Abstract:
:Changes in the expression levels of several genes have been described in aortic aneurysm specimens, however, the spectrum of diverse molecular alterations remains to be elucidated. We attempted to identify key molecules that modulate the pathogenesis of aortic aneurysm, using a complimentary DNA microarray carrying approximately 13,000 human genes. Segments of thoracic aortic aneurysms (TAA) and adjacent normal thoracic aortic tissues without aneurysmal changes (NTA) were obtained from 20 patients undergoing graft surgery. RNA obtained from five pairs of TAA and NTA samples was compared to determine aneurysm-specific alterations using microarray. Further, the expression levels of several genes of interest were verified in the remaining specimens by real-time reverse transcription-polymerase chain reaction (RT-PCR). In microarray assays, several types of the matrix metalloproteinases were upregulated as reported previously. Also, 220 genes suggested to be involved in protein degradation, inflammation, apoptosis, stress response, intracellular signaling, and other processes were significantly upregulated. Many of these genes have not been previously implicated in cardiovascular disease. The real time RT-PCR independently confirmed that the expression levels of MMP-2, MMP-9, ADAMTS-1, and caspase 4 were consistently increased in TAA. The results indicate that many genes are involved in a complicated manner in the pathogenesis of TAA. Investigation of these genes will help clarify the pathogenesis of this disease, and may lead to the discovery of novel therapeutic targets.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Taketani T,Imai Y,Morota T,Maemura K,Morita H,Hayashi D,Yamazaki T,Nagai R,Takamoto Sdoi
10.1536/ihj.46.265subject
Has Abstractpub_date
2005-03-01 00:00:00pages
265-77issue
2eissn
1349-2365issn
1349-3299pii
JST.JSTAGE/ihj/46.265journal_volume
46pub_type
杂志文章abstract::Hypertrophic cardiomyopathy (HCM) has various morphological and clinical features. A decade has passed since the previous survey of the epidemiological and clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational study o...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.14-418
更新日期:2015-01-01 00:00:00
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journal_title:International heart journal
pub_type: 临床试验,杂志文章
doi:10.1536/ihj.48.69
更新日期:2007-01-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.795
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journal_title:International heart journal
pub_type: 杂志文章,meta分析
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.75
更新日期:2012-01-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-307
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abstract::Fungal endocarditis (FE) is a rare and fatal disease. The contemporary in-hospital and long-term surgical outcomes of FE have not been adequately evaluated. This study describes our experience with the surgical management of FE.Eight FE patients who underwent surgery in our center from January 2004 to November 2016 we...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-049
更新日期:2017-08-03 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2006-05-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.443
更新日期:2005-05-01 00:00:00
abstract::Coronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young ...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.47.343
更新日期:2006-05-01 00:00:00
abstract::Bleeding complications following percutaneous coronary interventions (PCI) have been closely associated with morbidity and mortality. Although radial arteries have been widely used in current PCI, including primary PCI, transfemoral PCI remains necessary for complex PCI. The purpose of this study was to compare the in...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-352
更新日期:2018-05-30 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-238
更新日期:2018-05-30 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-444
更新日期:2017-12-12 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-137
更新日期:2014-01-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-299
更新日期:2015-01-01 00:00:00
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journal_title:International heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1536/ihj.17-442
更新日期:2018-09-26 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.23
更新日期:2013-01-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.347
更新日期:2005-03-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.677
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journal_title:International heart journal
pub_type: 杂志文章
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journal_title:International heart journal
pub_type: 杂志文章
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.47.549
更新日期:2006-07-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2011-01-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章,评审
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更新日期:2016-07-27 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.47.795
更新日期:2006-09-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.13-357
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journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-436
更新日期:2016-09-28 00:00:00