Everolimus Attenuates Myocardial Hypertrophy and Improves Diastolic Function in Heart Transplant Recipients.

Abstract:

:Everolimus (EVL), one of the mammalian targets of rapamycin, is a next generation immunosuppressant that may have accessory anti-proliferative effects in heart transplant (HTx) recipients. However, little is known about the clinical relationship between EVL and regression of cardiac hypertrophy. A total of 42 HTx recipients received EVL therapy at post-HTx 150 days on median and had been followed at our institute for > 1 year between 2008 and 2014 [EVL (+) group]. We also observed 18 patients without EVL from post-HTx 150 days for 1 year [EVL (-) group]. There were no significant differences in baseline variables between the two groups. Left ventricular mass index (LVMI) and the ratio of early transmitral filling velocity to the peak early diastolic mitral annular motion velocity (E/e') decreased significantly during 1-year EVL treatment compared with the EVL (-) group. There were no differences in blood pressure and medications between the 2 groups. Improvement of LVMI and the E/e' ratio was not associated with trough levels of calcineurin inhibitors or EVL, but correlated with each baseline value. In conclusion, this EVL-incorporated immunosuppressant regimen attenuated cardiac hypertrophy as well as diastolic dysfunction in HTx recipients.

journal_name

Int Heart J

authors

Imamura T,Kinugawa K,Nitta D,Kinoshita O,Nawata K,Ono M

doi

10.1536/ihj.15-320

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

204-10

issue

2

eissn

1349-2365

issn

1349-3299

journal_volume

57

pub_type

杂志文章
  • A rare case of pulmonary hypertension. As a result of arteriovenous fistula after cardiac surgery.

    abstract::A 19 year-old woman who underwent corrective surgery for an atrial septal defect (ASD) and ventricular septal defect (VSD) 12 years previously presented with pulmonary hypertension. Cardiac catheterization showed a fistula between the right subclavian artery and vena jugularis interna. In this case, a rare example of ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.551

    authors: Tayyareci G,Dayi SU,Akgöz H,Terzi S,Akbulut T,Aydin A,Tuygun A

    更新日期:2005-05-01 00:00:00

  • Acute Coronary Syndrome Demonstrating Plaque Rupture in Calcified Lesions Visualized by Optical Frequency Domain Imaging.

    abstract::A 68-year-old female with acute coronary syndrome was transferred to our hospital. Emergency coronary angiography showed 90% stenosis with severe calcification in the proximal right coronary artery (RCA). Intravascular ultrasound (IVUS) images were obtained and showed circumferential heavy calcification without any ev...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-136

    authors: Goryo Y,Kume T,Kobayashi Y,Okamoto H,Kawamura A,Fukuhara K,Koyama T,Yamada R,Imai K,Neishi Y,Uemura S

    更新日期:2017-02-07 00:00:00

  • Effect of early versus late in-hospital initiation of statin therapy on the clinical outcomes of patients with acute coronary syndrome.

    abstract::Statins provide effective secondary prevention of cardiovascular events after acute coronary syndrome (ACS). Current guidelines recommend that statins be initiated in ACS patients before hospital discharge. In this retrospective study, we investigated the influence of early compared with late in-hospital initiation of...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.677

    authors: Li YH,Wu HL,Yang YH,Tsai HS,Chao TH

    更新日期:2007-11-01 00:00:00

  • Candidacy for a Subcutaneous Implantable Cardioverter Defibrillator in Patients with Cardiac Resynchronization Therapy.

    abstract::In patients requiring an implantable cardioverter defibrillator (ICD), the combined use of a prior pacemaker and a subcutaneous ICD (S-ICD) could be an alternative treatment option to implantation of new leads or upgrading of pacemakers to an ICD if vascular access is limited. Here, we assessed the prevalence of S-ICD...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-550

    authors: Kawabata M,Goya M,Takahashi Y,Maeda S,Yagishita A,Shirai Y,Kaneko M,Shiohira S,Hirao K

    更新日期:2018-09-26 00:00:00

  • Errata: Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α.

