Heart is the Target Organ of Endogenous Cardiac Natriuretic Peptides.

Abstract:

:This study aimed to evaluate whether the heart is the target organ of endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with heart failure (HF) with reduced ejection fraction (HFrEF).We measured the plasma levels of cyclic guanosine monophosphate (cGMP), which is a second messenger of ANP and BNP, in the aortic root (AO) and coronary sinus (CS) in 237 patients with HFrEF. Plasma levels of cGMP were significantly higher in the CS than those in the AO in 237 patients with HFrEF (10.0 ± 4.5 versus 10.5 ± 4.3 pmoL/mL, P < 0.0001) and were significantly higher in the CS than those in the AO (8.0 ± 3.6 versus 8.9 ± 3.8 pmoL/mL, P < 0.0001) in mild HF patients (New York Heart Association (NYHA) II, n = 114), but there was no difference in plasma cGMP between the AO and the CS (11.9 ± 4.4 versus 11.9 ± 4.3 pmoL/mL, NS) in severe HF patients (NYHA III-IV, n = 123). In mild HF patients, log (ANP + BNP) in the AO was an independent predictor of (CS-AO) cGMP among hemodynamics and nitrate therapy. There was a significant correlation between log [(CS-AO) ANP + (CS-AO) BNP] and (CS-AO) cGMP (r = 0.455, P < 0.0001) in mild HF patients.These findings indicate that cGMP is produced from the failing heart and that the heart is the target organ of endogenous ANP and BNP in patients with HFrEF. In severe HF patients, cGMP production may be attenuated because of the downregulation of biological receptors and/or increased cGMP degradation in the failing heart.

journal_name

Int Heart J

authors

Tsutamoto T,Sakai H,Yamamoto T,Nakagawa Y

doi

10.1536/ihj.19-379

subject

Has Abstract

pub_date

2020-01-31 00:00:00

pages

77-82

issue

1

eissn

1349-2365

issn

1349-3299

journal_volume

61

pub_type

杂志文章
  • Can Torsemide and Combination of Loop Diuretics Improve Mortality in Patients with Chronic Heart Failure After Discharge?

    abstract::The aim of this study was to investigate the effect on mortality of torsemide and a combination of loop diuretics (furosemide + torsemide) in contemporary practice in patients with chronic heart failure (HF).We investigated patients with HF in the Heart Failure Center of Fuwai Hospital from 2009 to 2013 who were disch...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-522

    authors: Yao Y,Zhang J,Zhang Y,Zhang R

    更新日期:2018-07-31 00:00:00

  • PPARγ Alleviates Right Ventricular Failure Secondary to Pulmonary Arterial Hypertension in Rats.

    abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved to ameliorate PAH. However, its effect on PAH-induced right ventricula...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-591

    authors: Xu Y,Gu Q,Liu N,Yan Y,Yang X,Hao Y,Qu C

    更新日期:2017-12-12 00:00:00

  • Comparison of Clinical Outcomes between the Ostial Versus Non-Ostial Culprit in Proximal Left Anterior Descending Artery Acute Myocardial Infarction.

    abstract::Percutaneous coronary interventions to the proximal left anterior descending artery (pLAD)-acute myocardial infarction (AMI) are still challenging, especially in the ostial pLAD. Clinical outcomes of the ostial pLAD-AMI were not well investigated. The aim of the present study was to compare clinical outcomes of the os...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-067

    authors: Yamamoto K,Sakakura K,Akashi N,Watanabe Y,Noguchi M,Taniguchi Y,Wada H,Momomura SI,Fujita H

    更新日期:2019-01-25 00:00:00

  • Impact of Compound Hypertonic Saline Solution on Decompensated Heart Failure.

    abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.16-313

    authors: Wan Y,Li L,Niu H,Ma X,Yang J,Yuan C,Mu G,Zhang J

    更新日期:2017-08-03 00:00:00

  • Efficacy of Cognitive Behavioral Therapy for Heart Failure.

    abstract::Cognitive behavioral therapy has emerged as an important approach to alleviate the depression of patients with heart failure. However, the use of cognitive behavioral therapy for heart failure has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of cognitive behavior...

    journal_title:International heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1536/ihj.18-408

    authors: Peng Y,Fang J,Huang W,Qin S

    更新日期:2019-05-30 00:00:00

  • Prevalence and prognosis of patients with heart failure in Tokyo: a prospective cohort of Shinken Database 2004-5.

    abstract::Prognosis of patients with heart failure (HF) remains unclear in Japan and should be determined in a prospective fashion. A prospective cohort of The Shinken Database comprised details on all of the new patients, including both inpatients and outpatients, who visited The Cardiovascular Institute Hospital in 2004-2005....

