Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.

Abstract:

OBJECTIVES:Breast-fed C-allele carriers of the rs174575 single nucleotide polymorphism in the fatty acyl desaturase 2 (FADS2) gene have been reported to show a 6.4 to 7 IQ point advantage over formula-fed C-allele carriers, with no effect of breast-feeding in GG carriers. An Australian sample was examined to determine if an interaction between breast-feeding and the rs174575 single nucleotide polymorphism had any effect on IQ. METHOD:This hypothesis was tested in more than 700 families of adolescent twins assessed for IQ and breast-feeding, birth weight, and FADS2 polymorphisms, and parental socioeconomic status and education, and maternal FADS2 status. RESULTS:No significant evidence for a moderating effect on IQ of rs174575 C-carrier status and breast-feeding was found, and there no effects of maternal FADS2 status on offspring IQ. In addition, no main effects of any FADS2 polymorphisms on IQ were found when the genotype was kept as two-homozygote and one-heterozygote categories and indeed no evidence for effects of breast-feeding on IQ scores after controlling for parental socioeconomic status and education. The investigation was extended to two additional FADS2 polymorphisms (rs1535 and rs174583), but again, although these polymorphisms code alleles affecting fatty acid metabolism, no main or interaction effects were found on IQ. CONCLUSION:These results support the view that apparent effects of breast-feeding on IQ reflect differential likelihood of breast-feeding as a function of parental education and did not support the predicted interaction effect of FADS2 and breast-feeding on IQ.

authors

Martin NW,Benyamin B,Hansell NK,Montgomery GW,Martin NG,Wright MJ,Bates TC

doi

10.1016/j.jaac.2010.10.010

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

55-62.e4

issue

1

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(10)00787-2

journal_volume

50

pub_type

杂志文章
  • Applicability of personality disorder criteria to hospitalized adolescents: evaluation of internal consistency and criterion overlap.

    abstract:OBJECTIVE:The authors examined the applicability of personality disorder criteria to adolescent inpatients by evaluating internal consistency and criterion overlap. METHOD:Thirty-eight adolescents and 28 adults were assessed with the Personality Disorder Examination. Within-category cohesiveness (internal consistency)...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-199902000-00020

    authors: Becker DF,Grilo CM,Morey LC,Walker ML,Edell WS,McGlashan TH

    更新日期:1999-02-01 00:00:00

  • Sleep patterns in preschool-age children with autism, developmental delay, and typical development.

    abstract:OBJECTIVE:A prominent noncore symptom of autistic disorder is disturbed sleep, but relatively few studies have investigated this symptom. METHOD:A multimethod approach assessed the quantity and quality of sleep in 194 children (68 with autism [AUT], 57 with developmental delay without autism [DD], 69 with typical deve...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.ObO13e3181799f7c

    authors: Goodlin-Jones BL,Tang K,Liu J,Anders TF

    更新日期:2008-08-01 00:00:00

  • Children's mental health service needs and utilization patterns in an urban community: an epidemiological assessment.

    abstract::To assess children's mental health service needs and utilization patterns for a state planning effort, a cross-sectional survey that sampled 822 children aged 6 to 11 of a metropolitan center was conducted. When reports of parents and teachers were combined, 38.5% of children were screened to be at risk of psychiatric...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199209000-00025

    authors: Zahner GE,Pawelkiewicz W,DeFrancesco JJ,Adnopoz J

    更新日期:1992-09-01 00:00:00

  • Sex Differences in the Relationship Between Conduct Disorder and Cortical Structure in Adolescents.

    abstract:OBJECTIVE:Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such s...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jaac.2017.05.015

    authors: Smaragdi A,Cornwell H,Toschi N,Riccelli R,Gonzalez-Madruga K,Wells A,Clanton R,Baker R,Rogers J,Martin-Key N,Puzzo I,Batchelor M,Sidlauskaite J,Bernhard A,Martinelli A,Kohls G,Konrad K,Baumann S,Raschle N,Stadler C

    更新日期:2017-08-01 00:00:00

  • Editorial: Could a Treatment for Youth Anxiety Specifically Prevent the Emergence of Depression 2 Years Later?

    abstract::The comorbidity of depression and anxiety is a major global health problem. A 2015 report examining response patterns of 74,000 adults across 27 World Mental Health surveys in 24 countries showed a very high comorbidity between a diagnosis of lifetime DSM-IV1 major depressive disorder and a diagnosis of any anxiety di...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2019.01.003

    authors: Glowinski AL

    更新日期:2019-03-01 00:00:00

  • Dr. Loades and Prof. Reynolds Reply.

