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Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China.

Abstract：

:This study investigated the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity. A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. At each hospital, Chinese T2DM patients with central obesity who were aged over 20 years, whose serum uric acid levels were measured, and who had lived in Guangdong Province for >=1 year, were recruited. Hyperuricemia was defined as serum uric acid >420 μmol/L in men and >360 μmol/L in women. Binary logistic regression was used to assess associated risk factors for hyperu-ricemia. A total of 2,917 T2DM patients with central obesity took part. The overall prevalence of hyperuricemia was 32.6% (36.1% for women, 28.4% for men). Binary logistic regression analyses demonstrated that women (OR: 1.576; 95% confidence interval (CI): 1.231, 2.018), high BMI (OR: 1.228; 95% CI: 1.094, 1.379), waist cir-cumference (OR: 1.135; 95% CI: 1.009, 1.276), hypertension (OR: 1.603; 95% CI: 1.263, 2.035), high total cho-lesterol (OR: 1.133; 95% CI: 1.002, 1.281), triglycerides (OR: 1.134; 95% CI: 1.069, 1.203), low HDL-cholesterol (OR: 0.820; 95% CI: 0.677, 0.995) and low estimated glomerular filtration rate (OR: 0.840; 95% CI: 0.815, 0.866) were risk factors associated with hyperuricemia. Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR. :本研究旨在探讨高尿酸血症在中国2 型糖尿病合并腹型肥胖患者中的患病率，并分析其相关危险因素。2011 年8 月至2012 年3 月期间，在广东省内进行多中心、以医院为基础的横断面调查。在广东省内居住满一年且年龄在20 岁以上，确诊2 型糖尿病合并腹型肥胖且检测血尿酸水平的患者纳入本研究。高尿酸血症定义：男性血尿酸 >420 μmol/L 或女性血尿酸 >360 μmol/L。采用二分类logistic 回归分析高尿酸血症的危险因素。共2917 名2 型糖尿病合并腹型肥胖的患者纳入本研究。高尿酸血症的患病率为32.6%(女性为36.1%，男性为28.4%)。二分类logistic 回归分析显示，女性、高体重指数和腰围、高血压、高总胆固醇和甘油三酯、低高密度脂蛋白胆固醇和低肾小球滤过率是高尿酸血症的危险因素。高尿酸血症在中国2 型糖尿病合并腹型肥胖患者中盛行，与女性、心血管危险因素如肥胖、高血压、血脂異常症和低肾小球滤过率呈显著相关。

journal_name

Asia Pac J Clin Nutr

journal_title

Asia Pacific journal of clinical nutrition

authors

Wang J,Chen RP,Lei L,Song QQ,Zhang RY,Li YB,Yang C,Lin SD,Chen LS,Wang YL,Zhao F,Liang GX,Hu BC,Lin JC,Cai DH

doi

10.6133/apjcn.2013.22.4.16

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

590-8

issue

eissn

0964-7058

issn

1440-6047

journal_volume

pub_type

杂志文章,多中心研究

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Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China.