Spiritual activation in very elderly individuals assessed as heart rate variability and plasma IL/10/IL-6 ratios.


:Proinflammatory cytokine responses might occur in elderly individuals with cardiovascular (CV) disease, cerebro-vascular (CVA) disease, and/or pulmonary disease (PD). Spiritual activation is an important coping mechanism, since psychiatric depression is an important risk factor for these individuals. Thirty-three very elderly individuals (87 ± 8 years) with previous CVD, CVA and/or PD participated in weekly 30 minute sermons by chaplains for over 20 months of chaplain liturgy (CL group). All underwent Holter ECG during the procedures and cardiac autonomic activities were assessed by maximum entropy analysis. Plasma IL-10 and IL-6 levels were compared with 26 age-matched (85 ± 10 years) individuals who did not participate in these activities (non-CL group). Both high frequency (HF) and pNN50 of heart rate variability (HRV) were higher in the CL group than in the non-CL group (HF, 190 ± 55 versus 92 ± 43 nu, P < 0.05; pNN50, 10.5 ± 16% versus 3.6 ± 3.8%, P < 0.05), whereas LF/HF was lower (1.4 ± 1.5 versus 2.2 ± 2.8, P < 0.05). Levels of IL-10/IL-6 were higher in the CL group (3.96 ± 5.0 versus 1.79 ± 1.6, P < 0.05). Hospitalization rates due to CVD and/or PD were lower in the CL group than in the non-CL group (4/33 versus 11/26, P < 0.05). We conclude that spiritual activation can modify proinflammatory cytokines and suppress CVD, CVA and/or PD via vagal modifications. Spiritual activation might be helpful for health in these very elderly individuals.


Int Heart J


Kurita A,Takase B,Shinagawa N,Kodani E,Okada K,Iwahara S,Kusama Y,Atarashi H




Has Abstract


2011-01-01 00:00:00














  • Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model.

    abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Sung PH,Sun CK,Ko SF,Chang LT,Sheu JJ,Lee FY,Wu CJ,Chua S,Yip HK

    更新日期:2009-03-01 00:00:00

  • The Clinical Efficacy of Endothelin Receptor Antagonists in Patients with Pulmonary Arterial Hypertension.

    abstract::Therapeutic strategies for pulmonary arterial hypertension (PAH) have made remarkable progress over the last two decades. Currently, 3 types of drugs can be used to treat PAH; prostacyclins, phosphodiesterase 5 inhibitors, and endothelin receptor antagonists (ERA). In Japan, the first generation ERA bosentan was reimb...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Maki H,Hara T,Tsuji M,Saito A,Minatsuki S,Inaba T,Amiya E,Hosoya Y,Hatano M,Morita H,Yao A,Kinugawa K,Komuro I

    更新日期:2020-01-01 00:00:00

  • Effects of Statins and Xuezhikang on the Expression of Secretory Phospholipase A2, Group IIA in Rat Vascular Smooth Muscle Cells.

    abstract::Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Xie Q,Zhang D

    更新日期:2017-02-07 00:00:00

  • Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome.

    abstract::Marfan syndrome (MFS) is an inherited connective tissue disorder mainly caused by the fibrillin-1 mutation. Deficient fibrillin-1 is thought to result in the failed sequestration of transforming growth factor β (TGFβ) and subsequent activation of the TGFβ signaling pathway, suggesting that the circulating TGFβ level m...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ogawa N,Imai Y,Nishimura H,Kato M,Takeda N,Nawata K,Taketani T,Morota T,Takamoto S,Nagai R,Hirata Y

    更新日期:2013-01-01 00:00:00

  • Coronary artery spasm following off-pump coronary artery bypass surgery.

    abstract::Coronary artery spasm after coronary artery bypass surgery may result in life-threatening arrhythmias, circulatory collapse, or death. We report two cases of coronary artery spasm after coronary artery bypass surgery, one of which developed ventricular fibrillation requiring extracorporeal membrane oxygenation support...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Unai S,Hirose H,Cook G,Lee Y,Miura S,Kigawa I,Fukuda S,Miyairi T

