Abstract:
:Apelin was proved to attenuate cardiac interstitial fibrosis. However, the association between apelin level and myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) is still unclear.This study aims to determine whether apelin is associated with myocardial fibrosis in HCM and investigate the predictive values of apelin for myocardial fibrosis in HCM.One hundred sixteen patients with HCM were enrolled in this study. Plasma apelin-13 and high-sensitivity cardiac troponin I (cTNI) were measured. The cardiac systolic and diastolic functions were evaluated by echocardiography, and the presence and extent of cardiac fibrosis were assessed by cardiac magnetic resonance. All statistical data were analyzed by SPSS version 21.0.The percentage of late gadolinium enhancement (LGE) was negatively correlated with apelin and positively correlated with cTNI, maximum wall thickness (MWT), and left ventricular mass index in the overall patients with HCM and LGE. Apelin, cTNI, MWT, and left ventricular ejection fraction were independent predictors of the presence of LGE. The cutoff values of apelin, cTNI, and MWT were 1.24 pg/mL, 0.031 ng/mL, and 19 mm, respectively, for the prediction of LGE. The combined measurements of MWT ≥ 19 mm and/or apelin ≤ 1.24 pg/mL, as well as the combined measurements of MWT ≥ 19 mm and/or cTNI ≥ 0.031 ng/mL, obtained higher specificity and higher sensitivity, thus, indicating the presence of LGE.Plasma apelin and cTNI are independent predictors of myocardial fibrosis. The combined measurements of serum apelin and MWT, as well as cTNI and MWT, showed higher predictive values for predicting myocardial fibrosis in patients with HCM.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Zhou Y,Yuan J,Wang Y,Qiao Sdoi
10.1536/ihj.18-598subject
Has Abstractpub_date
2019-05-30 00:00:00pages
648-655issue
3eissn
1349-2365issn
1349-3299journal_volume
60pub_type
杂志文章abstract::The objective of the present prospective multicenter case-control study was to investigate the long-term clinical outcome (5 years) of primary stenting compared to primary percutaneous transluminal coronary angioplasty (PTCA) without stenting (POBA) in patients with acute myocardial infarction at 7 cardiovascular cent...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1536/ihj.47.47
更新日期:2006-01-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved to ameliorate PAH. However, its effect on PAH-induced right ventricula...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-591
更新日期:2017-12-12 00:00:00
abstract::Plaque erosion (PE) is a significant substrate of acute coronary thrombosis. An improved ability to distinguish plaque phenotype in vivo among patients with ST-segment elevation myocardial infarction (STEMI) is of considerable interest because of the potential to formulate tailored treatment. This study assessed the p...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-014
更新日期:2019-09-27 00:00:00
abstract::Friedreich's ataxia (FRDA), the most common subtype of early onset hereditary ataxia, is an autosomal recessive neurodegenerative disorder caused by unstable GAA expansions. Two-dimensional, pulse, and pulse tissue Doppler echocardiographic examinations were performed on 21 patients with GAA expansion. There was no as...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.443
更新日期:2005-05-01 00:00:00
abstract::Several studies have reported that the left ventricular (LV) lead implant success rate ranges between 88.0% and 92.4%. Coronary venous anatomy differs among patients thus, necessitating multiple types of leads. To date, the implant success rate among Japanese patients utilizing a pre-specified family LV leads (includi...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1536/ihj.17-442
更新日期:2018-09-26 00:00:00
abstract::Infective endocarditis (IE) caused by Serratia liquefaciens has been reported in only 2 adults. We experienced the first pediatric (neonatal) case of IE caused by S. liquefaciens, with mitral valve vegetation 4 days after a palliative heart surgery. This report underscores the importance of treating for both gram-posi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-595
更新日期:2018-11-28 00:00:00
abstract::A 19 year-old woman who underwent corrective surgery for an atrial septal defect (ASD) and ventricular septal defect (VSD) 12 years previously presented with pulmonary hypertension. Cardiac catheterization showed a fistula between the right subclavian artery and vena jugularis interna. In this case, a rare example of ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.551
更新日期:2005-05-01 00:00:00
abstract::Mechanical heart valve replacement (MHVR) entails lifetime oral anticoagulation to eliminate thrombosis. However, adverse events may still occur despite proper anticoagulation therapy. In this study, we investigated whether D-dimer can predict the clinical events in post-MHVR patients during oral anticoagulation thera...
