The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease.

Abstract:

:Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively.Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.

journal_name

Int Heart J

authors

Huang M,Zheng J,Chen Z,You C,Huang Q

doi

10.1536/ihj.19-277

subject

Has Abstract

pub_date

2020-01-31 00:00:00

pages

115-120

issue

1

eissn

1349-2365

issn

1349-3299

journal_volume

61

pub_type

杂志文章
  • Assessment of transthyretin combined with mini nutritional assessment on admission provides useful prognostic information in patients with acute decompensated heart failure.

    abstract::Decreased Transthyretin (TTR) can be observed in heart failure patients with malnutrition evaluated by the Mini Nutritional Assessment (MNA). This study investigated whether a combination of different nutritional assessment methods would be useful for assessing prognosis in patients with acute decompensated heart fail...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-255

    authors: Suzuki N,Kida K,Suzuki K,Harada T,Akashi YJ

    更新日期:2015-01-01 00:00:00

  • Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.

    abstract::The aim of this study was to investigate the effects of taurine (Tau) on primary cultured neonatal myocardial cells treated with hydrogen peroxide (H2O2) and the underlying mechanism. Primary cardiac myocytes from neonatal Wistar rats were pre-incubated with Tau, and its effects on cell viability and expression of CaM...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-372

    authors: Wang J,Qi C,Liu L,Zhao L,Cui W,Tian Y,Liu B,Li J

    更新日期:2018-01-27 00:00:00

  • Comparison of the correlation of rebreathing method and echocardiography in heart failure patients with moderate to severe mitral regurgitation.

    abstract:OBJECTIVE:To follow-up and estimate cardiac function in 11 heart failure patients with moderate to severe mitral regurgitation who underwent cardiac resynchronization therapy (CRT) and to compare echocardiography to the rebreathing method (indirect Fick method) which were used for estimation. DESIGN:Prospective, obser...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1536/ihj.48.69

    authors: Dong L,Wang JA,Yang Q,He H,Sun Y,Chen DD

    更新日期:2007-01-01 00:00:00

  • Electrophysiological Measurement of Rat Atrial Epicardium Using a Novel Stereotaxic Apparatus.

    abstract::Flexible, in vivo maneuverable electrophysiology mapping techniques are not available in rat models. A novel cardiac stereotactic electrophysiology epicardial mapping system (CREAMS) allows for various measurements, including: (1) recording unipolar electrograms at multiple sites; (2) positioning of mapped sites and p...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-215

    authors: Fan B,Wang H,Wu T,Li Y,Lin Z,Li M,Li Q,Zhang W,Zheng Q

    更新日期:2019-03-20 00:00:00

  • Atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats.

    abstract::Statins improve left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). This study was designed to investigate the effects of atorvastatin administered in the early stage on LV remodeling in SHRs, and to explore the underlying mechanisms.Sixteen male 8-week-old SHRs were randomized to receive disti...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.426

    authors: Zhao XY,Li L,Zhang JY,Liu GQ,Chen YL,Yang PL,Liu RY

    更新日期:2010-01-01 00:00:00

  • Redo mitral valve operation via right minithoracotomy--"no touch" technique.

    abstract::Five patients who had had previous cardiac operations underwent minimally invasive beating heart mitral valve operations via a right minithoracotomy between November 2006 and February 2009. The mean age was 64 ± 10 years and 4 were female. Under general anesthesia with single-lumen ventilation, cardiopulmonary bypass ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.107

    authors: Kitamura T,Stuklis RG,Edwards J

    更新日期:2011-01-01 00:00:00

  • Comparison of Procedural and 1-Year Clinical Results of Transcatheter Aortic Valve Implantation Using Prostheses with Different Design of Support Frame.

    abstract::Our study aimed to investigate whether the frame design of transcatheter heart valve (THV) affects the procedural and clinical results of transcatheter aortic valve implantation (TAVI).We retrospectively reviewed 163 patients with aortic stenosis who underwent TAVI using different types of THV (Edwards SAPIEN, n = 31;...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-398

    authors: Li F,Wang X,Wang Y,Li X,Xu D,Zhao S,Wang C,Guo Y,Wu Y,Wang W

    更新日期:2020-11-28 00:00:00

  • The associations of epicardial adipose tissue with coronary artery disease and coronary atherosclerosis.

