Abstract:
:A new controlled-release isosorbide-5-mononitrate (CR-ISMN) preparation has been developed to meet the requirement for a low nitrate concentration interval in order to avoid nitrate tolerance. We conducted a randomized, double-blind, placebo-controlled study in 31 Japanese patients with stable effort angina pectoris to investigate the efficacy and safety of CR-ISMN. Patients were randomly assigned to either CR-ISMN (40 mg once daily) or placebo groups for 2 weeks after two consecutive symptom-limited treadmill exercise tests using the Bruce protocol to ascertain the reproducibility of exercise tolerance during the placebo run-in period. Exercise tests were repeated at 5, 12, and 24 hours after administration on the final day. No significant difference in exercise time to moderate angina was identified between the CR-ISMN and placebo groups at 5, 12, or 24 hours after administration. However, the changes in exercise were prolonged at 5 hours but not shortened at 24 hours in the CR-ISMN group. The results of subgroup analysis suggested that the concomitant use of insulin might lead to confounding results. Although headache was the most frequent adverse effect in the CR-ISMN group, all symptoms were mild and at self-limiting levels. The plasma concentrations of CR-ISMN maintained therapeutic levels at 5 and 12 hours, and gradually decreased to less than the minimum therapeutic concentration (100 ng/mL) at 24 hours after administration. This study demonstrates that CR-ISMN improves exercise tolerance during the daytime and is well-tolerated in Japanese patients with stable effort angina pectoris without increasing the number of serious adverse effects.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Shimada K,Sunayama S,Nakazato K,Satoh H,Kusama Y,Kawakubo K,Daida Hdoi
10.1536/ihj.47.695subject
Has Abstractpub_date
2006-09-01 00:00:00pages
695-705issue
5eissn
1349-2365issn
1349-3299pii
JST.JSTAGE/ihj/47.695journal_volume
47pub_type
杂志文章,随机对照试验abstract::Ablation catheters with multiple electrodes are effective for the creation of linear atrial lesions but are associated with an increased risk of coagulum formation. In an animal study, we used a novel 9Fr deflectable ablation catheter with two saline/foam electrode pocket covered with 20 mm tubing. Each pocket contain...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.365
更新日期:2009-05-01 00:00:00
abstract::Low-density lipoprotein (LDL) particles are known to be atherogenic agents in coronary artery diseases. They adjust to other electronegative forms and can be the subject for the enhancement of inflammatory events in vessel subendothelial spaces. The LDL uptake is related to the membrane scavenger receptors, including ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-043
更新日期:2020-01-01 00:00:00
abstract::There have been very few studies on serum biomarkers associated with hypertension in disaster situations. We assessed biomarkers associated with disaster-related hypertension (DRH) due to the Great East Japan Earthquake of March 2011.We collected blood samples from members of the Japan Self Defense Forces (JSDF) (n = ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-303
更新日期:2016-01-01 00:00:00
abstract::The usefulness of coronary magnetic resonance angiography (cMRA) has been reported, although the difference in the diagnostic accuracy of different protocols has not been established.We compared conventional coronary angiography (CAG) and cMRA, conducted within 6 months in 24 consecutive patients between September 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-436
更新日期:2016-09-28 00:00:00
abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.16-313
更新日期:2017-08-03 00:00:00
abstract::A 61-year-old man with prior anteroseptal myocardial infarction (ejection fraction: 40%) presented with recurrent episodes of palpitations. Twelve-lead ECG during palpitations showed an incessant ventricular tachycardia (VT1) with right bundle branch block (RBBB) morphology and inferior axis. Electrophysiologic study ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.49.119
更新日期:2008-01-01 00:00:00
abstract::Activation of mineralocorticoid receptor (MR) is shown in resistant hypertension including diabetes mellitus. Although protein kinase C (PKC) signaling is involved in the pathogenesis of diabetic complications, an association between PKC and MR is not known. Activation of PKCα and PKCβ by TPA (12-O-Tetradecanoylphorbo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-649
更新日期:2017-10-21 00:00:00
abstract::Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) co...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-083
更新日期:2017-04-06 00:00:00
abstract::Cognitive behavioral therapy has emerged as an important approach to alleviate the depression of patients with heart failure. However, the use of cognitive behavioral therapy for heart failure has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of cognitive behavior...
