Prednisone adding to usual care treatment for refractory decompensated congestive heart failure.


:The aim of the present study was to determine if prednisone, a glucocorticoid, added to conventional treatment for patients with decompensated congestive heart failure (DCHF) refractory to the conventional care, results in significant relief of congestive symptoms and improvement of clinical status. Diuretic-based strategies, as the mainstay in DCHF management, are not always effective in eliciting diuresis. However, the addition of prednisone to standard care may induce potent diuresis in this clinical setting. Thirty-five patients with DCHF were enrolled in the study, and prednisone (1 mg/kg/day with maximum dosage of 60 mg/day) was added to the standard treatment. Primary endpoints were the effects on daily urine volume, patient and physician assessed dyspnea and global clinical status, and changes in renal function. The addition of prednisone induced potent diuresis with time. As a result of the diuresis, congestive symptoms improved markedly in 80% and global clinical status improved markedly in 68.6% of the DCHF patients at the end of the study (P < 0.001). The change in serum creatinine from baseline was -12.21 micromol/L (P < 0.05). Adding prednisone to conventional care in the patients with refractory DCHF induced potent diuresis accompanied by a dramatic relief of congestive symptoms and improvements in clinical status and renal function.


Int Heart J


Zhang H,Liu C,Ji Z,Liu G,Zhao Q,Ao YG,Wang L,Deng B,Zhen Y,Tian L,Ji L,Liu K




Has Abstract


2008-09-01 00:00:00














  • The Refinement of Risk Stratification for Atrial Thrombus or Spontaneous Echo Contrast in Nonvalvular Atrial Fibrillation.

    abstract::As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ning W,Li Y,Ma C,Qiu L,Yu B

    更新日期:2017-12-12 00:00:00

  • Usefulness and Safety of a Novel Modification of the Retrograde Approach for the Long Tortuous Chronic Total Occlusion of Coronary Arteries.

    abstract::The aim of this study was to evaluate the feasibility and efficacy of the Guidezilla guide extension catheter in a reverse controlled antegrade and retrograde subintimal tracking (CART) technique for chronic total occlusion (CTO) recanalization.We retrospectively collected 80 CTO cases using reverse CART technology fr...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Huang Z,Zhang B,Chai W,Ma D,Liao H,Zhong Z,Wang F,Lin J

    更新日期:2017-05-31 00:00:00

  • Everolimus Attenuates Myocardial Hypertrophy and Improves Diastolic Function in Heart Transplant Recipients.

    abstract::Everolimus (EVL), one of the mammalian targets of rapamycin, is a next generation immunosuppressant that may have accessory anti-proliferative effects in heart transplant (HTx) recipients. However, little is known about the clinical relationship between EVL and regression of cardiac hypertrophy. A total of 42 HTx reci...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Imamura T,Kinugawa K,Nitta D,Kinoshita O,Nawata K,Ono M

    更新日期:2016-01-01 00:00:00

  • A critical increase in right-to-left shunt after acute myocardial infarction in a 68-year-old male with tetralogy of Fallot.

    abstract::A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Izawa A,Sekimura N,Uchikawa S,Yazaki Y,Kinoshita O,Owa M,Kubo K,Ikeda U,Sekiguchi M,Kitahara H,Amano J,Imamura H

    更新日期:2005-01-01 00:00:00

  • Radiofrequency catheter ablation of ventricular tachycardia originating in the left posterior and left anterior fascicles in a patient with prior myocardial infarction.

    abstract::A 61-year-old man with prior anteroseptal myocardial infarction (ejection fraction: 40%) presented with recurrent episodes of palpitations. Twelve-lead ECG during palpitations showed an incessant ventricular tachycardia (VT1) with right bundle branch block (RBBB) morphology and inferior axis. Electrophysiologic study ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ashino S,Watanabe I,Kofune M,Okumura Y,Kawauchi K,Yamada T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Saito S,Hirayama A

    更新日期:2008-01-01 00:00:00

  • Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy.

    abstract::The metabolism of branched-chain amino acids (BCAAs) is reported to change in heart failure (HF) and correlate with cardiac function. However, the effect of BCAAs on HF remains controversial. We investigate the prognostic value of the plasma BCAA level in nonischemic dilated cardiomyopathy (NIDCM).This study enrolled ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kimura Y,Okumura T,Kazama S,Shibata N,Oishi H,Arao Y,Kuwayama T,Kato H,Yamaguchi S,Hiraiwa H,Kondo T,Morimoto R,Murohara T

