Abstract:
:Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Soma K,Abe H,Takeda N,Shintani Y,Takazawa Y,Kojima T,Fujiu K,Semba H,Yamashita H,Hirata Y,Fukayama M,Nagai Rdoi
10.1536/ihj.53.75subject
Has Abstractpub_date
2012-01-01 00:00:00pages
75-7issue
1eissn
1349-2365issn
1349-3299pii
JST.JSTAGE/ihj/53.75journal_volume
53pub_type
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