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Coffee consumption is associated with lower serum aminotransferases in the general Korean population and in those at high risk for hepatic disease.

Abstract：

BACKGROUND AND OBJECTIVES:The favourable effects of coffee on liver enzymes have been reported worldwide. This study investigated the association between coffee consumption and serum aminotransferase concentration in Korean adults. METHODS AND STUDY DESIGN:Data were obtained from the fourth and fifth Korea National Health and Nutrition Examination Surveys. Elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentration were defined as >30 IU/L for men and >19 IU/L for women. The risk of elevated ALT and AST according to general characteristics and frequency of coffee consumption were tested by chi-square tests and multiple logistic regression analyses. RESULTS:The prevalence of elevated ALT was 27.4%, 27.8%, and 26.9% in subjects who drank <1, 1, and >=2 times/day, respectively. The proportions of individuals with elevated AST were 32.5%, 33.1%, and 26.7% in subjects who drank <1, 1, and >=2 times/day, respectively. The aORs for elevated ALT and AST were significantly lower in subjects who drank >=2 times of coffee/day than in those who drank <1 time/day (ALT: aOR=0.86, 95% CI=0.79-0.94; AST: aOR=0.83, 95% CI=0.76-0.91). In subgroup analysis, consumption of >=2 times/day was associated with lower ORs for elevated ALT in the high-risk group overall and in the viral hepatitis and obesity subgroups, respectively. In sensitivity analysis, reduced frequency of coffee consumption was associated with an increased risk for elevated liver enzymes, although an association between coffee consumption and elevated ALT was not observed in women or current smokers. CONCLUSIONS:Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults. :背景和目的：咖啡对肝酶的有利影响已在世界范围内被报道。该研究调查了在韩国成年人的咖啡消费量和血清转氨酶浓度之间的关系。方法与研究设计：数据来自第四和第五次韩国国家健康和营养检测普查。男性丙氨酸氨基转移酶（ALT）和谷草转氨酶（AST）大于30 IU/L，女性大于19 IU/L 为升高。采用卡方检验和多因素Logistic 回归分析，探讨一般特征和咖啡消费频率与ALT 和AST 升高的风险。结果：咖啡摄入频率<1，1 和>=2 次/天的人群高 ALT 的发生率分别为27.4%、27.8%和26.9%，高AST 的发生率分别为 32.5%、33.1%和26.7%。咖啡摄入频率>=2 次/天的人群比<1 次/的人群调整 OR 显著降低（ALT：aOR=0.86，95% CI =0.79-0.94；AST：aOR=0.83，95% CI=0.76-0.91）。亚组分析显示，高危人群整体以及病毒性肝炎组和肥胖组中咖啡摄入频率>=2 次/天的人群ALT 升高的风险低。敏感性分析显示：减少咖啡消费频率与肝酶升高的风险增加相关，但在女性和当前吸烟者中并未发现咖啡消费量与ALT 升高之间的关系。结论：韩国成人较高的咖啡消费量与氨基转移酶浓度升高的风险较低有关。.

journal_name

Asia Pac J Clin Nutr

journal_title

Asia Pacific journal of clinical nutrition

authors

Oh MG,Han MA,Kim MW,Park CG,Kim YD,Lee J

doi

10.6133/apjcn.092015.36

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

767-775

issue

eissn

0964-7058

issn

1440-6047

journal_volume

pub_type

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Coffee consumption is associated with lower serum aminotransferases in the general Korean population and in those at high risk for hepatic disease.