Abstract:
:Myocardial infarction (MI) occurs when the heart muscle is severely damaged due to a decrease in blood flow from the coronary arteries. During recovery from an MI, cardiac fibroblasts become activated and produce extracellular matrices, contributing to the wound healing process in the damaged heart. Inappropriate activation of the fibroblasts leads to excessive fibrosis in the heart. However, the molecular pathways by which cardiac fibroblasts are activated have not yet been fully elucidated.Here we show that serum deprivation, which recapitulates the cellular microenvironment of the MI area, strikingly induces collagen production in C3H/10T1/2 cells. Based on transcriptomic and pharmacological studies, we found that cell cycle perturbation is directly linked to collagen production in fibroblasts. Importantly, collagen synthesis is increased independently of the transcriptional levels of type I collagen genes. These results reveal a novel mode of fibroblast activation in the ischemic area, which will allow us to gain insights into the molecular mechanisms underlying cardiac fibrosis and establish a basis for anti-fibrotic therapy.
journal_name
Int Heart Jjournal_title
International heart journalauthors
Wake M,Takeda N,Isagawa T,Sato T,Nakagama Y,Morioka MS,Hirota Y,Asagiri M,Maemura K,Manabe I,Tanabe K,Komuro Idoi
10.1536/ihj.18-710subject
Has Abstractpub_date
2019-07-27 00:00:00pages
958-963issue
4eissn
1349-2365issn
1349-3299journal_volume
60pub_type
杂志文章abstract::Percutaneous coronary intervention for the treatment of a severe calcified lesion is still one of the most technically challenging areas of interventional cardiology. Calcified lesions are a cause of stent underexpansion, which significantly increases the subsequent risks of in-stent restenosis and thrombosis, even wh...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-605
更新日期:2017-12-12 00:00:00
abstract::Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have incre...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.41
更新日期:2010-01-01 00:00:00
abstract::Friedreich's ataxia (FRDA), the most common subtype of early onset hereditary ataxia, is an autosomal recessive neurodegenerative disorder caused by unstable GAA expansions. Two-dimensional, pulse, and pulse tissue Doppler echocardiographic examinations were performed on 21 patients with GAA expansion. There was no as...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.46.443
更新日期:2005-05-01 00:00:00
abstract::Five patients who had had previous cardiac operations underwent minimally invasive beating heart mitral valve operations via a right minithoracotomy between November 2006 and February 2009. The mean age was 64 ± 10 years and 4 were female. Under general anesthesia with single-lumen ventilation, cardiopulmonary bypass ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.107
更新日期:2011-01-01 00:00:00
abstract::Our study aimed to investigate whether the frame design of transcatheter heart valve (THV) affects the procedural and clinical results of transcatheter aortic valve implantation (TAVI).We retrospectively reviewed 163 patients with aortic stenosis who underwent TAVI using different types of THV (Edwards SAPIEN, n = 31;...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.20-398
更新日期:2020-11-28 00:00:00
abstract::Ablation catheters with multiple electrodes are effective for the creation of linear atrial lesions but are associated with an increased risk of coagulum formation. In an animal study, we used a novel 9Fr deflectable ablation catheter with two saline/foam electrode pocket covered with 20 mm tubing. Each pocket contain...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.365
更新日期:2009-05-01 00:00:00
abstract::This study aimed to evaluate the clinical characteristics and surgical treatment of bicuspid aortic valve (BAV) infective endocarditis (IE) compared with tricuspid aortic valve (TAV) IE in China.The relevant pre-, intra- and post-operative materials of all IE patients undergoing cardiac surgery in our center between J...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-284
更新日期:2017-04-06 00:00:00
abstract::HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.1
更新日期:2011-01-01 00:00:00
abstract::Since diabetes mellitus (DM) is the most common cause of heart failure (HF), it is critically important to clarify whether incretin hormones including glucagon-like peptide-1 (GLP-1), which play an important role in blood glucose control, mediate cardioprotection. There are many lines of basic research evidence indica...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.15-028
更新日期:2015-01-01 00:00:00
abstract::The literature on malignant cardiac tumors is relatively limited because they are rare, especially among the Chinese population. We analyzed 14 patients diagnosed with malignant cardiac tumors in Fuwai Hospital and present the results of surgical treatments on the tumors. The mean age at tumor diagnosis was 47 years i...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.18-269
更新日期:2019-07-27 00:00:00
abstract::The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.16-313
更新日期:2017-08-03 00:00:00
abstract::Myocardial infarction (MI) is one of the major causes of death worldwide, and the therapeutic strategies of MI are still limited. In this study, we investigated the function of miR-665 in MI. In the present study, an ischemia/reperfusion (I/R) rat model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell model were su...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.19-416
更新日期:2020-03-28 00:00:00
abstract::Same-day discharge transradial percutaneous coronary intervention (TRI) has been reported to be safe and feasible in Western countries. However, Asia has not produced any reports related to this matter. The present study explored the safety and feasibility of patients with indications for TR coronary angiography and a...
