Abstract:
:Prevalent atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) represents an important issue with regard to stroke events caused by embolization and is associated with high mortality. Increased epicardial adipose tissue (EAT), which shows high metabolic activity, can locally influence the activity of the autonomic ganglia, enhancing autonomic dysregulation and increasing the likelihood of AF. We tested the hypothesis that EAT is associated with prevalent AF in HCM patients. Sixty-two patients with idiopathic HCM diagnosed on the basis of ultrasound cardiography findings and histopathological evaluation of myocardium obtained by right ventricular biopsy underwent cardiac magnetic resonance imaging to estimate the extent of EAT. EAT area was significantly higher in the group with AF episodes than in the group without. An increased incidence of AF was found to be significantly related to an increase in EAT, and this association persisted after adjustment for body mass index, sex, and age. Time domain measures of heart rate variability measured by Holter electrocardiography, standard deviation of normal to normal, and standard deviation of the average of normal to normal were negatively related to EAT area. EAT was positively correlated with intraventricular septal thickness and cystatin C level and negatively correlated with the 24-hour creatinine clearance rate. Increased EAT area in HCM patients is significantly related to the presence of AF, which is associated with changes in baseline autonomic nervous tone, left ventricular mass, and chronic kidney disease.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Muhib S,Fujino T,Sato N,Hasebe Ndoi
10.1536/ihj.54.297subject
Has Abstractpub_date
2013-01-01 00:00:00pages
297-303issue
5eissn
1349-2365issn
1349-3299pii
DN/JST.JSTAGE/ihj/54.297journal_volume
54pub_type
杂志文章abstract::A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonan...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-713
更新日期:2018-11-28 00:00:00
abstract::Direct oral anticoagulants (DOACs) have been shown to be safe and effective for the prevention of stroke in nonvalvular atrial fibrillation (NVAF) patients, however, experience with peri-AF ablation management of DOACs is scarce. This study aimed to investigate the safety and feasibility of periprocedural anticoagulat...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.16-147
更新日期:2016-12-02 00:00:00
abstract::There is little data on management and outcomes of atrial fibrillation (AF) patients on direct oral anticoagulants (DOAC) undergoing general surgery.We retrospectively assessed 98 surgeries in 85 nonvalvular AF patients aged 73 ± 8 (59 men) receiving DOACs. Cardiac, emergency, and minimally invasive surgeries were exc...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-625
更新日期:2020-09-29 00:00:00
abstract::An aorto-cutaneous fistula is a rare complication that occurs after aortic surgery. Due to its rarity, postoperative complications are not normally highlighted in most standard teaching. We report here a case of aorto-cutaneous fistula after surgical treatment of a Stanford type A aortic dissection (AD) in a 67-year-o...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-109
更新日期:2018-01-27 00:00:00
abstract::The significance of pulse pressure (PP) and mean blood pressure (MBP) for blood pressure (BP) control is unclear. The aim of this study was to examine the relationship between PP and MBP and BP control. We obtained home BP measurements for 117 patients aged 40-75 years with either office systolic BP (SBP) >or= 140 mmH...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.691
更新日期:2005-07-01 00:00:00
abstract::Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection,...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.199
更新日期:2012-01-01 00:00:00
abstract::The metabolism of branched-chain amino acids (BCAAs) is reported to change in heart failure (HF) and correlate with cardiac function. However, the effect of BCAAs on HF remains controversial. We investigate the prognostic value of the plasma BCAA level in nonischemic dilated cardiomyopathy (NIDCM).This study enrolled ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-010
更新日期:2020-07-30 00:00:00
abstract::Coronary artery spasm after coronary artery bypass surgery may result in life-threatening arrhythmias, circulatory collapse, or death. We report two cases of coronary artery spasm after coronary artery bypass surgery, one of which developed ventricular fibrillation requiring extracorporeal membrane oxygenation support...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-357
更新日期:2014-01-01 00:00:00
abstract::Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring systems (RSS) are in use in clinical practice, there is no dedicated RSS for MVD in ST-segment elevation myocardial infarction (STEMI). The primary objective of this ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-337
更新日期:2019-05-30 00:00:00
abstract::Sleep-disordered breathing (SDB) is frequently observed in patients with congestive heart failure. Recent studies have shown that SDB negatively affects the onset of congestive heart failure; however, no studies have addressed the relationship between the level of SDB and the onset time of acute dyspnea. We hypothesiz...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.49.471
更新日期:2008-07-01 00:00:00
abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.170
更新日期:2011-01-01 00:00:00
abstract::Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with Sirt1 activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also h...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-506
