Abstract:
PURPOSE:To assess outcomes 1 year after Descemet's stripping automated endothelial keratoplasty (DSAEK) in comparison with penetrating keratoplasty (PKP) from the Specular Microscopy Ancillary Study (SMAS) of the Cornea Donor Study. DESIGN:Multicenter, prospective, nonrandomized clinical trial. PARTICIPANTS:A total of 173 subjects undergoing DSAEK for a moderate risk condition (principally Fuchs' dystrophy or pseudophakic/aphakic corneal edema) compared with 410 subjects undergoing PKP from the SMAS who had clear grafts with at least 1 postoperative specular image within a 15-month follow-up period. METHODS:The DSAEK procedures were performed by 2 experienced surgeons per their individual techniques, using the same donor and similar recipient criteria as for the PKP procedures in the SMAS performed by 68 surgeons at 45 sites, with donors provided from 31 eye banks. Graft success and complications for the DSAEK group were assessed and compared with the SMAS group. Endothelial cell density (ECD) was determined from baseline donor, 6-month (range, 5-7 months), and 12-month (range, 9-15 months) postoperative central endothelial images by the same reading center used in the SMAS. MAIN OUTCOME MEASURES:Endothelial cell density and graft survival at 1 year. RESULTS:Although the DSAEK recipient group criteria were similar to the PKP group, Fuchs' dystrophy was more prevalent in the DSAEK group (85% vs. 64%) and pseudophakic corneal edema was less prevalent (13% vs. 32%, P<0.001). The regraft rate within 15 months was 2.3% (DSAEK group) and 1.3% (PKP group) (P = 0.50). Percent endothelial cell loss was 34+/-22% versus 11+/-20% (6 months) and 38+/-22% versus 20+/-23% (12 months) in the DSAEK and PKP groups, respectively (both P<0.001). Preoperative diagnosis affected endothelial cell loss over time; in the PKP group, the subjects with pseudophakic/aphakic corneal edema experienced significantly higher 12-month cell loss than the subjects with Fuchs' dystrophy (28% vs. 16%, P = 0.01), whereas in the DSAEK group, the 12-month cell loss was comparable for the 2 diagnoses (41% vs. 37%, P = 0.59). CONCLUSIONS:One year post-transplantation, overall graft success was comparable for DSAEK and PKP procedures and endothelial cell loss was higher with DSAEK.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Price MO,Gorovoy M,Benetz BA,Price FW Jr,Menegay HJ,Debanne SM,Lass JHdoi
10.1016/j.ophtha.2009.07.036subject
Has Abstractpub_date
2010-03-01 00:00:00pages
438-44issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(09)00845-8journal_volume
117pub_type
临床试验,杂志文章,多中心研究相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:We studied the 3-year efficacy and safety results of a 4-year study evaluating fluocinolone acetonide (FA) intravitreal implants in eyes with persistent or recurrent diabetic macular edema (DME). DESIGN:Prospective, evaluator-masked, controlled, multicenter clinical trial. PARTICIPANTS:We included 196 eyes wi...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2011.02.048
更新日期:2011-08-01 00:00:00
abstract::After the appropriate workup, the size, location, and consistency of an orbital mass will dictate the surgical approach chosen. Masses in the muscle cone area or in the temporal portion of the orbit are most easily approached by the lateral orbitotomy. For lacrimal gland tumors a superior extension of the lateral orbi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35440-9
更新日期:1979-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of a single intravitreal injection of ocriplasmin 125 μg across relevant subpopulations of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT), including when associated with macular hole. DESIGN:Two multicenter, randomized, placebo-controlled, double-ma...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.07.045
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To report a series of patients with ocular infections caused by the rarely described gram-negative bacterium, Providencia rettgeri. DESIGN:Retrospective case series. PARTICIPANTS:Five patients with ocular infections who grew P. rettgeri after culture (2 keratitis, 1 dacryocystitis, 1 conjunctivitis, 1 conjunc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.03.047
更新日期:2006-08-01 00:00:00
abstract:PURPOSE:To study the nature of retinal inflammatory response in rd10 mice, an animal model of retinitis pigmentosa (RP), and to investigate the effect of an antioxidant on retinal inflammation and photoreceptor apoptosis. DESIGN:Experimental study. PARTICIPANTS AND CONTROLS:This study included 42 untreated rd10 mice,...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.07.008
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Perimacular retinal folds have been reported in the shaken baby syndrome, but have not been described in adults with Terson syndrome. METHODS:The authors present two patients with perimacular retinal folds in adults with Terson syndrome. In one patient, electron microscopy was used to examine the membrane s...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31507-1
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31479-x
更新日期:1993-09-01 00:00:00
abstract::The effects of high (71%) and low (38.6%) water content lenses on antibiotic delivery to the cornea were studied in rabbits by measuring corneal tobramycin concentrations 1, 2, 4 and 6 hours after topical application at intervals of 15 minutes. In the presence of the low water content lens corneal drug levels were hig...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34062-9
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:The authors quantified the vascular resistance for venous outflow in central retinal vein occlusion (CRVO). METHODS:The blood velocity in the central retinal vein (CRV) and central retinal artery (CRA) was measured by pulsed Doppler sonography (4-Mhz probe), and the pulse curve of the intraocular pressure (IOP...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30255-3
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:The diagnosis of macular holes is difficult. Confocal laser tomographic analysis of the retina permits the precise measurements of the macular surface. The authors used this technique to study the macular area of patients with full-thickness macular holes. The purposes of these studies is to perform three-dimen...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30847-0
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:A study was performed to determine if diabetic subjects who fail to respond to initial panretinal photocoagulation with regression of retinopathy risk factors do better with supplemental panretinal photocoagulation. METHODS:Thirty-five patients with 3 or more retinopathy risk factors who failed to respond to p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(92)31739-7
更新日期:1992-11-01 00:00:00
abstract:PURPOSE:To evaluate the effects of laser trabeculoplasty on 24-hour intraocular pressure (IOP) in a group of medically treated open-angle glaucoma patients. DESIGN:Prospective experimental study. PARTICIPANTS:Eighteen open-angle glaucoma patients. METHODS:Laser trabeculoplasty (180 degrees ) was performed on 28 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.07.058
