Does intravenous paracetamol administration affect body temperature in neonates?

Abstract:

INTRODUCTION:Intravenous paracetamol (acetaminophen) has recently been registered for treatment of pain in neonates but the pharmacodynamics, including effects on body temperature, have not been reported. METHODS:A pooled analysis on body temperature recordings in neonates exposed to intravenous paracetamol was performed. Body temperature was recorded by skin probe and registered before and every 2 h following initiation of single or repeated intravenous paracetamol administration (up to 48 h). Repeated measures ANOVA and paired analysis were used to quantify differences following paracetamol exposure. RESULTS:The pooled analysis was based on 99 neonates (median weight 2.7 (range 0.5-5.4) kg, median postmenstrual age 37 (range 27-50) weeks). Based on observations in 93 normothermic (<37.8°C) neonates and six neonates with fever, it was documented that paracetamol administration does not affect body temperature in normothermic patients. In neonates with fever, the median decrease (-0.8°C) is most prominent in the first 2 h (p<0.01) following paracetamol administration with subsequent further normalisation. CONCLUSIONS:Administration of intravenous paracetamol does not result in hypothermia in normothermic neonates. In those with fever, maximal temperature reduction is achieved within 2 h following paracetamol administration.

journal_name

Arch Dis Child

authors

Hopchet L,Kulo A,Rayyan M,Verbesselt R,Vanhole C,de Hoon JN,Allegaert K

doi

10.1136/adc.2010.203778

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

301-4

issue

3

eissn

0003-9888

issn

1468-2044

pii

adc.2010.203778

journal_volume

96

pub_type

杂志文章
  • Maternal insecurity and failure to thrive in Asian children.

    abstract::Four Asian babies were investigated because they failed to thrive. In all four cases the failure to thrive was a result of the mother's social isolation and inability to communicate, and to the father's refusal to accept that there was a problem in the family. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.3.369

    authors: Fenton TR,Bhat R,Davies A,West R

    更新日期:1989-03-01 00:00:00

  • Growth of primary school children: a validation of the 1990 references and their use in growth monitoring.

    abstract:AIMS:To determine whether the British 1990 growth charts are valid for cross sectional and longitudinal use in primary school children. METHODS:A total of 694 children aged 7-10 years from 10 Leeds primary schools were weighed and measured annually over three years by an expert auxologist. SD scores were calculated us...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.83.4.298

    authors: Rudolf MC,Cole TJ,Krom AJ,Sahota P,Walker J

    更新日期:2000-10-01 00:00:00

  • Serum cholecystokinin, basal acid secretion, and infantile pyloric stenosis.

    abstract::The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.10.773

    authors: Rogers IM,Drainer IK,Dougal AJ,Black J,Logan R

    更新日期:1979-10-01 00:00:00

  • Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.

    abstract:OBJECTIVE:Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce. METHODS:The effect of two different SNP (INSIG2: rs7566605, FTO: rs9939609) was analysed on the ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.147652

    authors: Reinehr T,Hinney A,Toschke AM,Hebebrand J

    更新日期:2009-12-01 00:00:00

  • Female genital mutilation: what every paediatrician should know.

    abstract::Female genital mutilation (FGM) is almost always performed on children and consequently paediatricians should have a central role in the detection and prevention of FGM. FGM has no health benefits and can cause lifelong damage to physical and psychological health. Extensive migration of FGM practising communities mean...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2014-307234

    authors: Creighton SM,Hodes D

    更新日期:2016-03-01 00:00:00

  • An objective study of acid reflux and cough in children using an ambulatory pHmetry-cough logger.

    abstract:OBJECTIVE:There are no objective ambulatory studies on the temporal relationship between reflux and cough in children. Commercial pHmetry loggers have slow capture rates (0.25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal association between cough and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.177733

    authors: Chang AB,Connor FL,Petsky HL,Eastburn MM,Lewindon PJ,Hall C,Wilson SJ,Katelaris PH

    更新日期:2011-05-01 00:00:00

  • Survival after balloon atrial septostomy for complete transposition of great arteries.

    abstract::Mortality before surgery must be taken into account when comparing the surgical mortality of atrial redirection procedures (Mustard's or Senning's operation) and the arterial switch operation for patients with complete transposition. This is because the switch operation is usually performed within the neonatal period ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.6.549

    authors: Mok Q,Darvell F,Mattos S,Smith T,Fayers P,Rigby ML,Shinebourne EA

    更新日期:1987-06-01 00:00:00

  • Evolution of pseudohypoparathyroidism: an informative family study.

    abstract::An adult woman with pseudopseudohypoparathyroidism had a child with normal calcium and parathyroid hormone concentrations and cyclic AMP response to injected parathyroid hormone in infancy. By 2.5 years he had features of pseudohypoparathyroidism with raised parathyroid hormone and 'flat' cyclic AMP response. This is ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.4.337

    authors: Barr DG,Stirling HF,Darling JA

    更新日期:1994-04-01 00:00:00

  • Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia.