    abstract::It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and adolescents is associated with increased depression and anxiety symptoms both cross-sectionally and long...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,信件

    doi:10.1016/j.jaac.2020.08.437

    authors: Loades ME,Reynolds S

    更新日期:2021-01-01 00:00:00

  • Effects of risperidone and parent training on adaptive functioning in children with pervasive developmental disorders and serious behavioral problems.

    abstract:OBJECTIVE:Children with Pervasive Developmental Disorders (PDDs) have social interaction deficits, delayed communication, and repetitive behaviors as well as impairments in adaptive functioning. Many children actually show a decline in adaptive skills compared with age mates over time. METHOD:This 24-week, three-site,...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jaac.2011.11.010

    authors: Scahill L,McDougle CJ,Aman MG,Johnson C,Handen B,Bearss K,Dziura J,Butter E,Swiezy NG,Arnold LE,Stigler KA,Sukhodolsky DD,Lecavalier L,Pozdol SL,Nikolov R,Hollway JA,Korzekwa P,Gavaletz A,Kohn AE,Koenig K,Grinnon

    更新日期:2012-02-01 00:00:00

  • Is adolescent-onset first-episode psychosis different from adult onset?

    abstract:OBJECTIVE:To examine whether first-episode psychosis patients with onset during adolescence (ages 15-18) differ significantly from those with young-adult onset (ages 19-30). METHOD:Consecutive patients presenting with first-episode psychosis (N = 242) were assessed for demographic and illness characteristics such as d...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000164591.55942.ea

    authors: Ballageer T,Malla A,Manchanda R,Takhar J,Haricharan R

    更新日期:2005-08-01 00:00:00

  • Influence of race on diagnosis in adolescent psychiatric inpatients.

    abstract:OBJECTIVE:To examine racial differences in 352 psychiatric inpatients, aged 12 to 18 years, at a state hospital facility that accepted admissions from throughout South Carolina. These were all the adolescent admissions during an entire calendar year (1988). There were 101 African-American and 251 white subjects. METHO...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199501000-00016

    authors: Kilgus MD,Pumariega AJ,Cuffe SP

    更新日期:1995-01-01 00:00:00

  • CBCL clinical scales discriminate prepubertal children with structured interview-derived diagnosis of mania from those with ADHD.

    abstract:OBJECTIVE:To evaluate the discriminative ability of the Child Behavior Checklist (CBCL) to identify children with structured interview-derived diagnosis of bipolar disorder. METHOD:We evaluated the convergence of CBCL scales with the diagnosis of mania in 31 children with mania, 120 children with attention-deficit hyp...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:

    authors: Biederman J,Wozniak J,Kiely K,Ablon S,Faraone S,Mick E,Mundy E,Kraus I

    更新日期:1995-04-01 00:00:00

  • Findings from the Pittsburgh Youth Study: cognitive impulsivity and intelligence as predictors of the age-crime curve.

    abstract:OBJECTIVE:This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later off...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaac.2012.08.019

    authors: Loeber R,Menting B,Lynam DR,Moffitt TE,Stouthamer-Loeber M,Stallings R,Farrington DP,Pardini D

    更新日期:2012-11-01 00:00:00

  • Psychopathology and health care use among preschool children: a retrospective analysis.

    abstract:OBJECTIVE:To examine the relationship between psychopathology and health care utilization beginning in the preschool (ages 2 to 5) years. METHOD:Five hundred ten preschool children were enrolled through 68 primary care physicians. The test battery used for diagnoses included the Child Behavior Checklist, a development...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199803000-00010

    authors: Lavigne JV,Binns HJ,Arend R,Rosenbaum D,Christoffel KK,Hayford JR,Gibbons RD

    更新日期:1998-03-01 00:00:00

  • Family discord, parental depression, and psychopathology in offspring: 20-year follow-up.

    abstract:OBJECTIVE:To determine the independent effects of parental depression and family discord on offspring psychopathology among children at high and low risk of depression. METHOD:Family discord factors were assessed when subjects were approximately 17 years old, and offspring diagnoses were assessed about 20 years later....

