Abstract:
:Low-density lipoprotein (LDL) particles are known to be atherogenic agents in coronary artery diseases. They adjust to other electronegative forms and can be the subject for the enhancement of inflammatory events in vessel subendothelial spaces. The LDL uptake is related to the membrane scavenger receptors, including LDL receptor (LDLR). The LDLR expression is closely associated with LDL uptake and occurrence of diseases, such as atherosclerotic cardiovascular diseases. Our findings identified USP16 as a novel regulator of LDLR due to its ability to prevent ubiquitylation-dependent LDLR degradation, further promoting the uptake of LDL. The enhancement of USP16-mediated deubiquitination andthe suppressive degradation of the LDLR cause the presentation of a potential strategy to increase LDL cholesterol clearance.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Li Y,Rao Y,Zhu H,Jiang B,Zhu Mdoi
10.1536/ihj.20-043subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1034-1040issue
5eissn
1349-2365issn
1349-3299journal_volume
61pub_type
杂志文章abstract::Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-238
更新日期:2018-05-30 00:00:00
abstract::Same-day discharge transradial percutaneous coronary intervention (TRI) has been reported to be safe and feasible in Western countries. However, Asia has not produced any reports related to this matter. The present study explored the safety and feasibility of patients with indications for TR coronary angiography and a...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1536/ihj.51.371
更新日期:2010-01-01 00:00:00
abstract::Everolimus (EVL), one of the mammalian targets of rapamycin, is a next generation immunosuppressant that may have accessory anti-proliferative effects in heart transplant (HTx) recipients. However, little is known about the clinical relationship between EVL and regression of cardiac hypertrophy. A total of 42 HTx reci...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-320
更新日期:2016-01-01 00:00:00
abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.191
更新日期:2009-03-01 00:00:00
abstract::Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigra...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-220
更新日期:2015-01-01 00:00:00
abstract::Enlargement of the mitral valve (MV) has gained attention as a compensatory mechanism for functional mitral regurgitation (FMR). We aimed to determine if MV leaflet area is associated with MV coaptation-zone area and identify the clinical factors associated with MV leaflet size and coaptation-zone area in patients wit...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-148
更新日期:2021-01-16 00:00:00
abstract::The aim of this study was to evaluate the feasibility and efficacy of the Guidezilla guide extension catheter in a reverse controlled antegrade and retrograde subintimal tracking (CART) technique for chronic total occlusion (CTO) recanalization.We retrospectively collected 80 CTO cases using reverse CART technology fr...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-337
更新日期:2017-05-31 00:00:00
abstract::Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) co...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-083
更新日期:2017-04-06 00:00:00
abstract::Patients with ischemic heart disease are associated with poor prognosis, and their number has increased globally. Therefore, biomarkers that could predict post-acute myocardial infarction (AMI) heart failure (HF) would be helpful to guide appropriate treatment. Based on the diagnosis on admission and results of echoca...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-306
更新日期:2019-03-20 00:00:00
abstract::Five patients who had had previous cardiac operations underwent minimally invasive beating heart mitral valve operations via a right minithoracotomy between November 2006 and February 2009. The mean age was 64 ± 10 years and 4 were female. Under general anesthesia with single-lumen ventilation, cardiopulmonary bypass ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.107
更新日期:2011-01-01 00:00:00
abstract::microRNA-99a (miR-99a) is recently recognized as a key regulator in various cancers and cardiovascular diseases. In the present study, we sought to investigate the effects of miR-99a in rat cardiomyocyte H9c2 cells against oxidative injury induced by lipopolysaccharide (LPS).MTT assay, reactive oxygen species (ROS) as...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-261
更新日期:2017-05-31 00:00:00
abstract::Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we ai...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-277
更新日期:2020-01-31 00:00:00
abstract::Electrocardiography (ECG) is used to screen for pulmonary hypertension (PH). However, it is unclear which parameters of ECG are the most useful for screening.ECG parameters related to right ventricular hypertrophy criteria were examined in 145 ECGs of subjects who were suspected to have PH and underwent right heart ca...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-647
