Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model.

Abstract:

:This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control, n = 8). Diabetic rats and 8 healthy rats serving as controls (group 3) were sacrificed on day 28 after DM induction. The results demonstrated that HbA(1C) on day 28 was higher in group 1 than in groups 2 and 3 (P < 0.0001). The mRNA expressions of MMP-9 and endothelin-1 were elevated in group 1 compared with that in groups 2 and 3 (P < 0.05), whereas PGC-1alpha and eNOS were lower in group 1 than in groups 2 and 3 (P < 0.05). The number of apoptotic nuclei was higher in group 1 than in groups 2 and 3 (P < 0.01). The integrated area (microm(2)) of connexin43 (Cx43), Cx43 protein expression, and LV function were lower in group 1 than in groups 2 and 3 (P < 0.05). Moreover, PKC-epsilon expression in the mitochondrial compartment was decreased in group 1 compared to that in groups 2 and 3 (P < 0.005).

journal_name

Int Heart J

authors

Sung PH,Sun CK,Ko SF,Chang LT,Sheu JJ,Lee FY,Wu CJ,Chua S,Yip HK

doi

10.1536/ihj.50.191

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

191-206

issue

2

eissn

1349-2365

issn

1349-3299

pii

JST.JSTAGE/ihj/50.191

journal_volume

50

pub_type

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