Abstract:
BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological properties in CAF patients. METHODS AND RESULTS:In 42 CAF patients without overt HF, the atrial monophasic action potential duration (MAPD) at pacing cycle lengths (CLs) of 300-800 msec and P-wave signal-averaged electrograms were recorded after cardioversion. The MAPDs for all CLs were significantly longer in patients with a BNP concentration greater than the 50th percentile (group 1, BNP = 215 +/- 118.2 pg/mL) than in patients with a concentration less than the 50th percentile (group 2, BNP = 68.3 +/- 20.9 pg/mL), resulting in a similar value in the MAPDs at CLs of 350 and 600 msec for group 1 and the control patients (n = 8). The slope value of the MAPDs between CLs of 350 and 600 msec was normal in group 1, but slightly lower in group 2 than in group 1 and control patients. The filtered P-wave duration did not differ between the two groups. CONCLUSIONS:These electrophysiological characteristics related to the BNP level suggest that the atrial repolarization may be affected by a latent ventricular dysfunction.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Okumura Y,Watanabe I,Ashino S,Kofune M,Takagi Y,Kofune T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Kasamaki Y,Saito Sdoi
10.1536/ihj.48.485subject
Has Abstractpub_date
2007-07-01 00:00:00pages
485-96issue
4eissn
1349-2365issn
1349-3299pii
JST.JSTAGE/ihj/48.485journal_volume
48pub_type
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