    abstract::An error appeared in the article entitled "Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α" by Zongqiu Wang, Zhihua Zhang, Jing Zhao, Chunming Yong, and Yongjun Mao (Vol. 60, No. 4, 964-973, 2019).The second affiliation of the authors on ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.60-5_Erratum

    authors: Wang Z,Zhang Z,Zhao J,Yong C,Mao Y

    更新日期:2019-01-01 00:00:00

  • Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats.

    abstract::Most previous studies have examined the effects of antihypertensive drugs in hypertensive animals for only a few months, and little information has been provided as to the protective effects of lifetime antihypertensive medication against cardiovascular organ injury. In this study, spontaneously hypertensive rats (SHR...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.359

    authors: Ishimitsu T,Honda T,Ohno E,Furukata S,Sudo Y,Nakano N,Takahashi T,Ono H,Matsuoka H

    更新日期:2010-01-01 00:00:00

  • Significance of mean blood pressure for blood pressure control.

    abstract::The significance of pulse pressure (PP) and mean blood pressure (MBP) for blood pressure (BP) control is unclear. The aim of this study was to examine the relationship between PP and MBP and BP control. We obtained home BP measurements for 117 patients aged 40-75 years with either office systolic BP (SBP) >or= 140 mmH...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.691

    authors: Yoshitomi Y,Nagakura C,Miyauchi A

    更新日期:2005-07-01 00:00:00

  • Successful conversion to everolimus after cytomegalovirus infection in a heart transplant recipient.

    abstract::Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection,...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.199

    authors: Imamura T,Shiga T,Kinugawa K,Kato N,Endo M,Inaba T,Maki H,Hatano M,Yao A,Hirata Y,Nagai R

    更新日期:2012-01-01 00:00:00

  • Effects of Statins and Xuezhikang on the Expression of Secretory Phospholipase A2, Group IIA in Rat Vascular Smooth Muscle Cells.

    abstract::Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-163

    authors: Xie Q,Zhang D

    更新日期:2017-02-07 00:00:00

  • Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model.

    abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.50.191

    authors: Sung PH,Sun CK,Ko SF,Chang LT,Sheu JJ,Lee FY,Wu CJ,Chua S,Yip HK

    更新日期:2009-03-01 00:00:00

  • Announcement: UEDA Heart Award for 2016.

    abstract::We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2016.First PlaceDelivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial HypertensionSatoshi Akagi, Kazufumi Nakamura, Daiji Mi...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.57-6_UEDA

    authors:

    更新日期:2016-01-01 00:00:00

  • Impact of Compound Hypertonic Saline Solution on Decompensated Heart Failure.

    abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.16-313

    authors: Wan Y,Li L,Niu H,Ma X,Yang J,Yuan C,Mu G,Zhang J

    更新日期:2017-08-03 00:00:00

  • Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy.

    abstract::The metabolism of branched-chain amino acids (BCAAs) is reported to change in heart failure (HF) and correlate with cardiac function. However, the effect of BCAAs on HF remains controversial. We investigate the prognostic value of the plasma BCAA level in nonischemic dilated cardiomyopathy (NIDCM).This study enrolled ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-010

    authors: Kimura Y,Okumura T,Kazama S,Shibata N,Oishi H,Arao Y,Kuwayama T,Kato H,Yamaguchi S,Hiraiwa H,Kondo T,Morimoto R,Murohara T

    更新日期:2020-07-30 00:00:00

  • Long-term effects of antihypertensive drugs on the risk of new-onset diabetes in elderly Taiwanese hypertensives.

    abstract::Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, the effects of these drugs on the development of NOD in elderly Taiwanese hypertensive patients have not been well determined. We examined the association between antihypertensive drug therapy and the risk of NOD in a population-based study....

