Abstract:
:Left ventricular outflow tract obstruction (LVOTO) is commonly observed in patients with hypertrophic cardiomyopathy (HCM) or left ventricular hypertrophy (LVH). While some patients develop LVOTO at rest, it can also be provoked by physical exertion, and hence termed latent LVOTO (L-LVOTO). Recent reports demonstrated that L-LVOTO develops not only in LVH patients, but also in patients without LVH (non-LVH). However, the prevalence and clinical prognosis of non-LVH patients with L-LVOTO are not yet elucidated. In this study, we retrospectively investigated the echocardiographic features of patients with malignancy who underwent dobutamine stress echocardiography (DSE) to evaluate preoperative cardiac risk. One hundred ninety-nine patients were found not to have LVH or coronary artery disease. Among them, 106 patients exhibited L-LVOTO after DSE. We next compared the baseline echocardiographic features of L-LVOTO (+) patients with those of L-LVOTO (-) patients, and identified the left ventricular outflow tract (LVOT) ratio (systolic LVOT diameter/diastolic LVOT diameter) as a significant predictor of L-LVOTO. An LVOT ratio ≤ 0.83 was the best cutoff value to detect the presence of L-LVOTO, with a sensitivity of 81.1% and specificity of 80.6%. Overall, L-LVOTO was found to develop in almost half of non-LVH patients with malignancy. In addition, the baseline LVOT ratio was strongly related to the presence of L-LVOTO in non-LVH patients. Therefore, patients with dynamic LVOT narrowing may benefit from DSE to detect the presence of L-LVOTO.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Semba H,Sawada H,Uejima T,Takeda N,Soma K,Abe H,Yamashita T,Nagai Rdoi
10.1536/ihj.53.230subject
Has Abstractpub_date
2012-01-01 00:00:00pages
230-3issue
4eissn
1349-2365issn
1349-3299pii
DN/JST.JSTAGE/ihj/53.230journal_volume
53pub_type
杂志文章abstract::Tenascin-C (TNC) is involved in aortic disease pathophysiology. This study aims to evaluate TNC's value for predicting in-hospital death in acute aortic dissection (AD).We prospectively enrolled consecutive patients with suspected acute AD within 48 hours from symptom onset. Serum TNC and C-reactive protein (CRP) leve...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-462
更新日期:2019-07-27 00:00:00
abstract::Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catech...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.95
更新日期:2009-01-01 00:00:00
abstract::Our previous study showed that pravastatin prevents ischemia and reperfusion-induced lethal ventricular fibrillation in rats. This study explored whether pravastatin decreases myocardial infarct size and this effect is associated with endothelial nitric oxide synthase (eNOS) expression in myocardium. Rats were treated...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-607
更新日期:2018-01-01 00:00:00
abstract::After the new left ventricular ejection fraction (LVEF) classification criteria emerged, many studies have focused on the differences between heart failure (HF) with reduced EF (HFrEF), HF with midrange EF (HFmrEF), and HF with preserved EF (HFpEF). However, the lack of consensus on sex-related differences in prognosi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-321
更新日期:2020-11-28 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved to ameliorate PAH. However, its effect on PAH-induced right ventricula...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-591
更新日期:2017-12-12 00:00:00
abstract::Statins provide effective secondary prevention of cardiovascular events after acute coronary syndrome (ACS). Current guidelines recommend that statins be initiated in ACS patients before hospital discharge. In this retrospective study, we investigated the influence of early compared with late in-hospital initiation of...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.677
更新日期:2007-11-01 00:00:00
abstract::Prevalent atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) represents an important issue with regard to stroke events caused by embolization and is associated with high mortality. Increased epicardial adipose tissue (EAT), which shows high metabolic activity, can locally influence the activi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.297
更新日期:2013-01-01 00:00:00
abstract::Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have incre...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.41
更新日期:2010-01-01 00:00:00
abstract::Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigra...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-220
更新日期:2015-01-01 00:00:00
abstract::Several studies have revealed that stress after catastrophic disasters can trigger cardiovascular events, however, little is known about its association with the occurrence of heart failure in past earthquakes. The objective of the present study was to determine whether the Great East Japan Earthquake on March 11, 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-215
更新日期:2014-01-01 00:00:00
abstract::Direct oral anticoagulants (DOACs) have been shown to be safe and effective for the prevention of stroke in nonvalvular atrial fibrillation (NVAF) patients, however, experience with peri-AF ablation management of DOACs is scarce. This study aimed to investigate the safety and feasibility of periprocedural anticoagulat...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.16-147
更新日期:2016-12-02 00:00:00
abstract::To investigate parameters which were related with long-term mortality in patients hospitalized for acute heart failure (AHF).A total of 287 patients with AHF presenting to the First Affiliated Hospital of Nanjing Medical University were enrolled into the registry from April 2012 to January 2015. The primary endpoint w...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-219
