Abstract:
:This paper investigates the main characteristics of the magneto-hemodynamic (MHD) response for application as a biomarker of vascular blood flow. The induced surface potential changes of a volunteer exposed to a 3 T static B0 field of a magnetic resonance imaging (MRI) magnet were measured over time at multiple locations by an electrocardiogram device and compared to simulation results. The flow simulations were based on boundary conditions derived from MRI flow measurements restricted to the aorta and vena cava. A dedicated and validated low-frequency electromagnetic solver was applied to determine the induced temporal surface potential change from the obtained 4D flow distribution using a detailed whole-body model of the volunteer. The simulated MHD signal agreed with major characteristics of the measured signal (temporal location of main peak, magnitude, variation across chest and along torso) except in the vicinity of the heart. The MHD signal is mostly influenced by the aorta; however, more vessels and better boundary conditions are needed to analyze the finer details of the response. The results show that the MHD signal is strongly position dependent with highly variable but reproducibly measurable distinguished characteristics. Additional investigations are necessary before determining whether the MHD effect is a reliable reference for location-specific information on blood flow.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Kyriakou A,Neufeld E,Szczerba D,Kainz W,Luechinger R,Kozerke S,McGregor R,Kuster Ndoi
10.1088/0967-3334/33/2/117subject
Has Abstractpub_date
2012-02-01 00:00:00pages
117-30issue
2eissn
0967-3334issn
1361-6579journal_volume
33pub_type
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journal_title:Physiological measurement
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journal_title:Physiological measurement
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更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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更新日期:2010-05-01 00:00:00
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