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.49.205

    authors: Liou YS,Ma T,Tien L,Chien C,Chou P,Jong GP

    更新日期:2008-03-01 00:00:00

  • Early statin therapy within 48 hours decreased one-year major adverse cardiac events in patients with acute myocardial infarction.

    abstract::HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.1

    authors: Kim MC,Ahn Y,Cho KH,Lee MG,Ko JS,Park KH,Sim DS,Yoon NS,Yoon HJ,Kim KH,Hong YJ,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC

    更新日期:2011-01-01 00:00:00

  • Long-term outcome after primary stenting versus balloon angioplasty for acute myocardial infarction.

    abstract::The objective of the present prospective multicenter case-control study was to investigate the long-term clinical outcome (5 years) of primary stenting compared to primary percutaneous transluminal coronary angioplasty (PTCA) without stenting (POBA) in patients with acute myocardial infarction at 7 cardiovascular cent...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1536/ihj.47.47

    authors: Sasao H,Tsuchihashi K,Nagao K,Miyamoto K,Murakami H,Doi A,Shimoshige S,Hasegawa K,Kyuma M,Noda R,Shimamoto K

    更新日期:2006-01-01 00:00:00

  • Edema index-guided disease management improves 6-month outcomes of patients with acute heart failure.

    abstract::The efficacy of heart failure (HF) management programs is compromised by the challenge of early identification of patients at imminent risk. Segmental multifrequency bioelectrical impedance analysis can generate an "edema index" (EI) as a surrogate for the body fluid status. In this study, we tested whether integratio...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.53.11

    authors: Liu MH,Wang CH,Huang YY,Tung TH,Lee CM,Yang NI,Wang JS,Kuo LT,Cherng WJ

    更新日期:2012-01-01 00:00:00

  • Efficacy of catheter ablation for atrial fibrillation in patients with a permanent pacemaker for atrioventricular block.

    abstract::Catheter ablation has been established to be an effective therapy for drug-refractory paroxysmal AF and is recommended as the treatment of choice for many patients, including those with a permanent pacemaker (PM). However, the clinical efficacy of catheter ablation of paroxysmal AF in patients with a permanent PM for ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-099

    authors: Wu JT,Dong JZ,Wang SL,Chu YJ,Wang LX,Yang CK

    更新日期:2014-01-01 00:00:00

  • Addition of a Nitric Oxide Donor to an Angiotensin II Type 1 Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects.

    abstract::While physiological levels of nitric oxide (NO) protect the endothelium and have vasodilatory effects, excessive NO has adverse effects on the cardiovascular system. Recently, new NO-releasing pharmacodynamic hybrids of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) have been developed.We analyzed wheth...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-200

    authors: Yahiro E,Miura S,Suematsu Y,Matsuo Y,Arimura T,Kuwano T,Imaizumi S,Iwata A,Uehara Y,Saku K

    更新日期:2015-01-01 00:00:00

  • Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.

    abstract::Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); however, the specific conclusion is still controversial.To get a more accurate conclusion, we used a meta-analysis to evaluat...

    journal_title:International heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1536/ihj.19-389

    authors: Liu PF,Ding B,Zhang JY,Mei XF,Li F,Wu P,Mei CH,Zhou YF,Chen T

    更新日期:2020-05-30 00:00:00

  • Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.

    abstract::The aim of this study was to investigate the effects of taurine (Tau) on primary cultured neonatal myocardial cells treated with hydrogen peroxide (H2O2) and the underlying mechanism. Primary cardiac myocytes from neonatal Wistar rats were pre-incubated with Tau, and its effects on cell viability and expression of CaM...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-372

    authors: Wang J,Qi C,Liu L,Zhao L,Cui W,Tian Y,Liu B,Li J

    更新日期:2018-01-27 00:00:00

  • Experiences With Aggressive Cardiac Rehabilitation in Pediatric Patients Receiving Mechanical Circulatory Supports.

    abstract::Although some patients with fulminant myocarditis can be rescued owing to the improvements in mechanical circulatory support therapy, there are few reports providing evidence of cardiac rehabilitation during mechanical circulatory supports, particularly among pediatric patients. We treated two pediatric patients who u...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-067

    authors: Amao R,Imamura T,Sawada Y,Endo S,Ozaki S,Okamura K,Masuzawa A,Takaoka T,Hirata Y,Shindo T,Ono M,Haga N

