Early statin therapy within 48 hours decreased one-year major adverse cardiac events in patients with acute myocardial infarction.


:HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They were grouped by initiation time of statin administration after admission as follows: group I; n = 945, ≤ 48 hours, group II; n = 214, > 48 hours.Cardiovascular risk factors and noncardiac comorbidities were not different between the two groups. ST-elevation MI as initial diagnosis was more prevalent in group I (68.4% versus 59.3%, P = 0.013). In-hospital mortality was not different in the two groups (0.8% versus 0.5%, P = 0.483). In one-year clinical follow-up, MACE and repercutaneous coronary intervention were lower in group I (17.8% versus 24.6%, P = 0.016, 10.2% versus 15.5%, P = 0.021, respectively). However, there was no difference in mortality (3.8% versus 4.7%, P = 0.319). In multivariate analysis, statin initiation within 48 hours after admission was an independent predictor of one-year MACE (OR 1.49, 95% CI = 1.00-2.21, P = 0.045).Consequently, early statin therapy within 48 hours after admission reduced MACE at one-year follow-up in patients with AMI.


Int Heart J


Kim MC,Ahn Y,Cho KH,Lee MG,Ko JS,Park KH,Sim DS,Yoon NS,Yoon HJ,Kim KH,Hong YJ,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC




Has Abstract


2011-01-01 00:00:00














  • A rare case of pulmonary hypertension. As a result of arteriovenous fistula after cardiac surgery.

    abstract::A 19 year-old woman who underwent corrective surgery for an atrial septal defect (ASD) and ventricular septal defect (VSD) 12 years previously presented with pulmonary hypertension. Cardiac catheterization showed a fistula between the right subclavian artery and vena jugularis interna. In this case, a rare example of ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Tayyareci G,Dayi SU,Akgöz H,Terzi S,Akbulut T,Aydin A,Tuygun A

    更新日期:2005-05-01 00:00:00

  • Effects of Statins and Xuezhikang on the Expression of Secretory Phospholipase A2, Group IIA in Rat Vascular Smooth Muscle Cells.

    abstract::Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Xie Q,Zhang D

    更新日期:2017-02-07 00:00:00

  • Predictors of Long-Term Mortality in Patients With Acute Heart Failure.

    abstract::To investigate parameters which were related with long-term mortality in patients hospitalized for acute heart failure (AHF).A total of 287 patients with AHF presenting to the First Affiliated Hospital of Nanjing Medical University were enrolled into the registry from April 2012 to January 2015. The primary endpoint w...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Jin M,Wei S,Gao R,Wang K,Xu X,Yao W,Zhang H,Zhou Y,Xu D,Zhou F,Li X

    更新日期:2017-05-31 00:00:00

  • Basilar Artery Dissection Complicated with Infective Endocarditis.

    abstract::A 14 year-old boy developed infective endocarditis of the mitral valve caused by Methicillin-sensitive Staphylococcus aureus and became comatose. Isolated basilar artery dissection was initially observed on the 3rd day by magnetic resonance imaging (MRI), ie, it did not exist on day 1. He underwent successful urgent m...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kawano A,Masutani S,Inui A,Honma H,Igarashi T,Tsuneoka H,Sakamoto W,Sakurai Y,Dembo T,Imanaka K

    更新日期:2021-01-16 00:00:00

  • Basic echocardiographic features of patients with latent left ventricular outflow tract obstruction without left ventricular hypertrophy.

    abstract::Left ventricular outflow tract obstruction (LVOTO) is commonly observed in patients with hypertrophic cardiomyopathy (HCM) or left ventricular hypertrophy (LVH). While some patients develop LVOTO at rest, it can also be provoked by physical exertion, and hence termed latent LVOTO (L-LVOTO). Recent reports demonstrated...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Semba H,Sawada H,Uejima T,Takeda N,Soma K,Abe H,Yamashita T,Nagai R

    更新日期:2012-01-01 00:00:00

  • Low Consultation Rate of General Population with Atrial Fibrillation.

    abstract::In order to prevent ischemic stroke, it is important to identify and treat patients with atrial fibrillation (AF) who do not consult a doctor in a medical institution. The aim of this study was to determine the consultation rate at medical institutions for patients with AF in group medical examinations conducted in a ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Matsumi H,Nakamura K,Eguchi E,Miyoshi T,Nakagawa K,Nishii N,Watanabe A,Ueoka A,Yoshida M,Tokunaga N,Amioka N,Yamada N,Saito D,Morita H,Ogino K,Ito H,Ibara-AF Investigators.

