当前位置： SCI文献检索 > HUMAN REPRODUCTION UPDATE期刊下所有文献 > Endometriosis: a dysfunction and disease of the archimetra.

Endometriosis: a dysfunction and disease of the archimetra.

Abstract：

:Endometriosis is considered primarily a disease of the endometrial-subendometrial unit or archimetra. The clinical picture of endometriosis characterises this disease as a hyperactivation of genuine archimetrial functions such as proliferation, inflammatory defence and peristalsis. While the aetiology of the disease remains to be elucidated, a key event appears to consist in the local production of extraovarian oestrogen by a pathological expression of the P450 aromatase. The starting event may consist in a hyperactivity of the endometrial inflammatory defence, a hyperactivity of the endometrial oxytocin/oxytocin receptor system or in the pathological expression of the P450 aromatase system itself. Regardless of which of these levels the starting event is localized in, they influence each other on both the level of the archimetra and the endometriotic lesions. Locally elevated oestrogen levels inevitably up-regulate the endometrial oxytocin mRNA and increased levels of oxytocin result in uterine hyperperistalsis, increased transtubal seeding of endometrial tissue fragments and finally subfertility and infertility by impairment of the uterine mechanism of rapid and sustained sperm transport. Locally increased levels of oestrogen lead, on both the level of the endometrial-subendometrial unit and the endometriotic lesion, to processes of hyperproliferation. These processes result, on the level of the uterus, in an infiltrative growth of elements of the archimetra into the neometra and, on the level of the endometriotic lesion, in infiltrative endometriosis. There is circumstantial evidence that trauma might be an important initial event that induces the specific biochemical and cellular responses of the archimetra. This model is able to explain both the pleiomorphic appearance of endometriosis and the, up until now, enigmatic infertility associated with mild and moderate endometriosis.

journal_name

Hum Reprod Update

journal_title

Human reproduction update

authors

Leyendecker G,Kunz G,Noe M,Herbertz M,Mall G

doi

10.1093/humupd/4.5.752

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

752-62

issue

eissn

1355-4786

issn

1460-2369

journal_volume

pub_type

杂志文章,评审

在线工具

Endometriosis: a dysfunction and disease of the archimetra.