Low Stroke Rate of Carotid Stenosis Under the Guideline-Oriented Medical Treatment Compared With Surgical Treatment.

Abstract:

:Medical treatment for asymptomatic carotid artery stenosis (ACAS) has advanced recently. The outcomes of medical treatment and surgical treatment were evaluated to clarify the optimal treatment for ACAS.Patients with ACAS of ≥ 50% luminal narrowing underwent serial follow-up carotid artery ultrasonography for one year or more at the Center for Cardiovascular Disease Prevention between November 2006 and October 2013. The incidence of cardiovascular events (stroke, myocardial infarction, cardiovascular death) was examined in 64 patients (medical treatment group), and in 47 patients (surgical group) who underwent surgical treatment (carotid endarterectomy or carotid artery stenting) during this same period at the Department of Neurosurgery.Annual cardiovascular event rate was 0.91% (2/219 person-year) in the group of guideline-oriented medical treatment with an annual check-up for disease management and 5.6% (6/107 person-year) in the surgical group (log-rank P = 0.027; HR in the medical treatment group, 0.19 [medical treatment/surgical]; 95% confidence interval [CI], 0.028 to 0.87). Annual stroke event rate was 0.46% (1/219 person-year) in the medical treatment group and 4.7% (5/107 personyear) in the surgical group (log-rank P = 0.016; HR in the medical treatment group, 0.11 [medical treatment/surgical]; 95% CI, 0.0057 to 0.70). Multivariate logistic analysis showed that the surgical group was an independent variable associated with cardiovascular events (P = 0.049).Annual cardiovascular and stroke event rates were low in patients receiving medical treatment for ACAS and better than surgical treatment. The present study shows that medical treatment is an important option for ACAS.

journal_name

Int Heart J

authors

Sato K,Fujiyoshi K,Hoshi K,Noda C,Yamaoka-Tojo M,Ako J,Kumabe T

doi

10.1536/ihj.15-196

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

80-6

issue

1

eissn

1349-2365

issn

1349-3299

journal_volume

57

pub_type

杂志文章,随机对照试验
  • Gender-Related Association of Serum Uric Acid Levels with Premature Ventricular Contraction.

    abstract::In this study, we aim to investigate the association of serum uric acid (SUA) with the prevalence of premature ventricular contraction (PVC). The relationship between SUA and the prevalence of PVC in 98,965 subjects (79,034 male subjects, mean age: 51.9 ± 12.6 years old) in the Kailuan cohort study (n = 101,510, age r...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-474

    authors: Chen Y,Wu S,Li W,Wang B,Lv H,Yang X,Khalid BW,Yin X,Xia Y

    更新日期:2018-11-28 00:00:00

  • Myocardial involvement in patients with osteogenesis imperfecta.

    abstract::Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.75

    authors: Soma K,Abe H,Takeda N,Shintani Y,Takazawa Y,Kojima T,Fujiu K,Semba H,Yamashita H,Hirata Y,Fukayama M,Nagai R

    更新日期:2012-01-01 00:00:00

  • High mobility group box 1 levels in on and off-pump cardiac surgery patients.

    abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.170

    authors: Haque A,Kunimoto F,Narahara H,Okawa M,Hinohara H,Kurabayashi M,Saito S

    更新日期:2011-01-01 00:00:00

  • Comparison of utility of arterial stiffness parameters for predicting cardiovascular events in the general population.

    abstract::Several recent studies have suggested that arterial stiffness parameters such as peripheral pulse pressure (PPP), central blood pressure (CBP), and pulse wave velocity (PWV) are more accurate markers than brachial blood pressure for prediction of cardiovascular (CV) events. However, it remains unknown which arterial s...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.54.160

    authors: Ishisone T,Koeda Y,Tanaka F,Sato K,Nagano M,Nakamura M

    更新日期:2013-01-01 00:00:00

  • A critical increase in right-to-left shunt after acute myocardial infarction in a 68-year-old male with tetralogy of Fallot.

    abstract::A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.167

    authors: Izawa A,Sekimura N,Uchikawa S,Yazaki Y,Kinoshita O,Owa M,Kubo K,Ikeda U,Sekiguchi M,Kitahara H,Amano J,Imamura H

    更新日期:2005-01-01 00:00:00

  • Elevation of Derivatives of Reactive Oxygen Metabolites Elevated in Young "Disaster Responders" in Hypertension due to Great East Japan Earthquake.

    abstract::There have been very few studies on serum biomarkers associated with hypertension in disaster situations. We assessed biomarkers associated with disaster-related hypertension (DRH) due to the Great East Japan Earthquake of March 2011.We collected blood samples from members of the Japan Self Defense Forces (JSDF) (n = ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-303

    authors: Shiraishi Y,Kujiraoka T,Hakuno D,Masaki N,Tokuno S,Adachi T

    更新日期:2016-01-01 00:00:00

  • Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction.