    abstract::Epicardial adipose tissue (EAT) is presumed to play an important role in the development of coronary artery disease (CAD). The purpose of our study was to examine the influence of EAT volume measured by cardiac CT on the severity and presence of CAD. A total of 209 subjects (114 normal subjects and 95 patients with CA...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.13-303

    authors: Kim SH,Chung JH,Kwon BJ,Song SW,Choi WS

    更新日期:2014-01-01 00:00:00

  • Improvement of Left Ventricular Ejection Fraction by Baroreflex Activation Therapy in a Young Man with Dilated Cardiomyopathy.

    abstract::The progression of heart failure with reduced ejection fraction is promoted by sympathovagal imbalance. Baroreflex activation therapy (BAT) by the electrical stimulation of baroreceptors at the carotid sinus significantly improved exercise capacity and NT-proBNP levels in a randomized trial; however, no significant di...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-400

    authors: Halbach M,Fritz T,Madershahian N,Pfister R,Reuter H

    更新日期:2017-12-12 00:00:00

  • Skeletal Muscle Abnormalities in Heart Failure.

    abstract::Exercise capacity is lowered in patients with heart failure, which limits their daily activities and also reduces their quality of life. Furthermore, lowered exercise capacity has been well demonstrated to be closely related to the severity and prognosis of heart failure. Skeletal muscle abnormalities including abnorm...

    journal_title:International heart journal

    pub_type: 杂志文章,评审

    doi:10.1536/ihj.15-108

    authors: Kinugawa S,Takada S,Matsushima S,Okita K,Tsutsui H

    更新日期:2015-01-01 00:00:00

  • Interleukin-18.

    abstract::A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study....

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-154

    authors: Wang S,Chen F,Yang S,Shi J

    更新日期:2018-07-31 00:00:00

  • Renoprotective effect of vasopressin v2 receptor antagonist tolvaptan in Dahl rats with end-stage heart failure.

    abstract::Tolvaptan is a highly selective and orally effective arginine vasopressin V2 receptor antagonist, and is potentially useful for the treatment of heart failure (HF) patients. However, the renoprotective effect of long-term tolvaptan therapy and its underlying mechanisms remain unknown. We evaluated the effects of chron...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.54.98

    authors: Ishikawa M,Kobayashi N,Sugiyama F,Onoda S,Ishimitsu T

    更新日期:2013-01-01 00:00:00

  • Electrophysiological properties of the atrium after cardioversion of chronic atrial fibrillation: relation to the plasma brain natriuretic peptide level.

    abstract:BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological pr...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.485

    authors: Okumura Y,Watanabe I,Ashino S,Kofune M,Takagi Y,Kofune T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Kasamaki Y,Saito S

    更新日期:2007-07-01 00:00:00

  • A Survey of Direct Oral Anticoagulant Cessation in General Surgery and Outcomes in Patients with Nonvalvular Atrial Fibrillation.

    abstract::There is little data on management and outcomes of atrial fibrillation (AF) patients on direct oral anticoagulants (DOAC) undergoing general surgery.We retrospectively assessed 98 surgeries in 85 nonvalvular AF patients aged 73 ± 8 (59 men) receiving DOACs. Cardiac, emergency, and minimally invasive surgeries were exc...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-625

    authors: Kawabata M,Goya M,Maeda S,Yagishita A,Takahashi Y,Sasano T,Hirao K

    更新日期:2020-09-29 00:00:00

  • Prolonged use for at least 10 days of intraaortic balloon pumping (IABP) for heart failure.

    abstract::Intraaortic balloon pumping (IABP) is a useful therapy for refractory heart failure. However, the safe duration of this therapy and possible complications due to long-term IABP support remain unclear. In this study, we reviewed retrospectively patients requiring the long-term use of IABP, defined here as 10 days or mo...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.1041

    authors: Oshima K,Morishita Y,Hinohara H,Kadoi Y,Hayashi Y,Tajima Y,Kunimoto F

    更新日期:2005-11-01 00:00:00

  • Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure?