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.50.609

    authors: Goda A,Yamashita T,Suzuki S,Ohtsuka T,Uejima T,Oikawa Y,Yajima J,Koike A,Nagashima K,Kirigaya H,Sagara K,Ogasawara K,Isobe M,Sawada H,Aizawa T

    更新日期:2009-09-01 00:00:00

  • High Levels of Circulating MicroRNA-3667-3p Are Associated with Coronary Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.

    abstract::Plaque erosion (PE) is a significant substrate of acute coronary thrombosis. An improved ability to distinguish plaque phenotype in vivo among patients with ST-segment elevation myocardial infarction (STEMI) is of considerable interest because of the potential to formulate tailored treatment. This study assessed the p...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-014

    authors: Dong H,Hu S,Sun R,Wang C,Dai J,Pan W,Xing L,Liu X,Wu J,Liu J,Jia H,Yu B

    更新日期:2019-09-27 00:00:00

  • Clinical Manifestation, Timing Course, Precipitating Factors, and Protective Factors of Ventricular Free Wall Rupture Following ST-Segment Elevation Myocardial Infarction.

    abstract::Ventricular free wall rupture (FWR) is a catastrophic complication of that occurs after acute myocardial infarction (AMI), and at present, its clinical characteristics are unclear. We analyzed a total of 6,712 consecutive patients who presented with ST-segment elevation myocardial infarction (STEMI), and 78 patients w...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-541

    authors: Gong W,Shi H,Yan M,Yan Y,Wang X,Li S,He X,Nie S

    更新日期:2020-07-30 00:00:00

  • Prolonged use for at least 10 days of intraaortic balloon pumping (IABP) for heart failure.

    abstract::Intraaortic balloon pumping (IABP) is a useful therapy for refractory heart failure. However, the safe duration of this therapy and possible complications due to long-term IABP support remain unclear. In this study, we reviewed retrospectively patients requiring the long-term use of IABP, defined here as 10 days or mo...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.1041

    authors: Oshima K,Morishita Y,Hinohara H,Kadoi Y,Hayashi Y,Tajima Y,Kunimoto F

    更新日期:2005-11-01 00:00:00

  • C-reactive protein is related to impaired oxygenation in patients with acute aortic dissection.

    abstract::Impaired oxygenation sometimes occurs in patients with acute aortic dissection, however, the mechanism has not been fully investigated. We hypothesized that impaired oxygenation is related to inflammation secondary due to aortic dissection. Patients with acute aortic dissection who had received 14 days of conservative...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.46.795

    authors: Komukai K,Shibata T,Mochizuki S

    更新日期:2005-09-01 00:00:00

  • Outcome and Pathological Characteristics of Primary Malignant Cardiac Tumors.

    abstract::The literature on malignant cardiac tumors is relatively limited because they are rare, especially among the Chinese population. We analyzed 14 patients diagnosed with malignant cardiac tumors in Fuwai Hospital and present the results of surgical treatments on the tumors. The mean age at tumor diagnosis was 47 years i...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.18-269

    authors: Guo GR,Wang X,Yang J,Chen L,Song JP,Wang LQ

    更新日期:2019-07-27 00:00:00

  • A novel technique for multi-track percutaneous balloon mitral valvoplasty.

    abstract::Percutaneous balloon mitral valvoplasty (PBMV) has become the treatment of choice for severe pliable rheumatic mitral stenosis. The multi-track system is a recent variation of the double-balloon technique and is easier owing to the use of a monorail balloon and a simple, single-guidewire approach. In the present study...

    journal_title:International heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1536/ihj.54.196

    authors: Sakr SA,Ramadan MM,Osama M

    更新日期:2013-01-01 00:00:00

  • The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease.

    abstract::Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we ai...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.19-277

    authors: Huang M,Zheng J,Chen Z,You C,Huang Q

    更新日期:2020-01-31 00:00:00

  • Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.