    abstract::In this study we aimed to investigate whether there is an association between the neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) in patients with non-ST segment elevation myocardial infarction (NSTEMI) using the SYNTAX score (SXscore). A total of 414 patients with NSTEMI who underwe...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-175

    authors: Kurtul S,Sarli B,Baktir AO,Demirbas M,Saglam H,Doğan Y,Sahin O,Akpek M,Odabas H,Arinc H,Kaya MG

    更新日期:2015-01-01 00:00:00

  • Use of a novel irrigated balloon catheter to generate continuous right atrial lesions by radiofrequency ablation.

    abstract::Ablation catheters with multiple electrodes are effective for the creation of linear atrial lesions but are associated with an increased risk of coagulum formation. In an animal study, we used a novel 9Fr deflectable ablation catheter with two saline/foam electrode pocket covered with 20 mm tubing. Each pocket contain...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.50.365

    authors: Watanabe I,Min N,Okumura Y,Kofune M,Ashino S,Ohkubo K,Nakai T,Kunimoto S,Kasamaki Y,Hirayama A

    更新日期:2009-05-01 00:00:00

  • Native Myocardial T1 Mapping, Are We There Yet?

    abstract::T1 or longitudinal relaxation time is one of the very fundamental magnetic resonance imaging (MRI) time constants and a tissue characterizing parameter. Only during the last decade did it become possible to quantify T1 values of the myocardium through T1 mapping. Evolving from only region of interest analysis and long...

    journal_title:International heart journal

    pub_type: 杂志文章,评审

    doi:10.1536/ihj.16-169

    authors: Hamdy A,Kitagawa K,Ishida M,Sakuma H

    更新日期:2016-07-27 00:00:00

  • Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.

    abstract::It has been reported that K-ATP channel openers have a cardioprotective effect in acute ischemia as a pharmacological preconditioning effect. In the present study, the chronic effects of clinical K-ATP channel openers, ie, nicorandil (Nic) and mexiletine (Mex), on cardiac function were evaluated in a rat model of expe...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.139

    authors: Niwano S,Hirasawa S,Niwano H,Sasaki S,Masuda R,Sato K,Masuda T,Izumi T

    更新日期:2012-01-01 00:00:00

  • Cell Cycle Perturbation Induces Collagen Production in Fibroblasts.

    abstract::Myocardial infarction (MI) occurs when the heart muscle is severely damaged due to a decrease in blood flow from the coronary arteries. During recovery from an MI, cardiac fibroblasts become activated and produce extracellular matrices, contributing to the wound healing process in the damaged heart. Inappropriate acti...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-710

    authors: Wake M,Takeda N,Isagawa T,Sato T,Nakagama Y,Morioka MS,Hirota Y,Asagiri M,Maemura K,Manabe I,Tanabe K,Komuro I

    更新日期:2019-07-27 00:00:00

  • Hypertrophic cardiomyopathy due to the mitochondrial DNA mutation m.3303C>T diagnosed in an adult male.

    abstract::Mitochondrial disorders comprise a heterogeneous group of diseases with multisystem involvement including myocardium. Most cases of mitochondrial cardiomyopathy are associated with myopathy and encephalopathy and are generally present in infancy or childhood. The disease often exhibits a rapid downward course with dea...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.383

    authors: Palecek T,Tesarova M,Kuchynka P,Dytrych V,Elleder M,Hulkova H,Hansikova H,Honzik T,Zeman J,Linhart A

    更新日期:2012-01-01 00:00:00

  • Radiofrequency catheter ablation of ventricular tachycardia originating in the left posterior and left anterior fascicles in a patient with prior myocardial infarction.

    abstract::A 61-year-old man with prior anteroseptal myocardial infarction (ejection fraction: 40%) presented with recurrent episodes of palpitations. Twelve-lead ECG during palpitations showed an incessant ventricular tachycardia (VT1) with right bundle branch block (RBBB) morphology and inferior axis. Electrophysiologic study ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.49.119

    authors: Ashino S,Watanabe I,Kofune M,Okumura Y,Kawauchi K,Yamada T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Saito S,Hirayama A

    更新日期:2008-01-01 00:00:00

  • Coronary artery fistula from the left circumflex to the coronary sinus.

    abstract::A 27-year-old woman, who had received mitral valve repair for mitral regurgitation resulting from infective endocarditis, was admitted for a close examination of abnormal echocardiographic findings in the left atrium. Transthoracic echocardiography showed trivial mitral regurgitation with normal left ventricular contr...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.47.147

    authors: Aoyagi S,Fukunaga S,Ishihara K,Egawa N,Hosokawa Y,Nakamura E

    更新日期:2006-01-01 00:00:00

  • Relation of Systolic Blood Pressure on the Following Day with Post-Discharge Mortality in Hospitalized Heart Failure Patients with Preserved Ejection Fraction.

