Regulation of male fertility by CFTR and implications in male infertility.

abstract：BACKGROUND:Overall, the incidence of male reproductive disorders has increased in recent decades. Testicular development during fetal life is crucial for subsequent male reproductive function. Non-genomic factors such as environmental chemicals, pharmaceuticals and lifestyle have been proposed to impact on human fetal ...

journal_title：Human reproduction update

authors： Kilcoyne KR,Mitchell RT

更新日期：2019-07-01 00:00:00

abstract：:During the elongating spermatid stage of spermiogenesis, human sperm chromatin undergoes a complex transition in which histones are extensively replaced by protamines in a carefully regulated transition including histone modifications and intermediate and temporary replacement of the histones by sperm-specific transit...

journal_title：Human reproduction update

authors： Carrell DT,Emery BR,Hammoud S

更新日期：2007-05-01 00:00:00

abstract：:Maternal use of marijuana, in which the exocannabinoid Delta(9)-tetrahydrocannabinol is the most active psychoactive ingredient, is known to have adverse effects on various aspects of reproduction including ovulation, spermatogenesis, implantation and pregnancy duration. Endogenous cannabinoids of which Anandamide is ...

journal_title：Human reproduction update

authors： Taylor AH,Ang C,Bell SC,Konje JC

更新日期：2007-09-01 00:00:00

abstract：:Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After transfection into various cell types it has proven to be a very fusogenic pr...

journal_title：Human reproduction update

authors： Pötgens AJ,Drewlo S,Kokozidou M,Kaufmann P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Anti-Müllerian hormone (AMH) is an established marker of ovarian reserve and a good predictor of poor or excessive ovarian response after controlled hyperstimulation. However, it is unclear whether it can predict the ultimate outcome of assisted conception, live birth. We undertook a systematic review and me...

journal_title：Human reproduction update

authors： Iliodromiti S,Kelsey TW,Wu O,Anderson RA,Nelson SM

更新日期：2014-07-01 00:00:00

abstract：:Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is approximately 4.3%, in infertile patients approximately 3.5% and in patients with recurrent pregnancy losses approximate...

journal_title：Human reproduction update

authors： Grimbizis GF,Camus M,Tarlatzis BC,Bontis JN,Devroey P

更新日期：2001-03-01 00:00:00

abstract：:Pregnancy induces physiological alterations in thyroid function which may make difficult the interpretation of results of thyroid hormone measurement. A state of hyperstimulation of the thyroid gland is common in early pregnancy. In a few cases, thyroid hormone values will deviate from the normal range, which correspo...

journal_title：Human reproduction update

authors： Rodien P,Jordan N,Lefèvre A,Royer J,Vasseur C,Savagner F,Bourdelot A,Rohmer V

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Threatened miscarriage affects one in five women and is associated with significant emotional distress. The uncertainty around the prognosis of threatened miscarriage makes it equally challenging to the healthcare professionals. Various biochemical markers have been investigated in the past to predict the ou...

journal_title：Human reproduction update

authors： Pillai RN,Konje JC,Tincello DG,Potdar N

更新日期：2016-03-01 00:00:00

abstract：:Ca(2+) is a ubiquitous intracellular messenger which encodes information by temporal and spatial patterns of concentration. In spermatozoa, several key functions, including acrosome reaction and motility, are regulated by cytoplasmic Ca(2+) concentration. Despite the very small size and apparent structural simplicity ...

journal_title：Human reproduction update

authors： Jimenez-Gonzalez C,Michelangeli F,Harper CV,Barratt CL,Publicover SJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Human long non-coding RNAs (lncRNAs) are an emerging category of transcripts with increasingly documented functional roles during development. LncRNAs and roles during human early embryo development have recently begun to be unravelled. OBJECTIVE AND RATIONALE:This review summarizes the most recent knowledg...

journal_title：Human reproduction update

authors： Bouckenheimer J,Assou S,Riquier S,Hou C,Philippe N,Sansac C,Lavabre-Bertrand T,Commes T,Lemaître JM,Boureux A,De Vos J

更新日期：2016-12-01 00:00:00

abstract：:Hormonal contraception has become more effective and more widely used, while the world population has grown from 3000 million in 1960 to 6000 million in 2000. There is a need for improved contraception, because legal abortion is used in a high proportion of pregnancies and illegal abortion continues to be common in so...

journal_title：Human reproduction update

authors：

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Estrogens are known to orchestrate reproductive events and to regulate the immune system during infections and following tissue damage. Recent findings suggest that, in the absence of any danger signal, estrogens trigger the physiological expansion and functional specialization of macrophages, which are immu...

journal_title：Human reproduction update

authors： Pepe G,Locati M,Della Torre S,Mornata F,Cignarella A,Maggi A,Vegeto E

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Important roles for G-protein-coupled receptors (GPCRs) have been identified in the maternal physiological adaptations to pregnancy and in the pathogenesis of preeclampsia. On this basis, GPCRs are potential therapeutic targets for preeclampsia. OBJECTIVES AND RATIONALE:In this review, vasopressin and apeli...

journal_title：Human reproduction update

authors： Conrad KP

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Clinical trials yield discrepant information about the impact of hormone therapy on verbal memory and executive function. This issue is clinically relevant because declines in verbal memory are the earliest predictor of Alzheimer's disease and declines in executive function are central to some theories of no...

