Abstract:
:Some studies, that consider polymorphisms of the apolipoprotein B (APOB) gene as risk factors for coronary artery disease (CAD), have reported discordant results. The aim of the present study was to search for associations between plasma lipid profiles with the DNA Xba I polymorphism of the APOB gene in CAD patients diagnosed by angiography (CAD+). In the present study we compared 114 Mexican patients (80 men and 34 women) with CAD+ and 132 control patients (59 men and 73 women) without evidence of ischemia or arterial damage (CAD-). The frequency of X+/X+ genotype of Xba I polymorphism, in CAD+ group, was 23% (26/114) compared with 8% (11/132) in the CAD- (OR 3.25, p = 0.002). The patients with X+/X+ for the Xba I genotype APOB gene had higher concentration of triglycerides (TG) and VLDL in plasma than CAD- (p< 0.05). The genotype X+/X+ in the CAD had an effect increasing the TG and VLDL plasma levels when compared with individuals with X-/X- and X-/X+ genotypes. The present study indicated that the X+X+ genotype of Xba I polymorphism is associated with CAD+ patients and high plasma levels of TG and VLDL, in the Mexican population.
journal_name
Asia Pac J Clin Nutrjournal_title
Asia Pacific journal of clinical nutritionauthors
Gallegos-Arreola MP,Valdez Y,Zúñiga-Corona M,Figuera LE,Arnaud-López L,Robles-Cervantes JA,González-Ortiz M,Martínez-Abundis E,Puebla-Pérez AM,Zúñiga-González GMsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
312-8issue
2eissn
0964-7058issn
1440-6047journal_volume
21pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Fast-food companies have been reproached for rising obesity levels due to aggressive marketing tactics targeted at children. They have countered that parents should be held responsible considering their critical role as nutritional gatekeepers. This study examined the comparative effects of me...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.122016.04
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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doi:10.6133/apjcn.042018.06
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:10.6133/apjcn.2013.22.1.15
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journal_title:Asia Pacific journal of clinical nutrition
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doi:
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Asia Pacific journal of clinical nutrition
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