    abstract::West, R. J., Lloyd, J. K., and Turner, W. M. L. (1975). Archives of Disease in Childhood, 50, 703. Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia. A syndrome comprising unusual facies, dry skin, acanthosis nigricans, thickened nails, hirsutism, dental precocity and dysplasia, a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.9.703

    authors: West RJ,Lloyd JK,Turner WM

    更新日期:1975-09-01 00:00:00

  • Importance of timing of risk factors for cerebral oedema during therapy for diabetic ketoacidosis.

    abstract::Cerebral oedema is the most common cause of mortality and morbidity during the first day of conventional treatment for diabetic ketoacidosis in paediatric patients. It is possible that therapy contributes to its development. Risk factors that predispose to cerebral oedema should lead to an expansion of the intracellul...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.2.170

    authors: Carlotti AP,Bohn D,Halperin ML

    更新日期:2003-02-01 00:00:00

  • Adenovirus type 8 conjunctivitis outbreak in a neonatal intensive care unit.

    abstract::An outbreak of adenovirus type 8 conjunctivitis occurred in seven premature infants who had undergone ophthalmological examination four to seven days previously. Three of the affected infants, treated with steroids because of bronchopulmonary dysplasia, showed systemic manifestations and deterioration of their respira...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.5_spec_no.610

    authors: Birenbaum E,Linder N,Varsano N,Azar R,Kuint J,Spierer A,Reichman B

    更新日期:1993-05-01 00:00:00

  • The natural history of Noonan syndrome: a long-term follow-up study.

    abstract:OBJECTIVE:To define better the adult phenotype and natural history of Noonan syndrome. DESIGN:A prospective observational study of a large cohort. RESULTS:Data are presented for 112 individuals with Noonan syndrome (mean age 25.3 (range 12-71) years), who were followed up for a mean of 12.02 years. Mutations in PTPN1...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.104547

    authors: Shaw AC,Kalidas K,Crosby AH,Jeffery S,Patton MA

    更新日期:2007-02-01 00:00:00

  • Early development of infants 1000 g or less at birth.

    abstract::In a 4-year period the neonatal survival rate for 26 infants weighing 501-750 g was 42% and for 81 infants weighing 751-1000 g it was 61%. All 59 surviving infants have been assessed at follow-up; 39 were at least 2 years old (corrected for prematurity) and data from the remaining 20 were derived from assessment at 1 ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.57.11.823

    authors: Orgill AA,Astbury J,Bajuk B,Yu VY

    更新日期:1982-11-01 00:00:00

  • Clinical and subclinical deficits at 8 years in a geographically defined cohort of low birthweight infants.

    abstract:OBJECTIVE:To determine the prevalence of subclinical deficits in cognitive and motor function in low birthweight infants. DESIGN:Children of birth weight < or = 2000 g born to mothers resident in Merseyside in 1980-1 assessed using the Wechsler Intelligence Scale for Children (WISC), the Neale analysis of reading abil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.4.264

    authors: Pharoah PO,Stevenson CJ,Cooke RW,Stevenson RC

    更新日期:1994-04-01 00:00:00

  • "Unresolving pneumonia" as the main manifestation of atypical Kawasaki disease.

    abstract::Two cases of atypical Kawasaki disease (KD) manifested as persistent lobar lung consolidation, prolonged fever, and active inflammatory laboratory markers unresponsive to antibiotic treatment are reported. One of the children developed a giant coronary aneurysm. Atypical KD should be considered in the differential dia...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.10.940

    authors: Uziel Y,Hashkes PJ,Kassem E,Gottesman G,Wolach B

    更新日期:2003-10-01 00:00:00

  • Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.

    abstract:BACKGROUND:The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often lim...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2020-318841

    authors: Penner J,Hernstadt H,Burns JE,Randell P,Lyall H

    更新日期:2021-02-01 00:00:00

  • Severe neonatal pertussis treated by salbutamol.

    abstract::Two neonates with severe culture proven pertussis were successfully treated with salbutamol 0.5 mg three times daily. There was a demonstrable decrease in the total number of coughing spasms, their mean duration and severity. In one baby this was shown by the transcutaneous oxygen tension measurements. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.6.600

    authors: Tam AY,Yeung CY

    更新日期:1986-06-01 00:00:00

  • Prevalence and risk factors for transmission of infection among children in household contact with adults having pulmonary tuberculosis.

    abstract:AIMS:To study the prevalence of tuberculosis infection among children in household contact with adults having pulmonary tuberculosis, and identify the possible risk factors. METHODS:Children under the age of 5 years who were in household contact with 200 consecutive adults with pulmonary tuberculosis underwent tubercu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.044255

    authors: Singh M,Mynak ML,Kumar L,Mathew JL,Jindal SK

    更新日期:2005-06-01 00:00:00

  • Protracted diarrhoea in infancy. Analysis of 82 cases with particular reference to diagnosis and management.

    abstract::Eighty-two cases of protracted diarrhoea in infancy presenting over a 6-year period have been analysed, with particular reference to diagnosis and management. The patients fell into 1 of 2 categories according to whether a specific diagnosis was established or not. A diagnosis (category 1) was established in 59 (72%),...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.8.597

    authors: Larcher VF,Shepherd R,Francis DE,Harries JT

    更新日期:1977-08-01 00:00:00

  • Non-cardiac benefits of human recombinant erythropoietin in end stage renal failure and anaemia.