    更新日期:2014-01-01 00:00:00

  • Altered patterns of gene expression specific to thoracic aortic aneurysms: microarray analysis of surgically resected specimens.

    abstract::Changes in the expression levels of several genes have been described in aortic aneurysm specimens, however, the spectrum of diverse molecular alterations remains to be elucidated. We attempted to identify key molecules that modulate the pathogenesis of aortic aneurysm, using a complimentary DNA microarray carrying ap...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Taketani T,Imai Y,Morota T,Maemura K,Morita H,Hayashi D,Yamazaki T,Nagai R,Takamoto S

    更新日期:2005-03-01 00:00:00

  • Exogenous Hydrogen Sulfide Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1α Signaling Pathway.

    abstract::Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with Sirt1 activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also h...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Hu MZ,Zhou B,Mao HY,Sheng Q,Du B,Chen JL,Pang QF,Ji Y

    更新日期:2016-07-27 00:00:00

  • The Refinement of Risk Stratification for Atrial Thrombus or Spontaneous Echo Contrast in Nonvalvular Atrial Fibrillation.

    abstract::As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ning W,Li Y,Ma C,Qiu L,Yu B

    更新日期:2017-12-12 00:00:00

  • Single Femoral Venous Drainage Versus Both Vena Cava Drainage in Isolated Repeat Tricuspid Valve Surgery.

    abstract::To assess the potential advantages of minimally invasive surgery using a single femoral venous drainage method versus femoral venous and superior vena cava or jugular venous drainage method during repeat tricuspid valve surgery.From January 2010 to December 2016, 50 repeat tricuspid valve procedures were performed usi...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Peng R,Shi H,Ba J,Wang C

    更新日期:2018-05-30 00:00:00

  • Change of Exhaled Acetone Concentration Levels in Patients with Acute Decompensated Heart Failure.

    abstract::Exhaled acetone concentration is one of the expected compounds to be a breath biomarker in heart failure. However, it has not been clarified how exhaled acetone concentration changes in clinical course of heart failure.To investigate whether exhaled acetone concentration changes after treatment in acute decompensated ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Yokokawa T,Sato T,Suzuki S,Oikawa M,Yoshihisa A,Kobayashi A,Yamaki T,Kunii H,Nakazato K,Suzuki H,Saitoh SI,Ishida T,Shimouchi A,Takeishi Y

    更新日期:2018-07-31 00:00:00

  • Initial and Secondary ST-T Alternans During Acute Myocardial Ischemia in the In-Situ Pig Heart.

    abstract::The factors responsible for the ST-T wave alternans (STTA) and associated arrhythmias during acute ischemia have not been clarified.In acutely ischemic porcine myocardium, we recorded transmural unipolar and bipolar electrocardiograms and mid-myocardial extracellular K(+) ([K(+)]e) from the center of the ischemic zone...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Watanabe I,Gettes LS

    更新日期:2016-05-25 00:00:00

  • Native Myocardial T1 Mapping, Are We There Yet?

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    journal_title:International heart journal

    pub_type: 杂志文章,评审


    authors: Hamdy A,Kitagawa K,Ishida M,Sakuma H

    更新日期:2016-07-27 00:00:00

  • Predictive Values of Apelin for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.

    abstract::Apelin was proved to attenuate cardiac interstitial fibrosis. However, the association between apelin level and myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) is still unclear.This study aims to determine whether apelin is associated with myocardial fibrosis in HCM and investigate the predictiv...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Zhou Y,Yuan J,Wang Y,Qiao S

    更新日期:2019-05-30 00:00:00

  • Knockdown of miR-665 Protects Against Cardiomyocyte Ischemia/Reperfusion Injury-Induced ROS Accumulation and Apoptosis Through the Activation of Pak1/Akt Signaling in Myocardial Infarction.

    abstract::Myocardial infarction (MI) is one of the major causes of death worldwide, and the therapeutic strategies of MI are still limited. In this study, we investigated the function of miR-665 in MI. In the present study, an ischemia/reperfusion (I/R) rat model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell model were su...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Liu C,Tang M,Zhang X,Li J,Cao G

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  • Transradial percutaneous coronary intervention for acute myocardial infarction reduces CCU stay in patients 80 or older.