    abstract::The aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation o...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.47.441

    authors: Dobsák P,Nováková M,Fiser B,Siegelová J,Balcárková P,Spinarová L,Vítovec J,Minami N,Nagasaka M,Kohzuki M,Yambe T,Imachi K,Nitta S,Eicher JC,Wolf JE

    更新日期:2006-05-01 00:00:00

  • Coronary artery fistula from the left circumflex to the coronary sinus.

    abstract::A 27-year-old woman, who had received mitral valve repair for mitral regurgitation resulting from infective endocarditis, was admitted for a close examination of abnormal echocardiographic findings in the left atrium. Transthoracic echocardiography showed trivial mitral regurgitation with normal left ventricular contr...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.47.147

    authors: Aoyagi S,Fukunaga S,Ishihara K,Egawa N,Hosokawa Y,Nakamura E

    更新日期:2006-01-01 00:00:00

  • Comparison of Clinical Outcomes between the Ostial Versus Non-Ostial Culprit in Proximal Left Anterior Descending Artery Acute Myocardial Infarction.

    abstract::Percutaneous coronary interventions to the proximal left anterior descending artery (pLAD)-acute myocardial infarction (AMI) are still challenging, especially in the ostial pLAD. Clinical outcomes of the ostial pLAD-AMI were not well investigated. The aim of the present study was to compare clinical outcomes of the os...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-067

    authors: Yamamoto K,Sakakura K,Akashi N,Watanabe Y,Noguchi M,Taniguchi Y,Wada H,Momomura SI,Fujita H

    更新日期:2019-01-25 00:00:00

  • Acute Coronary Syndrome Demonstrating Plaque Rupture in Calcified Lesions Visualized by Optical Frequency Domain Imaging.

    abstract::A 68-year-old female with acute coronary syndrome was transferred to our hospital. Emergency coronary angiography showed 90% stenosis with severe calcification in the proximal right coronary artery (RCA). Intravascular ultrasound (IVUS) images were obtained and showed circumferential heavy calcification without any ev...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-136

    authors: Goryo Y,Kume T,Kobayashi Y,Okamoto H,Kawamura A,Fukuhara K,Koyama T,Yamada R,Imai K,Neishi Y,Uemura S

    更新日期:2017-02-07 00:00:00

  • Low-Level Vagus Nerve Stimulation Reverses Cardiac Dysfunction and Subcellular Calcium Handling in Rats With Post-Myocardial Infarction Heart Failure.

    abstract::Vagus nerve stimulation (VNS), targeting the imbalanced autonomic nervous system, is a promising therapeutic approach for chronic heart failure (HF). Moreover, calcium cycling is an important part of cardiac excitation-contraction coupling (ECC), which also participates in the antiarrhythmic effects of VNS. We hypothe...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-516

    authors: Zhang Y,Chen A,Song L,Li M,Luo Z,Zhang W,Chen Y,He B

    更新日期:2016-05-25 00:00:00

  • Impaired Flow-Mediated Dilation and Severity and Vulnerability of Culprit Plaque in Patients with Coronary Artery Disease.

    abstract::The association between endothelial function, evaluated using flow-mediated dilatation (FMD), and the severity of coronary artery disease remains to be elucidated.A total of 245 consecutive patients with stable angina were prospectively enrolled. FMD was evaluated in the brachial artery before percutaneous coronary in...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-531

    authors: Nemoto T,Minami Y,Yamaoka-Tojo M,Sato T,Muramatsu Y,Kakizaki R,Fujiyoshi K,Hashimoto T,Meguro K,Shimohama T,Tojo T,Ako J

    更新日期:2019-05-30 00:00:00

  • Who Needs Longer Tolvaptan Treatment?

