The body cell mass and altered protein energy metabolism in cystic fibrosis.

Abstract:

:To further investigate the body cell mass (BCM) in CF, as the central metabolically active body compartment, and to determine if measures used as reference standards after comparative differences in protein energy metabolism, BCM was measured by K40 analysis (n= 144 CF, 69 M, 71 F, ages 0.3-17 years) related to age and gender control date (n=1478). Protein synthesis was studied by whole body C13 leucine kinetics (LSYN, n=10 well nourished vs 7 undernourished CFs matched for Ht, Sex and FEV1). Energy expenditure (REE) was studied by indirect calorimetry (n=4 Δ F508 CF infants with no lung disease vs n=12 age, wt, ht and sex matched healthy infants). BCM was <1 sd below 50th centile in 75% of CFs although only 15 and l0% had weights or heights <1 sd below 50th centile. Mean LSYN and REE did not significantly differ between groups in absolute values or corrected for weight, height or surface area, but were accelerated (P<0.01) when corrected for BCM.

journal_name

Asia Pac J Clin Nutr

authors

Thomson M,Bucolo S,Thomas B,Holt T,Shepherd R

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

141-2

issue

1

eissn

0964-7058

issn

1440-6047

journal_volume

4

pub_type

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