    abstract::Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); however, the specific conclusion is still controversial.To get a more accurate conclusion, we used a meta-analysis to evaluat...

    journal_title:International heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1536/ihj.19-389

    authors: Liu PF,Ding B,Zhang JY,Mei XF,Li F,Wu P,Mei CH,Zhou YF,Chen T

    更新日期:2020-05-30 00:00:00

  • High Glucose Stimulates Mineralocorticoid Receptor Transcriptional Activity Through the Protein Kinase C β Signaling.

    abstract::Activation of mineralocorticoid receptor (MR) is shown in resistant hypertension including diabetes mellitus. Although protein kinase C (PKC) signaling is involved in the pathogenesis of diabetic complications, an association between PKC and MR is not known. Activation of PKCα and PKCβ by TPA (12-O-Tetradecanoylphorbo...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-649

    authors: Hayashi T,Shibata H,Kurihara I,Yokota K,Mitsuishi Y,Ohashi K,Murai-Takeda A,Jo R,Ohyama T,Sakamoto M,Tojo K,Tajima N,Utsunomiya K,Itoh H

    更新日期:2017-10-21 00:00:00

  • Efficacy of catheter ablation for atrial fibrillation in patients with a permanent pacemaker for atrioventricular block.

    abstract::Catheter ablation has been established to be an effective therapy for drug-refractory paroxysmal AF and is recommended as the treatment of choice for many patients, including those with a permanent pacemaker (PM). However, the clinical efficacy of catheter ablation of paroxysmal AF in patients with a permanent PM for ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-099

    authors: Wu JT,Dong JZ,Wang SL,Chu YJ,Wang LX,Yang CK

    更新日期:2014-01-01 00:00:00

  • Who Needs Longer Tolvaptan Treatment?

    abstract::The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and ...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.16-249

    authors: Kinugawa K,Inomata T,Sato N,Yasuda M,Shimakawa T,Bando K,Fukuta Y

    更新日期:2017-02-07 00:00:00

  • Induction of c-fos mRNA expression by pure pressure overload in cultured cardiac myocytes.

    abstract::Mechanical stress by pressure overload due to hypertension or valvular heart disease such as aortic valve stenosis induces cardiac hypertrophy. It has been well established that the mechanical stretch of cardiac myocytes in vitro induces hypertrophic responses such as the expression of immediate early response genes i...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.48.359

    authors: Sakai H,Urasawa K,Oyama N,Kaneta S,Saito T,Kitabatake A,Tsutsui H

    更新日期:2007-05-01 00:00:00

  • Myocardial involvement in patients with osteogenesis imperfecta.

    abstract::Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.75

    authors: Soma K,Abe H,Takeda N,Shintani Y,Takazawa Y,Kojima T,Fujiu K,Semba H,Yamashita H,Hirata Y,Fukayama M,Nagai R

    更新日期:2012-01-01 00:00:00

  • Therapeutic vaccines for hypertension and dyslipidemia.

    abstract::Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...

    journal_title:International heart journal

    pub_type: 杂志文章,评审

    doi:10.1536/ihj.13-383

    authors: Nakagami H,Koriyama H,Morishita R

    更新日期:2014-01-01 00:00:00

  • Platelet-derived growth factor receptor-tyrosine kinase inhibitor, imatinib, is effective for treating pulmonary hypertension induced by pulmonary tumor thrombotic microangiopathy.

    abstract::Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigra...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.14-220

    authors: Minatsuki S,Miura I,Yao A,Abe H,Muraoka H,Tanaka M,Imamura T,Inaba T,Maki H,Hatano M,Kinugawa K,Yao T,Fukayama M,Nagai R,Komuro I

    更新日期:2015-01-01 00:00:00

  • Mechanism of pressure-overload right ventricular hypertrophy in infant rabbits.

    abstract::Although pressure-overload right ventricular hypertrophy is a long-term risk in some congenital heart diseases such as tetralogy of Fallot, how it develops is unclear. The aim of this study was to investigate the mechanism of development of this right ventricular heart failure.Pulmonary artery banding in 10-day-old ra...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.52.56

    authors: Minegishi S,Kitahori K,Murakami A,Ono M

    更新日期:2011-01-01 00:00:00

  • A New Aortic Arch Inclusion Technique with Frozen Elephant Trunk for Aortic Arch Aneurysm Treatment.

