Abstract:
OBJECTIVE:To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leukocyte antigen (HLA) class II alleles in these patients. DESIGN:Fifty-three patients with the diagnosis of pars planitis underwent clinical record review or telephone interview for follow-up or both; 32 of these underwent phlebotomy for analysis of HLA class II alleles. MAIN OUTCOME MEASURES:Outcomes included visual acuity, occurrence of multiple sclerosis and/or optic neuritis, and HLA class II gene frequencies. RESULTS:With a mean follow-up of 2 years, approximately 90% of patients maintained a visual acuity better than 20/40 in at least one eye. The most frequently encountered ophthalmic complications included cystoid macular edema, cataract, and epiretinal membrane formation. Of 37 patients with pars planitis who had medical or neurologic follow-up evaluations, 6 (16.2%) developed multiple sclerosis. The HLA-DR15 allele, coding for one of the two HLA-DR2 subtypes, was associated with pars planitis (odds ratio = 2.86, 95% confidence interval = 1.42-5.78, P = 0.004). CONCLUSIONS:A common immunogenetic predisposition to multiple sclerosis and pars planitis may be associated with the HLA-DR15 allele. This association may represent genetic linkage to the HLA-DR locus or a role for the HLA-DR15 gene product in the pathogenesis of both of these diseases.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Raja SC,Jabs DA,Dunn JP,Fekrat S,Machan CH,Marsh MJ,Bressler NMdoi
10.1016/S0161-6420(99)90122-7subject
Has Abstractpub_date
1999-03-01 00:00:00pages
594-9issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(99)90122-7journal_volume
106pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis. DESIGN:Retrospective observational case series. PARTICIPANTS:Records of 5 patients with biopsy-proven DLE were reviewed. METHODS:Clinical and pathology records were examined. MAIN OUTCOME MEASURES:Patients...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.01.035
更新日期:2005-05-01 00:00:00
abstract::The zonules of 27 postmortem eyes were studied grossly using a histologic staining technique that allowed easy visualization of the zonules. Large disinsertions of the zonules were present in 5 of the 20 eyes that had undergone extracapsular cataract extraction (ECCE). ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33423-2
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the outcome of phototherapeutic keratectomy (PTK) treatment of epithelial basement membrane dystrophy (EBMD) patients and to examine clinical and morphologic signs of recurrent dystrophy. DESIGN:Cross-sectional, clinic-based study. PARTICIPANTS:Fifty-two eyes of 39 patients diagnosed with EBMD w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.07.003
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To describe the results from a statewide preschool vision screening program using the MTI PhotoScreener (Medical Technology and Innovations, Inc., Cedar Falls, IA). DESIGN:Cross-sectional study. PARTICIPANTS:A total of 15,059 children aged 6 to 47 months enrolled in childcare and preschool settings throughout...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00298-0
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:Cataract and glaucoma commonly coexist in elderly patients and present complex treatment options. This study investigates the results of simultaneous treatment of both conditions using phacoemulsification with posterior chamber lens implant and mitomycin-augmented trabeculectomy (combined surgery). METHODS:A r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30571-x
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:To describe and classify patterns of abnormal fundus autofluorescence (FAF) of patients with β-thalassemia receiving long-term treatment with deferoxamine (DFO). DESIGN:Prospective, cross-sectional, case-control study. PARTICIPANTS:A total of 197 consecutive patients with β-thalassemia major or intermedia wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.01.039
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To present a previously unreported African American family with 1 variation and 1 mutation of the homeobox transcription factor gene, VSX1 (RINX), and to describe the clinical features of family members. DESIGN:Family genotype and clinical studies. PARTICIPANTS:A 3-generation family with 7 available family me...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.07.006
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To compare functional and surgical outcomes of a subperiosteal midface lift with and without the placement of a hard palate mucosal graft (HPMG) in patients with lower eyelid retraction. DESIGN:Retrospective, comparative, interventional case series. PARTICIPANTS:Thirty-four patients with lower eyelid retracti...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.05.014
更新日期:2006-10-01 00:00:00
abstract::Three hundred eight patients with strabismus were treated with botulinum A toxin (Oculinum) chemodenervation; 153 were followed by the authors for at least 6 months. In this study group, 97 received botulinum A toxin injections as the primary method of treatment of their ocular deviation. Fifty-six received injections...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32776-x
更新日期:1989-07-01 00:00:00
abstract:PURPOSE:Genome-wide association studies and targeted sequencing studies of candidate genes have identified common and rare variants that are associated with age-related macular degeneration (AMD). Whole-exome sequencing (WES) studies allow a more comprehensive analysis of rare coding variants across all genes of the ge...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2018.03.040
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To obtain objective measurements of corneal light scattering after excimer laser keratectomy, and to evaluate the relation of light scattering to clinical haze grading and visual acuity. METHODS:The authors measured best-corrected visual acuity, subjective clinical haze grade, and corneal light-scattering inde...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30674-x
更新日期:1996-03-01 00:00:00
abstract::Ten eyes of eight patients with open-angle glaucoma (OAG) had neodymium (Nd):YAG trabeculopuncture performed in an investigational protocol as an alternative to surgical intervention. In each, at four to six sites in the mid-trabecular meshwork, three to six superimposed applications were made (2 to 6 mJ). In four of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33932-5
更新日期:1985-07-01 00:00:00
abstract::Autosomal dominant vitreoretinochoroidopathy (ADVIRC), a recently described disease, is clinically characterized by a slowly progressive or stationary circumferential peripheral pigmentary retinopathy with fibrillar condensation of the vitreous. Histopathologic study of an 88-year-old patient with this disease showed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32663-7