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    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Jinnouchi H,Sakakura K,Wada H,Kubo N,Sugawara Y,Nakamura T,Funayama H,Ako J,Momomura S

    更新日期:2012-01-01 00:00:00

  • Case of Invasive Streptococcus Dysgalactiae Infection Presenting as Infective Endocarditis with Multiple Brain Embolisms.

    abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Takahashi F,Wada Y,Hasebe N

    更新日期:2019-01-25 00:00:00

  • Correlation Between Arteriosclerosis and Periodontal Condition Assessed by Lactoferrin and α1-Antitrypsin Levels in Gingival Crevicular Fluid.

    abstract::Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Hayashi S,Yamada H,Fukui M,Ito HO,Sata M

    更新日期:2015-01-01 00:00:00

  • A Simple Method to Differentiate Atrioventricular Node Reentrant Tachycardia from Orthodromic Reciprocating Tachycardia.

    abstract::Discrimination between atrioventricular node reentry tachycardia (AVNRT) and orthodromic reciprocating tachycardia (ORT) during an electrophysiological study is sometimes challenging. This study aimed to investigate if the difference in the local VA (ventricle-atrium) interval during ventricular entrainment pacing and...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: He Q,Lei S,Jia FP,Gao LY,W X Zhu D

    更新日期:2018-01-27 00:00:00

  • A case of marked diuresis by combined dopamine and atrial natriuretic peptide administration without renal injury in acute decompensated heart failure.

    abstract::Renal injury is an important factor for worsening outcome in acute decompensated heart failure (ADHF). An 81-year-old woman was admitted due to ADHF with dyspnea and mild peripheral edema. The patient was managed with intravenous administration of atrial natriuretic peptide (ANP) at a dose of 0.0125 μg/kg/minute, whic...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kamiya M,Sato N,Akiya M,Okazaki H,Takahashi Y,Mizuno K

    更新日期:2013-01-01 00:00:00

  • Comparison of utility of arterial stiffness parameters for predicting cardiovascular events in the general population.

    abstract::Several recent studies have suggested that arterial stiffness parameters such as peripheral pulse pressure (PPP), central blood pressure (CBP), and pulse wave velocity (PWV) are more accurate markers than brachial blood pressure for prediction of cardiovascular (CV) events. However, it remains unknown which arterial s...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ishisone T,Koeda Y,Tanaka F,Sato K,Nagano M,Nakamura M

    更新日期:2013-01-01 00:00:00

  • Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia.

    abstract::Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catech...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Okada K,Kurita A,Takase B,Otsuka T,Kodani E,Kusama Y,Atarashi H,Mizuno K

    更新日期:2009-01-01 00:00:00

  • Low Stroke Rate of Carotid Stenosis Under the Guideline-Oriented Medical Treatment Compared With Surgical Treatment.

    abstract::Medical treatment for asymptomatic carotid artery stenosis (ACAS) has advanced recently. The outcomes of medical treatment and surgical treatment were evaluated to clarify the optimal treatment for ACAS.Patients with ACAS of ≥ 50% luminal narrowing underwent serial follow-up carotid artery ultrasonography for one year...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Sato K,Fujiyoshi K,Hoshi K,Noda C,Yamaoka-Tojo M,Ako J,Kumabe T

    更新日期:2016-01-01 00:00:00

  • Risk factors for new-onset atrial fibrillation during routine medical checkups of Japanese male workers.

