Abstract：
OBJECTIVE:The purpose of the study was to measure the effect of the topical carbonic anhydrase inhibitor, 2% dorzolamide hydrochloride, on the rate of aqueous humor flow in sleeping humans. DESIGN:A randomized, double-masked, placebo-controlled study. PARTICIPANTS:Twenty-five normal human subjects. INTERVENTION:Topical instillation of 2% dorzolamide hydrochloride versus topical placebo. MAIN OUTCOME MEASURES:Rate of aqueous humor flow in sleeping humans and intraocular pressure immediately after awakening from sleep. RESULTS:The rate of flow in sleeping subjects at night (12 AM to 6 AM) was 1.28 +/- 0.30 microliters/min (mean +/- standard deviation; n = 25) in placebo-treated eyes, whereas the nighttime flow in dorzolamide-treated eyes was 1.17 +/- 0.38 microliters/min (P = < 0.001), resulting in a nighttime reduction of 9% (P = 0.032). In contrast, the daytime (8 AM to 4 PM) rate of flow in ambulatory subjects was 2.97 +/- 0.64 microliters/min in placebo-treated eyes and 2.60 +/- 0.63 microliters/min (P = 0.032) in dorzolamide-treated eyes, resulting in a daytime reduction of 13% (P = < 0.001). CONCLUSIONS:Topically administered dorzolamide hydrochloride is effective for reducing the rate of aqueous humor flow in normal human eyes during the day and at night during sleep. The efficacy of dorzolamide at these two times is approximately half that of systematically administered acetazolamide.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Vanlandingham BD,Maus TL,Brubaker RFdoi
10.1016/S0161-6420(98)98043-5subject
Has Abstractpub_date
1998-08-01 00:00:00pages
1537-40issue
8eissn
0161-6420issn
1549-4713pii
S0161-6420(98)98043-5journal_volume
105pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:To evaluate whether ketorolac ophthalmic drops prescribed four times a day can be associated with improved visual acuity and prompt resolution of edema for patients with pseudophakic cystoid macular edema identified more than 24 months after cataract surgery. DESIGN:Prospective, nonrandomized, comparative (s...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/S0161-6420(99)90366-4
更新日期：1999-09-01 00:00:00
abstract：PURPOSE:Multiple independent laboratories have confirmed the histologic observation that some tumor microcirculation patterns (MCPs) in uveal melanomas are associated strongly with death resulting from metastatic disease. Because these patterns are imageable with confocal indocyanine green angiography (ICG), we designe...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(02)01266-6
更新日期：2002-12-01 00:00:00
abstract：PURPOSE:Choroidal detachment and anterior chamber (AC) shallowing develop in some cases after scleral buckling surgery for rhegmatogenous retinal detachment (RD). Postoperative angle-closure glaucoma has been reported to occur in 4% of cases. It is supposed that compression by the local scleral buckling induces ciliary...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.09.023
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort with type 2 idiopathic macular telangiectasia (MacTel). DESIGN:Case-control study. PARTICIPANTS:Patients with and without retinal crystals from the Macular Telangiectasia Project, an internati...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2011.05.022
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To use optical coherence tomography (OCT) to evaluate the femtosecond laser intrastromal incisions made during cataract surgery to reduce corneal astigmatism. DESIGN:Retrospective case series. PARTICIPANTS:Seventy-seven eyes of 77 patients. METHODS:Paired intrastromal incisions were created using the Catalys...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2017.03.022
更新日期：2017-08-01 00:00:00
abstract：:The first 290 consecutive eyes (192 patients) to undergo radial keratotomy by one surgeon were evaluated prospectively. All had had complete preoperative evaluation and 269 (93%) were examined one or more years after surgery. Preoperatively, all patients except one had worse than 20/100 uncorrected visual acuity, 65% ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34264-6
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVE:We compared outcomes after dacryocystorhinostomies (DCRs) performed by the traditional external approach (EX-DCR) or by a nonlaser, nonendoscopic endonasal approach (EN-DCR). DESIGN:Retrospective, nonrandomized, comparative interventional case series. PARTICIPANTS:A total of 354 consecutive cases of DCR wer...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01452-5
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leukocyte antigen (HLA) class II alleles in these patients. DESIGN:Fi...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)90122-7
更新日期：1999-03-01 00:00:00
abstract：:Simple strategies for visual field screening with automated perimeters can detect abnormalities at acceptable rates. However, the information available from a screening field chart is often insufficient to assign the field into a diagnostic category, and further field testing is necessary. Automated perimeters can be ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(85)33879-4
更新日期：1985-09-01 00:00:00
abstract：PURPOSE:The authors studied the coagulation cascade and fibrinolysis pathway in patients with untreated glaucoma (P = 0.00001 and P = 0.0003, respectively) and patients with normal pressure glaucoma ([NPG] P = 0.00001 and P = 0.03, respectively). METHODS:Forty-two untreated patients with NPG, 25 untreated patients wit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30245-0
更新日期：1997-04-01 00:00:00
abstract：PURPOSE:Accommodation of the eye can adversely affect optical tomography of the retina using a confocal scanning laser ophthalmoscope (cSLO). This study measured the dynamic accommodative response of young adult eyes while acquiring static retinal images with a cSLO without cycloplegia and also examined whether a scann...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.08.047
更新日期：2007-06-01 00:00:00
abstract：:Granulomatous uveitis has infrequently been described as a manifestation of the autoimmune phenomena of multiple sclerosis (MS). The authors describe six cases of anterior granulomatous uveitis in patients with MS. All six patients had features of iridocyclitis and three patients had features of periphlebitis, which w...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32324-8
更新日期：1991-02-01 00:00:00
