Longitudinal age-related changes in 24-hour total heart beats and premature beats and their relationship in healthy elderly subjects.

Abstract:

:The aim of this study was to conduct a longitudinal follow-up on age-related changes in 24-hour total heart beats (THBs) and total premature beats and their correlations in healthy elderly subjects. In 15 healthy elderly subjects (mean age, 70.0 +/- 4.1, age range at 1st recording, 64 to 80 years, 10 females, 5 males), we conducted Holter monitoring twice at an interval of 15 years and analysed age-related changes in THBs, atrial premature beats (APBs), and ventricular premature beats (VPBs), as well as their correlations. The results indicated that THBs, APBs, and VPBs all significantly increased with age in the healthy elderly subjects at a mean age of 70.0 +/- 4.1 (THB: 91074.1 +/- 11515.3 versus 99457.5 +/- 12131.0; P = 0.0004, APB:119.2 +/- 97.8 versus 884.4 +/- 1193.8; P = 0.0008, VPB: 15.2 +/- 53.6 versus 140.7 +/- 228.9; P = 0.0328). Moreover, we divided the subjects into increase and nonincrease groups based on the age-related changes in APB and VPB for 15 years ([n]; Inc-APB: Noninc-APB = 6 : 9, Inc-VPB: Noninc-VPB = 5 : 10). In the increase groups, premature beats tended to increase in proportion to changes in THBs with age (APB: Y = 207.488 + 0.136 X, r = 0.848, P = 0.0303; VPB: Y = -27.594 + 0.028 X, r = 0.727, P = 0.1921). In conclusion, this 15-year follow-up of Holter recordings in healthy elderly subjects revealed that THBs, APBs, and VPBs increased with age, and that the increases in premature beats, especially APBs, were in proportion to those in THBs.

journal_name

Int Heart J

authors

Tasaki H,Serita T,Ueyama C,Kitano K,Seto S,Yano K,Camm AJ

doi

10.1536/ihj.47.549

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

549-63

issue

4

eissn

1349-2365

issn

1349-3299

pii

JST.JSTAGE/ihj/47.549

journal_volume

47

pub_type

杂志文章
  • Effect of early versus late in-hospital initiation of statin therapy on the clinical outcomes of patients with acute coronary syndrome.

    abstract::Statins provide effective secondary prevention of cardiovascular events after acute coronary syndrome (ACS). Current guidelines recommend that statins be initiated in ACS patients before hospital discharge. In this retrospective study, we investigated the influence of early compared with late in-hospital initiation of...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.677

    authors: Li YH,Wu HL,Yang YH,Tsai HS,Chao TH

    更新日期:2007-11-01 00:00:00

  • Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy.

    abstract::The metabolism of branched-chain amino acids (BCAAs) is reported to change in heart failure (HF) and correlate with cardiac function. However, the effect of BCAAs on HF remains controversial. We investigate the prognostic value of the plasma BCAA level in nonischemic dilated cardiomyopathy (NIDCM).This study enrolled ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-010

    authors: Kimura Y,Okumura T,Kazama S,Shibata N,Oishi H,Arao Y,Kuwayama T,Kato H,Yamaguchi S,Hiraiwa H,Kondo T,Morimoto R,Murohara T

    更新日期:2020-07-30 00:00:00

  • Comparison of prognostic value of red cell distribution width and NT-proBNP for short-term clinical outcomes in acute heart failure patients.

    abstract::Comparison of the prognostic value of red cell distribution width (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP) for short-term clinical outcomes in acute heart failure (AHF) patients has not been fully investigated.A total of 128 patients with AHF were enrolled and followed for 3 months. Primary endp...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1536/ihj.13-172

    authors: He W,Jia J,Chen J,Qin S,Tao H,Kong Q,Xue Q,Zhang D

    更新日期:2014-01-01 00:00:00

  • Myocardial involvement in patients with osteogenesis imperfecta.

    abstract::Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.75

    authors: Soma K,Abe H,Takeda N,Shintani Y,Takazawa Y,Kojima T,Fujiu K,Semba H,Yamashita H,Hirata Y,Fukayama M,Nagai R

    更新日期:2012-01-01 00:00:00

  • Temperature-controlled cooled-tip radiofrequency ablation in left ventricular myocardium.