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000198592.23078.8d

    authors: Pilowsky DJ,Wickramaratne P,Nomura Y,Weissman MM

    更新日期:2006-04-01 00:00:00

  • Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children.

    abstract:OBJECTIVE:To investigate systematically the overlap between mania and conduct disorder (CD) in a sample of consecutively referred youths. It was hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the 2 disorders would have correlates of both. METHOD:Subjects wer...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199904000-00021

    authors: Biederman J,Faraone SV,Chu MP,Wozniak J

    更新日期:1999-04-01 00:00:00

  • Long-term attention problems in children with traumatic brain injury.

    abstract:OBJECTIVE:To examine long-term attention problems and their cognitive correlates after childhood traumatic brain injury (TBI). METHOD:Data were drawn from a prospective, longitudinal study conducted between 1992 and 2002. Participants included 41 children with severe TBI, 41 with moderate TBI, and 50 with orthopedic i...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.chi.0000159947.50523.64

    authors: Yeates KO,Armstrong K,Janusz J,Taylor HG,Wade S,Stancin T,Drotar D

    更新日期:2005-06-01 00:00:00

  • Depression in substance-dependent delinquents.

    abstract:OBJECTIVE:Depression often is comorbid with conduct disorder. The purpose of this study is to assess whether, among youths with conduct disorder, those with depression differ in other ways from those without depression. METHOD:Ninety-nine delinquent boys (aged 13 through 19 years) were evaluated with the Diagnostic In...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199506000-00017

    authors: Riggs PD,Baker S,Mikulich SK,Young SE,Crowley TJ

    更新日期:1995-06-01 00:00:00

  • Neuropsychiatric "Comorbidity" as Causal Influence in Autism.

    abstract::Behavioral comorbidity is the rule rather than the exception in autism spectrum disorder (ASD), and the co-occurrence of autistic traits with subclinical manifestations of other psychiatric syndromes (eg, anxiety, developmental coordination disorder) extends to the general population, where there is strong evidence fo...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 社论

    doi:10.1016/j.jaac.2019.07.008

    authors: Hawks ZW,Constantino JN

    更新日期:2020-02-01 00:00:00

  • Psychiatric comorbidity and the 16-month trajectory of substance-abusing and substance-dependent juvenile offenders.

    abstract:OBJECTIVES:To examine the concurrent correlates of internalizing and externalizing disorders among substance-abusing and substance-dependent juvenile offenders and to determine the association between psychiatric comorbidity and psychosocial functioning of the youths 16 months later. METHOD:Participants were 118 juven...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199909000-00015

    authors: Randall J,Henggeler SW,Pickrel SG,Brondino MJ

    更新日期:1999-09-01 00:00:00

  • Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome.

    abstract:OBJECTIVE:To investigate whether eye-gaze avoidance, a striking phenotypic feature in fragile X syndrome (FXS), is associated with high levels of "hyperarousal" during social interactions with others. To date, almost all studies in this area have been confounded by inclusion of task demands in addition to social demand...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.0b013e318195bd15

    authors: Hall SS,Lightbody AA,Huffman LC,Lazzeroni LC,Reiss AL

    更新日期:2009-03-01 00:00:00

  • Identity, Conformity, and Nonconformity: A Closer Look.

    abstract::As clinicians, we have been vigilant to screen for underlying psychopathology in children and adolescents who meet criteria for gender dysphoria (GD) based on the risk these individuals have for developing externalizing and/or internalizing disorders, likely driven by a stigmatizing society. However, we have not paid ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2018.05.001

    authors: Daniolos PT

    更新日期:2018-07-01 00:00:00

  • Desipramine clearance in children and adolescents: absence of effect of development and gender.

    abstract:OBJECTIVE:To examine the influence of development and gender on the pharmacokinetics of desipramine (DMI) in the pediatric population. METHOD:DMI pharmacokinetic parameters were calculated from 407 routinely drawn, dose- and weight-normalized serum concentrations in 173 youths receiving DMI (90 children, 83 adolescent...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199901000-00023

    authors: Cohen LG,Biederman J,Wilens TE,Spencer TJ,Mick E,Faraone SV,Prince J,Flood JG

    更新日期:1999-01-01 00:00:00

  • Parsing heterogeneity in autism spectrum disorders: visual scanning of dynamic social scenes in school-aged children.

    abstract:OBJECTIVE:To examine patterns of variability in social visual engagement and their relationship to standardized measures of social disability in a heterogeneous sample of school-aged children with autism spectrum disorders (ASD). METHOD:Eye-tracking measures of visual fixation during free-viewing of dynamic social sce...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2011.12.017

    authors: Rice K,Moriuchi JM,Jones W,Klin A

    更新日期:2012-03-01 00:00:00

  • Dialectical Behavior Therapy Compared With Enhanced Usual Care for Adolescents With Repeated Suicidal and Self-Harming Behavior: Outcomes Over a One-Year Follow-Up.