更新日期:2016-07-27 00:00:00
abstract::Although atrial ischemic damage is an atrial fibrillation (AF) risk factor, the impact of atrial branches' occlusion on AF development after acute myocardial infarction (AMI) is unclear. Therefore, this study's purpose was to identify predictors of new-onset AF with regard to atrial branches' occlusion. We retrospecti...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-713
更新日期:2019-11-30 00:00:00
abstract::Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with high mortality. Hypertension is a well known risk factor of AAD. There have been previous reports about the association between circadian variation of blood pressure (BP) and cardiovascular events. However, little is known about the associ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-328
更新日期:2015-05-13 00:00:00
abstract::The aim of this study was to investigate the effect on mortality of torsemide and a combination of loop diuretics (furosemide + torsemide) in contemporary practice in patients with chronic heart failure (HF).We investigated patients with HF in the Heart Failure Center of Fuwai Hospital from 2009 to 2013 who were disch...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-522
更新日期:2018-07-31 00:00:00
abstract::Several studies have revealed that stress after catastrophic disasters can trigger cardiovascular events, however, little is known about its association with the occurrence of heart failure in past earthquakes. The objective of the present study was to determine whether the Great East Japan Earthquake on March 11, 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-215
更新日期:2014-01-01 00:00:00
abstract::Decreased Transthyretin (TTR) can be observed in heart failure patients with malnutrition evaluated by the Mini Nutritional Assessment (MNA). This study investigated whether a combination of different nutritional assessment methods would be useful for assessing prognosis in patients with acute decompensated heart fail...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-255
更新日期:2015-01-01 00:00:00
abstract::Exercise preconditioning may protect against cardiac injury induced by lipopolysaccharide (LPS), but the mechanism is unresolved. The aim of this study is to explore whether the general control nonderepressible 2 (GCN2) kinase gene is associated with the protective effect of exercise preconditioning. Eight-week-old ma...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-307
更新日期:2020-01-31 00:00:00
abstract::The clinical scenario, which is based on systolic blood pressure (SBP) upon admission, is useful for classifying and determining initial treatment for acute heart failure (HF). However, the prognostic significance of SBP following the initial treatment is unclear.The Japanese Heart Failure Syndrome with Preserved Ejec...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.18-699
更新日期:2019-07-27 00:00:00
abstract::High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.593
更新日期:2005-07-01 00:00:00
abstract::Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-218
更新日期:2015-01-01 00:00:00
abstract::HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.1
更新日期:2011-01-01 00:00:00
abstract::The incidence of ventricular arrhythmia in patients with an implanted pacemaker is not yet known. The aim of this study was to analyze non-sustained ventricular tachycardia (NSVT) episodes based on stored electrograms (EGM) and determine the occurrence rate and risk factors for NSVT in a pacemaker population.This stud...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-141
更新日期:2020-09-29 00:00:00
abstract::As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-444
更新日期:2017-12-12 00:00:00
abstract::The chronic use of bosentan has been reported to reduce the plasma concentration of sildenafil. However, it remains unclear how sildenafil exerts the effect at reduced concentrations in pulmonary arterial hypertension (PAH) patients chronically treated with bosentan.We examined the hemodynamic effects of sildenafil (5...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.52.233
更新日期:2011-01-01 00:00:00
abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-595
更新日期:2018-11-28 00:00:00
abstract::T1 or longitudinal relaxation time is one of the very fundamental magnetic resonance imaging (MRI) time constants and a tissue characterizing parameter. Only during the last decade did it become possible to quantify T1 values of the myocardium through T1 mapping. Evolving from only region of interest analysis and long...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.16-169
更新日期:2016-07-27 00:00:00
abstract::Myocardial infarction (MI) occurs when the heart muscle is severely damaged due to a decrease in blood flow from the coronary arteries. During recovery from an MI, cardiac fibroblasts become activated and produce extracellular matrices, contributing to the wound healing process in the damaged heart. Inappropriate acti...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-710
更新日期:2019-07-27 00:00:00
abstract::Adipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.149
更新日期:2007-03-01 00:00:00
abstract::The purpose of this study was to clarify the effect of standing balance training on walking speed (short-term outcome) and cardiac events (long-term outcome) in elderly ischemic heart disease (IHD) patients. This was a retrospective cohort study. Ninety-two elderly (≥ 65 years) IHD patients who underwent an inpatient ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-017
更新日期:2014-01-01 00:00:00