    abstract::The clinical scenario, which is based on systolic blood pressure (SBP) upon admission, is useful for classifying and determining initial treatment for acute heart failure (HF). However, the prognostic significance of SBP following the initial treatment is unclear.The Japanese Heart Failure Syndrome with Preserved Ejec...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.18-699

    authors: Sato Y,Yoshihisa A,Oikawa M,Nagai T,Yoshikawa T,Saito Y,Yamamoto K,Takeishi Y,Anzai T

    更新日期:2019-07-27 00:00:00

  • Cardiac output response to exercise in chronic cardiac failure patients.

    abstract::The purpose of this study was to investigate the precise pattern of stroke volume (SV) response during exercise in patients with chronic heart failure (CHF) compared with age-matched controls. Fourteen patients with CHF and 7 controls performed symptom-limited bicycle exercise testing with respiratory gas exchange mea...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.293

    authors: Fukuda T,Matsumoto A,Kurano M,Takano H,Iida H,Morita T,Yamashita H,Hirata Y,Nagai R,Nakajima T

    更新日期:2012-01-01 00:00:00

  • The evaluation of left ventricular systolic and diastolic functions in patients with Friedreich ataxia. A pulse tissue Doppler study.

    abstract::Friedreich's ataxia (FRDA), the most common subtype of early onset hereditary ataxia, is an autosomal recessive neurodegenerative disorder caused by unstable GAA expansions. Two-dimensional, pulse, and pulse tissue Doppler echocardiographic examinations were performed on 21 patients with GAA expansion. There was no as...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.443

    authors: Koc F,Akpinar O,Yerdelen D,Demir M,Sarica Y,Kanadasi M

    更新日期:2005-05-01 00:00:00

  • Prevalence and prognosis of patients with heart failure in Tokyo: a prospective cohort of Shinken Database 2004-5.

    abstract::Prognosis of patients with heart failure (HF) remains unclear in Japan and should be determined in a prospective fashion. A prospective cohort of The Shinken Database comprised details on all of the new patients, including both inpatients and outpatients, who visited The Cardiovascular Institute Hospital in 2004-2005....

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.50.609

    authors: Goda A,Yamashita T,Suzuki S,Ohtsuka T,Uejima T,Oikawa Y,Yajima J,Koike A,Nagashima K,Kirigaya H,Sagara K,Ogasawara K,Isobe M,Sawada H,Aizawa T

    更新日期:2009-09-01 00:00:00

  • Effect of early versus late in-hospital initiation of statin therapy on the clinical outcomes of patients with acute coronary syndrome.

    abstract::Statins provide effective secondary prevention of cardiovascular events after acute coronary syndrome (ACS). Current guidelines recommend that statins be initiated in ACS patients before hospital discharge. In this retrospective study, we investigated the influence of early compared with late in-hospital initiation of...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.677

    authors: Li YH,Wu HL,Yang YH,Tsai HS,Chao TH

    更新日期:2007-11-01 00:00:00

  • Elevated Heart Rate in Combination with Elevated Blood Pressure Predicts Lower Cardiovascular Mortality in Acute Decompensated Heart Failure.

    abstract::Despite its clinical relevance, a subclass of acute decompensated heart failure (ADHF) with elevated blood pressure, known as hypertensive ADHF (HT-ADHF), has been less intensively evaluated. This study aimed to characterize the prognostic nature and pathophysiology of HT-ADHF. A total of 509 consecutive patients with...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-521

    authors: Hiki M,Iwata H,Takasu K,Nojiri S,Ishikawa G,Chikata Y,C Mattson P,Kasai T,Miyazaki T,Inoue K,Fujiwara Y,Sumiyoshi M,Kinugawa K,Daida H

    更新日期:2020-03-28 00:00:00

  • Platelet Glycoprotein IIb/IIIa Inhibitor Tirofiban Ameliorates Cardiac Reperfusion Injury.

    abstract::There are many published articles on the effects of the antithrombolytic function of platelet glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa inhibitors) in myocardial infarction. However, few studies have explored the effects and optimal concentration of tirofibans in diminishing the extent of myocardial reperfusion in...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-322

    authors: Chang ST,Chung CM,Chu CM,Yang TY,Pan KL,Hsu JT,Hsiao JF

    更新日期:2015-05-13 00:00:00

  • Impact of Double Loading Regimen of Clopidogrel on Final Angiographic Results, Incidence of Upper Gastrointestinal Bleeding and Clinical Outcomes in Patients with STEMI Undergoing Primary Coronary Intervention.

