Abstract:
:Vagus nerve stimulation (VNS), targeting the imbalanced autonomic nervous system, is a promising therapeutic approach for chronic heart failure (HF). Moreover, calcium cycling is an important part of cardiac excitation-contraction coupling (ECC), which also participates in the antiarrhythmic effects of VNS. We hypothesized that low-level VNS (LL-VNS) could improve cardiac function by regulation of intracellular calcium handling properties. The experimental HF model was established by ligation of the left anterior descending coronary artery (LAD). Thirty-two male Sprague-Dawley rats were divided into 3 groups as follows; control group (sham operated without coronary ligation, n = 10), HF-VNS group (HF rats with VNS, n = 12), and HF-SS group (HF rats with sham nerve stimulation, n = 10). After 8 weeks of treatment, LL-VNS significantly improved left ventricular ejection fraction (LVEF) and attenuated myocardial interstitial fibrosis in the HF-VNS group compared with the HF-SS group. Elevated plasma norepinephrine and dopamine, but not epinephrine, were partially reduced by LL-VNS. Additionally, LL-VNS restored the protein and mRNA levels of sarcoplasmic reticulum Ca(2+) ATPase (SERCA2a), Na(+)-Ca(2+) exchanger 1 (NCX1), and phospholamban (PLB) whereas the expression of ryanodine receptor 2 (RyR2) as well as mRNA level was unaffected. Thus, our study results suggest that the improvement of cardiac performance by LL-VNS is accompanied by the reversal of dysfunctional calcium handling properties including SERCA2a, NCX1, and PLB which may be a potential molecular mechanism of VNS for HF.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Zhang Y,Chen A,Song L,Li M,Luo Z,Zhang W,Chen Y,He Bdoi
10.1536/ihj.15-516subject
Has Abstractpub_date
2016-05-25 00:00:00pages
350-5issue
3eissn
1349-2365issn
1349-3299journal_volume
57pub_type
杂志文章abstract::Ventricular free wall rupture (FWR) is a catastrophic complication of that occurs after acute myocardial infarction (AMI), and at present, its clinical characteristics are unclear. We analyzed a total of 6,712 consecutive patients who presented with ST-segment elevation myocardial infarction (STEMI), and 78 patients w...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-541
更新日期:2020-07-30 00:00:00
abstract::Everolimus (EVL), one of the mammalian targets of rapamycin, is a next generation immunosuppressant that may have accessory anti-proliferative effects in heart transplant (HTx) recipients. However, little is known about the clinical relationship between EVL and regression of cardiac hypertrophy. A total of 42 HTx reci...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-320
更新日期:2016-01-01 00:00:00
abstract::The transradial approach for coronary diagnostic and therapeutic interventions is a well-established, safe, and effective technique that has shown a success rate comparable to that of the transfemoral approach for chronic total occlusion (CTO) with less access site complications. Recently, the transulnar approach was ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.137
更新日期:2010-03-01 00:00:00
abstract::An aorto-cutaneous fistula is a rare complication that occurs after aortic surgery. Due to its rarity, postoperative complications are not normally highlighted in most standard teaching. We report here a case of aorto-cutaneous fistula after surgical treatment of a Stanford type A aortic dissection (AD) in a 67-year-o...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-109
更新日期:2018-01-27 00:00:00
abstract::It is of concern that women are more likely to undergo fewer diagnostic tests and receive less treatment for acute myocardial infarction (AMI) than men. However, it is still unclear whether gender differences exist according to age groups. Therefore, we studied the influence of gender on the delivery of cardiac manage...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.939
更新日期:2005-11-01 00:00:00
abstract::Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) co...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-083
更新日期:2017-04-06 00:00:00
abstract::Activation of mineralocorticoid receptor (MR) is shown in resistant hypertension including diabetes mellitus. Although protein kinase C (PKC) signaling is involved in the pathogenesis of diabetic complications, an association between PKC and MR is not known. Activation of PKCα and PKCβ by TPA (12-O-Tetradecanoylphorbo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-649
更新日期:2017-10-21 00:00:00
abstract::A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.167
更新日期:2005-01-01 00:00:00
abstract::An error appeared in the article entitled "Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α" by Zongqiu Wang, Zhihua Zhang, Jing Zhao, Chunming Yong, and Yongjun Mao (Vol. 60, No. 4, 964-973, 2019).The second affiliation of the authors on ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.60-5_Erratum
更新日期:2019-01-01 00:00:00
abstract::Several studies have revealed that stress after catastrophic disasters can trigger cardiovascular events, however, little is known about its association with the occurrence of heart failure in past earthquakes. The objective of the present study was to determine whether the Great East Japan Earthquake on March 11, 201...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-215
更新日期:2014-01-01 00:00:00
abstract::Enlargement of the mitral valve (MV) has gained attention as a compensatory mechanism for functional mitral regurgitation (FMR). We aimed to determine if MV leaflet area is associated with MV coaptation-zone area and identify the clinical factors associated with MV leaflet size and coaptation-zone area in patients wit...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-148
更新日期:2021-01-16 00:00:00
abstract::A 68-year-old female with acute coronary syndrome was transferred to our hospital. Emergency coronary angiography showed 90% stenosis with severe calcification in the proximal right coronary artery (RCA). Intravascular ultrasound (IVUS) images were obtained and showed circumferential heavy calcification without any ev...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-136
