abstract：OBJECTIVES:This study compares three major elements of evidence-based medicine (EBM) practices, namely evidence synthesis, clinical practice guidelines (CPGs), and real-world prescriptions in the United States, regarding antidepressant treatments of major depression over the past 3 decades. STUDY DESIGN AND SETTING:We...

journal_title：Journal of clinical epidemiology

authors： Luo Y,Ostinelli EG,Sahker E,Chaimani A,Kataoka Y,Ogawa Y,Cipriani A,Salanti G,Furukawa TA

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is considerable actual and potential waste in research. Using evidence-based research (EBR) can ensure the value of a new study. The aim of this article, the third in a series, is to describe an EBR approach to putting research results into context. STUDY DESIGN AND SETTING:EBR is the us...

journal_title：Journal of clinical epidemiology

authors： Lund H,Juhl CB,Nørgaard B,Draborg E,Henriksen M,Andreasen J,Christensen R,Nasser M,Ciliska D,Tugwell P,Clarke M,Blaine C,Martin J,Ban JW,Brunnhuber K,Robinson KA,Evidence-Based Research Network.

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:We aimed to generate evidence on patients' values and preferences to inform the development of the German national Evidence-based Anal Cancer Guideline. STUDY DESIGN AND SETTING:We developed a list of health outcomes based on a systematic search. We then asked anal cancer patients and experts of the guidelin...

journal_title：Journal of clinical epidemiology

authors： Werner RN,Gaskins M,Dressler C,Nast A,Schaefer C,Aigner F,Siegel R

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The massive growth in the publication of meta-analyses may cause redundancy and wasted efforts. We performed a metaepidemiologic study to evaluate the extent of potential redundancy in published meta-analyses in genetic epidemiology. STUDY DESIGN AND SETTING:Using a sample of 38 index meta-analyses of genet...

journal_title：Journal of clinical epidemiology

authors： Sigurdson MK,Khoury MJ,Ioannidis JPA

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:The objective of the study is to estimate the proportion of statistically significant survival improvements reported in randomized trials of cancer treatments that are also compatible with a clinically negligible benefit. STUDY DESIGN AND SETTING:This is a cross-sectional study of reports of randomized clin...

journal_title：Journal of clinical epidemiology

authors： Perneger TV,Brindel P,Combescure C,Gayet-Ageron A

更新日期：2020-11-01 00:00:00

abstract：:Core outcome sets (COSs) are agreed-on standardized sets of outcomes that should be minimally measured in all trials of a given disease. To enhance the uptake of COSs in trials, their generalizability should be increased by a change in the number and diversity of stakeholders involved in their development. Also, their...

journal_title：Journal of clinical epidemiology

authors： Chevance A,Tran VT,Ravaud P

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the coronavirus disease 2019 (COVID-19) pandemic. The number of registered trials related to COVID-19 is increasing by the day. The objective of this study was to describe ...

journal_title：Journal of clinical epidemiology

authors： Nasrallah AA,Farran SH,Nasrallah ZA,Chahrour MA,Salhab HA,Fares MY,Khachfe HH,Akl EA

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The objective of the study is to examine the time from publication of the protocol for a Cochrane review to publication of the Cochrane review for the entire Cochrane Database of Systematic Reviews (CDSR). STUDY DESIGN AND SETTINGS:Cochrane reviews from the CDSR published between 1995 and 2019 were assessed...

journal_title：Journal of clinical epidemiology

authors： Andersen MZ,Gülen S,Fonnes S,Andresen K,Rosenberg J

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Network meta-analysis (NMA) may produce more precise estimates of treatment effects than pairwise meta-analysis. We examined the relative contribution of network paths of different lengths to estimates of treatment effects. STUDY DESIGN AND SETTING:We analyzed 213 published NMAs. We categorized network shap...

journal_title：Journal of clinical epidemiology

authors： Papakonstantinou T,Nikolakopoulou A,Egger M,Salanti G

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:This study investigated trial consultations to identify whether and to what extent discussions of retention are present. STUDY DESIGN AND SETTING:This embedded mixed-methods study design included a purposive sample of audio-recorded trial consultations obtained from four sites of a large multicenter UK-base...