    abstract::This study tested the therapeutic impact of double-loading dose (i.e., 600 mg) versus standard-loading dose (i.e., 300 mg) of clopidogrel on ST-segment-elevation-myocardial-infarction (STEMI) patients undergoing primary-coronary-intervention (PCI).Between January 2005 and December 2013, a total of 1461 STEMI patients ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-325

    authors: Tong MS,Sung PH,Liu CF,Chen KH,Chung SY,Chua S,Chen CJ,Lee WC,Chai HT,Yip HK,Chang HW

    更新日期:2017-10-21 00:00:00

  • Reduced adiponectin level is associated with severity of coronary artery disease.

    abstract::Adipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.149

    authors: Hara K,Yamauchi T,Imai Y,Manabe I,Nagai R,Kadowaki T

    更新日期:2007-03-01 00:00:00

  • Acute effect of sildenafil is maintained in pulmonary arterial hypertension patients chronically treated with bosentan.

    abstract::The chronic use of bosentan has been reported to reduce the plasma concentration of sildenafil. However, it remains unclear how sildenafil exerts the effect at reduced concentrations in pulmonary arterial hypertension (PAH) patients chronically treated with bosentan.We examined the hemodynamic effects of sildenafil (5...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.52.233

    authors: Hatano M,Yao A,Kinugawa K,Hirata Y,Nagai R

    更新日期:2011-01-01 00:00:00

  • First Pediatric Case of Infective Endocarditis Caused by Serratia Liquefaciens.

    abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-595

    authors: Momose T,Masutani S,Oshima A,Kawasaki H,Tanaka R,Iwamoto Y,Ishido H,Senzaki H

    更新日期:2018-11-28 00:00:00

  • Prostaglandin F2alpha inhibits SERCA2 gene transcription through an induction of Egr-1 in cultured neonatal rat cardiac myocytes.

    abstract::Prostaglandin F(2alpha) (PGF(2alpha)) stimulates hypertrophic growth of neonatal rat cardiac myocytes, a feature of which includes downregulation of the Ca(2+)-ATPase (SERCA2), a major Ca(2+) transport protein in SR. The molecular mechanisms by which PGF(2alpha) inhibits SERCA2 gene expression remain unknown. We deter...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.49.329

    authors: Hara S,Arai M,Tomaru K,Doi H,Koitabashi N,Iso T,Watanabe A,Tanaka T,Maeno T,Suga T,Yokoyama T,Kurabayashi M

    更新日期:2008-05-01 00:00:00

  • Initial and Secondary ST-T Alternans During Acute Myocardial Ischemia in the In-Situ Pig Heart.

    abstract::The factors responsible for the ST-T wave alternans (STTA) and associated arrhythmias during acute ischemia have not been clarified.In acutely ischemic porcine myocardium, we recorded transmural unipolar and bipolar electrocardiograms and mid-myocardial extracellular K(+) ([K(+)]e) from the center of the ischemic zone...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-337

    authors: Watanabe I,Gettes LS

    更新日期:2016-05-25 00:00:00

  • Effect of balance training on walking speed and cardiac events in elderly patients with ischemic heart disease.

    abstract::The purpose of this study was to clarify the effect of standing balance training on walking speed (short-term outcome) and cardiac events (long-term outcome) in elderly ischemic heart disease (IHD) patients. This was a retrospective cohort study. Ninety-two elderly (≥ 65 years) IHD patients who underwent an inpatient ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-017

    authors: Yamamoto S,Matsunaga A,Wang G,Hoshi K,Kamiya K,Noda C,Kimura M,Yamaoka-Tojo M,Masuda T

    更新日期:2014-01-01 00:00:00

  • The Role of Serum Tenascin-C in Predicting In-Hospital Death in Acute Aortic Dissection.

    abstract::Tenascin-C (TNC) is involved in aortic disease pathophysiology. This study aims to evaluate TNC's value for predicting in-hospital death in acute aortic dissection (AD).We prospectively enrolled consecutive patients with suspected acute AD within 48 hours from symptom onset. Serum TNC and C-reactive protein (CRP) leve...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-462

    authors: Guo T,Zhou X,Zhu A,Peng W,Zhong Y,Chai X

    更新日期:2019-07-27 00:00:00

  • Prolonged Inflation Technique Using a Scoring Balloon for Severe Calcified Lesion.

    abstract::Percutaneous coronary intervention for the treatment of a severe calcified lesion is still one of the most technically challenging areas of interventional cardiology. Calcified lesions are a cause of stent underexpansion, which significantly increases the subsequent risks of in-stent restenosis and thrombosis, even wh...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-605

    authors: Otsuka Y,Koyama T,Imoto Y,Katsuki Y,Kawahara M,Nakamura K,Kodama S,Noguchi H,Iwasaki K

    更新日期:2017-12-12 00:00:00