    更新日期:2019-11-30 00:00:00

  • Efficacy of Cognitive Behavioral Therapy for Heart Failure.

    abstract::Cognitive behavioral therapy has emerged as an important approach to alleviate the depression of patients with heart failure. However, the use of cognitive behavioral therapy for heart failure has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of cognitive behavior...

    journal_title:International heart journal

    pub_type: 杂志文章,meta分析


    authors: Peng Y,Fang J,Huang W,Qin S

    更新日期:2019-05-30 00:00:00

  • Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats.

    abstract::Most previous studies have examined the effects of antihypertensive drugs in hypertensive animals for only a few months, and little information has been provided as to the protective effects of lifetime antihypertensive medication against cardiovascular organ injury. In this study, spontaneously hypertensive rats (SHR...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ishimitsu T,Honda T,Ohno E,Furukata S,Sudo Y,Nakano N,Takahashi T,Ono H,Matsuoka H

    更新日期:2010-01-01 00:00:00

  • Elevated Heart Rate in Combination with Elevated Blood Pressure Predicts Lower Cardiovascular Mortality in Acute Decompensated Heart Failure.

    abstract::Despite its clinical relevance, a subclass of acute decompensated heart failure (ADHF) with elevated blood pressure, known as hypertensive ADHF (HT-ADHF), has been less intensively evaluated. This study aimed to characterize the prognostic nature and pathophysiology of HT-ADHF. A total of 509 consecutive patients with...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Hiki M,Iwata H,Takasu K,Nojiri S,Ishikawa G,Chikata Y,C Mattson P,Kasai T,Miyazaki T,Inoue K,Fujiwara Y,Sumiyoshi M,Kinugawa K,Daida H

    更新日期:2020-03-28 00:00:00

  • Paracorporeal Ventricular Assist Device Implantation in a Patient with Transposition of the Great Arteries After Senning Operation.

    abstract::We experienced a 33-year-old patient with D-looped transposition of the great arteries (D-TGA) and a history of Senning operation who was referred to our institute with cardiogenic shock and subsequently underwent urgent paracorporeal ventricular assist device (VAD) implantation, which was a first in Japan, that was e...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Nakamura M,Imamura T,Kuwahara H,Nakagaito M,Yokoyama S,Doi T,Fukahara K,Yoshimura N,Kinugawa K

    更新日期:2020-05-30 00:00:00

  • A Survey of Direct Oral Anticoagulant Cessation in General Surgery and Outcomes in Patients with Nonvalvular Atrial Fibrillation.

    abstract::There is little data on management and outcomes of atrial fibrillation (AF) patients on direct oral anticoagulants (DOAC) undergoing general surgery.We retrospectively assessed 98 surgeries in 85 nonvalvular AF patients aged 73 ± 8 (59 men) receiving DOACs. Cardiac, emergency, and minimally invasive surgeries were exc...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kawabata M,Goya M,Maeda S,Yagishita A,Takahashi Y,Sasano T,Hirao K

    更新日期:2020-09-29 00:00:00

  • Usefulness and Safety of a Novel Modification of the Retrograde Approach for the Long Tortuous Chronic Total Occlusion of Coronary Arteries.

    abstract::The aim of this study was to evaluate the feasibility and efficacy of the Guidezilla guide extension catheter in a reverse controlled antegrade and retrograde subintimal tracking (CART) technique for chronic total occlusion (CTO) recanalization.We retrospectively collected 80 CTO cases using reverse CART technology fr...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Huang Z,Zhang B,Chai W,Ma D,Liao H,Zhong Z,Wang F,Lin J

    更新日期:2017-05-31 00:00:00

  • Interleukin-18.

    abstract::A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study....

