Mania associated with fluoxetine treatment in adolescents.

Abstract:

:Fluoxetine, a selective serotonin reuptake inhibitor, is gaining increased acceptance in the treatment of adolescent depression. Generally safe and well tolerated by adults, fluoxetine has been reported to induce mania. The cases of five depressed adolescents, 14-16 years of age, who developed mania during pharmacotherapy with fluoxetine, are reported here. Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder. Further study is needed to determine the optimal dosage and to identify risk factors that increase individual vulnerability to fluoxetine induced mania in adolescents.

authors

Venkataraman S,Naylor MW,King CA

doi

10.1097/00004583-199203000-00015

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

276-81

issue

2

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)64451-8

journal_volume

31

pub_type

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