journal_title:International heart journal
pub_type: 临床试验,杂志文章
doi:10.1536/ihj.18-237
更新日期:2019-05-30 00:00:00
abstract::There are many published articles on the effects of the antithrombolytic function of platelet glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa inhibitors) in myocardial infarction. However, few studies have explored the effects and optimal concentration of tirofibans in diminishing the extent of myocardial reperfusion in...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-322
更新日期:2015-05-13 00:00:00
abstract::Exercise capacity is lowered in patients with heart failure, which limits their daily activities and also reduces their quality of life. Furthermore, lowered exercise capacity has been well demonstrated to be closely related to the severity and prognosis of heart failure. Skeletal muscle abnormalities including abnorm...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.15-108
更新日期:2015-01-01 00:00:00
abstract::Statins improve left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). This study was designed to investigate the effects of atorvastatin administered in the early stage on LV remodeling in SHRs, and to explore the underlying mechanisms.Sixteen male 8-week-old SHRs were randomized to receive disti...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.426
更新日期:2010-01-01 00:00:00
abstract::Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catech...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.95
更新日期:2009-01-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.16-313
更新日期:2017-08-03 00:00:00
abstract::Although calcium channel blockers (CCB) are expected to improve the augmentation index (AI) in CKD patients, the potential effect of benidipine on AI has been poorly studied.The present study aimed to compare the effect of benidipine and amlodipine in the treatment of CKD patients as measured through AI and urinary al...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.15-208
更新日期:2016-01-01 00:00:00
abstract::Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); however, the specific conclusion is still controversial.To get a more accurate conclusion, we used a meta-analysis to evaluat...
journal_title:International heart journal
pub_type: 杂志文章,meta分析
doi:10.1536/ihj.19-389
更新日期:2020-05-30 00:00:00
abstract::It has been reported that K-ATP channel openers have a cardioprotective effect in acute ischemia as a pharmacological preconditioning effect. In the present study, the chronic effects of clinical K-ATP channel openers, ie, nicorandil (Nic) and mexiletine (Mex), on cardiac function were evaluated in a rat model of expe...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.139
更新日期:2012-01-01 00:00:00
abstract::Several recent studies have suggested that arterial stiffness parameters such as peripheral pulse pressure (PPP), central blood pressure (CBP), and pulse wave velocity (PWV) are more accurate markers than brachial blood pressure for prediction of cardiovascular (CV) events. However, it remains unknown which arterial s...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.160
更新日期:2013-01-01 00:00:00
abstract::High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.593
更新日期:2005-07-01 00:00:00
abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-700
更新日期:2019-01-25 00:00:00
abstract::Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-218
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to determine whether symptoms of atrial fibrillation (AF) differ between patients with and without subsequent permanent AF. Sixty-four patients (68 +/- 10 years old, 45 males) were recruited. AF follow-up was started at the age of 61 +/- 10 years and accomplished in a median period of ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.242
更新日期:2010-07-01 00:00:00
abstract::The relationship between mild-to-moderate renal dysfunction and cardiac diastolic dysfunction and cardiac events in patients with nonischemic dilated cardiomyopathy (NDCM) has not been fully elucidated. The aim of this study was to investigate the relationship between renal and cardiac function, as well as clinical ou...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.366
更新日期:2011-01-01 00:00:00
abstract::Myocardial infarction (MI) occurs when the heart muscle is severely damaged due to a decrease in blood flow from the coronary arteries. During recovery from an MI, cardiac fibroblasts become activated and produce extracellular matrices, contributing to the wound healing process in the damaged heart. Inappropriate acti...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-710
更新日期:2019-07-27 00:00:00
abstract::A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.167
更新日期:2005-01-01 00:00:00
abstract::We experienced a 33-year-old patient with D-looped transposition of the great arteries (D-TGA) and a history of Senning operation who was referred to our institute with cardiogenic shock and subsequently underwent urgent paracorporeal ventricular assist device (VAD) implantation, which was a first in Japan, that was e...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-670
更新日期:2020-05-30 00:00:00
abstract::Coronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young ...
journal_title:International heart journal
pub_type: 杂志文章,多中心研究
doi:10.1536/ihj.47.343
更新日期:2006-05-01 00:00:00
abstract::Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-163
更新日期:2017-02-07 00:00:00
abstract::This study aimed to evaluate the potential associations of intermediate monocytes (CD14(++)CD16(+)) with myocardial remodelling in ST segment elevation myocardial infarction (STEMI) patients with diabetes.A total of 67 STEMI patients with diabetes were enrolled. The control group consisted of 65 STEMI patients without...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-174
更新日期:2015-01-01 00:00:00
abstract::Vagus nerve stimulation (VNS), targeting the imbalanced autonomic nervous system, is a promising therapeutic approach for chronic heart failure (HF). Moreover, calcium cycling is an important part of cardiac excitation-contraction coupling (ECC), which also participates in the antiarrhythmic effects of VNS. We hypothe...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.15-516
更新日期:2016-05-25 00:00:00
abstract::Patients with ischemic heart disease are associated with poor prognosis, and their number has increased globally. Therefore, biomarkers that could predict post-acute myocardial infarction (AMI) heart failure (HF) would be helpful to guide appropriate treatment. Based on the diagnosis on admission and results of echoca...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-306
更新日期:2019-03-20 00:00:00