Abstract:
:In this study we aimed to investigate whether there is an association between the neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) in patients with non-ST segment elevation myocardial infarction (NSTEMI) using the SYNTAX score (SXscore). A total of 414 patients with NSTEMI who underwent coronary angiography were enrolled in the study. NLR was measured for all patients at presentation. The study population was then divided into 3 tertiles based on the SYNTAX trial results.(1)) The low syntax group (n = 329) was defined as those with an SXscore ≤ 22, the intermediate syntax group (n = 58) was defined as an SXscore ≥ 23 and < 33, and the high syntax group (n = 27) as those with an SXscore ≥ 33. NLR was significantly lower in patients with a low SXscore compared to patients with an intermediate SXscore or high SXscore (3.7 ± 4 to 4.6 ± 2 and 7.9 ± 4, P < 0.001). Linear regression analysis revealed that NLR (coefficientβ = 0.380, 95%CI: 1.165-1.917, P < 0.001) was significantly associated with the SXscore in patients with NSTEMI. Our results indicate that NLR is independently associated with the severity of CAD in patients with NSTEMI.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Kurtul S,Sarli B,Baktir AO,Demirbas M,Saglam H,Doğan Y,Sahin O,Akpek M,Odabas H,Arinc H,Kaya MGdoi
10.1536/ihj.14-175subject
Has Abstractpub_date
2015-01-01 00:00:00pages
18-21issue
1eissn
1349-2365issn
1349-3299journal_volume
56pub_type
杂志文章abstract::Cardiac output (CO) is often desirable for assessing the hemodynamic condition of a patient, especially in critically ill cardiac patients. Various noninvasive methods are available for this purpose. Inert gas rebreathing (IGR) and 2D-Doppler echocardiography methods have been validated. Based on the relationship betw...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.395
更新日期:2013-01-01 00:00:00
abstract::To assess the potential advantages of minimally invasive surgery using a single femoral venous drainage method versus femoral venous and superior vena cava or jugular venous drainage method during repeat tricuspid valve surgery.From January 2010 to December 2016, 50 repeat tricuspid valve procedures were performed usi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-169
更新日期:2018-05-30 00:00:00
abstract::There are many published articles on the effects of the antithrombolytic function of platelet glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa inhibitors) in myocardial infarction. However, few studies have explored the effects and optimal concentration of tirofibans in diminishing the extent of myocardial reperfusion in...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-322
更新日期:2015-05-13 00:00:00
abstract::Comparison of the prognostic value of red cell distribution width (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP) for short-term clinical outcomes in acute heart failure (AHF) patients has not been fully investigated.A total of 128 patients with AHF were enrolled and followed for 3 months. Primary endp...
journal_title:International heart journal
pub_type: 临床试验,杂志文章
doi:10.1536/ihj.13-172
更新日期:2014-01-01 00:00:00
abstract::An aorto-cutaneous fistula is a rare complication that occurs after aortic surgery. Due to its rarity, postoperative complications are not normally highlighted in most standard teaching. We report here a case of aorto-cutaneous fistula after surgical treatment of a Stanford type A aortic dissection (AD) in a 67-year-o...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-109
更新日期:2018-01-27 00:00:00
abstract::Sarcoidosis is a systemic granulomatous disorder whose prognosis worsens when the heart is involved, and early diagnosis is important. Endomyocardial biopsy is the most helpful diagnostic examination, but suffers from low sensitivity and low specificity. Microvolt T wave alternans (MVTWA) is utilized in noninvasive ex...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.731
更新日期:2009-11-01 00:00:00
abstract::HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.1
更新日期:2011-01-01 00:00:00
abstract::Changes of global and segmental ventricular strain at different deterioration levels of cardiac function in patients with dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) have not yet been explored. In total, 101 patients diagnosed with DCM consecutively underwent CMR. They were categorized accordin...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-558
更新日期:2018-11-28 00:00:00
abstract::Mitochondrial disorders comprise a heterogeneous group of diseases with multisystem involvement including myocardium. Most cases of mitochondrial cardiomyopathy are associated with myopathy and encephalopathy and are generally present in infancy or childhood. The disease often exhibits a rapid downward course with dea...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.383
更新日期:2012-01-01 00:00:00
abstract::Our previous study showed that pravastatin prevents ischemia and reperfusion-induced lethal ventricular fibrillation in rats. This study explored whether pravastatin decreases myocardial infarct size and this effect is associated with endothelial nitric oxide synthase (eNOS) expression in myocardium. Rats were treated...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-607
更新日期:2018-01-01 00:00:00
abstract::The efficacy of heart failure (HF) management programs is compromised by the challenge of early identification of patients at imminent risk. Segmental multifrequency bioelectrical impedance analysis can generate an "edema index" (EI) as a surrogate for the body fluid status. In this study, we tested whether integratio...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.53.11
更新日期:2012-01-01 00:00:00
abstract::Although pressure-overload right ventricular hypertrophy is a long-term risk in some congenital heart diseases such as tetralogy of Fallot, how it develops is unclear. The aim of this study was to investigate the mechanism of development of this right ventricular heart failure.Pulmonary artery banding in 10-day-old ra...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.56
更新日期:2011-01-01 00:00:00