journal_title：Human reproduction update

authors： Maki PM,Sundermann E

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Preimplantation embryos are particularly susceptible to in vitro developmental blocks. These could be alleviated by lowering culture medium osmolarity. Because mammalian cells regulate their volumes by adjusting intracellular osmotic pressure, cell volume regulation could be critical to early embryos. METHO...

journal_title：Human reproduction update

authors： Baltz JM,Tartia AP

更新日期：2010-03-01 00:00:00

abstract：:Prior to the development of high-throughput methods for the analysis of differential gene expression, genes required for proper ovarian function were identified on a case-by-case basis. Recently, however, several techniques have been developed that enable investigators to study large-scale changes in gene expression u...

journal_title：Human reproduction update

authors： Hennebold JD

更新日期：2004-05-01 00:00:00

abstract：:The wide use of assisted conception methods has risen dramatically. The greater proportion of singletons, twins and high order of multiplicity conceived by those methods have already focused the medical community to various obstetric complications. Recently, there have been suggestions that the levels of mid-gestation...

journal_title：Human reproduction update

authors： Maymon R,Dreazen E,Weinraub Z,Bukovsky I,Herman A

更新日期：1999-09-01 00:00:00

abstract：:Varicocele is often cited as the most common cause of male factor infertility. Arguments in support of this statement include reports of increased prevalence of varicocele in populations of infertile men compared with fertile or otherwise unselected men, association of varicocele with abnormal semen parameters, and im...

journal_title：Human reproduction update

authors： Redmon JB,Carey P,Pryor JL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Approximately half recurrent miscarriage (RM) cases remain unexplained after standard investigations. Secondary RM (SRM) is, in contrast to primary RM, preceded by a birth, which increases the transfer of fetal cells into the maternal circulation. Mothers of boys are often immunized against male-specific min...

journal_title：Human reproduction update

authors： Nielsen HS

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Every year 30% of individuals above age 65 fall, and falls are the principal cause of bone fractures. To reduce fracture incidence requires both prevention of falls and maintenance of bone strength. METHODS:PubMed searches were performed, for studies of the epidemiology of fractures, bone physiology, endocr...

journal_title：Human reproduction update

authors： ESHRE Capri Workshop Group.

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas is estimated as up to 75%. Except for hysterectomy, most therapies or treatments often provide only partial or temporary relief and are not succe...

journal_title：Human reproduction update

authors： Commandeur AE,Styer AK,Teixeira JM

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many ye...

journal_title：Human reproduction update

authors： Zimmerman Y,Eijkemans MJ,Coelingh Bennink HJ,Blankenstein MA,Fauser BC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (en...

journal_title：Human reproduction update

authors： Moser G,Drewlo S,Huppertz B,Armant DR

更新日期：2018-07-01 00:00:00

abstract：:At present, the management of non-organ confined prostate cancer, whether it is a recurrence or metastasis, continues to evolve based on prostate cancer detection using prostate-specific antigen and the development of medications as alternatives for the classical orchiectomy, which induced irreversible implications fo...

journal_title：Human reproduction update

authors： d'Ancona FC,Debruyne FM

更新日期：2005-05-01 00:00:00

abstract：:Women suffer a higher incidence of osteoporosis than men, in part due to oestrogen deficiency after menopause. In fact, the administration of oestrogen to post-menopausal women is associated with a decrease of bone resorption. Tamoxifen is a widely used selective oestrogen receptor modulator in women with breast cance...

journal_title：Human reproduction update

authors： Díez JL

更新日期：2000-05-01 00:00:00

abstract：:Leiomyomata represent the most common gynaecological tumour in women of reproductive age, and are the primary indication for hysterectomy in the USA. Cytogenetic and genetic studies have, in recent years, advanced our understanding of the aetiology of these tumours. Cytogenetic aberrations involving chromosomes 6, 7, ...

journal_title：Human reproduction update

authors： Ligon AH,Morton CC

更新日期：2001-01-01 00:00:00

abstract：:This review presents detailed risk estimates from relevant epidemiological and other studies on the comparative safety of second and third generation oral contraceptives (OC). Written with the intention of presenting a repository of the available information, it also discourses briefly into the symptomatology and diag...

journal_title：Human reproduction update

authors： Edwards RG,Cohen J

更新日期：1999-11-01 00:00:00

abstract：:In 1987, Nigel Harris cautioned against over-diagnosing the antiphospholipid syndrome (APS). In what was a rather prophetic editorial titled 'The Syndrome of the Black Swan', he suggested that while patients with APS do indeed exist, they are probably much more unusual than many medical professionals might like to bel...

journal_title：Human reproduction update

authors： Clark CA,Laskin CA,Spitzer KA

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The main objective of individualization of treatment in IVF is to offer every single woman the best treatment tailored to her own unique characteristics, thus maximizing the chances of pregnancy and eliminating the iatrogenic and avoidable risks resulting from ovarian stimulation. Personalization of treatmen...

journal_title：Human reproduction update

authors： La Marca A,Sunkara SK

更新日期：2014-01-01 00:00:00

abstract：:The improved long-term survival of adolescents and young women treated for cancer has resulted in an increased focus on the effects of chemotherapy on ovarian function and its preservation. These women may seek advice and treatment regarding their reproductive status, including ways of preserving their fertility and p...

journal_title：Human reproduction update

authors： Lutchman Singh K,Davies M,Chatterjee R

更新日期：2005-01-01 00:00:00