Abstract:
OBJECTIVES:Vitamin B-12 and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentrations. However, the combined effect of these nutrients on Hcy and ferritin, and C-reactive protein is limited and inconclusive. The objective was to examine the synergistic effect of vitamin B-12 in combination of n-3 PUFA on plasma Hcy, ferritin, and other biochemical markers. METHODS:In a randomized controlled trial, thirty eligible subjects were randomly divided into three groups, and assigned to receive 1000 μg of vitamin B-12, 2 g fish oil, or 1000 μg vitamin B-12 and 2 g fish oil, respectively, for 8 weeks. Plasma phospholipids (PL) fatty acids and biochemical markers were determined. This study was registered under ClinicalTrials.gov Identifier: NCT01762072. RESULTS:Plasma PL 20:5n-3, 22:6n-3 and n-3 PUFA was increased after 4 and 8 week supplementation of fish oil, and vitamin B-12+fish oil. Plasma concentrations of triacylglycerol, uric acid, C-reactive protein, and ferritin were significantly decreased after 4 and 8 week supplementation of fish oil, and vitamin B-12+fish oil. In all groups, significant changes in plasma Hcy were observed during the study period. Vitamin B-12, fish oil, and vitamin B-12+fish oil supplementation lowered plasma Hcy concentrations by 22%, 19%, and 39%, respectively. CONCLUSIONS:The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of Hcy. :目的:维生素B-12 和欧米伽3 多不饱和脂肪酸能够降低血液同型半胱氨酸浓 度。但是,这两种营养元素是否对同型半胱氨酸、铁蛋白、C 反应蛋白有协 同效应仍不清楚。方法:为进一步解决该问题,我们开展了一项随机对照实 验,38 位参与者随机分为三组,每天分别食用1000 μg 维生素B-12、2 g 鱼 油、1000 μg 维生素B-12+2 g 鱼油。八周以后,收集受试者血样,测定血浆磷 脂脂肪酸组成,生物标志物等。结果:四周或者八周干预以后,鱼油组和鱼 油+维生素B-12 组的血浆磷脂20:5n-3、22:6n-3 和总欧米伽3 脂肪酸显著升 高,然而,血浆甘油三酯、尿酸、C 反应蛋白以及铁蛋白显著降低。维生素 B-12 组、鱼油组、维生素B-12+鱼油组,血浆同型半胱氨酸分别降低22%、19% 和39%。结论:维生素B-12 和鱼油在调节同型半胱氨酸代谢过程中存在协同 效应。.
journal_name
Asia Pac J Clin Nutrjournal_title
Asia Pacific journal of clinical nutritionauthors
Huang T,Li K,Asimi S,Chen Q,Li Ddoi
10.6133/apjcn.2015.24.3.19subject
Has Abstractpub_date
2015-01-01 00:00:00pages
403-11issue
3eissn
0964-7058issn
1440-6047journal_volume
24pub_type
临床试验,杂志文章,随机对照试验abstract::Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with alcohol consumption. Therefore, we conduct a meta-analysis of studies that assessed the association of alcohol consumption and the risk of endometrial cancer. A systematic literature search up to April 2010 was performed...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:
更新日期:2011-01-01 00:00:00
abstract::Glycaemic index (GI) was determined in 36 non-insulin-dependent diabetes mellitus (NIDDM) patients. The subjects were fed 50g carbohydrate portions of six foods consumed widely in India including Varagu (Plaspalum scorbiculatum) alone and in combination with whole and dehusked greengram (Phaseolus aureus Roxb), Bajra ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The aim of this study was to investigate the effects of sea buckthorn procyanidins (SBPC) on healing of acetic acid-induced lesions in the rat stomach and its possible mechanism. The sea buckthorn procyanidins (SBPC) were extracted with 60% alcohol/H2O from sea buckthorn bark and purified by macropore adsorption resin...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Breastfeeding is the foundation of good nutrition and provides the basis for health throughout the life span. The WHO and the Chinese Ministry of Public Health recommend exclusive breastfeeding to six months of age. The practice of giving prelacteal feeds may interfere with the establishment of good breastfeeding prac...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the pathogenesis of many chronic diseases, including cardiovascular disease. Increased dietary intake of linoleic acid (LA) leads to oxidation of low-density lipoprotein (LDL), platelet aggregation, and interferes with the incorporation of es...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To document dietary intakes and food sources of fatty acids among older Australians. DESIGN:Population-based survivor cohort. SETTING:Two postcode areas in the Blue Mountains, West of Sydney, Australia. SUBJECTS:In 1997-9, 2334 people aged 55 years and over, participated in a 5-year follow-up of the cohort...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of our study was to estimate the national prevalence of metabolic syndrome, its individual components and its changes in the past decade. METHODS AND STUDY DESIGN:Two national-representative cross-sectional surveys: the China National Nutrition and Health Survey 2002 (CNNHS 2002) ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.201909_28(3).0023
更新日期:2019-01-01 00:00:00
abstract::A number of imperatives require a re-think of science in general and of nutrition science in particular. Nutrition science has never been a body of knowledge in its own right and many other sciences have been nutritional in their orientation. At its best "nutrition science" has been integrative as well as reductionist...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::The aim of this study was to assess the prevalence of six healthy dietary behaviours and associated factors in university students from 26 low, middle and high income countries. In a cross-sectional survey, we used a self-administered questionnaire (largely based on the European Health and Behaviour Survey) among 1950...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.2015.24.4.21
更新日期:2015-01-01 00:00:00
abstract::To further investigate the body cell mass (BCM) in CF, as the central metabolically active body compartment, and to determine if measures used as reference standards after comparative differences in protein energy metabolism, BCM was measured by K40 analysis (n= 144 CF, 69 M, 71 F, ages 0.3-17 years) related to age an...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::To evaluate the validity of habitual marine fish intake, the relation between fatty acid composition of serum phospholipids and dietary patterns were investigated. Dietary intake and serum fatty acid concentrations were measured in healthy subjects of coastal fish consuming and non-fish consuming populations. Amongst ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::The aim of this study was to compare mean blood pressure (BP), anthropometric and body compositional measurements in three Chinese communities and to examine relationships between BP and body composition in these communities. A total of 935 adult (aged >= 25 years) men and women were randomly sampled from three commun...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::The present study was undertaken in two backward districts namely Phulbani and Sundargarh, of Orissa State, India, to study operational aspects of the distribution programme of iron fortified salt (IFS), and the extent of any overlap with the ongoing National Nutritional Anaemia Control Programme (NNACP) and possible ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Little is known about purchasing micronutrient powders (MNP) for children 2-5 years. We describe acceptability for purchasing and price points for MNP for children 2-5 years among caregivers living in districts where free MNP are distributed for children 6-23 months. METHODS AND STUDY DESIGN:C...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.102015.07
