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Trade-off between benefit and harm is crucial in health screening recommendations. Part I: general principles.

Abstract：

:Health screening is defined as the use of a test or a series of tests to detect unrecognized health risks or preclinical disease in apparently healthy populations to permit prevention and timely intervention. A health screening strategy consists of the sequence of a screening test, confirmatory test(s), and finally, treatment(s) for the condition detected. The potential benefits of health screening are easy to understand, but the huge potential for physical and psychological harm is less well recognized. Thus, health screening should only be recommended when five criteria are satisfied: (1) the burden of illness should be high, (2) the tests for screening and confirmation should be accurate, (3) early treatment (or prevention) must be more effective than late treatment, (4) the test(s) and treatment(s) must be safe, and (5) the cost of the screening strategy must be commensurate with potential benefit. Direct evidence from screening trials is subject to less bias. In some instances, indirect evidence may be acceptable, e.g., when the condition screened for is a risk factor for a disease rather than the disease itself.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Dans LF,Silvestre MA,Dans AL

doi

10.1016/j.jclinepi.2010.09.009

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

231-9

issue

3

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(10)00319-7

journal_volume

64

pub_type

杂志文章

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