-generating enzymes (nitric oxide synthases, NOS) ...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.5.565
更新日期:1998-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/8.5.395
更新日期:2002-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/1.4.303
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely uncle...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmy020
更新日期:2018-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dms009
更新日期:2012-07-01 00:00:00
abstract::The results of the Transnational Study on Oral Contraceptives and the Health of Young Women studies are reviewed, potential biases shown, and new analyses are presented. The initial finding was a slight increase in the risk of venous thromboboembolism (VTE) when users of third generation OC (containing the progestins ...
journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/5.6.707
更新日期:1999-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,meta分析
doi:10.1093/humupd/dmz046
更新日期:2020-02-28 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmn048
更新日期:2009-03-01 00:00:00
abstract::The use of physical techniques such as scanning electron microscopy and microprobe analysis permits the analysis of valuable details of the structure of dried samples of mid-cycle cervical mucus during the period of maximum ferning. From a crystallographic point of view, particular attention was paid to the location, ...
journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/3.4.347
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Genetic testing of preimplantation embryos has been used for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). Microarray technology is being introduced in both these contexts, and whole genome sequencing of blastomeres is also expeted to become possible soon. The amount of...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmt009
更新日期:2013-07-01 00:00:00
abstract::This paper investigates the relationship of features of in-vitro fertilization (IVF) embryos and the associated oocyte and follicle to the outcome of transfer. It differs from previous studies in including a range of features (n = 53) and in using class probability tree analysis. This is a non-parametric multivariate ...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.2.121
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorrhage (abruption) can occur throughout pregnancy from poorly transformed spiral ar...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmw004
更新日期:2016-06-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/6.6.578
更新日期:2000-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmp022
更新日期:2009-11-01 00:00:00
abstract::The examination of fetal cells, specifically erythroblasts, and cell-free fetal DNA from the blood of pregnant women is currently the subject of intense research with the aim of developing new risk-free methods for prenatal diagnosis. An unexpected finding made during these studies was that the traffic of fetal erythr...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/8.6.501
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. OBJECTIVE AND RATIONALE:Over the past several years, a number of paradigm-shifting breakthroughs have occurred in...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmz005
更新日期:2019-07-01 00:00:00
abstract::The improved long-term survival of adolescents and young women treated for cancer has resulted in an increased focus on the effects of chemotherapy on ovarian function and its preservation. These women may seek advice and treatment regarding their reproductive status, including ways of preserving their fertility and p...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh052
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Although fertility preservation (FP) treatment options have increased, the existing evidence suggests that many women with cancer do not feel well supported in making these decisions, but find them stressful and complex and fail to take up fertility care at this crucial time. Whilst existing reviews have all...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmx009
更新日期:2017-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,meta分析,评审
doi:10.1093/humupd/dmr029
更新日期:2011-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/dmz004
更新日期:2019-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,meta分析
doi:10.1093/humupd/dmz002
更新日期:2019-05-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh008
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:The main objective of individualization of treatment in IVF is to offer every single woman the best treatment tailored to her own unique characteristics, thus maximizing the chances of pregnancy and eliminating the iatrogenic and avoidable risks resulting from ovarian stimulation. Personalization of treatmen...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmt037
更新日期:2014-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/5.3.256
更新日期:1999-05-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/dmy037
更新日期:2019-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmn008
更新日期:2008-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/6.1.56
更新日期:2000-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 社论
doi:10.1093/humupd/dms020
更新日期:2012-09-01 00:00:00