    更新日期:2016-12-02 00:00:00

  • Exogenous Hydrogen Sulfide Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1α Signaling Pathway.

    abstract::Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with Sirt1 activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also h...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-506

    authors: Hu MZ,Zhou B,Mao HY,Sheng Q,Du B,Chen JL,Pang QF,Ji Y

    更新日期:2016-07-27 00:00:00

  • Additional Use of a 6-Fr Intra-Aortic Balloon Pump on Extracorporeal Membrane Oxygenation Was Effective in a Patient with Cardiogenic Shock with Low Pulse Pressure.

    abstract::We report the case of a 79-year-old man with acute myocardial infarction caused by left main trunk lesion, who experienced cardiogenic shock during percutaneous coronary intervention (PCI). To reverse the cardiogenic shock, we initiated veno-arterial extra corporeal membrane oxygenation (VA-ECMO) without an intra-aort...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-643

    authors: Kaneko D,Takahashi M,Fukutomi M,Funayama H,Kario K

    更新日期:2019-09-27 00:00:00

  • Intermediate monocytes lead to enhanced myocardial remodelling in STEMI patients with diabetes.

    abstract::This study aimed to evaluate the potential associations of intermediate monocytes (CD14(++)CD16(+)) with myocardial remodelling in ST segment elevation myocardial infarction (STEMI) patients with diabetes.A total of 67 STEMI patients with diabetes were enrolled. The control group consisted of 65 STEMI patients without...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-174

    authors: Lu W,Zhang Z,Fu C,Ma G

    更新日期:2015-01-01 00:00:00

  • Correlation Between Arteriosclerosis and Periodontal Condition Assessed by Lactoferrin and α1-Antitrypsin Levels in Gingival Crevicular Fluid.

    abstract::Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-218

    authors: Hayashi S,Yamada H,Fukui M,Ito HO,Sata M

    更新日期:2015-01-01 00:00:00

  • Long-Term Prognosis of Patients Who Underwent Percutaneous Transvenous Mitral Commissurotomy for Mitral Stenosis.

    abstract::The long-term prognosis for up to 20 years of patients who have undergone percutaneous transvenous mitral commissurotomy (PTMC) for mitral stenosis (MS) is unknown.We examined 77 of 93 patients (83%) with MS and who underwent PTMC from 1989 to 2002 at our institute, as well as the occurrence of either one of the follo...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-082

    authors: Kubota N,Ozaki K,Hoyano M,Nishida K,Takano T,Okubo T,Kimura S,Yanagawa T,Kashimura T,Minamino T

    更新日期:2020-11-28 00:00:00

  • Efficacy of intrathoracic impedance and remote monitoring in patients with an implantable device after the 2011 great East Japan earthquake.

    abstract::Several studies have revealed that stress after catastrophic disasters can trigger cardiovascular events, however, little is known about its association with the occurrence of heart failure in past earthquakes. The objective of the present study was to determine whether the Great East Japan Earthquake on March 11, 201...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.13-215

    authors: Suzuki H,Yamada S,Kamiyama Y,Takeishi Y

    更新日期:2014-01-01 00:00:00

  • Circadian variation of acute aortic dissection.

    abstract::Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with high mortality. Hypertension is a well known risk factor of AAD. There have been previous reports about the association between circadian variation of blood pressure (BP) and cardiovascular events. However, little is known about the associ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-328

    authors: Seguchi M,Wada H,Sakakura K,Nakagawa T,Ibe T,Ikeda N,Sugawara Y,Ako J,Momomura S

    更新日期:2015-05-13 00:00:00

  • Long-term exercise-training improves QT dispersion in the metabolic syndrome.

    abstract::Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have incre...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.41

    authors: Guiraud T,Gayda M,Curnier D,Juneau M,Talajic M,Fortier A,Nigam A

    更新日期:2010-01-01 00:00:00