abstract：:We compared the ocular-hypotensive efficacy and systemic and ocular safety of an ophthalmic solution of levobunolol (0.5% and 1%) twice daily, with timolol (0.5%) twice daily in a long-term double-masked study of 391 patients with open-angle glaucoma or ocular hypertension. Patients received the test medication in bot...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVE:To develop a simulator for training in phacoemulsification to be used as a learning device for both beginners and experienced surgeons to shorten the learning curve. DESIGN:Experimental study. METHODS:The system consists of a personal computer, a 3-dimensional visual interface, a phacoemulsification handpie...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.06.023
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:To update the findings from the Choroidal Neovascularization Prevention Trial (CNVPT) with respect to resolution of drusen, incidence of choroidal neovascularization, and visual function. DESIGN:A multicenter, randomized, controlled, pilot clinical trial. PARTICIPANTS:The 120 patients enrolled in the CNVPT. P...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/S0161-6420(03)00098-8
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To report clinical findings of rare retrobulbar optic nerve hemangioblastomas associated with von Hippel-Lindau disease (VHL). DESIGN:Retrospective observational case series. PARTICIPANTS:Nine patients with VHL. METHODS:The clinical course and magnetic resonance imaging findings of patients with VHL and he...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.01.027
更新日期：2008-08-01 00:00:00
abstract：:An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin. All five known long-acting corticosteroids, when...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(78)35593-7
更新日期：1978-09-01 00:00:00
abstract：:Reductions in flicker sensitivity in ocular hypertension are thought to precede manifest glaucomatous damage, but the proportion of patients with ocular hypertension reported to have losses in flicker sensitivity (50-90%) is far out of step with the proportion of ocular hypertensive patients in whom clinically defined...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32630-1
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:To determine whether the incidence and severity of retinopathy of prematurity (ROP) differs between infants conceived naturally and those born after assisted conception, and to analyze the impact of singleton versus multiple gestation on ROP. DESIGN:Comparative case series. PARTICIPANTS:The study group con...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.11.010
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:To investigate the potential contribution of inflammatory and immune-mediated processes contributing to the pathogenesis of proliferative vitreoretinopathy (PVR), an immunohistochemical study was undertaken to characterize the infiltrating inflammatory cells in epiretinal membranes surgically removed from th...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)31793-2
更新日期：1992-09-01 00:00:00
abstract：:From 1984 to 1989, 24 patients with desperate ocular surface wetting problems due to mucus deficiency syndrome with extensive symblephara or lid fusion were treated by autologous free transplants of nasal mucosa from the nasal conchae. This procedure covers the ocular surface not only with nonkeratinizing epithelium b...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32471-5
更新日期：1990-08-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between orbital bony geometry and the volume of the intraorbital structures in predicting compressive dysthyroid optic neuropathy (DON). DESIGN:Retrospective, consecutive case series. PARTICIPANTS:Images of 198 orbits from 99 patients suffering from thyroid-related orbitopathy wer...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.04.021
更新日期：2012-10-01 00:00:00
abstract：CASE REPORT:The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had prod...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)31005-6
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:To assess the long-term success rate and to determine factors that predict survival after 5-fluorouracil-augmented needling revision of poorly functioning trabeculectomy blebs. DESIGN:Prospective observational cohort study. PARTICIPANTS:Eighty-one consecutive patients undergoing bleb needling. METHODS:Surviv...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.10.023
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:To analyze the use of the Cutler-Beard transmarginal rotation entropion clamp (Karl Ilg & Co., St. Charles, IL) in patients undergoing the Cutler-Beard procedure for repair of eyelid defects after tumor excision or trauma. DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Twenty-five patients under...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(02)01995-4
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:To determine whether adjusting the intraocular pressure (IOP) change of the trial eye for the IOP change of the fellow eye (i.e., monocular trial) is a better assessment of medication response than testing each eye independently. DESIGN:Analysis of data from a prospective, randomized, clinical trial. PARTIC...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2010.02.020
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:This study was undertaken to evaluate the risk of eye injury in motor vehicle accidents in which airbags deploy. An attempt was made to assess the possible associations between eye injuries and eyewear in these accidents. DESIGN:Retrospective observational case series and literature review with analysis. PART...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00244-6
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN:Randomized, 20-month, multicenter, subject- and efficacy evaluator-masked, par...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2020.06.018
更新日期：2020-12-01 00:00:00
abstract：:Ocular inflammatory diseases and ocular adnexal lymphoid tumors have become less obscure and intimidating by virtue of our ability to study the infiltrates in these various diseases for their B-lymphocyte and T-lymphocyte composition. Comparisons are also possible between lymphocytic profiles in the peripheral blood a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34256-7
更新日期：1984-06-01 00:00:00
abstract：PURPOSE:To study the efficacy of liposomal benzoporphyrin derivative (BPD) (Verteportin) for the angiographic visualization and photodynamic therapy (PDT) of experimental iris neovascularization. METHODS:Experimental iris neovascularization was induced in eight cynomolgus monkey eyes by occluding all the branch retina...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30151-1
更新日期：1997-08-01 00:00:00