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Transconjunctival cryopexy of the vitreous base is clinically effective in patients with steroid nonresponsive pars planitis who have peripheral neovascularization. Cryoablation of the region previously has been thought to eliminate the areas of permeable neovascular tissue, thus removing the focus of exudat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31726-6
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Some congenital superior oblique palsies are known to be due to anomalous or lax superior oblique tendons. This prospective study of 24 patients with a diagnosis of superior oblique palsy was performed to determine the prevalence and significance of anatomic tendon anomaly or laxity as diagnosed by traction ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31854-8
更新日期:1992-07-01 00:00:00
abstract:PURPOSE:To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). DESIGN:Population-based cohort study. PARTICIPANTS:A total of 518 participants aged 40 to 80 years (baseline visit 2007-2009 and second visit 6 years later, 2013-2015), with diabetes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.011
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Corneal polarization axis (CPA) has been reported to affect retardation measurements obtained with scanning laser polarimetry. The purpose of this investigation was to evaluate the longitudinal stability of CPA measurements. DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Persons with normal co...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00569-3
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:The mechanism of cupping reversal seen after lowering intraocular pressure (IOP) in pediatric glaucoma is unknown. Theories include forward movement of the lamina cribrosa or shrinkage of a stretched scleral canal. Our study aimed to quantify changes in optic disc size occurring in children who had undergone gl...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.02.041
更新日期:2011-10-01 00:00:00
abstract::Vitreous amyloid may be the presenting clinical manifestation of types 1 and 2 familial amyloidotic polyneuropathy or complicate the course of these syndromes. Recent studies have shown that the major subunit protein composing amyloid fibrils in these conditions is a variant or abnormal prealbumin molecule and that af...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33531-6
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Several forms of retinal pigment epithelial detachment have been reported. The authors used indocyanine green (ICG) videoangiography, which is useful to study the choroidal vasculature and Bruch membrane, to study pigment epithelial detachments. METHODS:Ninety-eight pigment epithelial detachments in 75 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30990-6
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN:Retrospective case series. PARTICIPANTS:A total of 1059 patients with uveal melanoma. METHODS:Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOM...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.12.026
更新日期:2017-05-01 00:00:00
abstract::Clinical evaluations of the Autofield-I, CFA-120, and Fieldmaster Model 101-PR automated perimeters were performed in comparison with manual kinetic testing on the Goldmann perimeter. All the automated perimeters displayed similar high rates of detecting visual field defects, although their false-alarm (false-positive...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35162-2
更新日期:1980-08-01 00:00:00
abstract:PURPOSE:To compare efficacies of 1-day, 1-hour, and combined 1-day/1-hour preoperative topical gatifloxacin in eliminating conjunctival bacterial flora. DESIGN:Prospective, comparative case series. PARTICIPANTS:Sixty patients (120 eyes) scheduled to undergo anterior segment intraocular surgery at Stanford University ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2008.06.024
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To identify factors predictive of remission of inflammation in new-onset anterior uveitis cases treated at tertiary uveitis care facilities. DESIGN:Retrospective cohort study. PARTICIPANTS:Patients seeking treatment at participating academic uveitis clinics within 90 days of initial diagnosis of anterior uvei...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.09.041
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To determine the clinical efficacy of modified deep lamellar keratoplasty for the treatment of advanced-stage keratoconus with steep curvature. DESIGN:Retrospective, noncomparative clinical trial. PARTICIPANTS:Fifty-nine keratoconus patients with a curvature of more than 60 diopters (D) in 65 eyes were studie...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2009.07.005
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN:Cohort study. PARTICIPANTS:A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patien...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.04.014
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To evaluate a new high-resolution noncontact biometer (Lenstar; Haag-Streit AG, Koeniz, Switzerland) using optical low-coherence reflectometry and to compare the clinical measurements with those obtained from the IOLMaster (Carl Zeiss, Jena, Germany) and the Pachmumeter (Haag-Streit AG). DESIGN:Exploratory eva...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2009.04.019
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To investigate the adherence of one clinically relevant ocular isolate of Staphylococcus epidermidis to polymethyl methacrylate (PMMA) and Acrysof (Alcon Surgical, Fort Worth, TX) intraocular lenses (IOLs). DESIGN:Experimental study. PARTICIPANTS:The authors examined the in vitro adherence of one clinically r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00080-4
更新日期:2000-06-01 00:00:00
abstract::Long-term follow-up was recorded on the visual fields of 251 patients with chronic open-angle glaucoma and 826 patients with ocular hypertension. Observation periods exceeded ten years for 73 patients with manifest glaucoma. Initial glaucomatous defects appeared in 98 eyes of 72 patients while under continuous observa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34798-3
更新日期:1982-03-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of age-related change of macular and circumpapillary retinal nerve fiber layer (RNFL) measurements on evaluation of glaucoma progression. DESIGN:Prospective, longitudinal study. PARTICIPANTS:A total of 150 eyes of 90 patients with glaucoma and 72 eyes of 40 normal individuals. MET...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.07.021
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) and Toxoplasma gondii both cause necrotizing retinopathy in immunosuppressed hosts. Because of the high prevalence of serum antibodies to these agents in the general population and the risks associated with retinal biopsies, diagnosis of these infections is usually based on clinical fin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31267-6
更新日期:1994-03-01 00:00:00