Abstract:
:Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection, but is often associated with neutropenia, especially when used with mycophenolate mophetil (MMF). We experienced an HTx recipient with positive CMV antigenemia who suffered progressive neutropenia after administration of VGC. We switched MMF to everolimus (EVL) and assay for CMV antigenemia was constantly negative even after discontinuation of VGC. In all other 14 HTx recipients who received EVL for any reason, we found that assay for CMV antigenemia remained negative throughout the period of EVL administration. Considering the prophylactic effect on CMV, EVL can not only be an alternative to rescue from comorbidity, but might also be indicated earlier especially in CMV-seronegative HTx recipients.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Imamura T,Shiga T,Kinugawa K,Kato N,Endo M,Inaba T,Maki H,Hatano M,Yao A,Hirata Y,Nagai Rdoi
10.1536/ihj.53.199subject
Has Abstractpub_date
2012-01-01 00:00:00pages
199-201issue
3eissn
1349-2365issn
1349-3299pii
DN/JST.JSTAGE/ihj/53.199journal_volume
53pub_type
杂志文章abstract::The long-term prognosis for up to 20 years of patients who have undergone percutaneous transvenous mitral commissurotomy (PTMC) for mitral stenosis (MS) is unknown.We examined 77 of 93 patients (83%) with MS and who underwent PTMC from 1989 to 2002 at our institute, as well as the occurrence of either one of the follo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-082
更新日期:2020-11-28 00:00:00
abstract::Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-163
更新日期:2017-02-07 00:00:00
abstract::A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.167
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to investigate the effect on mortality of torsemide and a combination of loop diuretics (furosemide + torsemide) in contemporary practice in patients with chronic heart failure (HF).We investigated patients with HF in the Heart Failure Center of Fuwai Hospital from 2009 to 2013 who were disch...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-522
更新日期:2018-07-31 00:00:00
abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.191
更新日期:2009-03-01 00:00:00
abstract::The 5-hydroxytryptamine2A receptor antagonist sarpogrelate hydrochloride exerts its effect not only by inhibition of platelet aggregation, but also by some pleiotropic effects. We have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-377
更新日期:2014-01-01 00:00:00
abstract::Ventricular free wall rupture (FWR) is a catastrophic complication of that occurs after acute myocardial infarction (AMI), and at present, its clinical characteristics are unclear. We analyzed a total of 6,712 consecutive patients who presented with ST-segment elevation myocardial infarction (STEMI), and 78 patients w...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-541
更新日期:2020-07-30 00:00:00
abstract::The aim of the present study was to determine if prednisone, a glucocorticoid, added to conventional treatment for patients with decompensated congestive heart failure (DCHF) refractory to the conventional care, results in significant relief of congestive symptoms and improvement of clinical status. Diuretic-based str...
journal_title:International heart journal
pub_type: 临床试验,杂志文章
doi:10.1536/ihj.49.587
更新日期:2008-09-01 00:00:00
abstract::The clinical scenario, which is based on systolic blood pressure (SBP) upon admission, is useful for classifying and determining initial treatment for acute heart failure (HF). However, the prognostic significance of SBP following the initial treatment is unclear.The Japanese Heart Failure Syndrome with Preserved Ejec...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.18-699
更新日期:2019-07-27 00:00:00
abstract::HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.1
更新日期:2011-01-01 00:00:00
abstract::Left ventricular outflow tract obstruction (LVOTO) is commonly observed in patients with hypertrophic cardiomyopathy (HCM) or left ventricular hypertrophy (LVH). While some patients develop LVOTO at rest, it can also be provoked by physical exertion, and hence termed latent LVOTO (L-LVOTO). Recent reports demonstrated...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.230
更新日期:2012-01-01 00:00:00
abstract::Changes of global and segmental ventricular strain at different deterioration levels of cardiac function in patients with dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) have not yet been explored. In total, 101 patients diagnosed with DCM consecutively underwent CMR. They were categorized accordin...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-558
更新日期:2018-11-28 00:00:00
abstract::Coronary artery ectasia (CAE) is characterised by irregular, diffuse, saccular, or fusiform dilatation of the coronary arteries. Although the underlying mechanisms are not fully understood, CAE is considered to be an original form of vascular remodelling in response to atherosclerosis. However, it is not clear why som...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.89
更新日期:2005-01-01 00:00:00
abstract::We report the case of a 79-year-old man with acute myocardial infarction caused by left main trunk lesion, who experienced cardiogenic shock during percutaneous coronary intervention (PCI). To reverse the cardiogenic shock, we initiated veno-arterial extra corporeal membrane oxygenation (VA-ECMO) without an intra-aort...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-643
更新日期:2019-09-27 00:00:00