journal_title：Journal of clinical epidemiology

authors： Tunji-Ajayi P,Duncan EM,Gillies K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The objective of the study was to identify determinants of external validity of prognostic models. STUDY DESIGN AND SETTING:We systematically searched for studies reporting prognostic models of heart failure (HF) and examined their performance for predicting 30-day death in a cohort of consecutive 3,452 acu...

journal_title：Journal of clinical epidemiology

authors： Iwakami N,Nagai T,Furukawa TA,Tajika A,Onishi A,Nishimura K,Ogata S,Nakai M,Takegami M,Nakano H,Kawasaki Y,Alba AC,Guyatt GH,Shiraishi Y,Kohsaka S,Kohno T,Goda A,Mizuno A,Yoshikawa T,Anzai T,investigators for the

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to reanalyze and reinterpret data obtained in Paracetamol in Acute Low Back Pain (PACE), the first large randomized controlled trial evaluating the efficacy of paracetamol in acute low back pain, to assess the inferential reproducibility of the original conclusions. STUDY DESIGN AN...

journal_title：Journal of clinical epidemiology

authors： Schreijenberg M,Chiarotto A,Mauff KAL,Lin CC,Maher CG,Koes BW

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to identify the range of issues labeled as "non-financial conflicts of interest" in biomedicine, articulate the associated concerns, and analyze the implications of defining these issues as conflicts of interest. STUDY DESIGN AND SETTING:This was a qualitative study, triangulating d...

journal_title：Journal of clinical epidemiology

authors： Grundy Q,Mayes C,Holloway K,Mazzarello S,Thombs BD,Bero L

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Our study aimed to systematically assess and report the methodological quality used in epidemiological systematic reviews (SRs) and meta-analysis (MA) of pathogen genotypes/genogroups. STUDY DESIGN AND SETTING:Nine electronic databases and manual search of reference lists were used to identify relevant stud...

journal_title：Journal of clinical epidemiology

authors： Tran L,Nhu Y M,Le Ba Nghia T,Hendam A,Vuong NL,Alzalal E,Sayed AM,Hussain MM,Sharma A,Tieu T,Mathenge PG,Hirayama K,Alexander N,Huy NT

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate the effect of number of studies in a meta-analysis on the detection of publication bias using P value-driven methods. METHODS:The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests to have asymmetry suggestive of publication bias wer...

journal_title：Journal of clinical epidemiology

authors： Furuya-Kanamori L,Xu C,Lin L,Doan T,Chu H,Thalib L,Doi SAR

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To provide GRADE guidance on how to prepare Summary of Findings tables and Evidence Profiles for time-to-event outcomes with a focus on the calculation of the corresponding absolute effect estimates. STUDY DESIGN AND SETTING:This guidance was justified by a research project identifying frequent errors and l...

journal_title：Journal of clinical epidemiology

authors： Skoetz N,Goldkuhle M,van Dalen EC,Akl EA,Trivella M,Mustafa RA,Nowak A,Dahm P,Schünemann H,Bender R,GRADE Working Group.

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to assess the completeness of reporting of methods in overviews. STUDY DESIGN AND SETTING:Assessment of the adequacy of reporting of methods in a random sample of 50 overviews was based on a published framework of methods for conducting overviews. Descriptive summary statistics were...

journal_title：Journal of clinical epidemiology

authors： Lunny C,Brennan SE,Reid J,McDonald S,McKenzie JE

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To evaluate how estimated treatment effects agree between nonrandomized studies using causal modeling with marginal structural models (MSM-studies) and randomized trials (RCTs). STUDY DESIGN:Meta-epidemiological study. SETTING:MSM-studies providing effect estimates on any healthcare outcome of any treatmen...

journal_title：Journal of clinical epidemiology

authors： Ewald H,Ioannidis JPA,Ladanie A,Mc Cord K,Bucher HC,Hemkens LG

更新日期：2020-02-01 00:00:00

abstract：:In this project, we set out to identify ways to increase the uptake of core outcome sets in clinical research. In doing so, we uncovered a growing recognition, across many different health care sectors, of the need for common, relevant outcomes to improve the quality of decision-making. This has led to a plethora of p...

journal_title：Journal of clinical epidemiology

authors： Moloney RM,Messner DA,Tunis SR

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to assess if there is evidence of publication bias in prognostic accuracy studies of middle cerebral artery (MCA) or cerebroplacental ratio (CPR) for adverse perinatal outcome. STUDY DESIGN AND SETTING:We queried PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov an...