    abstract::Steam pop and intramural charring have been reported during cooled-tip radiofrequency catheter ablation (RFCA). We studied the feasibility of temperature-controlled cooled-tip RFCA in the canine heart.An internally cooled ablation catheter was inserted into the left ventricle. A custom-made radiofrequency (RF) generat...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.193

    authors: Watanabe I,Nuo M,Okumura Y,Ohkubo K,Ashino S,Kofune M,Kofune T,Nakai T,Kasamaki Y,Hirayama A

    更新日期:2010-05-01 00:00:00

  • Therapeutic vaccines for hypertension and dyslipidemia.

    abstract::Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...

    journal_title:International heart journal

    pub_type: 杂志文章,评审

    doi:10.1536/ihj.13-383

    authors: Nakagami H,Koriyama H,Morishita R

    更新日期:2014-01-01 00:00:00

  • Renoprotective effect of vasopressin v2 receptor antagonist tolvaptan in Dahl rats with end-stage heart failure.

    abstract::Tolvaptan is a highly selective and orally effective arginine vasopressin V2 receptor antagonist, and is potentially useful for the treatment of heart failure (HF) patients. However, the renoprotective effect of long-term tolvaptan therapy and its underlying mechanisms remain unknown. We evaluated the effects of chron...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.54.98

    authors: Ishikawa M,Kobayashi N,Sugiyama F,Onoda S,Ishimitsu T

    更新日期:2013-01-01 00:00:00

  • A Rare Case of Rush Progression of Purulent Pericarditis by Escherichia coli in a Patient with Malignant Lymphoma.

    abstract::Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-238

    authors: Horii S,Yada H,Ito K,Osaki A,Sato A,Kimura T,Yasuda R,Toya T,Namba T,Masaki N,Adachi T

    更新日期:2018-05-30 00:00:00

  • Electrophysiological Measurement of Rat Atrial Epicardium Using a Novel Stereotaxic Apparatus.

    abstract::Flexible, in vivo maneuverable electrophysiology mapping techniques are not available in rat models. A novel cardiac stereotactic electrophysiology epicardial mapping system (CREAMS) allows for various measurements, including: (1) recording unipolar electrograms at multiple sites; (2) positioning of mapped sites and p...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-215

    authors: Fan B,Wang H,Wu T,Li Y,Lin Z,Li M,Li Q,Zhang W,Zheng Q

    更新日期:2019-03-20 00:00:00

  • Age-related differences in the delivery of cardiac management to women versus men with acute myocardial infarction in Japan: Tokai Acute Myocardial Infarction Study: TAMIS.

    abstract::It is of concern that women are more likely to undergo fewer diagnostic tests and receive less treatment for acute myocardial infarction (AMI) than men. However, it is still unclear whether gender differences exist according to age groups. Therefore, we studied the influence of gender on the delivery of cardiac manage...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.939

    authors: Hirakawa Y,Masuda Y,Uemura K,Kuzuya M,Kimata T,Iguchi A

    更新日期:2005-11-01 00:00:00

  • Long-Term Prognosis of Patients Who Underwent Percutaneous Transvenous Mitral Commissurotomy for Mitral Stenosis.

    abstract::The long-term prognosis for up to 20 years of patients who have undergone percutaneous transvenous mitral commissurotomy (PTMC) for mitral stenosis (MS) is unknown.We examined 77 of 93 patients (83%) with MS and who underwent PTMC from 1989 to 2002 at our institute, as well as the occurrence of either one of the follo...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-082

    authors: Kubota N,Ozaki K,Hoyano M,Nishida K,Takano T,Okubo T,Kimura S,Yanagawa T,Kashimura T,Minamino T

    更新日期:2020-11-28 00:00:00

  • High mobility group box 1 levels in on and off-pump cardiac surgery patients.

    abstract::High mobility group box 1 (HMGB1), which has properties similar to those of proinflammatory cytokines, is released from activated immune cells and necrotic cells. It is known that cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.170

    authors: Haque A,Kunimoto F,Narahara H,Okawa M,Hinohara H,Kurabayashi M,Saito S

    更新日期:2011-01-01 00:00:00

  • Usefulness and Safety of a Novel Modification of the Retrograde Approach for the Long Tortuous Chronic Total Occlusion of Coronary Arteries.