    abstract:OBJECTIVE:We conducted a 1-year prospective follow-up study of posttreatment clinical outcomes in adolescents with recent and repetitive self-harm who had been randomly allocated to receive 19 weeks of either dialectical behavior therapy adapted for adolescents (DBT-A) or enhanced usual care (EUC) at community child an...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaac.2016.01.005

    authors: Mehlum L,Ramberg M,Tørmoen AJ,Haga E,Diep LM,Stanley BH,Miller AL,Sund AM,Grøholt B

    更新日期:2016-04-01 00:00:00

  • Salivary cortisol, personality, and aggressive behavior in adolescent boys: a 5-year longitudinal study.

    abstract:OBJECTIVE:The present investigation tested the hypothesis that low resting salivary cortisol concentration in preadolescent boys would be associated with aggressive behavior later in adolescence. Second, it tested whether personality traits would mediate this relation. METHOD:Resting salivary cortisol concentrations f...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000070246.24125.6D

    authors: Shoal GD,Giancola PR,Kirillova GP

    更新日期:2003-09-01 00:00:00

  • School-based treatment for anxious african-american adolescents: a controlled pilot study.

    abstract:OBJECTIVE:To evaluate the feasibility and effectiveness of a school-based group cognitive-behavioral treatment (CBT) for anxiety disorders with African-American adolescents. METHOD:Twelve adolescents (mean age = 15.6 years) with anxiety disorders were randomly assigned to CBT (n = 6) or a group attention-support contr...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200207000-00007

    authors: Ginsburg GS,Drake KL

    更新日期:2002-07-01 00:00:00

  • Perceptions of P.R.N. psychotropic medications by hospitalized child and adolescent recipients.

    abstract:OBJECTIVE:To understand patient perceptions of p.r.n. medication for agitation used in institutional settings. METHOD:A questionnaire was administered to child and adolescent psychiatric inpatients within 12 hours of their receiving p.r.n. medication for agitation and repeated 4 hours later. Research staff completed a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000046817.95464.A6

    authors: Petti TA,Stigler KA,Gardner-Haycox J,Dumlao S

    更新日期:2003-04-01 00:00:00

  • Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms.

    abstract:OBJECTIVE:This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). METHOD:A total of 66 siblings of patients with COS were assessed for symptoms of schizop...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2015.11.008

    authors: Watsky RE,Pollard KL,Greenstein D,Shora L,Dillard-Broadnax D,Gochman P,Clasen LS,Berman RA,Rapoport JL,Gogtay N,Ordóñez AE

    更新日期:2016-02-01 00:00:00

  • Autistic Traits and Suicidal Thoughts, Plans, and Self-Harm in Late Adolescence: Population-Based Cohort Study.

    abstract:OBJECTIVE:To examine the hypothesis that autism spectrum disorders (ASD) diagnosis and traits in childhood are associated with suicidal thoughts, plans and self-harm at 16 years, and that any observed associations are explained by depression at 12 years. METHOD:We examined associations between ASD diagnosis and 4 dich...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2018.01.023

    authors: Culpin I,Mars B,Pearson RM,Golding J,Heron J,Bubak I,Carpenter P,Magnusson C,Gunnell D,Rai D

    更新日期:2018-05-01 00:00:00

  • Depressive disorders in maltreated children.

    abstract::This study examined the prevalence of depressive disorders in a sample of 56 7- to 12-year-old maltreated children. Overall, 18% of the sample met the diagnostic criteria for major depression, and 25% met the criteria for dysthymia, with the majority of the children who met the criteria for major depression also meeti...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199103000-00014

    authors: Kaufman J

    更新日期:1991-03-01 00:00:00

  • Mania associated with fluoxetine treatment in adolescents.

    abstract::Fluoxetine, a selective serotonin reuptake inhibitor, is gaining increased acceptance in the treatment of adolescent depression. Generally safe and well tolerated by adults, fluoxetine has been reported to induce mania. The cases of five depressed adolescents, 14-16 years of age, who developed mania during pharmacothe...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199203000-00015

    authors: Venkataraman S,Naylor MW,King CA

    更新日期:1992-03-01 00:00:00