Abstract:
BACKGROUND:The aim of this meta-analysis was to investigate whether any difference exists in success rate of clinical outcomes of assisted reproductive technologies (ART) between women who actively smoke cigarettes at the time of treatment and those who do not. METHODS:An intensive computerized search was conducted on published literature from eight databases, using search terms related to smoking, assisted reproduction and outcome measures. Eligible studies compared outcomes of ART between cigarette smoking patients and a control group of non-smoking patients and reported on live birth rate per cycle, clinical pregnancy rate per cycle, ectopic pregnancy rate per pregnancy or spontaneous miscarriage rate per pregnancy, and 21 studies were included in the meta-analyses. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated for the data, and statistical heterogeneity was tested for using chi(2) and I(2) values. A systematic review examined the effect of smoking upon fertilization rates across 17 studies. RESULTS:Smoking patients demonstrated significantly lower odds of live birth per cycle (OR 0.54, 95% CI 0.30-0.99), significantly lower odds of clinical pregnancy per cycle (OR 0.56, 95% CI 0.43-0.73), significantly higher odds of spontaneous miscarriage (OR 2.65, 95% CI 1.33-5.30) and significantly higher odds of ectopic pregnancy (OR 15.69, 95% CI 2.87-85.76). A systematic literature review revealed that fertilization rates were not significantly different between smoking and non-smoking groups in most studies. CONCLUSIONS:This meta-analysis provides compelling evidence for a significant negative effect of cigarette smoking upon clinical outcomes of ART and should be presented to infertility patients who smoke cigarettes in order to optimize success rates.
journal_name
Hum Reprod Updatejournal_title
Human reproduction updateauthors
Waylen AL,Metwally M,Jones GL,Wilkinson AJ,Ledger WLdoi
10.1093/humupd/dmn046subject
Has Abstractpub_date
2009-01-01 00:00:00pages
31-44issue
1eissn
1355-4786issn
1460-2369pii
dmn046journal_volume
15pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with male infertility. However, the underlying mechanisms remain elusive. METHODS:Literature databases were searched for papers on the topi...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dms027
更新日期:2012-11-01 00:00:00
abstract::In those clinical situations in which an immediate and profound suppression of gonadotrophins is desired, LHRH agonists have the disadvantage of producing an initial stimulatory effect on hormone secretion. Therefore, the use of GnRH antagonists which cause an immediate and dose-related inhibition of LH and FSH by com...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/6.4.322
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pub_type: 杂志文章
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journal_title:Human reproduction update
pub_type: 杂志文章,meta分析
doi:10.1093/humupd/dmn001
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmp024
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pub_type: 杂志文章,评审
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journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/4.5.667
更新日期:1998-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The use of nuclear transfer (NT) has been proposed as a novel reproductive treatment to overcome the transmission of maternally-inherited mitochondrial DNA (mtDNA) mutations. Pathogenic mutations in mtDNA can cause a wide-spectrum of life-limiting disorders, collectively known as mtDNA disease, for which the...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.5.752
更新日期:1998-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmi038
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/dmaa012
更新日期:2020-09-01 00:00:00