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Wang S,Chen F,Yang S,Shi J

    更新日期:2018-07-31 00:00:00

  • The role of angiotensin converting enzyme genotype in coronary artery ectasia.

    abstract::Coronary artery ectasia (CAE) is characterised by irregular, diffuse, saccular, or fusiform dilatation of the coronary arteries. Although the underlying mechanisms are not fully understood, CAE is considered to be an original form of vascular remodelling in response to atherosclerosis. However, it is not clear why som...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Uyarel H,Okmen E,Tartan Z,Kasikcioglu H,Dayi SU,Karabulut A,Uzunlar B,Samur H,Cam N

    更新日期:2005-01-01 00:00:00

  • Exogenous Hydrogen Sulfide Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1α Signaling Pathway.

    abstract::Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with Sirt1 activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also h...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Hu MZ,Zhou B,Mao HY,Sheng Q,Du B,Chen JL,Pang QF,Ji Y

    更新日期:2016-07-27 00:00:00

  • High-Sensitivity C-Reactive Protein Combined with Low-Density Lipoprotein Cholesterol as the Targets of Statin Therapy in Patients with Acute Coronary Syndrome.

    abstract::To investigate the combination of high-sensitivity C-reactive protein (hs-CRP) and Low-density lipoprotein (LDL)-C as the targets for statin treatment in patients with acute coronary syndrome (ACS). This single-center, prospective, randomized study was performed in 400 patients treated with atorvastatin 40 mg/day for ...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Fang M,Qian Q,Zhao Z,Zhu L,Su J,Li X

    更新日期:2018-03-30 00:00:00

  • Transradial approach percutaneous coronary interventions in an out-patient clinic.

    abstract::Same-day discharge transradial percutaneous coronary intervention (TRI) has been reported to be safe and feasible in Western countries. However, Asia has not produced any reports related to this matter. The present study explored the safety and feasibility of patients with indications for TR coronary angiography and a...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chung WJ,Fang HY,Tsai TH,Yang CH,Chen CJ,Chen SM,Cheng CI,Fang CY,Hsieh YK,Hang CL,Yip HK,Wu CJ

    更新日期:2010-01-01 00:00:00

  • Successful Infant Pneumonectomy with Unilateral Pulmonary Artery Occlusion Test.

    abstract::The use of unilateral pulmonary artery occlusion (UPAO) test for the preoperative evaluation of pneumonectomy was reported in adult patients. On the contrary, in infants, no strategies have yet been recommended to predict hemodynamics after pneumonectomy, nor has use of the UPAO test been reported. We describe the fir...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kato K,Kato T,Hayano S,Fukasawa Y,Numaguchi A,Hattori T,Saito A,Sato Y,Hayakawa M

    更新日期:2018-01-27 00:00:00

  • Effect of balance training on walking speed and cardiac events in elderly patients with ischemic heart disease.

    abstract::The purpose of this study was to clarify the effect of standing balance training on walking speed (short-term outcome) and cardiac events (long-term outcome) in elderly ischemic heart disease (IHD) patients. This was a retrospective cohort study. Ninety-two elderly (≥ 65 years) IHD patients who underwent an inpatient ...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Yamamoto S,Matsunaga A,Wang G,Hoshi K,Kamiya K,Noda C,Kimura M,Yamaoka-Tojo M,Masuda T

    更新日期:2014-01-01 00:00:00

  • Temperature-controlled cooled-tip radiofrequency ablation in left ventricular myocardium.

    abstract::Steam pop and intramural charring have been reported during cooled-tip radiofrequency catheter ablation (RFCA). We studied the feasibility of temperature-controlled cooled-tip RFCA in the canine heart.An internally cooled ablation catheter was inserted into the left ventricle. A custom-made radiofrequency (RF) generat...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Watanabe I,Nuo M,Okumura Y,Ohkubo K,Ashino S,Kofune M,Kofune T,Nakai T,Kasamaki Y,Hirayama A

    更新日期:2010-05-01 00:00:00

  • Initial and Secondary ST-T Alternans During Acute Myocardial Ischemia in the In-Situ Pig Heart.

    abstract::The factors responsible for the ST-T wave alternans (STTA) and associated arrhythmias during acute ischemia have not been clarified.In acutely ischemic porcine myocardium, we recorded transmural unipolar and bipolar electrocardiograms and mid-myocardial extracellular K(+) ([K(+)]e) from the center of the ischemic zone...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Watanabe I,Gettes LS

    更新日期:2016-05-25 00:00:00

  • Prevalence and prognosis of patients with heart failure in Tokyo: a prospective cohort of Shinken Database 2004-5.

    abstract::Prognosis of patients with heart failure (HF) remains unclear in Japan and should be determined in a prospective fashion. A prospective cohort of The Shinken Database comprised details on all of the new patients, including both inpatients and outpatients, who visited The Cardiovascular Institute Hospital in 2004-2005....