更新日期:2017-02-07 00:00:00
abstract::Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have incre...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.41
更新日期:2010-01-01 00:00:00
abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-190
更新日期:2017-04-06 00:00:00
abstract::Intraaortic balloon pumping (IABP) is a useful therapy for refractory heart failure. However, the safe duration of this therapy and possible complications due to long-term IABP support remain unclear. In this study, we reviewed retrospectively patients requiring the long-term use of IABP, defined here as 10 days or mo...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.1041
更新日期:2005-11-01 00:00:00
abstract::Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.13-383
更新日期:2014-01-01 00:00:00
abstract::Mechanical stress by pressure overload due to hypertension or valvular heart disease such as aortic valve stenosis induces cardiac hypertrophy. It has been well established that the mechanical stretch of cardiac myocytes in vitro induces hypertrophic responses such as the expression of immediate early response genes i...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.359
更新日期:2007-05-01 00:00:00
abstract::Percutaneous coronary interventions to the proximal left anterior descending artery (pLAD)-acute myocardial infarction (AMI) are still challenging, especially in the ostial pLAD. Clinical outcomes of the ostial pLAD-AMI were not well investigated. The aim of the present study was to compare clinical outcomes of the os...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-067
更新日期:2019-01-25 00:00:00
abstract::Plaque erosion (PE) is a significant substrate of acute coronary thrombosis. An improved ability to distinguish plaque phenotype in vivo among patients with ST-segment elevation myocardial infarction (STEMI) is of considerable interest because of the potential to formulate tailored treatment. This study assessed the p...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-014
更新日期:2019-09-27 00:00:00
abstract::Exercise preconditioning may protect against cardiac injury induced by lipopolysaccharide (LPS), but the mechanism is unresolved. The aim of this study is to explore whether the general control nonderepressible 2 (GCN2) kinase gene is associated with the protective effect of exercise preconditioning. Eight-week-old ma...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-307
更新日期:2020-01-31 00:00:00
abstract::Adipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.149
更新日期:2007-03-01 00:00:00
abstract::High sensitive C-reactive protein (hs-CRP) levels are associated with short- and long-term mortality in patients with acute coronary syndrome (ACS). We investigated whether baseline hs-CRP levels are associated with burden of coronary atherosclerosis assessed by SYNTAX score (SXScore).We enrolled 321 patients with ACS...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-299
更新日期:2015-01-01 00:00:00
abstract::Since diabetes mellitus (DM) is the most common cause of heart failure (HF), it is critically important to clarify whether incretin hormones including glucagon-like peptide-1 (GLP-1), which play an important role in blood glucose control, mediate cardioprotection. There are many lines of basic research evidence indica...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.15-028
更新日期:2015-01-01 00:00:00
abstract::We report the case of a 79-year-old man with acute myocardial infarction caused by left main trunk lesion, who experienced cardiogenic shock during percutaneous coronary intervention (PCI). To reverse the cardiogenic shock, we initiated veno-arterial extra corporeal membrane oxygenation (VA-ECMO) without an intra-aort...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-643
更新日期:2019-09-27 00:00:00
abstract::Prognosis of patients with heart failure (HF) remains unclear in Japan and should be determined in a prospective fashion. A prospective cohort of The Shinken Database comprised details on all of the new patients, including both inpatients and outpatients, who visited The Cardiovascular Institute Hospital in 2004-2005....
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.609
更新日期:2009-09-01 00:00:00
abstract::Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-238
更新日期:2018-05-30 00:00:00
abstract::The efficacy of heart failure (HF) management programs is compromised by the challenge of early identification of patients at imminent risk. Segmental multifrequency bioelectrical impedance analysis can generate an "edema index" (EI) as a surrogate for the body fluid status. In this study, we tested whether integratio...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.53.11
更新日期:2012-01-01 00:00:00
abstract::Uninterrupted anticoagulation therapy during atrial fibrillation (AF) ablation minimizes the risk of periprocedural thromboembolic events. Although the use of direct oral anticoagulants (DOACs) has rapidly developed in patients undergoing AF ablation, no antidote is available for factor Xa inhibitors. We sought to inv...
journal_title:International heart journal
pub_type: 临床试验,杂志文章
doi:10.1536/ihj.19-143
更新日期:2019-11-30 00:00:00
abstract::We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2016.First PlaceDelivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial HypertensionSatoshi Akagi, Kazufumi Nakamura, Daiji Mi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.57-6_UEDA
更新日期:2016-01-01 00:00:00
abstract::Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, the effects of these drugs on the development of NOD in elderly Taiwanese hypertensive patients have not been well determined. We examined the association between antihypertensive drug therapy and the risk of NOD in a population-based study....
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.49.205
更新日期:2008-03-01 00:00:00