Cardiac output response to exercise in chronic cardiac failure patients.

Abstract:

:The purpose of this study was to investigate the precise pattern of stroke volume (SV) response during exercise in patients with chronic heart failure (CHF) compared with age-matched controls. Fourteen patients with CHF and 7 controls performed symptom-limited bicycle exercise testing with respiratory gas exchange measurement. Patients were classified into group A (n = 7) with peak VO2 ≥ 18.0 mL/kg/minute and group B (n = 7) with peak VO2 < 18.0 mL/kg/ minute. SV and cardiac output (CO) were continuously measured during exercise using a novel thoracic impedance method (Physioflow). CO and SV were lower in the group B patients than those in controls at peak exercise [CO: 11.3 ± 1.0 (SE) versus 15.6 ± 0.9 L/minute, P < 0.05, SV: 89 ± 6 versus 110 ± 6 mL, P < 0.05]. SV reached its peak levels during submaximal exercise and remained close to the peak value until peak exercise in 6 of 7 group B patients (86%). On the other hand, it progressively increased until peak exercise in 6 of 7 controls (86%) and 5 of 7 group A patients (71%). In all subjects, CO at peak exercise was more closely correlated with SV at peak exercise (r = 0.86, P < 0.001) than with peak heart rate (r = 0.69, P < 0.001). CHF patients with impaired exercise capacity had attenuated increment of CO during exercise, and SV reached its peak levels during submaximal exercise.

journal_name

Int Heart J

authors

Fukuda T,Matsumoto A,Kurano M,Takano H,Iida H,Morita T,Yamashita H,Hirata Y,Nagai R,Nakajima T

doi

10.1536/ihj.53.293

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

293-8

issue

5

eissn

1349-2365

issn

1349-3299

pii

DN/JST.JSTAGE/ihj/53.293

journal_volume

53

pub_type

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