    abstract::Recombinant human erythropoietin (r-HuEpo) is now available to correct the anaemia of end stage renal failure. The clinical consequences of increasing the haemoglobin concentration in children on dialysis are incompletely documented; a placebo controlled study is essential when assessing subjective changes, for exampl...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.69.5.580

    authors: Morris KP,Sharp J,Watson S,Coulthard MG

    更新日期:1993-11-01 00:00:00

  • Diarrhoea in jaundiced neonates treated with phototherapy: role of intestinal secretion.

    abstract::Thirty jaundiced neonates with diarrhoea who were being treated with phototherapy and 30 matched control infants were studied to try and find out the cause of the diarrhoea. Faecal osmolality and electrolyte concentrations were measured, which gave clear evidence that the diarrhoea arose from intestinal secretion. Rec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.8.1161

    authors: De Curtis M,Guandalini S,Fasano A,Saitta F,Ciccimarra F

    更新日期:1989-08-01 00:00:00

  • Infantile meningitis in England and Wales: a two year study.

    abstract::A two year prospective study identified 1922 cases of meningitis in children under 1 year of age. A further 201 cases were identified from other sources. The annual incidence of meningitis during the first year of life was 1.6/1000; during the first 28 days of life it was 0.32/1000, and among postneonatal infants it w...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.5.603

    authors: de Louvois J,Blackbourn J,Hurley R,Harvey D

    更新日期:1991-05-01 00:00:00

  • Haem arginate in acute hereditary coproporphyria.

    abstract::An 11 year old boy presented with severe acute hereditary coproporphyria. Despite supportive measures his condition deteriorated after admission. Haem arginate, started two days after presentation, produced appreciable inhibition of porphyrin precursor overproduction and clinical improvement. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.6.730

    authors: Manning DJ,Gray TA

    更新日期:1991-06-01 00:00:00

  • Elimination of pethidine and bupivacaine in the newborn.

    abstract::Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. B...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.8.638

    authors: Cooper LV,Stephen GW,Aggett PJ

    更新日期:1977-08-01 00:00:00

  • A systematic review of time to diagnosis in children and young adults with cancer.

    abstract:PURPOSE:It is often assumed that prolonged time to diagnosis (TTD) for cancer negatively influences overall survival and survivorship through advanced stage disease at diagnosis. This systematic review assesses existing early diagnosis research in childhood and young adult cancer and aims to identify whether a consensu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2012-303034

    authors: Lethaby CD,Picton S,Kinsey SE,Phillips R,van Laar M,Feltbower RG

    更新日期:2013-05-01 00:00:00

  • Pyrexia after diphtheria/tetanus/pertussis and diphtheria/tetanus vaccines.

    abstract::The temperatures of 587 children were taken before and after diphtheria/tetanus/pertussis (DTP) or diphtheria/tetanus (DT) vaccine. Only slight temperature increases were found but these were notably more frequent after plain than adsorbed DTP vaccine preparations and the frequency increased with each successive dose....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.11.921

    authors: Waight PA,Pollock TM,Miller E,Coleman EM

    更新日期:1983-11-01 00:00:00

  • Size at birth and plasma insulin-like growth factor-1 concentrations.

    abstract:OBJECTIVE:To test the hypothesis that reduced fetal growth leads to altered plasma insulin-like growth factor-1 (IGF-1) concentrations in childhood. DESIGN:A follow up study of 4 year old children whose birth weights were recorded, and of 7 year old children whose weight, length, head circumference, and placental weig...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.4.287

    authors: Fall CH,Pandit AN,Law CM,Yajnik CS,Clark PM,Breier B,Osmond C,Shiell AW,Gluckman PD,Barker DJ

    更新日期:1995-10-01 00:00:00

  • Reye's syndrome; diagnosis by muscle biopsy?

    abstract::Three children with Reye's syndrome are described. One child died, the second had mild and transient illness, and the third had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibres with fat microdroplets as shown by the oil red O stain and by electron microscopical exam...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.4.287

    authors: Shapira Y,Deckelbaum R,Statter M,Tennenbaum A,Aker M,Yarom R

    更新日期:1981-04-01 00:00:00

  • Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in London.

    abstract:OBJECTIVE:To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London. DESIGN AND SUBJECTS:Cross-sectional survey of attendees at a sample of registered child day...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2007.126359

    authors: Roche A,Heath PT,Sharland M,Strachan D,Breathnach A,Haigh J,Young Y

    更新日期:2007-12-01 00:00:00

  • Plasma amino acids in small preterm infants fed on human milk or formula.

    abstract::Plasma amino acids were measured in 35 preterm infants, of whom 11 weighed less than 1000 g and 24 weighed between 1000 g and 1500 g at the time of sampling. Repeat samples were obtained in 18 at least seven days later. Seventeen infants were fed with preterm formula milk and 18 with expressed maternal breast milk at ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.12.1257

    authors: Ventura V,Brooke OG

    更新日期:1987-12-01 00:00:00