journal_title：Journal of clinical epidemiology

authors： Vollgraff Heidweiller-Schreurs CA,Korevaar DA,Mol BWJ,Bax CJ,de Groot CJM,de Boer MA,Bossuyt PMM

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:The objective of the study was to identify factors affecting the use of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement, specifically authors' attitudes toward and experiences with it. STUDY DESIGN AND SETTING:An online survey was distributed to authors of observa...

journal_title：Journal of clinical epidemiology

authors： Sharp MK,Bertizzolo L,Rius R,Wager E,Gómez G,Hren D

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To demonstrate how decision analytic models (DAMs) can be used to quantify impact of using a (diagnostic or prognostic) prediction model in clinical practice and provide general guidance on how to perform such assessments. STUDY DESIGN AND SETTING:A DAM was developed to assess the impact of using the HEART s...

journal_title：Journal of clinical epidemiology

authors： Jenniskens K,Lagerweij GR,Naaktgeboren CA,Hooft L,Moons KGM,Poldervaart JM,Koffijberg H,Reitsma JB

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Core outcome set (COS) development often begins with a systematic review to identify outcomes. Reviews frequently show heterogeneity in numbers of outcomes reported across trials. Contributing to this is a lack of a uniform definition for an outcome. This study proposes a first working definition for a uniqu...

journal_title：Journal of clinical epidemiology

authors： Young AE,Brookes ST,Avery KNL,Davies A,Metcalfe C,Blazeby JM

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Timely and comprehensive reporting of clinical trial results builds the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs). STUDY DESIGN AND SETT...

journal_title：Journal of clinical epidemiology

authors： Wieschowski S,Riedel N,Wollmann K,Kahrass H,Müller-Ohlraun S,Schürmann C,Kelley S,Kszuk U,Siegerink B,Dirnagl U,Meerpohl J,Strech D

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Novel cancer therapies are often approved with evidence from a single pivotal trial alone. There are concerns about the credibility of this evidence. Higher validity may be indicated by five methodological and statistical characteristics of pivotal trial evidence that were described by the U.S....

journal_title：Journal of clinical epidemiology

authors： Ladanie A,Speich B,Briel M,Sclafani F,Bucher HC,Agarwal A,Ioannidis JPA,Pereira TV,Kasenda B,Hemkens LG

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The Osteoarthritis Questionnaire (OA-Quest) is a new measure of individual burden of osteoarthritis, composing seven brief (4-11 items; total 42 items), independent scales. This study describes the psychometric evaluation of the OA-Quest. Specifically, temporal stability, convergent and discriminant validity...

journal_title：Journal of clinical epidemiology

authors： Busija L,Osborne RH,Tatangelo G,Niutta S,Buchbinder R

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to study if randomized controlled trials (RCTs) in rehabilitation (a field where complex interventions prevail) published in main journals include all the details needed to replicate the intervention in clinical practice (clinical replicability). STUDY DESIGN AND SETTING:Forty...

journal_title：Journal of clinical epidemiology

authors： Negrini S,Arienti C,Pollet J,Engkasan JP,Francisco GE,Frontera WR,Galeri S,Gworys K,Kujawa J,Mazlan M,Rathore FA,Schillebeeckx F,Kiekens C,REREP study participants.

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to examine the effectiveness of education and training interventions on recruitment to randomized and non-randomized trials. STUDY DESIGN AND SETTING:A systematic review of the effectiveness of education and training interventions for recruiters to trials. The review included ...

journal_title：Journal of clinical epidemiology

authors： Delaney H,Devane D,Hunter A,Hennessy M,Parker A,Murphy L,Cronin P,Smith V

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to analyze adequacy of judgments about risk of bias (RoB) for blinding of participants and personnel (performance bias) in Cochrane systematic reviews of randomized controlled trials (RCTs). STUDY DESIGN AND SETTING:We extracted judgments and supporting comments for performan...

journal_title：Journal of clinical epidemiology

authors： Barcot O,Boric M,Dosenovic S,Poklepovic Pericic T,Cavar M,Puljak L

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to describe the research environment of scientists in health services and policy research in China. STUDY DESIGN:Study was conducted during the 2016 Westlake Youth Forum with grantees of China Medical Board and key informants. Mixed methods used anonymous, survey of grantees, semist...