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:For delivery of parenteral nutrition (PN), long-term central access is often required in infants with intestinal failure (IF). Compared to central venous catheters (CVCs), peripherally inserted central catheters (PICCs) are less invasive, as they are smaller, and they can even be placed withou...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.201811_27(6).0008
更新日期:2018-01-01 00:00:00
abstract::It has been well acknowledged that Vietnam is undergoing a nutrition transition. With a rapid change in the country's reform and economic growth, food supply at the macronutrient level has improved. Changes of the Vietnamese diet include significantly more foods of animal origin, and an increase of fat/oils, and ripe ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the association between the level of weight-related stigmatizing experiences and binge eating in overweight adults in southern Taiwan. METHODS:This study design was a cross-sectional questionnaire survey with convenience sample. A total of 141 questionnaires were ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.2015.24.1.05
更新日期:2015-01-01 00:00:00
abstract::Thirty six-male New Zealand White rabbits subdivided into four dietary groups (9 animals per group) were fed high fat (36% en), cholesterol-free diets for nine months. The dietary oil blends were formulated to contain high levels of the target fatty acids namely trans-rich (partially hydrogenated soybean oil; TRANS), ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate the health and nutrition status in middle-aged and old people in the urban district of Chongqing City, China in order to provide a rational diet construction for the population. METHOD:This investigation was performed in 2004 and 1801 public officials both at post and retired in the urban dist...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study aimed to collect information on experiences in the Great East Japan Earthquake (hereafter, 3.11), current preparedness, and barriers to building up stockpiles in nursery schools in affected areas. Based on the needs heard from the staff, we decided what contents should be included i...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.012016.05
更新日期:2017-03-01 00:00:00
abstract::This special issue on the Nutrition and Health Survey in Taiwan Elementary School Children carried out during 2001-2002 (NAHSIT Children 2001-2002) portrays the current dilemma of the so-called "double nutritional burden" in Taiwanese children with papers addressing topics on the dietary characteristics, nutrition-rel...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. Extensive cross-sectional epidemiological studies showed that low selenium concentrations in cereal grai...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::Financial restraints and poverty lead to poor diets and poor health outcomes. Limited research shows that socioeconomic status is related to home availability of certain foods. However, studies in this area have used different socio-economic indicators, which may not equally influence eating-related behaviors. Using m...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.2014.23.4.04
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The present report summarized the best available evidence regarding consumption level and sources of free or added sugars in Indonesia. METHODS AND STUDY DESIGN:Information was extracted from food balance sheets, household expenditure surveys, nutrition surveys, published studies, unpublished...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.6133/apjcn.042017.07
更新日期:2018-01-01 00:00:00
abstract::Bacterial antagonism has been recognised for over a century but in recent years this phenomenon has received more scientific attention, particularly in the use of various strains of lactic acid bacteria (LAB). Antimicrobial compounds produced by LAB have provided these organisms with a competitive advantage over other...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::The Malaysian government recently introduced a ban on fast food advertisements targeting children on television. This study reports on data covering 6 months of television food advertising targeting children. Six out of seven of the Nation's commercial television networks participated (response rate = 85.7%). Based on...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To evaluate waist-to-height ratio (WTHR), waist girth and body mass index (BMI) as predictors of cardiovascular risk factors in Australian Aborigines. DESIGN:Indices were examined as predictors of mean blood pressures (BP), blood lipids, glucose, insulin and as predictors of hypertension, decreased HDL-chole...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Our aim has been to construct a portable prototype instrument for measuring the whole body composition in vivo of growing lambs in terms of fat. protein and water by determining the mass of carbon, nitrogen and oxygen present. A small and compact sealed tube neutron generator which has the capability of exploiting the...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::The aim of this study was to investigate prevalences of hyperuricemia and the metabolic syndrome (MS) in the Hangzhou population, and the relationship between serum uric acid and the MS. A cross-sectional study was conducted among 4155 subjects (2614 men and 1541 women) aged 20-80 years, recruited through a health che...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Traditional risk factors do not appear to explain fully the variation in the incidence of the cardiovascular diseases (CVD). Epidemiological studies have not been entirely consistent with regard to the relationship between antioxidant vitamin intake and CVD and there appears to be little data on this relationship in n...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00