    abstract::The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and ...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.16-249

    authors: Kinugawa K,Inomata T,Sato N,Yasuda M,Shimakawa T,Bando K,Fukuta Y

    更新日期:2017-02-07 00:00:00

  • Assessment of DNA Damage in Leukocytes of Patients With Coronary Artery Disease by Comet Assay.

    abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-190

    authors: Bhat MA,Gandhi G

    更新日期:2017-04-06 00:00:00

  • Relation of Systolic Blood Pressure on the Following Day with Post-Discharge Mortality in Hospitalized Heart Failure Patients with Preserved Ejection Fraction.

    abstract::The clinical scenario, which is based on systolic blood pressure (SBP) upon admission, is useful for classifying and determining initial treatment for acute heart failure (HF). However, the prognostic significance of SBP following the initial treatment is unclear.The Japanese Heart Failure Syndrome with Preserved Ejec...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.18-699

    authors: Sato Y,Yoshihisa A,Oikawa M,Nagai T,Yoshikawa T,Saito Y,Yamamoto K,Takeishi Y,Anzai T

    更新日期:2019-07-27 00:00:00

  • Announcement: UEDA Heart Award for 2016.

    abstract::We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2016.First PlaceDelivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial HypertensionSatoshi Akagi, Kazufumi Nakamura, Daiji Mi...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.57-6_UEDA

    authors:

    更新日期:2016-01-01 00:00:00

  • Efficacy and safety of controlled-release isosorbide-5-mononitrate in Japanese patients with stable effort angina pectoris.

    abstract::A new controlled-release isosorbide-5-mononitrate (CR-ISMN) preparation has been developed to meet the requirement for a low nitrate concentration interval in order to avoid nitrate tolerance. We conducted a randomized, double-blind, placebo-controlled study in 31 Japanese patients with stable effort angina pectoris t...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.47.695

    authors: Shimada K,Sunayama S,Nakazato K,Satoh H,Kusama Y,Kawakubo K,Daida H

    更新日期:2006-09-01 00:00:00

  • Sex Differences in Clinical Characteristics and 2-Year Prognosis of Patients with Heart Failure Grouped by Left Ventricular Ejection Fraction Status.

    abstract::After the new left ventricular ejection fraction (LVEF) classification criteria emerged, many studies have focused on the differences between heart failure (HF) with reduced EF (HFrEF), HF with midrange EF (HFmrEF), and HF with preserved EF (HFpEF). However, the lack of consensus on sex-related differences in prognosi...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-321

    authors: Wang C,Zhou Y,Zhong R,Bao Y,Li Z,Tian J

    更新日期:2020-11-28 00:00:00

  • Basilar Artery Dissection Complicated with Infective Endocarditis.

    abstract::A 14 year-old boy developed infective endocarditis of the mitral valve caused by Methicillin-sensitive Staphylococcus aureus and became comatose. Isolated basilar artery dissection was initially observed on the 3rd day by magnetic resonance imaging (MRI), ie, it did not exist on day 1. He underwent successful urgent m...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-474

    authors: Kawano A,Masutani S,Inui A,Honma H,Igarashi T,Tsuneoka H,Sakamoto W,Sakurai Y,Dembo T,Imanaka K

    更新日期:2021-01-16 00:00:00

  • Low Stroke Rate of Carotid Stenosis Under the Guideline-Oriented Medical Treatment Compared With Surgical Treatment.

    abstract::Medical treatment for asymptomatic carotid artery stenosis (ACAS) has advanced recently. The outcomes of medical treatment and surgical treatment were evaluated to clarify the optimal treatment for ACAS.Patients with ACAS of ≥ 50% luminal narrowing underwent serial follow-up carotid artery ultrasonography for one year...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.15-196

    authors: Sato K,Fujiyoshi K,Hoshi K,Noda C,Yamaoka-Tojo M,Ako J,Kumabe T

    更新日期:2016-01-01 00:00:00

  • High mobility group box 1 levels in on and off-pump cardiac surgery patients.

    abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.170

    authors: Haque A,Kunimoto F,Narahara H,Okawa M,Hinohara H,Kurabayashi M,Saito S

    更新日期:2011-01-01 00:00:00