    更新日期:2020-07-30 00:00:00

  • Feasibility of Uninterrupted Direct Oral Anticoagulants with Temporary Switching to Dabigatran ("Dabigatran Bridge") for Catheter Ablation of Atrial Fibrillation.

    abstract::Uninterrupted anticoagulation therapy during atrial fibrillation (AF) ablation minimizes the risk of periprocedural thromboembolic events. Although the use of direct oral anticoagulants (DOACs) has rapidly developed in patients undergoing AF ablation, no antidote is available for factor Xa inhibitors. We sought to inv...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章


    authors: Aoyama D,Miyazaki S,Hasegawa K,Kaseno K,Ishikawa E,Mukai M,Miyahara K,Aiki T,Matsui A,Yamaguchi J,Shiomi Y,Tama N,Ikeda H,Fukuoka Y,Morishita T,Ishida K,Uzui H,Tada H

    更新日期:2019-11-30 00:00:00

  • The evaluation of left ventricular systolic and diastolic functions in patients with Friedreich ataxia. A pulse tissue Doppler study.

    abstract::Friedreich's ataxia (FRDA), the most common subtype of early onset hereditary ataxia, is an autosomal recessive neurodegenerative disorder caused by unstable GAA expansions. Two-dimensional, pulse, and pulse tissue Doppler echocardiographic examinations were performed on 21 patients with GAA expansion. There was no as...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Koc F,Akpinar O,Yerdelen D,Demir M,Sarica Y,Kanadasi M

    更新日期:2005-05-01 00:00:00

  • Initial and Secondary ST-T Alternans During Acute Myocardial Ischemia in the In-Situ Pig Heart.

    abstract::The factors responsible for the ST-T wave alternans (STTA) and associated arrhythmias during acute ischemia have not been clarified.In acutely ischemic porcine myocardium, we recorded transmural unipolar and bipolar electrocardiograms and mid-myocardial extracellular K(+) ([K(+)]e) from the center of the ischemic zone...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Watanabe I,Gettes LS

    更新日期:2016-05-25 00:00:00

  • Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention.

    abstract::Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) co...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Gayed M,Yadak N,Qamhia W,Daralammouri Y,Ohlow MA

    更新日期:2017-04-06 00:00:00

  • Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome.

    abstract::Marfan syndrome (MFS) is an inherited connective tissue disorder mainly caused by the fibrillin-1 mutation. Deficient fibrillin-1 is thought to result in the failed sequestration of transforming growth factor β (TGFβ) and subsequent activation of the TGFβ signaling pathway, suggesting that the circulating TGFβ level m...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ogawa N,Imai Y,Nishimura H,Kato M,Takeda N,Nawata K,Taketani T,Morota T,Takamoto S,Nagai R,Hirata Y

    更新日期:2013-01-01 00:00:00

  • Right Ventricular End-Diastolic Pressure Is a Key to the Changes in Cardiac Output During Adaptive Servo-Ventilation Support in Patients With Heart Failure.

    abstract::Adaptive servo-ventilation (ASV) is a recently-developed non-invasive therapy that improves the clinical course of heart failure (HF) patients. However, the precise hemodynamic response and predictors of ASV therapy remain uncertain. Overall, 69 patients with New York Heart Association HF class II-IV underwent 10-minu...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Imamura T,Kinugawa K

    更新日期:2017-08-03 00:00:00

  • Spiritual activation in very elderly individuals assessed as heart rate variability and plasma IL/10/IL-6 ratios.

    abstract::Proinflammatory cytokine responses might occur in elderly individuals with cardiovascular (CV) disease, cerebro-vascular (CVA) disease, and/or pulmonary disease (PD). Spiritual activation is an important coping mechanism, since psychiatric depression is an important risk factor for these individuals. Thirty-three very...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kurita A,Takase B,Shinagawa N,Kodani E,Okada K,Iwahara S,Kusama Y,Atarashi H

    更新日期:2011-01-01 00:00:00

  • A case of atrioventricular nodal reentrant tachycardia with atresia of the coronary sinus ostium.