更新日期:1989-12-01 00:00:00
abstract::Gardner syndrome is a dominantly inherited familial cancer syndrome characterized by intestinal polyposis, bony hamartomata, and various soft tissue tumors. The risk of malignancy during adult life is essentially 100%, but as yet no phenotypic marker nor biochemical or serological linkage have been useful to identify ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34213-0
更新日期:1984-08-01 00:00:00
abstract:PURPOSE:To describe the relationship between chronic systemic immune suppression and conjunctival squamous cell carcinoma (SCC). DESIGN:Retrospective interventional case series. PARTICIPANTS:Thirteen immunosuppressed patients with conjunctival SCC. METHODS:Surgical excision in all cases plus additional topical inter...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.04.001
更新日期:2011-11-01 00:00:00
abstract::Thirty-three keratophakias were performed at Holy Cross Hospital in Mission Hills, California between August 1979 and October 1982. Nineteen were primary, combined with cataract surgery; 14 were secondary, performed on aphakic eyes. Data on the 23 cases that had a minimum follow-up time of one year were analyzed by an...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34515-2
更新日期:1983-06-01 00:00:00
abstract:PURPOSE:To assess agreement between rotating Scheimpflug camera and ultrasound pachymetry in measuring graft central thickness, and compare reproducibility/repeatability of these methods in corneal grafts and normal corneas. DESIGN:Experimental study. PARTICIPANTS:Sixty-five patients with corneal grafts after penetra...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.10.059
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:Nonspecific orbital inflammation, also called "orbital pseudotumor," has many of the features of thyroid-associated ophthalmopathy, especially when localized to the eye muscle. The purpose of this study is to test for circulating autoantibodies against eye muscle antigens and features of possible thyroid autoim...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)31066-4
更新日期:1995-01-01 00:00:00
abstract::A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus (CMV) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eyes disclosed CMV inclusions in all layers of the involved retinas including the retinal pigment...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33261-0
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVE:We compared outcomes after dacryocystorhinostomies (DCRs) performed by the traditional external approach (EX-DCR) or by a nonlaser, nonendoscopic endonasal approach (EN-DCR). DESIGN:Retrospective, nonrandomized, comparative interventional case series. PARTICIPANTS:A total of 354 consecutive cases of DCR wer...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01452-5
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To determine the intraocular pressure (IOP) profile during and after systemic dexamethasone treatment in preterm very low birth weight (VLBW; <1500 g) infants. DESIGN:A cohort study at a university-affiliated tertiary neonatal center. PARTICIPANTS:Twenty-seven VLBW infants who received a 3-week dose-tapering ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.01.010
更新日期:2008-05-01 00:00:00
abstract::Twenty-five ambulatory patients with acquired immunodeficiency syndrome (AIDS) were studied over a 6-month period. Fourteen (56%) of the patients were heterosexuals with a history of intravenous drug abuse. Ocular involvement was seen in 40% of patients, cotton-wool spots being the major manifestation. Findings consis...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Corneal sensitivity was tested in 145 cases of clear corneal transplants using Cochet-Bonnet aesthesiometer. The central area of corneal transplants was found to be either completely anesthetic or markedly hypesthetic even 32 years following corneal transplantation, as exemplified in a patient who had surgery for kera...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33857-5
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Beta-radiation has been used since 1950 as a postoperative measure to reduce the recurrence of pterygia. Scleral necrosis has been a major complication after radiotherapy that has led to perforation of the globe, endophthalmitis, and visual loss in some cases. METHOD:A patient is presented in whom scleral n...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30914-1
更新日期:1995-07-01 00:00:00
abstract::Superior sulcus deformity is a late sequela of surgical anophthalmos. Many methods have been proposed to treat this difficult problem. A technique using autogenous costal cartilage that has resulted in satisfactory repair is presented. In addition to standard photographs and exophthalmometry measurements to follow the...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34772-7
更新日期:1982-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of systemic factors on best-corrected visual acuity (BCVA) achieved with ranibizumab (Lucentis; Genentech, Inc, South San Francisco, CA) for treatment of diabetic macular edema (DME) in the RIDE and RISE phase 3 studies. DESIGN:Exploratory, post hoc analysis of 2 randomized, double-maske...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2016.03.038
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:It has been recently documented that multiple bilateral pigmented lesions at the level of the retinal pigment epithelium may be an indicator of patients with familial adenomatous polyposis who are prone to develop intestinal cancer, particularly if there is a positive family history of these intestinal disor...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31736-1
更新日期:1992-11-01 00:00:00
abstract:PURPOSE:To compare the prevalence of and risk factors for primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in urban and rural populations in the Andhra Pradesh Eye Disease Study. DESIGN:A population-based, cross-sectional study using a stratified, random, cluster, and systematic sampling st...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.11.006
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT). DESIGN:...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.01.042
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:We sought to determine whether genotype is associated with rate of growth of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD). DESIGN:Prospective analysis of participants in a randomized controlled clinical trial. PARTICIPANTS:We included 114 eyes of 114 participants in the Age-Rela...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2009.12.012
更新日期:2010-08-01 00:00:00