abstract::Catheter ablation has been established to be an effective therapy for drug-refractory paroxysmal AF and is recommended as the treatment of choice for many patients, including those with a permanent pacemaker (PM). However, the clinical efficacy of catheter ablation of paroxysmal AF in patients with a permanent PM for ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-099
更新日期:2014-01-01 00:00:00
abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-700
更新日期:2019-01-25 00:00:00
abstract::The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and ...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.16-249
更新日期:2017-02-07 00:00:00
abstract::Coronary artery spasm after coronary artery bypass surgery may result in life-threatening arrhythmias, circulatory collapse, or death. We report two cases of coronary artery spasm after coronary artery bypass surgery, one of which developed ventricular fibrillation requiring extracorporeal membrane oxygenation support...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-357
更新日期:2014-01-01 00:00:00
abstract::Our study aimed to investigate whether the frame design of transcatheter heart valve (THV) affects the procedural and clinical results of transcatheter aortic valve implantation (TAVI).We retrospectively reviewed 163 patients with aortic stenosis who underwent TAVI using different types of THV (Edwards SAPIEN, n = 31;...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-398
更新日期:2020-11-28 00:00:00
abstract::Decreased Transthyretin (TTR) can be observed in heart failure patients with malnutrition evaluated by the Mini Nutritional Assessment (MNA). This study investigated whether a combination of different nutritional assessment methods would be useful for assessing prognosis in patients with acute decompensated heart fail...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-255
更新日期:2015-01-01 00:00:00
abstract::Mitochondrial disorders comprise a heterogeneous group of diseases with multisystem involvement including myocardium. Most cases of mitochondrial cardiomyopathy are associated with myopathy and encephalopathy and are generally present in infancy or childhood. The disease often exhibits a rapid downward course with dea...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.383
更新日期:2012-01-01 00:00:00
abstract::The progression of heart failure with reduced ejection fraction is promoted by sympathovagal imbalance. Baroreflex activation therapy (BAT) by the electrical stimulation of baroreceptors at the carotid sinus significantly improved exercise capacity and NT-proBNP levels in a randomized trial; however, no significant di...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-400
更新日期:2017-12-12 00:00:00
abstract::We experienced a 33-year-old patient with D-looped transposition of the great arteries (D-TGA) and a history of Senning operation who was referred to our institute with cardiogenic shock and subsequently underwent urgent paracorporeal ventricular assist device (VAD) implantation, which was a first in Japan, that was e...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-670
更新日期:2020-05-30 00:00:00
abstract::The literature on malignant cardiac tumors is relatively limited because they are rare, especially among the Chinese population. We analyzed 14 patients diagnosed with malignant cardiac tumors in Fuwai Hospital and present the results of surgical treatments on the tumors. The mean age at tumor diagnosis was 47 years i...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-269
更新日期:2019-07-27 00:00:00
abstract::The relationship between mild-to-moderate renal dysfunction and cardiac diastolic dysfunction and cardiac events in patients with nonischemic dilated cardiomyopathy (NDCM) has not been fully elucidated. The aim of this study was to investigate the relationship between renal and cardiac function, as well as clinical ou...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.366
更新日期:2011-01-01 00:00:00
abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-595
更新日期:2018-11-28 00:00:00
abstract::The purpose of this study was to examine the relation between adiponectin levels and subclinical carotid atherosclerosis in patients undergoing coronary artery bypass grafting (CABG). Serum concentrations of adiponectin and carotid intima/media thickness (IMT) were measured in 84 consecutive patients who underwent CAB...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.47.855
更新日期:2006-11-01 00:00:00
abstract::The current study aimed to identify risk factors for atrial fibrillation (AF) detected during routine medical checkups of male workers in Japan. A nested case-control study was conducted using retrospective data from January 1998 to December 2006 collected at a hospital in Ishikawa Prefecture. Cases were those first d...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.457
更新日期:2009-07-01 00:00:00
abstract::The use of unilateral pulmonary artery occlusion (UPAO) test for the preoperative evaluation of pneumonectomy was reported in adult patients. On the contrary, in infants, no strategies have yet been recommended to predict hemodynamics after pneumonectomy, nor has use of the UPAO test been reported. We describe the fir...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-606
更新日期:2018-01-27 00:00:00
abstract::The efficacy of heart failure (HF) management programs is compromised by the challenge of early identification of patients at imminent risk. Segmental multifrequency bioelectrical impedance analysis can generate an "edema index" (EI) as a surrogate for the body fluid status. In this study, we tested whether integratio...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.53.11
更新日期:2012-01-01 00:00:00