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Goda A,Yamashita T,Suzuki S,Ohtsuka T,Uejima T,Oikawa Y,Yajima J,Koike A,Nagashima K,Kirigaya H,Sagara K,Ogasawara K,Isobe M,Sawada H,Aizawa T

    更新日期:2009-09-01 00:00:00

  • Longitudinal age-related changes in 24-hour total heart beats and premature beats and their relationship in healthy elderly subjects.

    abstract::The aim of this study was to conduct a longitudinal follow-up on age-related changes in 24-hour total heart beats (THBs) and total premature beats and their correlations in healthy elderly subjects. In 15 healthy elderly subjects (mean age, 70.0 +/- 4.1, age range at 1st recording, 64 to 80 years, 10 females, 5 males)...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Tasaki H,Serita T,Ueyama C,Kitano K,Seto S,Yano K,Camm AJ

    更新日期:2006-07-01 00:00:00

  • Induction of c-fos mRNA expression by pure pressure overload in cultured cardiac myocytes.

    abstract::Mechanical stress by pressure overload due to hypertension or valvular heart disease such as aortic valve stenosis induces cardiac hypertrophy. It has been well established that the mechanical stretch of cardiac myocytes in vitro induces hypertrophic responses such as the expression of immediate early response genes i...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Sakai H,Urasawa K,Oyama N,Kaneta S,Saito T,Kitabatake A,Tsutsui H

    更新日期:2007-05-01 00:00:00

  • Electrophysiological properties of the atrium after cardioversion of chronic atrial fibrillation: relation to the plasma brain natriuretic peptide level.

    abstract:BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological pr...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Okumura Y,Watanabe I,Ashino S,Kofune M,Takagi Y,Kofune T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Kasamaki Y,Saito S

    更新日期:2007-07-01 00:00:00

  • Serum bilirubin concentration in patients with an established coronary artery disease.

    abstract::Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with coronary artery disease and the control group 100 patients with normal...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Ghem C,Sarmento-Leite RE,de Quadros AS,Rossetto S,Gottschall CA

    更新日期:2010-03-01 00:00:00

  • The associations of epicardial adipose tissue with coronary artery disease and coronary atherosclerosis.

    abstract::Epicardial adipose tissue (EAT) is presumed to play an important role in the development of coronary artery disease (CAD). The purpose of our study was to examine the influence of EAT volume measured by cardiac CT on the severity and presence of CAD. A total of 209 subjects (114 normal subjects and 95 patients with CA...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kim SH,Chung JH,Kwon BJ,Song SW,Choi WS

    更新日期:2014-01-01 00:00:00

  • Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia.

    abstract::Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catech...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Okada K,Kurita A,Takase B,Otsuka T,Kodani E,Kusama Y,Atarashi H,Mizuno K

    更新日期:2009-01-01 00:00:00

  • Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure?

    abstract::The aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation o...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Dobsák P,Nováková M,Fiser B,Siegelová J,Balcárková P,Spinarová L,Vítovec J,Minami N,Nagasaka M,Kohzuki M,Yambe T,Imachi K,Nitta S,Eicher JC,Wolf JE

    更新日期:2006-05-01 00:00:00

  • A case of marked diuresis by combined dopamine and atrial natriuretic peptide administration without renal injury in acute decompensated heart failure.

    abstract::Renal injury is an important factor for worsening outcome in acute decompensated heart failure (ADHF). An 81-year-old woman was admitted due to ADHF with dyspnea and mild peripheral edema. The patient was managed with intravenous administration of atrial natriuretic peptide (ANP) at a dose of 0.0125 μg/kg/minute, whic...

    journal_title:International heart journal

    pub_type: 杂志文章


    authors: Kamiya M,Sato N,Akiya M,Okazaki H,Takahashi Y,Mizuno K

    更新日期:2013-01-01 00:00:00