更新日期:2018-01-27 00:00:00
abstract:BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological pr...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.485
更新日期:2007-07-01 00:00:00
abstract::An error appeared in the article entitled "Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α" by Zongqiu Wang, Zhihua Zhang, Jing Zhao, Chunming Yong, and Yongjun Mao (Vol. 60, No. 4, 964-973, 2019).The second affiliation of the authors on ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.60-5_Erratum
更新日期:2019-01-01 00:00:00
abstract::This study tested the therapeutic impact of double-loading dose (i.e., 600 mg) versus standard-loading dose (i.e., 300 mg) of clopidogrel on ST-segment-elevation-myocardial-infarction (STEMI) patients undergoing primary-coronary-intervention (PCI).Between January 2005 and December 2013, a total of 1461 STEMI patients ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-325
更新日期:2017-10-21 00:00:00
abstract::There are many published articles on the effects of the antithrombolytic function of platelet glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa inhibitors) in myocardial infarction. However, few studies have explored the effects and optimal concentration of tirofibans in diminishing the extent of myocardial reperfusion in...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-322
更新日期:2015-05-13 00:00:00
abstract::Although some patients with fulminant myocarditis can be rescued owing to the improvements in mechanical circulatory support therapy, there are few reports providing evidence of cardiac rehabilitation during mechanical circulatory supports, particularly among pediatric patients. We treated two pediatric patients who u...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-067
更新日期:2016-12-02 00:00:00
abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-700
更新日期:2019-01-25 00:00:00
abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.170
更新日期:2011-01-01 00:00:00
abstract::The long-term prognosis for up to 20 years of patients who have undergone percutaneous transvenous mitral commissurotomy (PTMC) for mitral stenosis (MS) is unknown.We examined 77 of 93 patients (83%) with MS and who underwent PTMC from 1989 to 2002 at our institute, as well as the occurrence of either one of the follo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-082
更新日期:2020-11-28 00:00:00
abstract::Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.13-383
更新日期:2014-01-01 00:00:00
abstract::Sleep-disordered breathing (SDB) is frequently observed in patients with congestive heart failure. Recent studies have shown that SDB negatively affects the onset of congestive heart failure; however, no studies have addressed the relationship between the level of SDB and the onset time of acute dyspnea. We hypothesiz...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.49.471
更新日期:2008-07-01 00:00:00
abstract::The current study aimed to identify risk factors for atrial fibrillation (AF) detected during routine medical checkups of male workers in Japan. A nested case-control study was conducted using retrospective data from January 1998 to December 2006 collected at a hospital in Ishikawa Prefecture. Cases were those first d...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.457
更新日期:2009-07-01 00:00:00
abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-190
更新日期:2017-04-06 00:00:00
abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.16-313
更新日期:2017-08-03 00:00:00
abstract::Steam pop and intramural charring have been reported during cooled-tip radiofrequency catheter ablation (RFCA). We studied the feasibility of temperature-controlled cooled-tip RFCA in the canine heart.An internally cooled ablation catheter was inserted into the left ventricle. A custom-made radiofrequency (RF) generat...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.193
更新日期:2010-05-01 00:00:00
abstract::Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have incre...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.41
更新日期:2010-01-01 00:00:00
abstract::Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with Sirt1 activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also h...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-506
更新日期:2016-07-27 00:00:00
abstract::Left ventricular outflow tract obstruction (LVOTO) is commonly observed in patients with hypertrophic cardiomyopathy (HCM) or left ventricular hypertrophy (LVH). While some patients develop LVOTO at rest, it can also be provoked by physical exertion, and hence termed latent LVOTO (L-LVOTO). Recent reports demonstrated...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.230
更新日期:2012-01-01 00:00:00