Myocardial involvement in patients with osteogenesis imperfecta.

Abstract:

:Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.

journal_name

Int Heart J

authors

Soma K,Abe H,Takeda N,Shintani Y,Takazawa Y,Kojima T,Fujiu K,Semba H,Yamashita H,Hirata Y,Fukayama M,Nagai R

doi

10.1536/ihj.53.75

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

75-7

issue

1

eissn

1349-2365

issn

1349-3299

pii

JST.JSTAGE/ihj/53.75

journal_volume

53

pub_type

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