    abstract::The aim of this study was to evaluate the feasibility and efficacy of the Guidezilla guide extension catheter in a reverse controlled antegrade and retrograde subintimal tracking (CART) technique for chronic total occlusion (CTO) recanalization.We retrospectively collected 80 CTO cases using reverse CART technology fr...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-337

    authors: Huang Z,Zhang B,Chai W,Ma D,Liao H,Zhong Z,Wang F,Lin J

    更新日期:2017-05-31 00:00:00

  • Contemporary In-Hospital and Long-Term Outcomes of Surgical Management for Fungal Endocarditis.

    abstract::Fungal endocarditis (FE) is a rare and fatal disease. The contemporary in-hospital and long-term surgical outcomes of FE have not been adequately evaluated. This study describes our experience with the surgical management of FE.Eight FE patients who underwent surgery in our center from January 2004 to November 2016 we...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-049

    authors: Chen J,Li J,Zhou T,Hu K,Yang Z,Wang Y,Zhu K,Hong T,Lai H,Wang C

    更新日期:2017-08-03 00:00:00

  • Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients.

    abstract::Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations of fibrillin-1. While MFS patients are at a high risk of periodontitis and aortic diseases, little causal information has been provided to date. To clarify the relationship, their oral condition and sinus of Valsalva (SoV) were ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.15-395

    authors: Suzuki J,Imai Y,Aoki M,Fujita D,Takeda N,Aoyama N,Wakayama K,Ikeda Y,Kumagai H,Akazawa H,Izumi Y,Isobe M,Komuro I,Hirata Y

    更新日期:2016-07-27 00:00:00

  • Comparison of Archival Angiographic Findings in Patients Later Developing Acute Coronary Syndrome or Stable Angina.

    abstract::Acute coronary syndrome (ACS) can develop in patients with mildly to moderately stenotic lesions. However, the angiographic characteristics of lesions in patients who will later develop ACS have not been systematically investigated. For this reason, we examined the earlier angiographic findings of such patients in a r...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-601

    authors: Yamaya S,Morino Y,Taguchi Y,Ninomiya R,Ishida M,Fusazaki T,Itoh T,Kimura T

    更新日期:2020-05-30 00:00:00

  • Interleukin-18.

    abstract::A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study....

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-154

    authors: Wang S,Chen F,Yang S,Shi J

    更新日期:2018-07-31 00:00:00

  • Atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats.

    abstract::Statins improve left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). This study was designed to investigate the effects of atorvastatin administered in the early stage on LV remodeling in SHRs, and to explore the underlying mechanisms.Sixteen male 8-week-old SHRs were randomized to receive disti...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.426

    authors: Zhao XY,Li L,Zhang JY,Liu GQ,Chen YL,Yang PL,Liu RY

    更新日期:2010-01-01 00:00:00

  • Impact of Either GLP-1 Agonists or DPP-4 Inhibitors on Pathophysiology of Heart Failure.

    abstract::Since diabetes mellitus (DM) is the most common cause of heart failure (HF), it is critically important to clarify whether incretin hormones including glucagon-like peptide-1 (GLP-1), which play an important role in blood glucose control, mediate cardioprotection. There are many lines of basic research evidence indica...

    journal_title:International heart journal

    pub_type: 杂志文章,评审

    doi:10.1536/ihj.15-028

    authors: Takahashi A,Ihara M,Yamazaki S,Asanuma H,Asakura M,Kitakaze M

    更新日期:2015-01-01 00:00:00

  • High-Sensitivity C-Reactive Protein Combined with Low-Density Lipoprotein Cholesterol as the Targets of Statin Therapy in Patients with Acute Coronary Syndrome.

    abstract::To investigate the combination of high-sensitivity C-reactive protein (hs-CRP) and Low-density lipoprotein (LDL)-C as the targets for statin treatment in patients with acute coronary syndrome (ACS). This single-center, prospective, randomized study was performed in 400 patients treated with atorvastatin 40 mg/day for ...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.17-101

    authors: Fang M,Qian Q,Zhao Z,Zhu L,Su J,Li X

    更新日期:2018-03-30 00:00:00

  • Serum bilirubin concentration in patients with an established coronary artery disease.

    abstract::Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with coronary artery disease and the control group 100 patients with normal...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.51.86

    authors: Ghem C,Sarmento-Leite RE,de Quadros AS,Rossetto S,Gottschall CA

    更新日期:2010-03-01 00:00:00

  • Radiofrequency catheter ablation of ventricular tachycardia originating in the left posterior and left anterior fascicles in a patient with prior myocardial infarction.