    abstract::We report a case of atrioventricular nodal reentrant tachycardia coexistent with atresia of the coronary sinus ostium. Radiofrequency current application between the supposed coronary sinus ostium and the tricuspid valve was effective at eliminating the tachycardia. A coronary venogram obtained by left coronary arteri...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Okuyama Y,Oka T,Mizuno H,Sakai T,Hirayama A,Kodama K

    更新日期:2005-09-01 00:00:00

  • Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.

    abstract::Atrial fibrillation has caused severe burden for people worldwide. Differentiation of fibroblasts into myofibroblasts, and consequent progress in atrial structural remodeling have been considered the basis for persistent atrial fibrillation, yet little is known about the molecular mechanisms underlying the process. He...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Sai C,Yunhan J,Zhao J,Yu Z,Yun Z,Zhezhe C,Fuqin T,Yingbin X,Ruiyan M

    更新日期:2019-03-20 00:00:00

  • Revascularization of malignant coronary instent restenosis resulting from Takayasu's arteritis using sirolimus-eluting stents.

    abstract::A 37 year-old female who had suffered from arteritis for 20 years underwent a Bentall operation. Since severe stenosis was observed in her left main coronary artery (LMCA) the following year, a minimally invasive direct coronary artery bypass (MIDCAB) operation was performed. Unfortunately, she again complained of ang...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Sakai H,Oyama N,Kishimoto N,Takahashi M,Urasawa K,Tsutsui H

    更新日期:2006-09-01 00:00:00

  • Candidacy for a Subcutaneous Implantable Cardioverter Defibrillator in Patients with Cardiac Resynchronization Therapy.

    abstract::In patients requiring an implantable cardioverter defibrillator (ICD), the combined use of a prior pacemaker and a subcutaneous ICD (S-ICD) could be an alternative treatment option to implantation of new leads or upgrading of pacemakers to an ICD if vascular access is limited. Here, we assessed the prevalence of S-ICD...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kawabata M,Goya M,Takahashi Y,Maeda S,Yagishita A,Shirai Y,Kaneko M,Shiohira S,Hirao K

    更新日期:2018-09-26 00:00:00

  • Case of Invasive Streptococcus Dysgalactiae Infection Presenting as Infective Endocarditis with Multiple Brain Embolisms.

    abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Takahashi F,Wada Y,Hasebe N

    更新日期:2019-01-25 00:00:00

  • Impact of Either GLP-1 Agonists or DPP-4 Inhibitors on Pathophysiology of Heart Failure.

    abstract::Since diabetes mellitus (DM) is the most common cause of heart failure (HF), it is critically important to clarify whether incretin hormones including glucagon-like peptide-1 (GLP-1), which play an important role in blood glucose control, mediate cardioprotection. There are many lines of basic research evidence indica...

    journal_title:International heart journal

    pub_type: 杂志文章,评审


    authors: Takahashi A,Ihara M,Yamazaki S,Asanuma H,Asakura M,Kitakaze M

    更新日期:2015-01-01 00:00:00

  • Native Myocardial T1 Mapping, Are We There Yet?

    abstract::T1 or longitudinal relaxation time is one of the very fundamental magnetic resonance imaging (MRI) time constants and a tissue characterizing parameter. Only during the last decade did it become possible to quantify T1 values of the myocardium through T1 mapping. Evolving from only region of interest analysis and long...

    journal_title:International heart journal

    pub_type: 杂志文章,评审


    authors: Hamdy A,Kitagawa K,Ishida M,Sakuma H

    更新日期:2016-07-27 00:00:00

  • Long-term coronary endothelial function after zotarolimus-eluting stent implantation. A 9 month comparison between zotarolimus-eluting and sirolimus-eluting stents.

    abstract::Implantation of a paclitaxel- or sirolimus-eluting stent (SES) may be associated with endothelial dysfunction. In the present study, we compared coronary endothelial function after zotarolimus-eluting stent (ZES) implantation to that after SES implantation. Patients who had one stent implantation for a single lesion i...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Shin DI,Seung KB,Kim PJ,Chang K,Choi JK,Jeon DS,Kim MJ,Lee MY,Chung WS

    更新日期:2008-11-01 00:00:00

  • Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model.

    abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Sung PH,Sun CK,Ko SF,Chang LT,Sheu JJ,Lee FY,Wu CJ,Chua S,Yip HK

    更新日期:2009-03-01 00:00:00

  • Who Needs Longer Tolvaptan Treatment?

    abstract::The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and ...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究


    authors: Kinugawa K,Inomata T,Sato N,Yasuda M,Shimakawa T,Bando K,Fukuta Y

    更新日期:2017-02-07 00:00:00

  • Low-Level Vagus Nerve Stimulation Reverses Cardiac Dysfunction and Subcellular Calcium Handling in Rats With Post-Myocardial Infarction Heart Failure.

    abstract::Vagus nerve stimulation (VNS), targeting the imbalanced autonomic nervous system, is a promising therapeutic approach for chronic heart failure (HF). Moreover, calcium cycling is an important part of cardiac excitation-contraction coupling (ECC), which also participates in the antiarrhythmic effects of VNS. We hypothe...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Zhang Y,Chen A,Song L,Li M,Luo Z,Zhang W,Chen Y,He B

    更新日期:2016-05-25 00:00:00

  • Cardiac output response to exercise in chronic cardiac failure patients.

    abstract::The purpose of this study was to investigate the precise pattern of stroke volume (SV) response during exercise in patients with chronic heart failure (CHF) compared with age-matched controls. Fourteen patients with CHF and 7 controls performed symptom-limited bicycle exercise testing with respiratory gas exchange mea...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Fukuda T,Matsumoto A,Kurano M,Takano H,Iida H,Morita T,Yamashita H,Hirata Y,Nagai R,Nakajima T

    更新日期:2012-01-01 00:00:00

  • Prolonged Inflation Technique Using a Scoring Balloon for Severe Calcified Lesion.

    abstract::Percutaneous coronary intervention for the treatment of a severe calcified lesion is still one of the most technically challenging areas of interventional cardiology. Calcified lesions are a cause of stent underexpansion, which significantly increases the subsequent risks of in-stent restenosis and thrombosis, even wh...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Otsuka Y,Koyama T,Imoto Y,Katsuki Y,Kawahara M,Nakamura K,Kodama S,Noguchi H,Iwasaki K

    更新日期:2017-12-12 00:00:00

  • Clinical Manifestation, Timing Course, Precipitating Factors, and Protective Factors of Ventricular Free Wall Rupture Following ST-Segment Elevation Myocardial Infarction.

    abstract::Ventricular free wall rupture (FWR) is a catastrophic complication of that occurs after acute myocardial infarction (AMI), and at present, its clinical characteristics are unclear. We analyzed a total of 6,712 consecutive patients who presented with ST-segment elevation myocardial infarction (STEMI), and 78 patients w...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Gong W,Shi H,Yan M,Yan Y,Wang X,Li S,He X,Nie S

    更新日期:2020-07-30 00:00:00

  • Involvement of Apelin/APJ Axis in Thrombogenesis in Valve Heart Disease Patients with Atrial Fibrillation.

    abstract::The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. The apelin/APJ axis parallel and counter-regulate with the angiotensin system. The present study hypothesizes that apelin/APJ axis exert its anti-thrombus effect in normal left atrial tissue and is disrupted by up-regulated ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Cheng H,Chen Y,Li X,Chen F,Zhao J,Hu J,Shan A,Qiao S,Wei Z,He G,Xu B

    更新日期:2019-01-25 00:00:00

  • Transradial percutaneous coronary intervention for acute myocardial infarction reduces CCU stay in patients 80 or older.

    abstract::Transradial percutaneous coronary intervention (PCI), which is less invasive than transfemoral PCI, may facilitate early rehabilitation of patients with acute myocardial infarction (AMI). The aim of our study was to investigate whether transradial PCI is associated with a shorter coronary care unit (CCU) stay in very ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Jinnouchi H,Sakakura K,Wada H,Kubo N,Sugawara Y,Nakamura T,Funayama H,Ako J,Momomura S

    更新日期:2012-01-01 00:00:00

  • First Pediatric Case of Infective Endocarditis Caused by Serratia Liquefaciens.

    abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Momose T,Masutani S,Oshima A,Kawasaki H,Tanaka R,Iwamoto Y,Ishido H,Senzaki H

    更新日期:2018-11-28 00:00:00