    abstract::Various surgical techniques have been proposed for treating aortic arch aneurysm (AAA); however, the optimal treatment has not been well defined. This study introduces a new aortic arch inclusion technique with frozen elephant trunk (FET) for AAA treatment.A retrospective analysis was performed among 22 patients for A...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.20-069

    authors: Zhu C,Piao H,Wang Y,Li B,Zhang Y,Xu J,Wang T,Zhu Z,Xu R,Li D,Liu K

    更新日期:2020-11-28 00:00:00

  • Coronary artery spasm following off-pump coronary artery bypass surgery.

    abstract::Coronary artery spasm after coronary artery bypass surgery may result in life-threatening arrhythmias, circulatory collapse, or death. We report two cases of coronary artery spasm after coronary artery bypass surgery, one of which developed ventricular fibrillation requiring extracorporeal membrane oxygenation support...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.13-357

    authors: Unai S,Hirose H,Cook G,Lee Y,Miura S,Kigawa I,Fukuda S,Miyairi T

    更新日期:2014-01-01 00:00:00

  • Rivaroxaban for Periprocedural Anticoagulation Therapy in Japanese Patients Undergoing Catheter Ablation of Paroxysmal Non-Valvular Atrial Fibrillation.

    abstract::Direct oral anticoagulants (DOACs) have been shown to be safe and effective for the prevention of stroke in nonvalvular atrial fibrillation (NVAF) patients, however, experience with peri-AF ablation management of DOACs is scarce. This study aimed to investigate the safety and feasibility of periprocedural anticoagulat...

    journal_title:International heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1536/ihj.16-147

    authors: Kawabata M,Sasaki T,Maeda S,Shirai Y,Yamauchi Y,Nitta J,Goya M,Hirao K

    更新日期:2016-12-02 00:00:00

  • Case of Invasive Streptococcus Dysgalactiae Infection Presenting as Infective Endocarditis with Multiple Brain Embolisms.

    abstract::A 65-year-old Japanese man complaining of general malaise and presenting with high fever was admitted to our hospital. He had untreated diabetes and hepatocellular carcinoma with liver cirrhosis. Overall findings of the patient indicated sepsis. Two blood cultures were positive for Streptococcus dysgalactiae, a group ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-700

    authors: Takahashi F,Wada Y,Hasebe N

    更新日期:2019-01-25 00:00:00

  • Assessment of DNA Damage in Leukocytes of Patients With Coronary Artery Disease by Comet Assay.

    abstract::DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hos...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.16-190

    authors: Bhat MA,Gandhi G

    更新日期:2017-04-06 00:00:00

  • Implant Characteristics of Quadripolar and Bipolar Left Ventricular Leads for Cardiac Resynchronization Therapy.

    abstract::Several studies have reported that the left ventricular (LV) lead implant success rate ranges between 88.0% and 92.4%. Coronary venous anatomy differs among patients thus, necessitating multiple types of leads. To date, the implant success rate among Japanese patients utilizing a pre-specified family LV leads (includi...

    journal_title:International heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1536/ihj.17-442

    authors: Ando K,Kanda S,Miura F,Ashikaga K,Ehara N,Sakai Y,Furukawa T,Yoshimura H,Adachi K

    更新日期:2018-09-26 00:00:00

  • Risk Scoring System for Prognosis Estimation of Multivessel Disease Among Patients with ST-Segment Elevation Myocardial Infarction.

    abstract::Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring systems (RSS) are in use in clinical practice, there is no dedicated RSS for MVD in ST-segment elevation myocardial infarction (STEMI). The primary objective of this ...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.17-337

    authors: Ryu KS,Bae JW,Jeong MH,Cho MC,Ryu KH,and other Korea Acute Myocardial Infarction Registry Investigators.

    更新日期:2019-05-30 00:00:00

  • Successful conversion to everolimus after cytomegalovirus infection in a heart transplant recipient.

    abstract::Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection,...

    journal_title:International heart journal

    pub_type: 杂志文章

    doi:10.1536/ihj.53.199

    authors: Imamura T,Shiga T,Kinugawa K,Kato N,Endo M,Inaba T,Maki H,Hatano M,Yao A,Hirata Y,Nagai R

    更新日期:2012-01-01 00:00:00