journal_title:International heart journal
pub_type: 杂志文章,meta分析
doi:10.1536/ihj.18-408
更新日期:2019-05-30 00:00:00
abstract::Worsening of mitral regurgitation (MR) is sometimes observed after closure of an atrial septal defect (ASD). However, since the mechanism of this deterioration remains unclear, the aim of our study was to investigate the effect of left (LV) and right ventricular (RV) geometry on MR after transcatheter closure of ASD.W...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-073
更新日期:2015-01-01 00:00:00
abstract::As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-444
更新日期:2017-12-12 00:00:00
abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-190
更新日期:2017-04-06 00:00:00
abstract::Despite its clinical relevance, a subclass of acute decompensated heart failure (ADHF) with elevated blood pressure, known as hypertensive ADHF (HT-ADHF), has been less intensively evaluated. This study aimed to characterize the prognostic nature and pathophysiology of HT-ADHF. A total of 509 consecutive patients with...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-521
更新日期:2020-03-28 00:00:00
abstract::Same-day discharge transradial percutaneous coronary intervention (TRI) has been reported to be safe and feasible in Western countries. However, Asia has not produced any reports related to this matter. The present study explored the safety and feasibility of patients with indications for TR coronary angiography and a...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1536/ihj.51.371
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to examine the relation between adiponectin levels and subclinical carotid atherosclerosis in patients undergoing coronary artery bypass grafting (CABG). Serum concentrations of adiponectin and carotid intima/media thickness (IMT) were measured in 84 consecutive patients who underwent CAB...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.47.855
更新日期:2006-11-01 00:00:00
abstract::Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection,...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.199
更新日期:2012-01-01 00:00:00
abstract::In patients requiring an implantable cardioverter defibrillator (ICD), the combined use of a prior pacemaker and a subcutaneous ICD (S-ICD) could be an alternative treatment option to implantation of new leads or upgrading of pacemakers to an ICD if vascular access is limited. Here, we assessed the prevalence of S-ICD...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-550
更新日期:2018-09-26 00:00:00
abstract::Fungal endocarditis (FE) is a rare and fatal disease. The contemporary in-hospital and long-term surgical outcomes of FE have not been adequately evaluated. This study describes our experience with the surgical management of FE.Eight FE patients who underwent surgery in our center from January 2004 to November 2016 we...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-049
更新日期:2017-08-03 00:00:00
abstract::The aim of this meta-analysis was to compare the clinical outcomes in patients who underwent rapid deployment aortic valve replacement (RDAVR) and conventional bio prosthetic aortic valve replacement (CAVR).We performed a literature search by August 2018. The primary outcomes were hospital and 1-year mortality, and th...
journal_title:International heart journal
pub_type: 杂志文章,meta分析
doi:10.1536/ihj.19-717
更新日期:2020-09-29 00:00:00
abstract::The aim of the present study was to determine whether symptoms of atrial fibrillation (AF) differ between patients with and without subsequent permanent AF. Sixty-four patients (68 +/- 10 years old, 45 males) were recruited. AF follow-up was started at the age of 61 +/- 10 years and accomplished in a median period of ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.242
更新日期:2010-07-01 00:00:00
abstract::Impaired oxygenation sometimes occurs in patients with acute aortic dissection, however, the mechanism has not been fully investigated. We hypothesized that impaired oxygenation is related to inflammation secondary due to aortic dissection. Patients with acute aortic dissection who had received 14 days of conservative...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.795
更新日期:2005-09-01 00:00:00
abstract::This study aimed to evaluate the clinical characteristics and surgical treatment of bicuspid aortic valve (BAV) infective endocarditis (IE) compared with tricuspid aortic valve (TAV) IE in China.The relevant pre-, intra- and post-operative materials of all IE patients undergoing cardiac surgery in our center between J...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-284
更新日期:2017-04-06 00:00:00
abstract::The clinical scenario, which is based on systolic blood pressure (SBP) upon admission, is useful for classifying and determining initial treatment for acute heart failure (HF). However, the prognostic significance of SBP following the initial treatment is unclear.The Japanese Heart Failure Syndrome with Preserved Ejec...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.18-699
更新日期:2019-07-27 00:00:00
abstract::Intraaortic balloon pumping (IABP) is a useful therapy for refractory heart failure. However, the safe duration of this therapy and possible complications due to long-term IABP support remain unclear. In this study, we reviewed retrospectively patients requiring the long-term use of IABP, defined here as 10 days or mo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.1041
更新日期:2005-11-01 00:00:00
abstract::Vagus nerve stimulation (VNS), targeting the imbalanced autonomic nervous system, is a promising therapeutic approach for chronic heart failure (HF). Moreover, calcium cycling is an important part of cardiac excitation-contraction coupling (ECC), which also participates in the antiarrhythmic effects of VNS. We hypothe...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-516
更新日期:2016-05-25 00:00:00
abstract::The chronic use of bosentan has been reported to reduce the plasma concentration of sildenafil. However, it remains unclear how sildenafil exerts the effect at reduced concentrations in pulmonary arterial hypertension (PAH) patients chronically treated with bosentan.We examined the hemodynamic effects of sildenafil (5...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.52.233
更新日期:2011-01-01 00:00:00
abstract::Although pressure-overload right ventricular hypertrophy is a long-term risk in some congenital heart diseases such as tetralogy of Fallot, how it develops is unclear. The aim of this study was to investigate the mechanism of development of this right ventricular heart failure.Pulmonary artery banding in 10-day-old ra...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.56
更新日期:2011-01-01 00:00:00
abstract::The 5-hydroxytryptamine2A receptor antagonist sarpogrelate hydrochloride exerts its effect not only by inhibition of platelet aggregation, but also by some pleiotropic effects. We have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-377
更新日期:2014-01-01 00:00:00
abstract::We report the case of a 79-year-old man with acute myocardial infarction caused by left main trunk lesion, who experienced cardiogenic shock during percutaneous coronary intervention (PCI). To reverse the cardiogenic shock, we initiated veno-arterial extra corporeal membrane oxygenation (VA-ECMO) without an intra-aort...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-643
更新日期:2019-09-27 00:00:00
abstract::Several studies have revealed that stress after catastrophic disasters can trigger cardiovascular events, however, little is known about its association with the occurrence of heart failure in past earthquakes. The objective of the present study was to determine whether the Great East Japan Earthquake on March 11, 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-215
更新日期:2014-01-01 00:00:00