    abstract::A 61-year-old man with prior anteroseptal myocardial infarction (ejection fraction: 40%) presented with recurrent episodes of palpitations. Twelve-lead ECG during palpitations showed an incessant ventricular tachycardia (VT1) with right bundle branch block (RBBB) morphology and inferior axis. Electrophysiologic study ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.49.119

    authors: Ashino S,Watanabe I,Kofune M,Okumura Y,Kawauchi K,Yamada T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Saito S,Hirayama A

    更新日期:2008-01-01 00:00:00

  • Impact of Compound Hypertonic Saline Solution on Decompensated Heart Failure.

    abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.16-313

    authors: Wan Y,Li L,Niu H,Ma X,Yang J,Yuan C,Mu G,Zhang J

    更新日期:2017-08-03 00:00:00

  • The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease.

    abstract::Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we ai...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-277

    authors: Huang M,Zheng J,Chen Z,You C,Huang Q

    更新日期:2020-01-31 00:00:00

  • Characteristics of metabolic and lifestyle risk factors in young Japanese patients with coronary heart disease: a comparison with older patients.

    abstract::Coronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young ...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.47.343

    authors: Azegami M,Hongo M,Yanagisawa S,Yamazaki A,Sakaguchi K,Yazaki Y,Imamura H

    更新日期:2006-05-01 00:00:00

  • The Clinical Efficacy of Endothelin Receptor Antagonists in Patients with Pulmonary Arterial Hypertension.

    abstract::Therapeutic strategies for pulmonary arterial hypertension (PAH) have made remarkable progress over the last two decades. Currently, 3 types of drugs can be used to treat PAH; prostacyclins, phosphodiesterase 5 inhibitors, and endothelin receptor antagonists (ERA). In Japan, the first generation ERA bosentan was reimb...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-173

    authors: Maki H,Hara T,Tsuji M,Saito A,Minatsuki S,Inaba T,Amiya E,Hosoya Y,Hatano M,Morita H,Yao A,Kinugawa K,Komuro I

    更新日期:2020-01-01 00:00:00

  • Cardiac Sarcoidosis Mimicking Septal Tumor with Intermittent Complete Atrioventricular Block.

    abstract::A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonan...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-713

    authors: Fujimoto R,Asano T,Maezawa H,Shimojima H,Tsujiuchi M,Hori Y,Ebato M,Suzuki H

    更新日期:2018-11-28 00:00:00

  • Geometrical characteristics of left ventricular dyssynchrony in advanced heart failure. Myocardial strain analysis by tagged MRI.

    abstract::The aims of this study were to quantify the geometrical differences in left ventricular (LV) dyssynchrony in patients with heart failure (HF) using cine-tagged MRI, and to investigate the relationship between dyssynchrony and major adverse cardiac events (MACE) in HF.In 67 patients with HF [mean LV ejection fraction (...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-137

    authors: Nagao M,Yamasaki Y,Yonezawa M,Kamitani T,Kawanami S,Mukai Y,Higo T,Yabuuchi H,Sunagawa K,Honda H

    更新日期:2014-01-01 00:00:00

  • High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome.

    abstract::High sensitive C-reactive protein (hs-CRP) levels are associated with short- and long-term mortality in patients with acute coronary syndrome (ACS). We investigated whether baseline hs-CRP levels are associated with burden of coronary atherosclerosis assessed by SYNTAX score (SXScore).We enrolled 321 patients with ACS...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-299

    authors: Karadeniz M,Duran M,Akyel A,Yarlıoğlueş M,Öcek AH,Çelik İE,Kılıç A,Yalcin AA,Ergün G,Murat SN

    更新日期:2015-01-01 00:00:00

  • Knockdown of miR-665 Protects Against Cardiomyocyte Ischemia/Reperfusion Injury-Induced ROS Accumulation and Apoptosis Through the Activation of Pak1/Akt Signaling in Myocardial Infarction.

    abstract::Myocardial infarction (MI) is one of the major causes of death worldwide, and the therapeutic strategies of MI are still limited. In this study, we investigated the function of miR-665 in MI. In the present study, an ischemia/reperfusion (I/R) rat model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell model were su...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-416

    authors: Liu C,Tang M,Zhang X,Li J,Cao G

    更新日期:2020-03-28 00:00:00