journal_title:International heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1536/ihj.51.371
更新日期:2010-01-01 00:00:00
abstract::T1 or longitudinal relaxation time is one of the very fundamental magnetic resonance imaging (MRI) time constants and a tissue characterizing parameter. Only during the last decade did it become possible to quantify T1 values of the myocardium through T1 mapping. Evolving from only region of interest analysis and long...
journal_title:International heart journal
pub_type: 杂志文章,评审
doi:10.1536/ihj.16-169
更新日期:2016-07-27 00:00:00
abstract::Discrimination between atrioventricular node reentry tachycardia (AVNRT) and orthodromic reciprocating tachycardia (ORT) during an electrophysiological study is sometimes challenging. This study aimed to investigate if the difference in the local VA (ventricle-atrium) interval during ventricular entrainment pacing and...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.17-002
更新日期:2018-01-27 00:00:00
abstract::Electrocardiography (ECG) is used to screen for pulmonary hypertension (PH). However, it is unclear which parameters of ECG are the most useful for screening.ECG parameters related to right ventricular hypertrophy criteria were examined in 145 ECGs of subjects who were suspected to have PH and underwent right heart ca...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-647
更新日期:2018-01-27 00:00:00
abstract::The use of unilateral pulmonary artery occlusion (UPAO) test for the preoperative evaluation of pneumonectomy was reported in adult patients. On the contrary, in infants, no strategies have yet been recommended to predict hemodynamics after pneumonectomy, nor has use of the UPAO test been reported. We describe the fir...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-606
更新日期:2018-01-27 00:00:00
abstract::microRNA-99a (miR-99a) is recently recognized as a key regulator in various cancers and cardiovascular diseases. In the present study, we sought to investigate the effects of miR-99a in rat cardiomyocyte H9c2 cells against oxidative injury induced by lipopolysaccharide (LPS).MTT assay, reactive oxygen species (ROS) as...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.16-261
更新日期:2017-05-31 00:00:00
abstract::Percutaneous balloon mitral valvoplasty (PBMV) has become the treatment of choice for severe pliable rheumatic mitral stenosis. The multi-track system is a recent variation of the double-balloon technique and is easier owing to the use of a monorail balloon and a simple, single-guidewire approach. In the present study...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.54.196
更新日期:2013-01-01 00:00:00
abstract::Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with high mortality. Hypertension is a well known risk factor of AAD. There have been previous reports about the association between circadian variation of blood pressure (BP) and cardiovascular events. However, little is known about the associ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-328
更新日期:2015-05-13 00:00:00
abstract::The purpose of this study was to investigate the precise pattern of stroke volume (SV) response during exercise in patients with chronic heart failure (CHF) compared with age-matched controls. Fourteen patients with CHF and 7 controls performed symptom-limited bicycle exercise testing with respiratory gas exchange mea...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.293
更新日期:2012-01-01 00:00:00
abstract::Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with coronary artery disease and the control group 100 patients with normal...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.51.86
更新日期:2010-03-01 00:00:00
abstract::The chronic use of bosentan has been reported to reduce the plasma concentration of sildenafil. However, it remains unclear how sildenafil exerts the effect at reduced concentrations in pulmonary arterial hypertension (PAH) patients chronically treated with bosentan.We examined the hemodynamic effects of sildenafil (5...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.52.233
更新日期:2011-01-01 00:00:00
abstract::In this study we aimed to investigate whether there is an association between the neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) in patients with non-ST segment elevation myocardial infarction (NSTEMI) using the SYNTAX score (SXscore). A total of 414 patients with NSTEMI who underwe...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.14-175
更新日期:2015-01-01 00:00:00
abstract::Transradial percutaneous coronary intervention (PCI), which is less invasive than transfemoral PCI, may facilitate early rehabilitation of patients with acute myocardial infarction (AMI). The aim of our study was to investigate whether transradial PCI is associated with a shorter coronary care unit (CCU) stay in very ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.53.79
更新日期:2012-01-01 00:00:00
abstract::Adipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as ...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.48.149
更新日期:2007-03-01 00:00:00
abstract::Proinflammatory cytokine responses might occur in elderly individuals with cardiovascular (CV) disease, cerebro-vascular (CVA) disease, and/or pulmonary disease (PD). Spiritual activation is an important coping mechanism, since psychiatric depression is an important risk factor for these individuals. Thirty-three very...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.52.299
更新日期:2011-01-01 00:00:00
abstract::This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control,...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.50.191
更新日期:2009-03-01 00:00:00
abstract::The aim of this study was to investigate whether electrical stimulation of skeletal muscles could represent a rehabilitation alternative for patients with chronic heart failure (CHF). Thirty patients with CHF and NYHA class II-III were randomly assigned to a rehabilitation program using either electrical stimulation o...
journal_title:International heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1536/ihj.47.441
更新日期:2006-05-01 00:00:00
abstract::Prevalent atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) represents an important issue with regard to stroke events caused by embolization and is associated with high mortality. Increased epicardial adipose tissue (EAT), which shows high metabolic activity, can locally influence the activi...
journal_title:International heart journal
pub_type: 杂志文章
doi:10.1536/ihj.54.297
更新日期:2013-01-01 00:00:00