journal_title：Journal of clinical epidemiology

authors： Gao M,Zhou L,Tang K,Liang MH

更新日期：2019-08-01 00:00:00

abstract：:A truly international and systematic review (SR) identifies and synthesizes relevant evidence regardless of the geographical provenance or language of publication. Despite recommendations, international SRs continue to exclude papers in languages other than English (LOE) at searching, screening, and analysis phases ei...

journal_title：Journal of clinical epidemiology

authors： Walpole SC

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Meta-analyses inform clinical practice by summarizing treatment effect estimates based on results from several trials. However, the statistical significance of a meta-analysis (i.e., whether the pooled treatment effect is statistically significant or not) may rely on the outcome of only a few patients from s...

journal_title：Journal of clinical epidemiology

authors： Atal I,Porcher R,Boutron I,Ravaud P

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:To evaluate whether noninferiority trials are designed to adequately preserve the historical treatment effect of their active comparators. STUDY DESIGN AND SETTING:We reviewed 162 noninferiority trials published in high-impact medical journals. We assessed whether trials were designed to ensure that interve...

journal_title：Journal of clinical epidemiology

authors： Tsui M,Rehal S,Jairath V,Kahan BC

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The determinants of guideline panels' recommendations remain uncertain. The objective of this study was to investigate factors considered by members of 8 panels convened by the American Society of Hematology (ASH) to develop guidelines using Grading of Recommendations Assessment, Development, ...

journal_title：Journal of clinical epidemiology

authors： Djulbegovic B,Reljic T,Elqayam S,Cuker A,Hozo I,Zhou Q,Li SA,Alexander P,Nieuwlaat R,Wiercioch W,Schünemann H,Guyatt G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To simulate possible changes in systematic review results if rapid review methods were used. STUDY DESIGN AND SETTING:We recalculated meta-analyses for binary primary outcomes in Cochrane systematic reviews, simulating rapid review methods. We simulated searching only PubMed, excluding older articles (5, 7, ...

journal_title：Journal of clinical epidemiology

authors： Marshall IJ,Marshall R,Wallace BC,Brassey J,Thomas J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Evidence-based guidelines recommend adjuvant chemotherapy in early stage breast cancer whenever treatment benefit is considered sufficient to outweigh the associated risks. However, many groups of patients were either excluded from or underrepresented in the clinical trials that form the evidence base for thi...

journal_title：Journal of clinical epidemiology

authors： Gray E,Marti J,Brewster DH,Wyatt JC,Piaget-Rossel R,Hall PS

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR)-based absolute effects in summary of findings (SoF) tables have been correctly calculated and reported. STUDY DESIGN AND SETTING:We identified all Cochrane cancer intervention reviews that reported an HR for at least one outcome and p...

journal_title：Journal of clinical epidemiology

authors： Skoetz N,Goldkuhle M,Weigl A,Dwan K,Labonté V,Dahm P,Meerpohl JJ,Djulbegovic B,van Dalen EC

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Meta-analyses sometimes summarize results in the presence of substantial unexplained between-study heterogeneity. As GRADE criteria highlight, unexplained heterogeneity reduces certainty in the evidence, resulting in limited confidence in average effect estimates. The aim of this paper is to p...

journal_title：Journal of clinical epidemiology

authors： Saad A,Yekutieli D,Lev-Ran S,Gross R,Guyatt G

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The aim of article was to assess the risk for random errors in outcomes graded as high certainty of evidence (CoE). STUDY DESIGN AND SETTING:We randomly selected 100 Cochrane reviews with dichotomous outcomes rated as high CoE using Grading of Recommendations Assessment, Development, and Evaluation. To dete...

journal_title：Journal of clinical epidemiology

authors： Gartlehner G,Nussbaumer-Streit B,Wagner G,Patel S,Swinson-Evans T,Dobrescu A,Gluud C

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:To identify, describe, and map contemporary nutrition guidelines (NGs) from reviews that used the Appraisal of Guidelines, Research and Evaluation (AGREE) tool. STUDY DESIGN AND SETTING:We performed an overview of reviews that systematically assessed the quality of NGs using the AGREE tool. We searched MEDL...

journal_title：Journal of clinical epidemiology

authors： Rabassa M,Garcia-Ribera Ruiz S,Solà I,Pardo-Hernandez H,Alonso-Coello P,Martínez García L

更新日期：2018-12-01 00:00:00