    abstract::The current study aimed to identify risk factors for atrial fibrillation (AF) detected during routine medical checkups of male workers in Japan. A nested case-control study was conducted using retrospective data from January 1998 to December 2006 collected at a hospital in Ishikawa Prefecture. Cases were those first d...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Minami M,Kobayashi Y,Toyokawa S,Inoue K,Takeshita Y

    更新日期:2009-07-01 00:00:00

  • Characteristics of metabolic and lifestyle risk factors in young Japanese patients with coronary heart disease: a comparison with older patients.

    abstract::Coronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young ...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究


    authors: Azegami M,Hongo M,Yanagisawa S,Yamazaki A,Sakaguchi K,Yazaki Y,Imamura H

    更新日期:2006-05-01 00:00:00

  • High mobility group box 1 levels in on and off-pump cardiac surgery patients.

    abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Haque A,Kunimoto F,Narahara H,Okawa M,Hinohara H,Kurabayashi M,Saito S

    更新日期:2011-01-01 00:00:00

  • Age-related differences in the delivery of cardiac management to women versus men with acute myocardial infarction in Japan: Tokai Acute Myocardial Infarction Study: TAMIS.

    abstract::It is of concern that women are more likely to undergo fewer diagnostic tests and receive less treatment for acute myocardial infarction (AMI) than men. However, it is still unclear whether gender differences exist according to age groups. Therefore, we studied the influence of gender on the delivery of cardiac manage...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Hirakawa Y,Masuda Y,Uemura K,Kuzuya M,Kimata T,Iguchi A

    更新日期:2005-11-01 00:00:00

  • Deeper S Wave in Lead V5 and Broader Extent of T Wave Inversions in the Precordial Leads are Clinically Useful Electrocardiographic Parameters for Predicting Pulmonary Hypertension.

    abstract::Electrocardiography (ECG) is used to screen for pulmonary hypertension (PH). However, it is unclear which parameters of ECG are the most useful for screening.ECG parameters related to right ventricular hypertrophy criteria were examined in 145 ECGs of subjects who were suspected to have PH and underwent right heart ca...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Miura M,Ikeda S,Yoshida T,Yamagata Y,Nakata T,Koga S,Koide Y,Kawano H,Maemura K

    更新日期:2018-01-27 00:00:00

  • Addition of a Nitric Oxide Donor to an Angiotensin II Type 1 Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects.

    abstract::While physiological levels of nitric oxide (NO) protect the endothelium and have vasodilatory effects, excessive NO has adverse effects on the cardiovascular system. Recently, new NO-releasing pharmacodynamic hybrids of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) have been developed.We analyzed wheth...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Yahiro E,Miura S,Suematsu Y,Matsuo Y,Arimura T,Kuwano T,Imaizumi S,Iwata A,Uehara Y,Saku K

    更新日期:2015-01-01 00:00:00

  • Elevation of Derivatives of Reactive Oxygen Metabolites Elevated in Young "Disaster Responders" in Hypertension due to Great East Japan Earthquake.

    abstract::There have been very few studies on serum biomarkers associated with hypertension in disaster situations. We assessed biomarkers associated with disaster-related hypertension (DRH) due to the Great East Japan Earthquake of March 2011.We collected blood samples from members of the Japan Self Defense Forces (JSDF) (n = ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Shiraishi Y,Kujiraoka T,Hakuno D,Masaki N,Tokuno S,Adachi T

    更新日期:2016-01-01 00:00:00

  • Temperature-controlled cooled-tip radiofrequency ablation in left ventricular myocardium.

    abstract::Steam pop and intramural charring have been reported during cooled-tip radiofrequency catheter ablation (RFCA). We studied the feasibility of temperature-controlled cooled-tip RFCA in the canine heart.An internally cooled ablation catheter was inserted into the left ventricle. A custom-made radiofrequency (RF) generat...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Watanabe I,Nuo M,Okumura Y,Ohkubo K,Ashino S,Kofune M,Kofune T,Nakai T,Kasamaki Y,Hirayama A

    更新日期:2010-05-01 00:00:00