abstract::This study aimed to evaluate whether the heart is the target organ of endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with heart failure (HF) with reduced ejection fraction (HFrEF).We measured the plasma levels of cyclic guanosine monophosphate (cGMP), which is a second mess...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-379
更新日期:2020-01-31 00:00:00
abstract::Changes in the expression levels of several genes have been described in aortic aneurysm specimens, however, the spectrum of diverse molecular alterations remains to be elucidated. We attempted to identify key molecules that modulate the pathogenesis of aortic aneurysm, using a complimentary DNA microarray carrying ap...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.265
更新日期:2005-03-01 00:00:00
abstract::An increase of pulmonary artery pressure in patients with pulmonary hypertension (PH) results in right ventricular failure and ultimately death. High-mobility group box 1 (HMGB1), a nuclear protein, acts as a pro-inflammatory cytokine by activating receptor for advanced glycation end-products (RAGE) in the extracellul...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-188
更新日期:2016-01-01 00:00:00
abstract::Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catech...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.95
更新日期:2009-01-01 00:00:00
abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-190
更新日期:2017-04-06 00:00:00
abstract::A 68-year-old female with acute coronary syndrome was transferred to our hospital. Emergency coronary angiography showed 90% stenosis with severe calcification in the proximal right coronary artery (RCA). Intravascular ultrasound (IVUS) images were obtained and showed circumferential heavy calcification without any ev...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-136
更新日期:2017-02-07 00:00:00
abstract::Flexible, in vivo maneuverable electrophysiology mapping techniques are not available in rat models. A novel cardiac stereotactic electrophysiology epicardial mapping system (CREAMS) allows for various measurements, including: (1) recording unipolar electrograms at multiple sites; (2) positioning of mapped sites and p...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-215
更新日期:2019-03-20 00:00:00
abstract::Apelin was proved to attenuate cardiac interstitial fibrosis. However, the association between apelin level and myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) is still unclear.This study aims to determine whether apelin is associated with myocardial fibrosis in HCM and investigate the predictiv...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-598
更新日期:2019-05-30 00:00:00
abstract::Several studies have reported that the left ventricular (LV) lead implant success rate ranges between 88.0% and 92.4%. Coronary venous anatomy differs among patients thus, necessitating multiple types of leads. To date, the implant success rate among Japanese patients utilizing a pre-specified family LV leads (includi...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1536/ihj.17-442
更新日期:2018-09-26 00:00:00
abstract::Tolvaptan is a highly selective and orally effective arginine vasopressin V2 receptor antagonist, and is potentially useful for the treatment of heart failure (HF) patients. However, the renoprotective effect of long-term tolvaptan therapy and its underlying mechanisms remain unknown. We evaluated the effects of chron...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.98
更新日期:2013-01-01 00:00:00
abstract::This study aimed to evaluate the clinical characteristics and surgical treatment of bicuspid aortic valve (BAV) infective endocarditis (IE) compared with tricuspid aortic valve (TAV) IE in China.The relevant pre-, intra- and post-operative materials of all IE patients undergoing cardiac surgery in our center between J...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-284
更新日期:2017-04-06 00:00:00
abstract::A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study....
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-154
更新日期:2018-07-31 00:00:00
abstract::A new controlled-release isosorbide-5-mononitrate (CR-ISMN) preparation has been developed to meet the requirement for a low nitrate concentration interval in order to avoid nitrate tolerance. We conducted a randomized, double-blind, placebo-controlled study in 31 Japanese patients with stable effort angina pectoris t...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.47.695
更新日期:2006-09-01 00:00:00
abstract::The usefulness of coronary magnetic resonance angiography (cMRA) has been reported, although the difference in the diagnostic accuracy of different protocols has not been established.We compared conventional coronary angiography (CAG) and cMRA, conducted within 6 months in 24 consecutive patients between September 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-436
更新日期:2016-09-28 00:00:00
abstract::Medical treatment for asymptomatic carotid artery stenosis (ACAS) has advanced recently. The outcomes of medical treatment and surgical treatment were evaluated to clarify the optimal treatment for ACAS.Patients with ACAS of ≥ 50% luminal narrowing underwent serial follow-up carotid artery ultrasonography for one year...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.15-196
更新日期:2016-01-01 00:00:00
abstract::There is little data on management and outcomes of atrial fibrillation (AF) patients on direct oral anticoagulants (DOAC) undergoing general surgery.We retrospectively assessed 98 surgeries in 85 nonvalvular AF patients aged 73 ± 8 (59 men) receiving DOACs. Cardiac, emergency, and minimally invasive surgeries were exc...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-625
更新日期:2020-09-29 00:00:00
abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-700
更新日期:2019-01-25 00:00:00
abstract::The progression of heart failure with reduced ejection fraction is promoted by sympathovagal imbalance. Baroreflex activation therapy (BAT) by the electrical stimulation of baroreceptors at the carotid sinus significantly improved exercise capacity and NT-proBNP levels in a randomized trial; however, no significant di...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-400
更新日期:2017-12-12 00:00:00