更新日期:2017-05-31 00:00:00
abstract::Supraventricular tachycardia (SVT) was observed in a 13-year-old male patient with complex clinical features that included univentricular heart with single atrium, pulmonary atresia, and polysplenia syndrome. During electrophysiologic study, atrial burst stimuli reproducibly induced and terminated the SVT, while the o...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.253
更新日期:2007-03-01 00:00:00
abstract::The association between endothelial function, evaluated using flow-mediated dilatation (FMD), and the severity of coronary artery disease remains to be elucidated.A total of 245 consecutive patients with stable angina were prospectively enrolled. FMD was evaluated in the brachial artery before percutaneous coronary in...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-531
更新日期:2019-05-30 00:00:00
abstract::Adaptive servo-ventilation (ASV) is a recently-developed non-invasive therapy that improves the clinical course of heart failure (HF) patients. However, the precise hemodynamic response and predictors of ASV therapy remain uncertain. Overall, 69 patients with New York Heart Association HF class II-IV underwent 10-minu...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-489
更新日期:2017-08-03 00:00:00
abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-595
更新日期:2018-11-28 00:00:00
abstract::Ventricular free wall rupture (FWR) is a catastrophic complication of that occurs after acute myocardial infarction (AMI), and at present, its clinical characteristics are unclear. We analyzed a total of 6,712 consecutive patients who presented with ST-segment elevation myocardial infarction (STEMI), and 78 patients w...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-541
更新日期:2020-07-30 00:00:00
abstract::The aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.47.441
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological pr...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.485
更新日期:2007-07-01 00:00:00
abstract::Although calcium channel blockers (CCB) are expected to improve the augmentation index (AI) in CKD patients, the potential effect of benidipine on AI has been poorly studied.The present study aimed to compare the effect of benidipine and amlodipine in the treatment of CKD patients as measured through AI and urinary al...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.15-208
更新日期:2016-01-01 00:00:00
abstract::Although atrial ischemic damage is an atrial fibrillation (AF) risk factor, the impact of atrial branches' occlusion on AF development after acute myocardial infarction (AMI) is unclear. Therefore, this study's purpose was to identify predictors of new-onset AF with regard to atrial branches' occlusion. We retrospecti...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-713
更新日期:2019-11-30 00:00:00
abstract::Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.13-383
更新日期:2014-01-01 00:00:00
abstract::Changes of global and segmental ventricular strain at different deterioration levels of cardiac function in patients with dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) have not yet been explored. In total, 101 patients diagnosed with DCM consecutively underwent CMR. They were categorized accordin...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-558
更新日期:2018-11-28 00:00:00
abstract::A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonan...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-713
更新日期:2018-11-28 00:00:00
abstract::Previous studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia. The impact of sex on CAC has not been fully evaluated. We aimed to determine the association of dyslipidemia and sex ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-481
更新日期:2017-10-21 00:00:00
abstract::Most previous studies have examined the effects of antihypertensive drugs in hypertensive animals for only a few months, and little information has been provided as to the protective effects of lifetime antihypertensive medication against cardiovascular organ injury. In this study, spontaneously hypertensive rats (SHR...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.359
更新日期:2010-01-01 00:00:00
abstract::Impaired oxygenation sometimes occurs in patients with acute aortic dissection, however, the mechanism has not been fully investigated. We hypothesized that impaired oxygenation is related to inflammation secondary due to aortic dissection. Patients with acute aortic dissection who had received 14 days of conservative...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.795
更新日期:2005-09-01 00:00:00
abstract::Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with coronary artery disease and the control group 100 patients with normal...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.86
更新日期:2010-03-01 00:00:00
abstract::The aim of this meta-analysis was to compare the clinical outcomes in patients who underwent rapid deployment aortic valve replacement (RDAVR) and conventional bio prosthetic aortic valve replacement (CAVR).We performed a literature search by August 2018. The primary outcomes were hospital and 1-year mortality, and th...
journal_title:International heart journal
pub_type: 杂志文章,meta分析
doi:10.1536/ihj.19-717
更新日期:2020-09-29 00:00:00
abstract::Despite wide interindividual variability in response to clopidogrel, platelet P2Y(12) ADP receptor inhibition in Japanese patients has not been fully studied using specific methodology. This study compared platelet P2Y(12) ADP receptor inhibition during treatment with clopidogrel versus clopidogrel plus cilostazol in ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.303
更新日期:2010-01-01 00:00:00