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Macular pigment changes in pseudophakic eyes quantified with resonance Raman spectroscopy.

Abstract：

PURPOSE:We examined changes in macular pigment optical density (MPOD) levels after cataract surgery and compared the MPOD between eyes with clear intraocular lenses (IOLs) and yellow-tinted IOLs. DESIGN:Prospective, comparative case series. PARTICIPANTS:The MPOD levels were measured in 480 eyes of 337 patients after cataract surgery. Among them, the data from 259 eyes (clear IOL group, 121 eyes; yellow-tinted IOL group, 138 eyes) of 259 Japanese patients were selected for statistical analyses on the basis of the inclusion criteria: a postoperative visual acuity (VA) of ≥0.8 and no fundus diseases. Only 1 eye of each patient was enrolled. Patients provided informed consent to participate in this study on the basis of the approval of the institutional review board before surgery. METHODS:The patients selected the type of IOL to be implanted. The MPOD levels were measured using resonance Raman spectroscopy on day 1 (baseline value); months 1, 3, and 6; and years 1 and 2 postoperatively. MAIN OUTCOME MEASURES:The difference in MPOD levels between the IOL groups was analyzed by unpaired t tests. The following parameters were analyzed by multiple regression analysis: age, gender, body mass index (BMI), smoking history, glaucoma, diabetes, preoperative VA, preoperative refractive error, and IOL power and type. RESULTS:We found no significant differences in the baseline characteristics between the 2 groups. Until 6 months postoperatively, the MPOD levels did not differ significantly between the groups. However, from 1 year onward, the levels were significantly higher in the yellow-tinted IOL group compared with the clear IOL group. By multiple regression analysis, 1 day postoperatively, older age and diabetes were correlated with lower MPOD levels; 1 year postoperatively and thereafter, however, lower MPOD levels were correlated with clear IOLs. CONCLUSIONS:Cataract surgery with clear IOLs induced a greater decrease in macular pigment levels compared with yellow-tinted IOLs during a longer follow-up period. These findings agreed with observations that excessive light exposure is associated inversely with MPOD, because clear IOLs transmit higher intensities of blue light than yellow-tinted IOLs.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Obana A,Tanito M,Gohto Y,Gellermann W,Okazaki S,Ohira A

doi

10.1016/j.ophtha.2011.02.017

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1852-8

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(11)00176-X

journal_volume

118

pub_type

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Macular pigment changes in pseudophakic eyes quantified with resonance Raman spectroscopy.