Early statin therapy within 48 hours decreased one-year major adverse cardiac events in patients with acute myocardial infarction.

Abstract:

:HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They were grouped by initiation time of statin administration after admission as follows: group I; n = 945, ≤ 48 hours, group II; n = 214, > 48 hours.Cardiovascular risk factors and noncardiac comorbidities were not different between the two groups. ST-elevation MI as initial diagnosis was more prevalent in group I (68.4% versus 59.3%, P = 0.013). In-hospital mortality was not different in the two groups (0.8% versus 0.5%, P = 0.483). In one-year clinical follow-up, MACE and repercutaneous coronary intervention were lower in group I (17.8% versus 24.6%, P = 0.016, 10.2% versus 15.5%, P = 0.021, respectively). However, there was no difference in mortality (3.8% versus 4.7%, P = 0.319). In multivariate analysis, statin initiation within 48 hours after admission was an independent predictor of one-year MACE (OR 1.49, 95% CI = 1.00-2.21, P = 0.045).Consequently, early statin therapy within 48 hours after admission reduced MACE at one-year follow-up in patients with AMI.

journal_name

Int Heart J

authors

Kim MC,Ahn Y,Cho KH,Lee MG,Ko JS,Park KH,Sim DS,Yoon NS,Yoon HJ,Kim KH,Hong YJ,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC

doi

10.1536/ihj.52.1

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1-6

issue

1

eissn

1349-2365

issn

1349-3299

pii

JST.JSTAGE/ihj/52.1

journal_volume

52

pub_type

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